Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children.

PubWeight™: 4.05‹?› | Rank: Top 1%

🔗 View Article (PMC 1797179)

Published in Malar J on January 21, 2007

Authors

Denise Njama-Meya1, Tamara D Clark, Bridget Nzarubara, Sarah Staedke, Moses R Kamya, Grant Dorsey

Author Affiliations

1: Makerere University Medical School, Kampala, Uganda. denise.meya@gmail.com

Associated clinical trials:

Can Treatment of Malaria be Restricted to Parasitologically Confirmed Malaria? | NCT00913146

Articles citing this

Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with fever. PLoS Med (2009) 4.49

Guidelines and mindlines: why do clinical staff over-diagnose malaria in Tanzania? A qualitative study. Malar J (2008) 4.22

Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda. Malar J (2010) 2.86

Effects of revised diagnostic recommendations on malaria treatment practices across age groups in Kenya. Trop Med Int Health (2008) 2.79

Abandoning presumptive antimalarial treatment for febrile children aged less than five years--a case of running before we can walk? PLoS Med (2009) 2.46

The burden of disease profile of residents of Nairobi's slums: results from a demographic surveillance system. Popul Health Metr (2008) 2.43

Impact of training in clinical and microscopy diagnosis of childhood malaria on antimalarial drug prescription and health outcome at primary health care level in Tanzania: a randomized controlled trial. Malar J (2008) 2.22

Working without a blindfold: the critical role of diagnostics in malaria control. Malar J (2008) 2.14

Use of an innovative, affordable, and open-source short message service-based tool to monitor malaria in remote areas of Uganda. Am J Trop Med Hyg (2011) 2.10

Accuracy of a rapid diagnostic test on the diagnosis of malaria infection and of malaria-attributable fever during low and high transmission season in Burkina Faso. Malar J (2010) 1.88

Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania. Am J Trop Med Hyg (2010) 1.83

Scale-up of malaria rapid diagnostic tests and artemisinin-based combination therapy: challenges and perspectives in sub-Saharan Africa. PLoS Med (2014) 1.61

Treatment guided by rapid diagnostic tests for malaria in Tanzanian children: safety and alternative bacterial diagnoses. Malar J (2011) 1.60

Stop ambiguous messages on malaria diagnosis. BMJ (2007) 1.58

Quality and safety of integrated community case management of malaria using rapid diagnostic tests and pneumonia by community health workers. Pathog Glob Health (2012) 1.54

Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria. Malar J (2008) 1.51

"Test and treat" or presumptive treatment for malaria in high transmission situations? A reflection on the latest WHO guidelines. Malar J (2011) 1.51

Improving rational treatment of malaria: perceptions and influence of RDTs on prescribing behaviour of health workers in southeast Nigeria. PLoS One (2011) 1.41

Malaria diagnosis and treatment practices following introduction of rapid diagnostic tests in Kibaha District, Coast Region, Tanzania. Malar J (2013) 1.36

Can treatment of malaria be restricted to parasitologically confirmed malaria? A school-based study in Benin in children with and without fever. Malar J (2010) 1.36

Accuracy of rapid tests for malaria and treatment outcomes for malaria and non-malaria cases among under-five children in rural Ghana. PLoS One (2012) 1.28

Determinants of use of intermittent preventive treatment of malaria in pregnancy: Jinja, Uganda. PLoS One (2010) 1.23

Field evaluation of an automated RDT reader and data management device for Plasmodium falciparum/Plasmodium vivax malaria in endemic areas of Colombia. Malar J (2014) 1.12

Rapid diagnostic tests for malaria and health workers' adherence to test results at health facilities in Zambia. Malar J (2014) 1.10

Diagnosis and treatment of malaria. BMJ (2007) 1.07

Costs of treating malaria according to test results. BMJ (2008) 1.04

Strict adherence to malaria rapid test results might lead to a neglect of other dangerous diseases: a cost benefit analysis from Burkina Faso. Malar J (2011) 1.00

Presumptive self-diagnosis of malaria and other febrile illnesses in Sierra Leone. Pan Afr Med J (2013) 0.98

Performance of the OptiMAL dipstick in the diagnosis of malaria infection in pregnancy. Ther Clin Risk Manag (2008) 0.98

Confirmed malaria cases among children under five with fever and history of fever in rural western Tanzania. BMC Res Notes (2011) 0.97

Patterns of anti-malarial drug treatment among pregnant women in Uganda. Malar J (2011) 0.97

Frequency and correlates of malaria over-treatment in areas of differing malaria transmission: a cross-sectional study in rural Western Kenya. Malar J (2015) 0.96

Prospective study on severe malaria among in-patients at Bombo regional hospital, Tanga, north-eastern Tanzania. BMC Infect Dis (2011) 0.95

Clinical performance of an automated reader in interpreting malaria rapid diagnostic tests in Tanzania. Malar J (2013) 0.95

Finding parasites and finding challenges: improved diagnostic access and trends in reported malaria and anti-malarial drug use in Livingstone district, Zambia. Malar J (2012) 0.93

Expanding Access to Malaria Diagnosis through Retail Shops in Western Kenya: What Do Shop Workers Think? Malar Res Treat (2013) 0.90

Low prevalence of Plasmodium falciparum antigenaemia among asymptomatic HAART-treated adults in an urban cohort in Uganda. Malar J (2011) 0.89

Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013. Malar J (2015) 0.87

Challenges Associated with Scaling up Artemisinin Combination Therapy in Sub-Saharan Africa A Review Article. Libyan J Med (2008) 0.87

Managing the Sick Child in the Era of Declining Malaria Transmission: Development of ALMANACH, an Electronic Algorithm for Appropriate Use of Antimicrobials. PLoS One (2015) 0.86

Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial. Malar J (2009) 0.85

KIR3DL1/S1 genotypes and KIR2DS4 allelic variants in the AB KIR genotypes are associated with Plasmodium-positive individuals in malaria infection. Immunogenetics (2010) 0.85

Effect of context on respiratory rate measurement in identifying non-severe pneumonia in African children. Trop Med Int Health (2015) 0.84

Effect of Test-Based versus Presumptive Treatment of Malaria in Under-Five Children in Rural Ghana - A Cluster-Randomised Trial. PLoS One (2016) 0.81

Absence of dry season Plasmodium parasitaemia, but high rates of reported acute respiratory infection and diarrhoea in preschool-aged children in Kaédi, southern Mauritania. Parasit Vectors (2012) 0.80

A comprehensive assessment of the malaria microscopy system of Aceh, Indonesia, in preparation for malaria elimination. Malar J (2015) 0.78

Malaria care in infants aged under six months in Uganda: an area of unmet needs! PLoS One (2015) 0.77

Malaria morbidity and temperature variation in a low risk Kenyan district: a case of overdiagnosis? Int J Biometeorol (2009) 0.77

Quality of inpatient pediatric case management for four leading causes of child mortality at six government-run Ugandan hospitals. PLoS One (2015) 0.76

Factors affecting adherence to national malaria treatment guidelines in management of malaria among public healthcare workers in Kamuli District, Uganda. Malar J (2016) 0.75

Articles cited by this

Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg (2000) 22.12

Malaria misdiagnosis: effects on the poor and vulnerable. Lancet (2004) 9.15

Microscopy and outpatient malaria case management among older children and adults in Kenya. Trop Med Int Health (2006) 6.26

Use of clinical algorithms for diagnosing malaria. Trop Med Int Health (2002) 5.77

Does the availability of blood slide microscopy for malaria at health centers improve the management of persons with fever in Zambia? Am J Trop Med Hyg (1999) 5.56

Diagnostic accuracy and case management of clinical malaria in the primary health services of a rural area in south-eastern Tanzania. Trop Med Int Health (2001) 3.62

The contribution of microscopy to targeting antimalarial treatment in a low transmission area of Tanzania. Malar J (2006) 3.31

Improving the accuracy of malaria-related laboratory tests in Ghana. Malar J (2004) 2.97

Clinical features cannot predict a diagnosis of malaria or differentiate the infecting species in children living in an area of low transmission. Trans R Soc Trop Med Hyg (1998) 2.54

Clinical algorithms for malaria diagnosis lack utility among people of different age groups. Trop Med Int Health (2005) 2.46

Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal. Trop Med Int Health (2005) 2.18

Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment. Malar J (2006) 1.81

Asymptomatic parasitaemia as a risk factor for symptomatic malaria in a cohort of Ugandan children. Trop Med Int Health (2004) 1.74

Urban malaria in the Sahel: prevalence and seasonality of presumptive malaria and parasitaemia at primary care level in Chad. Trop Med Int Health (2006) 1.51

Articles by these authors

Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis (2008) 4.60

In vivo parasitological measures of artemisinin susceptibility. J Infect Dis (2010) 4.25

Cost-effectiveness of serum cryptococcal antigen screening to prevent deaths among HIV-infected persons with a CD4+ cell count < or = 100 cells/microL who start HIV therapy in resource-limited settings. Clin Infect Dis (2010) 4.08

Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy. Clin Infect Dis (2008) 3.91

Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet (2002) 3.78

Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg (2003) 3.71

Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA (2007) 3.62

Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Lancet (2009) 3.21

Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet (2004) 3.12

Response to antiretroviral therapy in HIV-infected patients attending a public, urban clinic in Kampala, Uganda. Clin Infect Dis (2005) 3.00

Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet (2007) 2.99

Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. BMJ (2009) 2.84

Acceptability of routine HIV counselling and testing, and HIV seroprevalence in Ugandan hospitals. Bull World Health Organ (2008) 2.80

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One (2008) 2.78

Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother (2006) 2.74

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials (2006) 2.72

Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg (2003) 2.68

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials (2007) 2.63

Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis (2005) 2.51

Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop (2011) 2.46

Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis (2007) 2.44

Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Am J Trop Med Hyg (2006) 2.43

Improved malaria case management after integrated team-based training of health care workers in Uganda. Am J Trop Med Hyg (2008) 2.42

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis (2009) 2.42

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med (2005) 2.33

Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda. Am J Trop Med Hyg (2007) 2.30

Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis (2008) 2.28

Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey. PLoS One (2011) 2.24

Identifying locations of recent TB transmission in rural Uganda: a multidisciplinary approach. Trop Med Int Health (2015) 2.10

Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis. PLoS One (2009) 2.05

High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis (2008) 2.05

Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis (2011) 1.98

Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis (2012) 1.97

Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg (2003) 1.96

Improved malaria case management through the implementation of a health facility-based sentinel site surveillance system in Uganda. PLoS One (2011) 1.94

Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis (2006) 1.93

Gay and bisexual men in Kampala, Uganda. AIDS Behav (2007) 1.89

Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr (2009) 1.83

Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology. PLoS One (2012) 1.81

Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment. Malar J (2006) 1.81

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis. Malar J (2009) 1.80

Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS (2007) 1.79

PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan children. J Clin Microbiol (2010) 1.77

Leveraging rapid community-based HIV testing campaigns for non-communicable diseases in rural Uganda. PLoS One (2012) 1.77

Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. Antimicrob Agents Chemother (2007) 1.75

Asymptomatic parasitaemia as a risk factor for symptomatic malaria in a cohort of Ugandan children. Trop Med Int Health (2004) 1.74

The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005. Malar J (2006) 1.73

Estimating the annual entomological inoculation rate for Plasmodium falciparum transmitted by Anopheles gambiae s.l. using three sampling methods in three sites in Uganda. Malar J (2014) 1.73

Burden of tuberculosis in Kampala, Uganda. Bull World Health Organ (2004) 1.69

Linkage to HIV care and survival following inpatient HIV counseling and testing. AIDS Behav (2011) 1.66

Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. Malar J (2012) 1.65

Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am J Trop Med Hyg (2006) 1.64

Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trial. BMJ (2011) 1.62

Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda. AIDS (2007) 1.62

Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy. Am J Trop Med Hyg (2005) 1.59

Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria. Am J Trop Med Hyg (2003) 1.59

Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Am J Trop Med Hyg (2004) 1.58

Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med (2012) 1.58

World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. Malar J (2007) 1.56

Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Trop Med Int Health (2004) 1.56

Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda. Am J Trop Med Hyg (2005) 1.53

Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda. Antimicrob Agents Chemother (2009) 1.52