Published in Brain Res on December 28, 2006
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11
Interleukin-1 and interleukin-1 antagonism. Blood (1991) 7.67
Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. J Biol Chem (1988) 2.46
Fever and hypothermia in systemic inflammation: recent discoveries and revisions. Front Biosci (2005) 1.75
Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J Immunol (1987) 1.73
Opioids, opioid receptors, and the immune response. Drug Alcohol Depend (2001) 1.72
New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol (2003) 1.54
IL-1 beta is secreted by activated murine macrophages as biologically inactive precursor. J Immunol (1990) 1.38
Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection. J Immunol (2005) 1.35
Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. Biochem J (1996) 1.30
Stress-induced increases in hypothalamic IL-1: a systematic analysis of multiple stressor paradigms. Brain Res Bull (2005) 1.27
Roles of interleukin 1 beta and tumor necrosis factor in lipopolysaccharide fever in rats. Am J Physiol (1990) 1.16
MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. Brain Res Mol Brain Res (1998) 1.06
The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. J Leukoc Biol (2002) 1.02
Long-term alterations in neuroimmune responses after neonatal exposure to lipopolysaccharide. J Neurosci (2004) 1.02
Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene. Proc Natl Acad Sci U S A (1998) 0.98
Physiological disposition and metabolism of levo-methadone-1- 3 H in nontolerant and tolerant rats. J Pharmacol Exp Ther (1973) 0.96
The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis. Proc Soc Exp Biol Med (1996) 0.96
Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse. J Neurochem (2003) 0.94
Immunomodulatory effects of morphine withdrawal in the rat are time dependent and reversible by clonidine. Psychopharmacology (Berl) (1999) 0.94
Morphine inhibits NF-kappaB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism. Anesthesiology (2000) 0.94
Interleukin-1 beta causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats. Am J Physiol (1994) 0.93
Long term alterations in neuroimmune responses of female rats after neonatal exposure to lipopolysaccharide. Brain Behav Immun (2005) 0.92
Hypothalamo-pituitary control of the cell-mediated immunity in rat embryos: role of LHRH in regulation of lymphocyte proliferation. J Reprod Immunol (2000) 0.89
Opioid-induced immunosuppression: is it centrally mediated or peripherally mediated? Biochem Pharmacol (2003) 0.88
Withdrawal from morphine in mice suppresses splenic macrophage function, cytokine production, and costimulatory molecules. J Neuroimmunol (2003) 0.88
Experimental evidence for immunomodulatory effects of opioids. Adv Exp Med Biol (2003) 0.87
Endotoxin-induced fever is modulated by endogenous glucocorticoids in rats. Am J Physiol (1992) 0.87
Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation. Brain Behav Immun (2000) 0.86
Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system. J Neuroimmunol (1997) 0.85
Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am J Physiol (1993) 0.85
Evidence for beta adrenergic receptor involvement in the immunomodulatory effects of morphine. J Pharmacol Exp Ther (1993) 0.84
Febrile temperatures attenuate IL-1 beta release by inhibiting proteolytic processing of the proform and influence Th1/Th2 balance by favoring Th2 cytokines. J Immunol (2003) 0.84
Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats. J Pharmacol Exp Ther (1996) 0.84
Ontogeny of epinephrine metabolic pathways in the rat: role of glucocorticoids. Int J Dev Neurosci (2000) 0.84
Bacterial lipopolysaccharide increases prostaglandin production by rat astrocytes via inducible cyclo-oxygenase: evidence for the involvement of nuclear factor kappaB. Biochem Biophys Res Commun (1999) 0.83
Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor. Arzneimittelforschung (2005) 0.83
HPA axis dysregulation following prenatal opiate exposure and postnatal withdrawal. Neurotoxicol Teratol (2005) 0.83
Rapid elevation of plasma interleukin-6 by morphine is dependent on autonomic stimulation of adrenal gland. J Pharmacol Exp Ther (2002) 0.82
Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat. Am J Physiol (1993) 0.82
Developmental toxicity of levo-alpha-acetylmethadol (LAAM) in tolerant rats. Int J Toxicol (2002) 0.80
Effects of morphine withdrawal on food competition hierarchies and fighting behavior in rats. Psychopharmacology (Berl) (1979) 0.79
Effect of central and peripheral administration of a nitric oxide synthase inhibitor on morphine hyperthermia in rats. Brain Res (2001) 0.79
Metabolism and disposition of l-alpha-acetylmethadol in the rat. Drug Metab Dispos (1977) 0.79
Congenital behavioral effects in mature rats prenatally exposed to levo-alpha-acetylmethadol (LAAM). Neurobehav Toxicol Teratol (1983) 0.78
Morphine during pregnancy in the rat. Studies of cellular immunity in cross-fostered offspring. Adv Exp Med Biol (1998) 0.77
Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates. Brain Behav Immun (2004) 0.76
Prenatal morphine exposure interacts with adult stress to affect type and number of blood leucocytes. Adv Exp Med Biol (1996) 0.76
Effects of prenatal morphine exposure on NK cytotoxicity and responsiveness to LPS in rats. Pharmacol Biochem Behav (1998) 0.76
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis. J Clin Invest (2010) 2.32
Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection. J Immunol (2005) 1.35
Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa B signaling. J Immunol (2008) 1.24
Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed. Mol Ther (2010) 1.16
Morphine suppresses tumor angiogenesis through a HIF-1alpha/p38MAPK pathway. Am J Pathol (2010) 1.11
Opiate abuse, innate immunity, and bacterial infectious diseases. Arch Immunol Ther Exp (Warsz) (2008) 1.07
The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. J Leukoc Biol (2002) 1.02
Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling. J Biol Chem (2011) 1.00
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms. Am J Pathol (2012) 0.99
Chronic morphine administration delays wound healing by inhibiting immune cell recruitment to the wound site. Am J Pathol (2009) 0.99
Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection. Infect Immun (2009) 0.99
Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharmacol (2014) 0.99
Morphine modulation of toll-like receptors in microglial cells potentiates neuropathogenesis in a HIV-1 model of coinfection with pneumococcal pneumoniae. J Neurosci (2012) 0.97
Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways. J Biol Chem (2003) 0.95
Chronic morphine treatment inhibits LPS-induced angiogenesis: implications in wound healing. Cell Immunol (2010) 0.95
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Proc Natl Acad Sci U S A (2014) 0.93
PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus. Cardiovasc Diabetol (2010) 0.93
Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner. PLoS One (2013) 0.92
Hypoxia differentially regulates arterial and venous smooth muscle cell proliferation via PDGFR-β and VEGFR-2 expression. Am J Physiol Heart Circ Physiol (2011) 0.91
Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a. Sci Rep (2013) 0.89
Mu-opioid receptor mediates chronic restraint stress-induced lymphocyte apoptosis. J Immunol (2002) 0.88
Prenatal oxycodone exposure impairs spatial learning and/or memory in rats. Behav Brain Res (2010) 0.86
Role of the mu-opioid receptor in opioid modulation of immune function. Amino Acids (2011) 0.86
Mu and delta receptors mediate morphine effects on phagocytosis by murine peritoneal macrophages. J Neuroimmunol (2003) 0.86
Acute physiological stress promotes clustering of synaptic markers and alters spine morphology in the hippocampus. PLoS One (2013) 0.86
Morphine withdrawal contributes to Th cell differentiation by biasing cells toward the Th2 lineage. J Immunol (2005) 0.85
The role of arginine vasopressin and its receptors in the normal and failing rat heart. J Mol Cell Cardiol (2003) 0.85
Mechanism(s) involved in opioid drug abuse modulation of HAND. Curr HIV Res (2012) 0.83
HPA axis dysregulation following prenatal opiate exposure and postnatal withdrawal. Neurotoxicol Teratol (2005) 0.83
Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. J Biol Chem (2007) 0.83
Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Exp Neurol (2011) 0.83
An infectious murine model for studying the systemic effects of opioids on early HIV pathogenesis in the gut. J Neuroimmune Pharmacol (2014) 0.81
Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids. J Biol Chem (2011) 0.80
Acute oxycodone induces the pro-emetic pica response in rats. J Pharmacol Exp Ther (2011) 0.80
Opioids and infections in the intensive care unit should clinicians and patients be concerned? J Neuroimmune Pharmacol (2008) 0.80
PKMζ differentially utilized between sexes for remote long-term spatial memory. PLoS One (2013) 0.79
Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMP. J Immunol (2008) 0.79
Morphine induces splenocyte trafficking into the CNS. J Neuroimmune Pharmacol (2011) 0.78
Apolipoprotein e deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles. Biochim Biophys Acta (2007) 0.78
The role of short-term oxygen administration in the prevention of intimal hyperplasia. J Vasc Surg (2013) 0.76
Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium. J Neuroimmune Pharmacol (2014) 0.76
In vivo morphine treatment synergistically increases LPS-induced caspase activity in immune organs. J Neuroimmune Pharmacol (2010) 0.75
SNIP members in a recent international conference: World Summit of Antivirals. J Neuroimmune Pharmacol (2008) 0.75
Erratum: Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis. Sci Rep (2016) 0.75