Published in Exp Gerontol on January 03, 2007
Innate immunity and aging. Exp Gerontol (2008) 1.73
Trauma equals danger--damage control by the immune system. J Leukoc Biol (2012) 1.15
Rejuvenation of the inflammatory system stimulates fracture repair in aged mice. J Orthop Res (2010) 1.08
Aging and animal models of systemic insult: trauma, burn, and sepsis. Shock (2009) 0.96
Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling. J Neuroinflammation (2009) 0.87
Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult. Free Radic Biol Med (2009) 0.87
Effects of low-intensity non-coherent light therapy on the inflammatory process in the calcaneal tendon of ovariectomized rats. Lasers Med Sci (2015) 0.78
Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice. J Gerontol A Biol Sci Med Sci (2015) 0.77
Avenanthramide supplementation attenuates exercise-induced inflammation in postmenopausal women. Nutr J (2014) 0.76
Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci (2000) 8.26
Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab (1998) 7.05
Age-related changes in lymphocyte development and function. Nat Immunol (2004) 6.16
Adipose tissue as an endocrine organ. Trends Endocrinol Metab (2000) 4.07
Inflammatory mediators in the elderly. Exp Gerontol (2004) 3.91
Changes in proinflammatory cytokine activity after menopause. Endocr Rev (2002) 3.24
Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am (2003) 2.73
Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol (1995) 2.71
17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest (1992) 2.43
Gonadal steroids and immunity. Endocr Rev (1996) 2.25
The aging of the immune system. Adv Immunol (2002) 1.96
Aging and innate immune cells. J Leukoc Biol (2004) 1.94
Transcription factor cross-talk: the estrogen receptor and NF-kappaB. Trends Endocrinol Metab (2005) 1.93
Innate immunity in aging: impact on macrophage function. Aging Cell (2004) 1.88
The aging innate immune system. Curr Opin Immunol (2005) 1.81
Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. Ann Intern Med (1998) 1.74
Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury. J Leukoc Biol (1997) 1.63
Sex hormones as immunomodulators in health and disease. Int Immunopharmacol (2001) 1.61
Lipopolysaccharide-induced lethality and cytokine production in aged mice. Infect Immun (1996) 1.58
Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis (2000) 1.53
Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow. J Clin Invest (1994) 1.51
Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol (2003) 1.50
Antiinflammatory effects of estrogen on microglial activation. Endocrinology (2000) 1.44
Diversity in the mechanisms of gene regulation by estrogen receptors. Bioessays (2002) 1.43
Fat and protein redistribution with aging: metabolic considerations. Eur J Clin Nutr (2000) 1.43
Aging and developmental transitions in the B cell lineage. Int Immunol (2002) 1.40
17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest (1994) 1.37
Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study. J Clin Endocrinol Metab (2000) 1.25
Immunity and aging: the enemy within? Aging Cell (2004) 1.20
Signal transduction in the aging immune system. Curr Opin Immunol (2005) 1.14
Estrogen mediates the sex difference in post-burn immunosuppression. J Endocrinol (2000) 1.11
Aberrant acute-phase response in aged interleukin-6 knockout mice. Shock (2006) 1.11
Acute ethanol exposure prior to thermal injury results in decreased T-cell responses mediated in part by increased production of IL-6. Shock (1998) 1.10
Expression of interleukin-6 in atherosclerotic lesions of male ApoE-knockout mice: inhibition by 17beta-estradiol. Arterioscler Thromb Vasc Biol (1998) 1.06
Aging, traumatic injury, and estrogen treatment. Exp Gerontol (2005) 1.02
Immunoproteasomes and immunosenescence. Ageing Res Rev (2003) 1.00
Gender difference in cell-mediated immunity after thermal injury is mediated, in part, by elevated levels of interleukin-6. J Leukoc Biol (2000) 0.96
MacrophAging: a cellular and molecular review. Immunobiology (2005) 0.96
Ageing and the immune system. Novartis Found Symp (2001) 0.96
Bromocriptine restores tolerance in estrogen-treated mice. J Clin Invest (2000) 0.96
Strategies for blocking the systemic effects of cytokines in the sepsis syndrome. Crit Care Med (1995) 0.95
T lymphocyte subsets in osteoporosis. Effect of 1-alpha hydroxyvitamin D3. Miner Electrolyte Metab (1984) 0.94
Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production. J Leukoc Biol (2001) 0.94
Mechanism of the salutary effects of 17beta-estradiol following trauma-hemorrhage: direct downregulation of Kupffer cell proinflammatory cytokine production. Cytokine (2003) 0.93
Relationship between changes in body composition and insulin responsiveness in models of the aging rat. Am J Physiol (1995) 0.92
Aging enhances lymphocyte cytokine defects after injury. FASEB J (2003) 0.91
The regulation of GH secretion by sex steroids. Eur J Endocrinol (2004) 0.89
Bone-resorbing cytokines from peripheral blood mononuclear cells after hormone replacement therapy: a longitudinal study. Osteoporos Int (2001) 0.84
Blocking prostaglandin E2 after trauma attenuates pro-inflammatory cytokines and improves survival. Shock (2000) 0.83
Estrogen replacement, aging, and cell-mediated immunity after injury. J Leukoc Biol (2004) 0.83
Survival and cell mediated immunity after burn injury in aged mice. J Am Aging Assoc (2002) 0.82
Effects of 17beta-estradiol and progesterone on interleukin-6 production and proliferation of human umbilical vein endothelial cells. Exp Clin Endocrinol Diabetes (1998) 0.80
Effects of hormone replacement therapy on selected indices of immune function in postmenopausal women. Gynecol Obstet Invest (2000) 0.78
Aging and innate immune cells. J Leukoc Biol (2004) 1.94
The aging innate immune system. Curr Opin Immunol (2005) 1.81
Innate immunity and aging. Exp Gerontol (2008) 1.73
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol (2003) 1.67
The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Crit Care Med (2012) 1.62
Alcohol, injury, and cellular immunity. Alcohol (2002) 1.60
Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev (2005) 1.46
Heavy alcohol use in lung donors increases the risk for primary graft dysfunction. Alcohol Clin Exp Res (2014) 1.42
In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation. J Immunol (2005) 1.35
Exposure-dependent effects of ethanol on the innate immune system. Alcohol (2008) 1.32
Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injury. Alcohol (2004) 1.27
Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure. Crit Care Med (2007) 1.22
Acute and chronic alcohol abuse modulate immunity. Alcohol Clin Exp Res (2006) 1.18
Sex differences and estrogen modulation of the cellular immune response after injury. Cell Immunol (2008) 1.16
Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injury. J Burn Care Res (2008) 1.13
Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats. Am J Physiol Lung Cell Mol Physiol (2007) 1.13
An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. J Leukoc Biol (2008) 1.12
Organ-specific inflammation following acute ethanol and burn injury. J Leukoc Biol (2008) 1.12
Aberrant acute-phase response in aged interleukin-6 knockout mice. Shock (2006) 1.11
Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing. Am J Physiol Heart Circ Physiol (2005) 1.11
Cholecystocolonic fistula. Hawaii J Med Public Health (2012) 1.10
Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling. Alcohol Clin Exp Res (2010) 1.10
Effects of ethanol on pulmonary inflammation in postburn intratracheal infection. J Burn Care Res (2008) 1.09
Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. J Leukoc Biol (2003) 1.09
Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Am J Physiol Gastrointest Liver Physiol (2012) 1.07
Development of a combined radiation and burn injury model. J Burn Care Res (2011) 1.07
Aging of the Innate Immune System: An Update. Curr Immunol Rev (2011) 1.06
Gastroesophageal reflux disease after lung transplantation: pathophysiology and implications for treatment. Surgery (2010) 1.06
Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Burns (2005) 1.06
The aging lung. Clin Interv Aging (2013) 1.05
CD1d-restricted NKT cells contribute to the age-associated decline of T cell immunity. J Immunol (2005) 1.04
Advanced age impairs macrophage polarization. J Interferon Cytokine Res (2011) 1.04
Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol (2013) 1.02
Effects of acute ethanol exposure on the early inflammatory response after excisional injury. Alcohol Clin Exp Res (2007) 1.01
Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions. J Interferon Cytokine Res (2008) 1.01
Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model. Alcohol Clin Exp Res (2010) 1.01
Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. J Burn Care Res (2011) 1.00
The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery (2011) 0.99
Inhalation injury severity and systemic immune perturbations in burned adults. Ann Surg (2013) 0.99
Elevated monocyte chemoattractant protein-1 levels following thermal injury precede monocyte recruitment to the wound site and are controlled, in part, by tumor necrosis factor-alpha. Wound Repair Regen (2003) 0.99
Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration. Shock (2009) 0.98
Early pulmonary immune hyporesponsiveness is associated with mortality after burn and smoke inhalation injury. J Burn Care Res (2012) 0.98
Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am J Physiol Heart Circ Physiol (2008) 0.97
Chronic wound repair and healing in older adults: current status and future research. Wound Repair Regen (2015) 0.97
Decreased pulmonary inflammation after ethanol exposure and burn injury in intercellular adhesion molecule-1 knockout mice. J Burn Care Res (2010) 0.97
Aging and animal models of systemic insult: trauma, burn, and sepsis. Shock (2009) 0.96
Epigenetic targets for reversing immune defects caused by alcohol exposure. Alcohol Res (2013) 0.96
A role for CD1d-restricted NKT cells in injury-associated T cell suppression. J Leukoc Biol (2003) 0.95
Alcohol and inflammation and immune responses: summary of the 2005 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (2006) 0.95
Macrophage phagocytosis: effects of environmental pollutants, alcohol, cigarette smoke, and other external factors. J Leukoc Biol (2011) 0.94
Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury. Am J Physiol Regul Integr Comp Physiol (2005) 0.94
Alcohol and inflammation and immune responses: summary of the 2006 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (2008) 0.93
Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury. Shock (2013) 0.93
The early acute phase response after burn injury in mice. J Burn Care Res (2007) 0.92
Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6. Alcohol (2013) 0.92
Interleukin-6 contributes to age-related alteration of cytokine production by macrophages. Mediators Inflamm (2010) 0.92
Immunosuppression after injury in aged mice is associated with a TH1-TH2 shift, which can be restored by estrogen treatment. Mech Ageing Dev (2004) 0.92
Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis. Cell Immunol (2012) 0.92
Aspiration, localized pulmonary inflammation, and predictors of early-onset bronchiolitis obliterans syndrome after lung transplantation. J Am Coll Surg (2013) 0.91
Aging enhances lymphocyte cytokine defects after injury. FASEB J (2003) 0.91
Pepsin concentrations are elevated in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis after lung transplantation. J Surg Res (2013) 0.91
Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society. Alcohol (2009) 0.90
Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Am J Physiol Lung Cell Mol Physiol (2013) 0.89
Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models. Aging Dis (2011) 0.89
Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells. J Immunol (2006) 0.89
Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis (2012) 0.89
Prolonged chemokine expression and excessive neutrophil infiltration in the lungs of burn-injured mice exposed to ethanol and pulmonary infection. Shock (2011) 0.88
Implications of alcohol intoxication at the time of burn and smoke inhalation injury: an epidemiologic and clinical analysis. J Burn Care Res (2013) 0.88
Neutrophils and natural killer T cells as negative regulators of wound healing. Expert Rev Dermatol (2011) 0.88
Matrix proteolytic activity during wound healing: modulation by acute ethanol exposure. Alcohol Clin Exp Res (2007) 0.88
Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines. Alcohol Clin Exp Res (2003) 0.87
Implications of formal alcohol screening in burn patients. J Burn Care Res (2009) 0.87
Adipose inflammation and macrophage infiltration after binge ethanol and burn injury. Alcohol Clin Exp Res (2013) 0.87
Intestinal barrier disruption as a cause of mortality in combined radiation and burn injury. Shock (2013) 0.87
Effects of chronic ethanol (EtOH) administration on pro-inflammatory cytokines of the hypothalamic-pituitary-gonadal (HPG) axis in female rats. Endocr Res (2005) 0.87
Gender-based differences in cytokine production after burn injury: a role of interleukin-6. J Am Coll Surg (2009) 0.86
Pulmonary immune changes early after laparoscopic antireflux surgery in lung transplant patients with gastroesophageal reflux disease. J Surg Res (2012) 0.86
Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the skin after burn injury in aged mice. Burns (2003) 0.86
Laparoscopic antireflux surgery for gastroesophageal reflux disease after lung transplantation. J Surg Res (2011) 0.86
Effects of insulin on hepatic inflammation induced by ethanol and burn injury in a murine model of critical illness. J Burn Care Res (2007) 0.85
Hepatic estrogen receptors and alcohol intake. Mol Cell Endocrinol (2002) 0.85
Ethanol potentiates the acute fatty infiltration of liver caused by burn injury: prevention by insulin treatment. J Burn Care Res (2009) 0.85
The impact of burn injury and ethanol on the cytokine network of the mouse hypothalamus: reproductive implications. Cytokine (2005) 0.85
Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals. J Surg Res (2010) 0.85
A novel role for NKT cells in cutaneous wound repair. J Surg Res (2009) 0.84
Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Mol Med (2010) 0.83
Aging and impairment of innate immunity. Contrib Microbiol (2008) 0.83
Alcohol exposure and mechanisms of tissue injury and repair. Alcohol Clin Exp Res (2010) 0.83
Estrogen replacement, aging, and cell-mediated immunity after injury. J Leukoc Biol (2004) 0.83
Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice. Shock (2012) 0.83
Effect of acute ethanol exposure on the dermal inflammatory response after burn injury. Alcohol Clin Exp Res (2003) 0.82
Acute ethanol exposure combined with burn injury enhances IL-6 levels in the murine ileum. Alcohol Clin Exp Res (2007) 0.82
RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ damage. Alcohol Clin Exp Res (2005) 0.82
Survival and cell mediated immunity after burn injury in aged mice. J Am Aging Assoc (2002) 0.82
Combined radiation and burn injury results in exaggerated early pulmonary inflammation. Radiat Res (2013) 0.81
An improved cell isolation method for flow cytometric and functional analyses of cutaneous wound leukocytes. J Immunol Methods (2011) 0.81
A review of the role of GERD-induced aspiration after lung transplantation. Surg Endosc (2011) 0.80