Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 1808207)

Published in Genomics on January 10, 2007

Authors

Yasser Saad1, Michael R Garrett, Ezhilarasi Manickavasagam, Shane Yerga-Woolwine, Phyllis Farms, Tracy Radecki, Bina Joe

Author Affiliations

1: Department of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo, Health Science Campus, 3035 Arlington Avenue, Toledo, OH 43614-5804, USA.

Articles citing this

Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension. Hypertension (2011) 0.99

Molecular mechanisms of experimental salt-sensitive hypertension. J Am Heart Assoc (2012) 0.90

Mitochondrial polymorphisms in rat genetic models of hypertension. Mamm Genome (2010) 0.88

Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models. Hypertens Res (2011) 0.88

Closely linked non-additive blood pressure quantitative trait loci. Mamm Genome (2008) 0.86

Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model. Hypertension (2009) 0.85

Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain. Mamm Genome (2008) 0.84

Isolation and high-throughput sequencing of two closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains. Physiol Genomics (2013) 0.83

Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria. Am J Physiol Heart Circ Physiol (2012) 0.81

Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics (2008) 0.81

Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3. Sci Rep (2017) 0.79

Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain. Physiol Genomics (2010) 0.76

Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis. PLoS One (2016) 0.75

Life or death? A physiogenomic approach to understand individual variation in responses to hemorrhagic shock. Curr Genomics (2011) 0.75

High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass. Physiol Genomics (2016) 0.75

Articles cited by this

Ensembl 2005. Nucleic Acids Res (2005) 15.13

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell (1991) 9.99

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet (1999) 4.48

Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature (1991) 3.74

Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity (2004) 2.82

Combining mapping and arraying: An approach to candidate gene identification. Proc Natl Acad Sci U S A (2002) 2.67

Rat genetics: attaching physiology and pharmacology to the genome. Nat Rev Genet (2002) 2.44

The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci U S A (2001) 2.30

Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics (2003) 1.37

p72: a human nuclear DEAD box protein highly related to p68. Nucleic Acids Res (1996) 1.34

Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res (1998) 1.28

Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nat Genet (1992) 1.25

Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. J Am Soc Nephrol (2003) 1.19

Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Clin Invest (1995) 1.18

Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10. Mamm Genome (1997) 1.17

Transcriptional profiling with a blood pressure QTL interval-specific oligonucleotide array. Physiol Genomics (2005) 1.14

The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide. J Biol Chem (2006) 1.11

Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. Physiol Genomics (2002) 1.10

Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. Mamm Genome (2003) 1.09

Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J Clin Invest (1995) 0.97

Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hypertension (2005) 0.96

Utilization of marker-assisted congenics to map two blood pressure quantitative trait loci in Dahl rats. Mamm Genome (2001) 0.94

Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension. Hypertension (1998) 0.92

Use of a panel of congenic strains to evaluate differentially expressed genes as candidate genes for blood pressure quantitative trait loci. Hypertens Res (2003) 0.92

Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. Hypertension (2000) 0.89

Genetic mapping of quantitative trait loci influencing left ventricular mass in rats. Am J Physiol Heart Circ Physiol (2000) 0.89

Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Biochem Biophys Res Commun (1997) 0.88

Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. J Hypertens (1995) 0.88

High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. Genomics (2001) 0.86

Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats. Mamm Genome (1999) 0.86

Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains. Hypertension (2001) 0.86

Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Hum Mol Genet (2003) 0.86

Genetic determination of cardiac mass in normotensive rats: results from an F344xWKY cross. Hypertension (1999) 0.85

Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc Natl Acad Sci U S A (1995) 0.84

Functional alterations of the Nppa promoter are linked to cardiac ventricular hypertrophy in WKY/WKHA rat crosses. Circ Res (2001) 0.81

Functional genomics in rat models of hypertension: using differential expression and congenic strains to identify and evaluate candidate genes. Crit Rev Eukaryot Gene Expr (2002) 0.81

Accelerated congenics for mapping two blood pressure quantitative trait loci on chromosome 10 of Dahl rats. J Hypertens (2002) 0.81

Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Hypertension (2005) 0.81

Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure. Pulm Pharmacol Ther (2005) 0.80

Short tandem repeat polymorphic markers for the rat genome from marker-selected libraries. Mamm Genome (1998) 0.79

Aging and salt-loading modulate blood pressure QTLs in rats. Am J Hypertens (1999) 0.79

Angiotensin I converting enzyme gene cosegregates with blood pressure and heart weight in F2 progeny derived from spontaneously hypertensive and normotensive Wistar-Kyoto rats. Clin Exp Hypertens (1996) 0.78

The region of rat chromosome 10 (the ngfr gene locus) is associated with blood pressure increase in response to emotional stress. Dokl Biochem Biophys (2001) 0.77

Identifying candidate genes for blood pressure quantitative trait loci using differential gene expression and a panel of congenic strains. Hypertens Res (1998) 0.76

Articles by these authors

Substitution mapping of a blood pressure quantitative trait locus to a 2.73 Mb region on rat chromosome 1. J Hypertens (2003) 1.69

Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: substitution mapping and renal expression analysis. Hypertension (2005) 1.58

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell (2013) 1.53

Mutant p53 cooperates with ETS2 to promote etoposide resistance. Genes Dev (2012) 1.47

Positional identification of variants of Adamts16 linked to inherited hypertension. Hum Mol Genet (2009) 1.21

The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis. J Immunol (2005) 1.17

Transcriptional profiling with a blood pressure QTL interval-specific oligonucleotide array. Physiol Genomics (2005) 1.14

Do epistatic modules exist in the genetic control of blood pressure in Dahl rats? A critical perspective. Physiol Genomics (2013) 1.10

Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females. Arthritis Rheum (2002) 1.09

Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiol Renal Physiol (2008) 1.06

Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure. Hypertension (2007) 1.01

Targeted disruption of Adamts16 gene in a rat genetic model of hypertension. Proc Natl Acad Sci U S A (2012) 1.00

Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension. Hypertension (2011) 0.99

Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension. J Biol Chem (2011) 0.98

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Physiol Genomics (2007) 0.97

Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. Am J Physiol Renal Physiol (2006) 0.97

Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains. J Hypertens (2002) 0.96

Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains. Physiol Genomics (2006) 0.95

A genome scan for Loci associated with aerobic running capacity in rats. Genomics (2002) 0.93

High-throughput screen for inhibitors of transglycosylase and/or transpeptidase activities of Escherichia coli penicillin binding protein 1b. Antimicrob Agents Chemother (2004) 0.91

Characterization of the development of renal injury in Type-1 diabetic Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol (2013) 0.90

Localization of the mutation responsible for osteopetrosis in the op rat to a 1.5-cM genetic interval on rat chromosome 10: identification of positional candidate genes by radiation hybrid mapping. J Bone Miner Res (2002) 0.89

Heterogeneous stock rats: a new model to study the genetics of renal phenotypes. Am J Physiol Renal Physiol (2010) 0.89

Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat. Hypertension (2012) 0.89

Mitochondrial polymorphisms in rat genetic models of hypertension. Mamm Genome (2010) 0.88

Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models. Hypertens Res (2011) 0.88

Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation (2013) 0.87

Localization of a blood pressure QTL to a 2.4-cM interval on rat chromosome 9 using congenic strains. Genomics (2003) 0.87

Closely linked non-additive blood pressure quantitative trait loci. Mamm Genome (2008) 0.86

Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains. Am J Physiol Renal Physiol (2009) 0.86

Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Am J Physiol Renal Physiol (2009) 0.85

Blood pressure and proteinuria effects of multiple quantitative trait loci on rat chromosome 9 that differentiate the spontaneously hypertensive rat from the Dahl salt-sensitive rat. J Hypertens (2008) 0.85

Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model. Hypertension (2009) 0.85

Use of contiguous congenic strains in analyzing compound QTLs. Physiol Genomics (2011) 0.84

Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain. Mamm Genome (2008) 0.84

SWI/SNF chromatin remodeling enzymes are associated with cardiac hypertrophy in a genetic rat model of hypertension. J Cell Physiol (2013) 0.83

Substitution mapping in dahl rats identifies two distinct blood pressure quantitative trait loci within 1.12- and 1.25-mb intervals on chromosome 3. Genetics (2006) 0.83

Isolation and high-throughput sequencing of two closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains. Physiol Genomics (2013) 0.83

Cross-talk of expression quantitative trait loci within 2 interacting blood pressure quantitative trait loci. Hypertension (2007) 0.83

Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background. Physiol Genomics (2012) 0.82

Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria. Am J Physiol Heart Circ Physiol (2012) 0.81

Neointimal hyperplasia and vasoreactivity are controlled by genetic elements on rat chromosome 3. Hypertension (2009) 0.81

Improved methodology to induce hyperoxaluria without treatment using hydroxyproline. Urol Res (2011) 0.80

Renoprotective effects of C-peptide in the Dahl salt-sensitive rat. Am J Physiol Renal Physiol (2012) 0.80

Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Shock (2008) 0.80

Increased Expression of Rififylin in A < 330 Kb Congenic Strain is Linked to Impaired Endosomal Recycling in Proximal Tubules. Front Genet (2012) 0.80

Genetic influences on survival time after severe hemorrhage in inbred rat strains. Physiol Genomics (2011) 0.79

Genomic regions controlling corticosterone levels in rats. Biol Psychiatry (2004) 0.79

A mutation in the start codon of γ-crystallin D leads to nuclear cataracts in the Dahl SS/Jr-Ctr strain. Mamm Genome (2013) 0.78

Dysglycemia induces abnormal circadian blood pressure variability. Cardiovasc Diabetol (2011) 0.78

Prognostic biomarkers for HNSCC using quantitative real-time PCR and microarray analysis: β-tubulin isotypes and the p53 interactome. Cytoskeleton (Hoboken) (2014) 0.75

Placental ischemia induces changes in gene expression in chorionic tissue. Mamm Genome (2014) 0.75

Life or death? A physiogenomic approach to understand individual variation in responses to hemorrhagic shock. Curr Genomics (2011) 0.75

Celebrating physiological genomics at the 125th anniversary of the American Physiological Society. Physiol Genomics (2012) 0.75