PubRank

Goutham Narla

Author PubWeight™ 45.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma. Hepatology 2004 2.29
2 The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. Gastroenterology 2008 2.04
3 Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. J Hepatol 2006 1.98
4 Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet 2003 1.86
5 Krüppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest 2015 1.72
6 Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Gastroenterology 2004 1.59
7 Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. Cancer Res 2004 1.57
8 KLF6-SV1 drives breast cancer metastasis and is associated with poor survival. Sci Transl Med 2013 1.53
9 Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination. Clin Cancer Res 2006 1.51
10 Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J Biol Chem 2005 1.46
11 Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma. Gastroenterology 2008 1.21
12 Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. J Biol Chem 2012 1.21
13 Ribosomal protein S19 expression during erythroid differentiation. Blood 2002 1.20
14 Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation. Cancer Res 2005 1.20
15 Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma. Int J Cancer 2007 1.17
16 The role of KLF6 and its splice variants in cancer therapy. Drug Resist Updat 2008 1.13
17 A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response. Cancer Res 2008 1.12
18 Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization. J Biol Chem 2014 1.07
19 Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. Hepatology 2011 1.07
20 Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response. J Clin Invest 2012 1.04
21 Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. Endocrinology 2004 1.03
22 Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. Oncogene 2004 1.02
23 KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model. Cancer Res 2009 1.00
24 Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells. Int J Cancer 2009 0.99
25 Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression. Dig Dis Sci 2010 0.93
26 KLF6 degradation after apoptotic DNA damage. FEBS Lett 2006 0.93
27 Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer. Eur J Cancer 2008 0.93
28 TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction. Biochem J 2009 0.92
29 Lung adenocarcinoma: lessons in translation from bench to bedside. Mt Sinai J Med 2010 0.90
30 Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma. Lung Cancer 2009 0.89
31 Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner. Endocrinology 2008 0.88
32 KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma. Int J Cancer 2007 0.86
33 Functional role of the KLF6 tumour suppressor gene in gastric cancer. Eur J Cancer 2008 0.85
34 Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing. Hepatology 2012 0.85
35 Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene. FEBS Lett 2010 0.83
36 KLF6 is one transcription factor involved in regulating acid ceramidase gene expression. Biochim Biophys Acta 2006 0.83
37 Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones. Carcinogenesis 2005 0.82
38 Increased expression of the oncogenic KLF6-SV1 transcript in human glioblastoma. Clin Chem Lab Med 2010 0.77
39 Emerging roles of Kruppel-like factor 6 and Kruppel-like factor 6 splice variant 1 in ovarian cancer progression and treatment. Mt Sinai J Med 2009 0.77