Published in Neuropeptides on December 29, 2006
MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition. J Am Soc Nephrol (2012) 2.26
Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues. Histochem Cell Biol (2008) 1.07
Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity. J Histochem Cytochem (2009) 0.99
Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies. Pharmacol Ther (2008) 0.99
Peptidomics of prolyl endopeptidase in the central nervous system. Biochemistry (2009) 0.96
Processing of the phalloidin proprotein by prolyl oligopeptidase from the mushroom Conocybe albipes. J Biol Chem (2009) 0.93
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. Br J Pharmacol (2012) 0.92
Evidence of maternal QTL affecting growth and obesity in adult mice. Mamm Genome (2009) 0.91
Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner. Br J Pharmacol (2011) 0.91
Targeting inhibition of fibroblast activation protein-α and prolyl oligopeptidase activities on cells common to metastatic tumor microenvironments. Neoplasia (2013) 0.90
Peptidomics of the prolyl peptidases. AAPS J (2010) 0.89
Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. J Biol Chem (2010) 0.89
Robust substrate profiling method reveals striking differences in specificities of serum and lung fluid proteases. Biotechniques (2011) 0.89
Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors. J Histochem Cytochem (2012) 0.89
Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding. PLoS One (2011) 0.87
Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proc Natl Acad Sci U S A (2014) 0.85
Prolyl endopeptidase activity is correlated with colorectal cancer prognosis. Int J Med Sci (2014) 0.85
Maternal influence of prolyl endopeptidase on fat mass of adult progeny. Int J Obes (Lond) (2009) 0.83
Altered peptidase activities in thyroid neoplasia and hyperplasia. Dis Markers (2013) 0.82
Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis. J Neuroinflammation (2010) 0.81
Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase. Neoplasia (2015) 0.81
The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis. Front Immunol (2015) 0.80
In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice. Mol Brain (2009) 0.80
Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction. J Biol Chem (2015) 0.79
Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein α. FEBS Lett (2012) 0.79
Efficient access to enantiomerically pure cyclic alpha-amino esters through a lipase-catalyzed kinetic resolution. Tetrahedron Asymmetry (2009) 0.79
AcSDKP regulates cell proliferation through the PI3KCA/Akt signaling pathway. PLoS One (2013) 0.78
The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients. J Neuroinflammation (2015) 0.77
Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum. J Nat Prod (2015) 0.77
Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis (2015) 0.76
The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases. Am J Alzheimers Dis (Columbia) (2013) 0.76
Neuropeptidase activity is down-regulated by estradiol in steroid-sensitive regions of the hypothalamus in female mice. Neuropeptides (2012) 0.76
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. J Biol Chem (2014) 0.75
Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins? Front Aging Neurosci (2017) 0.75
The expression of proline-specific enzymes in the human lung. Ann Transl Med (2017) 0.75
Distribution, classification, domain architectures and evolution of prolyl oligopeptidases in prokaryotic lineages. BMC Genomics (2014) 0.75
Next Generation Sequencing Identifies Five Major Classes of Potentially Therapeutic Enzymes Secreted by Lucilia sericata Medical Maggots. Biomed Res Int (2016) 0.75
Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line. PLoS One (2016) 0.75
Kinetic Landscape of a Peptide Bond-Forming Prolyl Oligopeptidase. Biochemistry (2017) 0.75
A straightforward route to enantiopure alpha-substituted derivatives of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. Tetrahedron (2009) 0.75
Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes. PLoS One (2013) 0.75
Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates. PLoS One (2009) 0.75
Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta. J Mol Histol (2011) 0.75
Comparative liver toxicity of various erythromycin derivatives in animals. J Antimicrob Chemother (1988) 1.41
Impairing effect of food on ketoconazole absorption. Antimicrob Agents Chemother (1982) 1.32
Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route. Antimicrob Agents Chemother (1983) 1.24
Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors. J Med Chem (1989) 1.12
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol (1988) 1.09
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Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav Brain Res (1997) 0.97
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Improved assay of reaction products to quantitate catechol-O-methyltransferase activity by high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl (1995) 0.96
7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety. Psychopharmacology (Berl) (1997) 0.95
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. Br J Pharmacol (2012) 0.92
Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase (COMT) estimated by enzyme kinetic values. Med Hypotheses (2001) 0.91
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase. Gen Pharmacol (1994) 0.91
Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task. Neuropharmacology (2000) 0.91
Absorption of erythromycin acistrate and erythromycin base in the fasting and non-fasting state. J Antimicrob Chemother (1988) 0.91
Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner. Br J Pharmacol (2011) 0.91
The effect of an increased ratio of carbidopa to levodopa on the pharmacokinetics of levodopa. Acta Neurol Scand (1985) 0.90
Impairment of captopril bioavailability by concomitant food and antacid intake. Int J Clin Pharmacol Ther Toxicol (1984) 0.88
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. Clin Neuropharmacol (1995) 0.88
Modulation of histamine H3 receptors in the brain of 6-hydroxydopamine-lesioned rats. Eur J Neurosci (2000) 0.88
Striatal membrane-bound and soluble catechol-O-methyl-transferase after selective neuronal lesions in the rat. J Neural Transm (1987) 0.88
Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake. Eur J Pharmacol (1999) 0.87
Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging. Neuroscience (2008) 0.87
Effects of two erythromycins, doxycycline and phenoxymethylpenicillin on human leucocyte chemotaxis in vitro. J Antimicrob Chemother (1988) 0.86
Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system. Psychopharmacology (Berl) (2001) 0.85
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Tonsillar penetration of erythromycin and its 2'-acetyl ester in patients with chronic tonsillitis. J Antimicrob Chemother (1988) 0.84
Tumor-producing and skin-irritating activity of dithranol (anthralin) and its 10-acyl analogues in SENCAR mice. Carcinogenesis (1986) 0.84
Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum. J Neural Transm Park Dis Dement Sect (1992) 0.84
Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A. Clin Exp Immunol (2011) 0.84
Concentrations of metronidazole and tinidazole in male genital tissues. Antimicrob Agents Chemother (1985) 0.83
Modulation of rat brain endogenous dopamine metabolism by new inhibitors of catechol O-methyltransferase. Eur J Pharmacol (1993) 0.83
Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo. Neuroscience (2011) 0.83
Single- and multiple-dose pharmacokinetics of pipemidic acid in normal human volunteers. Antimicrob Agents Chemother (1984) 0.83
Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: an immunohistochemical colocalization study. Neuroscience (2008) 0.82
Increase of catechol-O-methyltransferase activity in rat brain microglia after intrastriatal infusion of fluorocitrate, a glial toxin. Neurosci Lett (1997) 0.81
Overflow of noradrenaline and dopamine in frontal cortex after [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis study in anaesthetized rats. Naunyn Schmiedebergs Arch Pharmacol (1997) 0.81
Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice. Br J Pharmacol (2009) 0.81
Antibiotic concentration in suction skin blister fluid and saliva after repeated dosage of erythromycin acistrate and erythromycin base. J Antimicrob Chemother (1988) 0.81
Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases. Neuroscience (2013) 0.80
Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats. Pharmacol Toxicol (1999) 0.80
Effects of aqueous extracts of Halimeda incrassata (Ellis) Lamouroux and Bryothamnion triquetrum (S.G.Gmelim) Howe on hydrogen peroxide and methyl mercury-induced oxidative stress in GT1-7 mouse hypothalamic immortalized cells. Phytomedicine (2003) 0.80
No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats. Eur J Pharmacol (1998) 0.80
Different renal effects of two inhibitors of catechol-O-methylation in the rat: entacapone and CGP 28014. Acta Physiol Scand (1998) 0.79
Pharmacokinetics of clofibrate and chlorophenoxy isobutyric aicd. I. Cross-over studies on human volunteers. Acta Pharmacol Toxicol (Copenh) (1975) 0.79
Inhibitors of catechol-O-methyltransferase sensitize mice to pain. Br J Pharmacol (2010) 0.79
Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells. Clin Exp Immunol (2010) 0.79
Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives. J Med Chem (1999) 0.79
L-Arginine abolishes the anxiolytic-like effect of diazepam in the elevated plus-maze test in rats. Eur J Pharmacol (1998) 0.79
Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation. Psychopharmacology (Berl) (1998) 0.78
Studies on the site and mechanism of the inhibitory action of intracerebral histamine on the cold-stimulated thyrotropin secretion in male rats. Brain Res (1985) 0.78
Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels. Eur Neuropsychopharmacol (1997) 0.78
N-nitro-L-arginine attenuates development of tolerance to antinociceptive but not to hormonal effects of morphine. Eur J Pharmacol (1994) 0.78
Modification of GABAergic activity and thyrotropin secretion in male rats. Acta Pharmacol Toxicol (Copenh) (1980) 0.78
Inhibition of the TSH secretion by histamine in male rats. Acta Endocrinol (Copenh) (1983) 0.78
Concentrations of erythromycin, 2'-acetyl erythromycin, and their anhydro forms in plasma and tonsillar tissue after repeated dosage of erythromycin stearate and erythromycin acistrate. Antimicrob Agents Chemother (1988) 0.78
Cholecystokinin-induced anxiety in rats: relevance of pre-experimental stress and seasonal variations. J Psychiatry Neurosci (2000) 0.78
Intravenous cefuroxime prophylaxis. Tissue levels after one 3-gram dose in 40 cases of hip fracture. Acta Orthop Scand (1995) 0.78
Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze. Neuroreport (1995) 0.78
Subdiaphragmatic vagotomy does not prevent the anti-exploratory effect of caerulein in the elevated plus-maze. Neuropeptides (1994) 0.78
Further evidence of the dual role of noradrenaline in regulation of thyrotrophin secretion in male rats. Acta Endocrinol (Copenh) (1981) 0.78
Effects of three types of catechol O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats. Eur J Pharmacol (1993) 0.78
The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat. Pflugers Arch (2001) 0.78
Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats. Neuropeptides (1989) 0.78
Absorption of various erythromycin esters and salts in mice after intragastric intubation. Methods Find Exp Clin Pharmacol (1992) 0.77
Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats. Behav Brain Res (1997) 0.77
Effect of chronic morphine treatment on thyrotropin and prolactin levels and acute hormone responses in the rat. J Pharmacol Exp Ther (1988) 0.77
Effects of acute hypotension and hypertension on serum TSH concentrations in male rats. Acta Physiol Scand (1979) 0.77
Different isotonic density gradients in separation of renin granules from rat kidney cortex. Med Biol (1983) 0.77
Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats. Naunyn Schmiedebergs Arch Pharmacol (1995) 0.77
Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein. Naunyn Schmiedebergs Arch Pharmacol (1993) 0.77
Morphine withdrawal alters anterior pituitary hormone secretion, brain endopeptidase activity and brain monoamine metabolism in the rat. Pharmacol Toxicol (1996) 0.77
Central regulation of thyrotropin secretion in rats: methodological aspects, problems and some progress. Med Biol (1983) 0.77
Brain prolyl oligopeptidase activity is associated with neuronal damage rather than beta-amyloid accumulation. Neuroreport (2001) 0.77
Neurochemical and psychomotor interactions of new selective COMT inhibitors with clorgyline and nomifensine in levodopa-treated rats and mice. Arch Int Pharmacodyn Ther (1993) 0.77
Tolcapone, an inhibitor of catechol O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert. Neuroreport (1995) 0.77
Comparison of oxolinic acid, trimethoprim, and trimethoprim-sulfamethoxazole in the treatment and long-term control of urinary tract infection. Curr Ther Res Clin Exp (1976) 0.77
An acute i.c.v. infusion of leptin has no effect on hypothalamic histamine and tele-methylhistamine contents in Wistar rats. Eur J Pharmacol (2000) 0.76
Cimetidine increases the plasma concentration of hydroxyzine. Acta Derm Venereol (1986) 0.76
Neurotransmitter control of thyrotrophin secretion in hypothyroid rats. Acta Endocrinol (Copenh) (1978) 0.76
Minor effect of tolcapone, a catechol-O-methyltransferase inhibitor, on extracellular dopamine levels modified by amphetamine or pargyline: a microdialysis study in anaesthetized rats. Pharmacol Toxicol (1996) 0.76
Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze. Neuropeptides (1998) 0.76
Apomorphine-induced behavioural sensitization in rats: individual differences, role of dopamine and NMDA receptors. Eur Neuropsychopharmacol (1999) 0.76
Tumor-producing activity of dithranol (anthralin) and two of its 10-acyl analogs in the dorsal skin of female NMRI mice. J Pharmacol Exp Ther (1984) 0.76
Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways. Neurochem Res (2012) 0.76
Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion. Neuropeptides (1992) 0.76
Further studies on the role of cholecystokinin-A and B receptors in secretion of anterior pituitary hormones in male rats. Neuropeptides (1995) 0.76
Differential disappearance of tolerance to thermal, hormonal and locomotor effects of morphine in the male rat. Eur J Pharmacol (1995) 0.76
Validation of assay of catechol-O-methyltransferase activity in human erythrocytes. J Pharm Biomed Anal (1996) 0.76
Further studies on properties of renin granules isolated from rat kidney cortex. Acta Physiol Scand (1981) 0.76
Opiate receptor subtypes in the regulation of thyrotropin and prolactin secretion in the rat. Horm Res (1988) 0.75
Dual action of morphine on cold-stimulated thyrotropin secretion in male rats. Life Sci (1984) 0.75
Effects of some putative amino acid neurotransmitters on the stimulated TSH secretion in male rats. Horm Res (1983) 0.75
Adrenalectomy modifies the effect of intracerebral histamine on the cold-stimulated TSH secretion in male rats. Agents Actions (1986) 0.75
Serum prolactin levels after a single and subchronic oral administration of chlorpromazine and sulpiride. A cross-over study in healthy volunteers. Arzneimittelforschung (1978) 0.75
Effects of lithium and rubidium on antinociception and behaviour in mice. I. Studies on narcotic analgesics and antagonists. Arch Int Pharmacodyn Ther (1976) 0.75
Potentiation of central effects of L-dopa by an inhibitor of catechol-O-methyltransferase. J Neural Transm (1987) 0.75