p53 homologue, p51/p63, maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity.

PubWeight™: 1.56‹?› | Rank: Top 4%

🔗 View Article (PMID 17237812)

Published in Oncogene on January 22, 2007

Authors

R Okuyama1, E Ogawa, H Nagoshi, M Yabuki, A Kurihara, T Terui, S Aiba, M Obinata, H Tagami, S Ikawa

Author Affiliations

1: Department of Dermatology, Tohoku University, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Japan.

Articles citing this

The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88

A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66

Dimorphic effects of Notch signaling in bone homeostasis. Nat Med (2008) 2.82

Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov (2012) 2.39

Notch tumor suppressor function. Oncogene (2008) 2.26

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10

Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer (2009) 1.79

Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol (2007) 1.78

Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method. Cancer (2010) 1.15

Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol (2009) 1.13

p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-terminal kinase pathway is counteracted by keratinocyte growth factor. J Biol Chem (2008) 0.94

Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. J Cell Mol Med (2009) 0.88

Epstein-Barr virus latent membrane protein-2A-induced DeltaNp63alpha expression is associated with impaired epithelial-cell differentiation. Oncogene (2010) 0.87

Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes. J Biol Chem (2010) 0.85

Regulation of miRNA expression by low-level laser therapy (LLLT) and photodynamic therapy (PDT). Int J Mol Sci (2013) 0.83

Notch signaling may be involved in the abnormal differentiation of epidermal keratinocytes in psoriasis. Acta Histochem Cytochem (2014) 0.83

Induction of ΔNp63 by the newly identified keratinocyte-specific transforming growth factor β Signaling Pathway with Smad2 and IκB Kinase α in squamous cell carcinoma. Neoplasia (2010) 0.81

α6 Integrin and CD44 enrich for a primary keratinocyte population that displays resistance to UV-induced apoptosis. PLoS One (2012) 0.79

p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1. J Cell Physiol (2015) 0.79

A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms. Nucleic Acids Res (2015) 0.78

Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis. Ann Dermatol (2016) 0.75

Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice. Biol Open (2013) 0.75

Articles by these authors

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature (1986) 6.67

Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins. Anal Chem (1998) 4.77

Germline-specific expression of the Oct-4/green fluorescent protein (GFP) transgene in mice. Dev Growth Differ (1999) 3.56

Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med (1998) 3.23

Nucleotide sequence of the tobacco mosaic virus (tomato strain) genome and comparison with the common strain genome. J Biochem (1984) 2.93

Cloning of the genes for penicillinase, penP and penI, of Bacillus licheniformis in some vector plasmids and their expression in Escherichia coli, Bacillus subtilis, and Bacillus licheniformis. J Bacteriol (1981) 2.93

Transformation of Bacillus stearothermophilus with plasmid DNA and characterization of shuttle vector plasmids between Bacillus stearothermophilus and Bacillus subtilis. J Bacteriol (1982) 2.80

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat Genet (2000) 2.69

Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol (1990) 2.69

Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene (1993) 2.67

Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J Biol Chem (1998) 2.64

Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110. J Bacteriol (1984) 2.40

Isolation and characterization of antibiotic resistance plasmids from thermophilic bacilli and construction of deletion plasmids. J Bacteriol (1981) 2.40

Production of human alpha-interferon in silkworm using a baculovirus vector. Nature (1985) 2.37

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol Cell Biol (1994) 2.27

Lumbar spinal stenosis and nerve root entrapment syndromes. Definition and classification. Clin Orthop Relat Res (1976) 2.25

Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett (2001) 2.15

Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J (1998) 2.13

Nucleotide sequence and promoter region for the neutral protease gene from Bacillus stearothermophilus. J Bacteriol (1985) 2.12

Chromatin boundaries and chromatin domains. Cold Spring Harb Symp Quant Biol (2004) 2.08

Nucleotide sequence of the penicillinase repressor gene penI of Bacillus licheniformis and regulation of penP and penI by the repressor. J Bacteriol (1986) 2.08

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. EMBO J (1999) 1.97

Three-dimensional evaluation of upper airway in patients with different anteroposterior skeletal patterns. Orthod Craniofac Res (2013) 1.97

Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension (1998) 1.88

Human oculocutaneous albinism caused by single base insertion in the tyrosinase gene. Biochem Biophys Res Commun (1989) 1.85

Nucleotide sequence of the Bacillus stearothermophilus alpha-amylase gene. J Bacteriol (1985) 1.81

Molecular cloning of a thermostable neutral protease gene from Bacillus stearothermophilus in a vector plasmid and its expression in Bacillus stearothermophilus and Bacillus subtilis. J Bacteriol (1983) 1.80

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit. Mol Cell Biol (1998) 1.80

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem (1994) 1.78

Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins. FEBS Lett (1998) 1.78

Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. Gene (1995) 1.71

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol Cell Biol (1996) 1.69

Leukotactic properties of soluble substances in psoriasis scale. Br J Dermatol (1976) 1.68

Site-specific deoxyribonucleases in Bacillus subtilis and other Bacillus strains. J Bacteriol (1976) 1.65

Homologous pairing promoted by the human Rad52 protein. J Biol Chem (2001) 1.64

Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars. Arch Dermatol (1996) 1.62

Non-pigmented nodular plantar melanoma in 12 Japanese patients. Br J Dermatol (1997) 1.60

Functional role of c-Src in gap junctions of the cardiomyopathic heart. Circ Res (1999) 1.60

Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore. Chem Pharm Bull (Tokyo) (1998) 1.60

Molecular basis for the heterogeneity of human tyrosinase. Tohoku J Exp Med (1988) 1.58

Culture-positive Lyme borreliosis. Med J Aust (1998) 1.58

The myristoylated amino terminus of ADP-ribosylation factor 1 is a phospholipid- and GTP-sensitive switch. J Biol Chem (1995) 1.57

Increased production of a knotted form of plasmid pBR322 DNA in Escherichia coli DNA topoisomerase mutants. J Mol Biol (1987) 1.52

Biophysical assessment of persistent effects of moisturizers after their daily applications: evaluation of corneotherapy. Dermatology (2000) 1.52

Cloning of the Membrane-Bound Aldehyde Dehydrogenase Gene of Acetobacter polyoxogenes and Improvement of Acetic Acid Production by Use of the Cloned Gene. Appl Environ Microbiol (1989) 1.52

The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes. Mol Cell Biol (2001) 1.51

Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation. Thorax (2008) 1.51

A global repressor (Mlc) is involved in glucose induction of the ptsG gene encoding major glucose transporter in Escherichia coli. Mol Microbiol (1998) 1.49

Pulmonary and systemic arteriovenous fistulas in patients with left isomerism. Cardiol Young (1998) 1.47

Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. Exp Cell Res (2003) 1.47

Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients. Am J Pathol (1998) 1.46

Molecular cloning of tetracycline resistance genes from Streptomyces rimosus in Streptomyces griseus and characterization of the cloned genes. J Bacteriol (1985) 1.46

Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C. Proc Natl Acad Sci U S A (2001) 1.46

Cerebral vascular resistance assessed by transcranial color Doppler ultrasonography in patients with chronic liver diseases. J Gastroenterol Hepatol (2001) 1.45

Phenotypic stability of trp operon recombinant plasmids in Escherichia coli. J Gen Microbiol (1980) 1.44

Bcl-2 inhibits apoptosis of spermatogonia and growth of spermatogonial stem cells in a cell-intrinsic manner. Mol Reprod Dev (2001) 1.43

Self-cloning in Streptomyces griseus of an str gene cluster for streptomycin biosynthesis and streptomycin resistance. J Bacteriol (1985) 1.43

Unilateral dermatomal pigmentary dermatosis: a variant dyschromatosis? J Am Acad Dermatol (1992) 1.42

Minimum 10-year outcome of decompressive laminectomy for degenerative lumbar spinal stenosis. Spine (Phila Pa 1976) (2000) 1.41

Eosinophilic pustular folliculitis starting initially only with palmoplantar pustular lesions. Report of a case and review of the literature. Dermatology (1992) 1.40

Plane warts under spontaneous regression. Immunopathologic study on cellular constituents leading to the inflammatory reaction. Arch Dermatol (1986) 1.39

Screening the p53 status of human cell lines using a yeast functional assay. Mol Carcinog (1997) 1.38

Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes. Circulation (1997) 1.38

Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF. Mol Cell Biol (1995) 1.38

Chronic vulvar purpura. Dermatologica (1990) 1.37

Inverse correlation between CD34 expression and proline-4-hydroxylase immunoreactivity on spindle cells noted in hypertrophic scars and keloids. J Cutan Pathol (1997) 1.37

Cumulative effect of intragenic amino-acid replacements on the thermostability of a protein. Nature (1986) 1.37

Screening for thermostable mutant of kanamycin nucleotidyltransferase by the use of a transformation system for a thermophile, Bacillus stearothermophilus. J Biol Chem (1985) 1.36

Genetic studies on site-specific endodeoxyribonucleases in Bacillus subtilis: multiple modification and restriction systems in transformants of Bacillus subtilis 168. Mol Gen Genet (1980) 1.34

Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res (1997) 1.33

A perspective on the application of genetic engineering: stability of recombinant plasmid. Ann N Y Acad Sci (1981) 1.33

Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction. J Immunol (1998) 1.32

Attachment and growth of fibroblast cells on silk fibroin. Biochem Biophys Res Commun (1995) 1.32

Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm Res (2000) 1.31

Left-sided gallbladder with anomalies of the intrahepatic portal vein and anomalous junction of the pancreaticobiliary ductal system: a case report. Hepatogastroenterology (1996) 1.31

Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum Genet (1997) 1.28

A ubiquitous repressor interacting with an F9 cell-specific silencer and its functional suppression by differentiated cell-specific positive factors. Cell Growth Differ (1990) 1.27

Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide. Proc Natl Acad Sci U S A (1994) 1.27

What is the 'true' function of skin? Exp Dermatol (2002) 1.26

Number of cell layers of the stratum corneum in normal skin - relationship to the anatomical location on the body, age, sex and physical parameters. Arch Dermatol Res (1999) 1.24

Effect of in vitro DNA rearrangement in the NH2-terminal region of the penicillinase gene from Bacillus licheniformis on the mode of expression in Bacillus subtilis. J Gen Microbiol (1985) 1.24

Cloning and nucleotide sequence of the penicillinase antirepressor gene penJ of Bacillus licheniformis. J Bacteriol (1987) 1.23

Epidemiology and prognosis of subungual melanoma in 34 Japanese patients. Br J Dermatol (1996) 1.23

Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides. Br J Dermatol (2008) 1.23

Rapid identification and typing of Staphylococcus aureus by nested PCR amplified ribosomal DNA spacer region. FEMS Microbiol Lett (1997) 1.23

Attachment and growth of cultured fibroblast cells on silk protein matrices. J Biomed Mater Res (1995) 1.21

Mutational analysis of Saccharomyces cerevisiae ARF1. J Biol Chem (1995) 1.20

Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina. Hum Mol Genet (2000) 1.19

Immunohistologic studies in Schamberg's disease. Evidence for cellular immune reaction in lesional skin. Arch Dermatol (1988) 1.19

Effects of individual mutations in the P-450(C21) pseudogene on the P-450(C21) activity and their distribution in the patient genomes of congenital steroid 21-hydroxylase deficiency. J Biochem (1991) 1.18

Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg (2000) 1.17

Negative regulation of the pts operon by Mlc: mechanism underlying glucose induction in Escherichia coli. Genes Cells (1999) 1.17

Complete nucleotide sequences of Bacillus plasmids pUB110dB, pRBH1 and its copy mutants. Mol Gen Genet (1986) 1.17

Analysis of the human intestinal microbiota from 92 volunteers after ingestion of identical meals. Benef Microbes (2013) 1.16

Reassessment of maintenance and energy uncoupling in the growth of Azotobacter vinelandii. J Gen Microbiol (1972) 1.16

A possible role of the C-terminal domain of the RecA protein. A gateway model for double-stranded DNA binding. J Biol Chem (1996) 1.16

Stage-specific tissue and cell interactions play key roles in mouse germ cell specification. Development (2001) 1.15

Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia. Development (1996) 1.14

Characterization of a leukotactic factor derived from psoriatic scale. Br J Dermatol (1977) 1.14