Published in J Cell Biol on November 01, 1991
A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J Clin Invest (1997) 2.37
Apatite-mediated actin dynamics in resorbing osteoclasts. Mol Biol Cell (2004) 1.91
Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J Exp Med (2003) 1.80
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase. J Clin Invest (1998) 1.74
Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Mol Biol Cell (2005) 1.35
CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts. Mol Biol Cell (2007) 1.13
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. Biomed Res Int (2015) 0.92
Regulation of osteoclast polarization. Odontology (2007) 0.89
Roles of hyaluronan in bone resorption. BMC Musculoskelet Disord (2004) 0.85
Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss. Cell Death Differ (2015) 0.81
Bone is not essential for osteoclast activation. PLoS One (2010) 0.81
The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins. J Biol Chem (2014) 0.78
Elucidation of a common structure of selective fibrinogen receptor antagonists. J Comput Aided Mol Des (1998) 0.76
Adhesion receptors of the immune system. Nature (1990) 28.86
Integrins: a family of cell surface receptors. Cell (1987) 21.14
New perspectives in cell adhesion: RGD and integrins. Science (1987) 18.41
A new method of preparing gold probes for multiple-labeling cytochemistry. Eur J Cell Biol (1985) 10.51
A technique for ultracryotomy of cell suspensions and tissues. J Cell Biol (1973) 8.64
Arg-Gly-Asp: a versatile cell recognition signal. Cell (1986) 7.89
A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci U S A (1985) 4.44
Use of colloidal gold particles in double-labeling immunoelectron microscopy of ultrathin frozen tissue sections. J Cell Biol (1981) 4.33
Osteoclastic bone resorption by a polarized vacuolar proton pump. Science (1989) 3.31
Osteopontin--a possible anchor of osteoclasts to bone. Proc Natl Acad Sci U S A (1990) 2.90
Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J Biol Chem (1987) 2.62
Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res (1985) 2.42
Resorption of bone by isolated rabbit osteoclasts. J Cell Sci (1984) 2.33
The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc Natl Acad Sci U S A (1989) 2.31
The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol (1989) 2.27
Effects of modifications of the RGD sequence and its context on recognition by the fibronectin receptor. J Biol Chem (1989) 2.00
Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro. J Bone Miner Res (1991) 1.67
Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts. J Cell Biol (1990) 1.62
Resorption of dentine by isolated osteoclasts in vitro. Br Dent J (1984) 1.60
Arg-Gly-Asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts. Exp Cell Res (1991) 1.57
Organization of osteoclast microfilaments during the attachment to bone surface in vitro. J Bone Miner Res (1989) 1.29
Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: a beta 3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells. Exp Cell Res (1989) 1.27
Perspectives: adhesion receptors in bone. J Bone Miner Res (1989) 1.14
Monoclonal antibodies against osteoclasts inhibit bone resorption in vitro. Bone Miner (1986) 1.13
Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption. Biochem Biophys Res Commun (1990) 1.03
Echistatin is a potent inhibitor of bone resorption in culture. J Cell Biol (1990) 1.00
Vitronectin receptor: tissue specific expression or adaptation to culture? Int J Exp Pathol (1990) 0.93
Biochemical characterization of an electrogenic vacuolar proton pump in purified chicken osteoclast plasma membrane vesicles. J Bone Miner Res (1990) 0.87
Calcitonin, prostaglandin E2, and dibutyryl cyclic adenosine 3',5'-monophosphate disperse the specific microfilament structure in resorbing osteoclasts. J Histochem Cytochem (1990) 0.86
Arginine-glycine-aspartic acid- and fibrinogen gamma-chain carboxyterminal peptides inhibit platelet adherence to arterial subendothelium at high wall shear rates. An effect dissociable from interference with adhesive protein binding. J Clin Invest (1990) 0.82
The collagen recognition sequence for fibroblasts depends on collagen topography. Exp Cell Res (1989) 0.79
Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med (1997) 2.77
Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res (1985) 2.42
A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J Clin Invest (1997) 2.37
Autosomal recessive osteopetrosis: variability of findings at diagnosis and during the natural course. Pediatrics (1994) 2.33
Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies. J Immunol (1997) 2.30
Removal of osteoclast bone resorption products by transcytosis. Science (1997) 2.08
Trafficking of matrix collagens through bone-resorbing osteoclasts. Science (1997) 1.93
Single integrin molecule adhesion forces in intact cells measured by atomic force microscopy. Biochem Biophys Res Commun (1999) 1.74
Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298. J Bone Miner Res (2000) 1.70
Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro. J Bone Miner Res (1991) 1.67
Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts. J Cell Biol (1990) 1.62
Arg-Gly-Asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts. Exp Cell Res (1991) 1.57
Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro. Calcif Tissue Int (1986) 1.55
Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis. FASEB J (1999) 1.53
Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption. J Bone Miner Res (2000) 1.52
Apoptosis induced by inhibition of intercellular contact. J Cell Biol (1994) 1.49
A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation. Oncogene (2000) 1.43
Failure of cells of the mononuclear phagocyte series to resorb bone. Calcif Tissue Int (1984) 1.43
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Res (1998) 1.39
Nitric oxide: a cytokine-induced regulator of bone resorption. J Bone Miner Res (1995) 1.37
Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. Bone (2001) 1.35
The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. Cancer (1988) 1.34
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. J Biol Chem (2001) 1.33
Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase. Endocrinology (2001) 1.32
Cell surface characterization of the human osteoclast: phenotypic relationship to other bone marrow-derived cell types. J Pathol (1984) 1.28
Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture. Bone (1998) 1.26
Beta 1 integrins and osteoclast function: involvement in collagen recognition and bone resorption. Bone (1996) 1.23
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem (2001) 1.22
The mechanical strength of bone in different rat models of experimental osteoporosis. Bone (1995) 1.20
Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J Biol Chem (1999) 1.19
Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a beta 3 integrin. J Bone Miner Res (1992) 1.19
Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol (1996) 1.19
Adapting atomic force microscopy for cell biology. Ultramicroscopy (2000) 1.19
A nonradioactive biochemical characterization of membrane proteins using enhanced chemiluminescence. Anal Biochem (1992) 1.15
Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts. J Cell Sci (1997) 1.14
Human macrophage colony-stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone. J Cell Physiol (1988) 1.13
Monoclonal antibodies against osteoclasts inhibit bone resorption in vitro. Bone Miner (1986) 1.13
Atomic force microscopy can be used to mechanically stimulate osteoblasts and evaluate cellular strain distributions. Ultramicroscopy (2001) 1.11
Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res (2000) 1.09
Antibody to beta3 integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat. Endocrinology (1996) 1.08
Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium. Clin Chem (2000) 1.08
Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent. Biochem Biophys Res Commun (1998) 1.08
Integrin expression in human melanoma cell lines: heterogeneity of vitronectin receptor composition and function. Int J Cancer (1991) 1.06
Cytoskeletal changes in osteoclasts during the resorption cycle. Microsc Res Tech (1996) 1.06
Human mast cells detected by monoclonal antibodies. J Clin Pathol (1984) 1.06
Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats. J Clin Invest (1994) 1.04
Co-ordinate expression of the alpha-6 integrin laminin receptor sub-unit and laminin in breast cancer. J Pathol (1991) 1.03
Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. J Clin Pathol (1990) 1.02
Estrogen reduces the depth of resorption pits by disturbing the organic bone matrix degradation activity of mature osteoclasts. Endocrinology (2001) 1.02
Serum tartrate-resistant acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density. Calcif Tissue Int (2002) 1.01
New sites of cellular vitronectin receptor immunoreactivity detected with osteoclast-reacting monoclonal antibodies 13C2 and 23C6. Bone Miner (1990) 1.01
Expression of the VLA family of integrins in human intestine. J Pathol (1990) 1.01
Integrins on rat osteoclasts: characterization of two monoclonal antibodies (F4 and F11) to rat beta 3. J Bone Miner Res (1992) 1.00
Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy. J Cell Sci (1993) 1.00
Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukaemia/lymphoma: implications for the mechanism of hypercalcaemia. Br J Cancer (1991) 1.00
Characterization of integrin chains in normal and neoplastic human pancreas. J Pathol (1991) 1.00
Hypoxia induces giant osteoclast formation and extensive bone resorption in the cat. Calcif Tissue Int (2006) 0.99
Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts. J Cell Sci (1993) 0.99
Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis. Br J Rheumatol (1997) 0.99
Immunohistochemical detection of parathyroid hormone-related protein in human fetal epithelia. J Clin Endocrinol Metab (1991) 0.99
Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption. Clin Chem (2001) 0.98
The identification and cloning of a murine major basic protein gene expressed in eosinophils. J Immunol (1995) 0.98
Characterization of human mast cells in long-term culture. Blood (1983) 0.97
Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae. Bone (1996) 0.96
Bone-resorbing osteoclasts reveal a dynamic division of basal plasma membrane into two different domains. J Cell Sci (1996) 0.94
Human fetal osteoclasts fail to express macrophage antigens. Br J Exp Pathol (1985) 0.94
New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis. Osteoporos Int (2010) 0.94
Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis. Apoptosis (2005) 0.94
A new specialized cell-matrix interaction in actively resorbing osteoclasts. J Cell Sci (2000) 0.94
Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo. J Immunol (2000) 0.94
Osteoblast-like cells complete osteoclastic bone resorption and form new mineralized bone matrix in vitro. Calcif Tissue Int (2004) 0.93
The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif Tissue Int (1994) 0.92
Adhesive properties of isolated chick osteocytes in vitro. Bone (1996) 0.92
Vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptor subtypes in mouse calvarial osteoblasts: presence of VIP-2 receptors and differentiation-induced expression of VIP-1 receptors. Endocrinology (2001) 0.92
The effect of oral glucose tolerance test on serum osteocalcin and bone turnover markers in young adults. Calcif Tissue Int (2011) 0.91
Human osteoclast-specific antigens are expressed by osteoclasts in a wide range of non-human species. Br J Exp Pathol (1986) 0.91
Development and evaluation of three immunofluorometric assays that measure different forms of osteocalcin in serum. Clin Chem (2000) 0.90
Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase. J Clin Invest (1994) 0.90
Calcitonin promotes osteoclast survival in vitro. Mol Cell Endocrinol (1996) 0.89
Genetic basis for Ly-6- defect: complementation between Ly-6- and Thy-1- mutant cell lines. Immunogenetics (1983) 0.89
Haematological features of angioimmunoblastic lymphadenopathy with dysproteinaemia. J Clin Pathol (1979) 0.89
Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+. Exp Cell Res (1998) 0.89
On the origin of the osteoclast: the cell surface phenotype of rodent osteoclasts. Calcif Tissue Int (1985) 0.89
Effect of impact exercise on bone metabolism. Osteoporos Int (2009) 0.89