Published in Arch Biochem Biophys on January 08, 2007
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Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model. Cancer Gene Ther (2007) 0.95
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Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes. J Biol Chem (2008) 0.87
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Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. J Biol Inorg Chem (2009) 0.79
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Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors. Acta Pharm Sin B (2012) 0.78
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Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase. Nat Biotechnol (2002) 1.64
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Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation. Biochemistry (2004) 1.09
Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products. Arch Biochem Biophys (2001) 1.09
Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. J Biol Chem (2005) 1.06
Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11. Mol Cancer Ther (2006) 1.05
Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. Mol Pharmacol (2004) 1.04
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Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys (2006) 1.00
Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding. Arch Biochem Biophys (2004) 0.99
A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5. J Biol Chem (2003) 0.99
Functional role of residues in the helix B' region of cytochrome P450 2B1. Arch Biochem Biophys (2005) 0.96
Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11. Biochim Biophys Acta (1997) 0.95
Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix. Arch Biochem Biophys (2004) 0.94
Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1. Chem Res Toxicol (2002) 0.93
Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties. Biochemistry (1999) 0.92
Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Drug Metab Dispos (2006) 0.90
Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer. Toxicol In Vitro (2005) 0.90
Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide. Protein Eng Des Sel (2006) 0.85
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Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26. Mol Pharmacol (1999) 0.77
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
The marine viromes of four oceanic regions. PLoS Biol (2006) 10.19
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res (2002) 4.92
Metagenomic analysis of the microbial community associated with the coral Porites astreoides. Environ Microbiol (2007) 4.21
Pluripotent stem cells from the adult mouse inner ear. Nat Med (2003) 3.92
Perioperative dexmedetomidine improves outcomes of cardiac surgery. Circulation (2013) 3.91
Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology (2006) 3.46
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis. AJNR Am J Neuroradiol (2005) 3.11
Preoperative aspirin use and outcomes in cardiac surgery patients. Ann Surg (2012) 3.03
Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation (2010) 2.95
Viral and microbial community dynamics in four aquatic environments. ISME J (2010) 2.95
Uroflowmetry in healthy women: Development and validation of flow-volume and corrected flow-age nomograms. Neurourol Urodyn (2009) 2.84
A survey on gas sensing technology. Sensors (Basel) (2012) 2.79
An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proc Natl Acad Sci U S A (2003) 2.74
Biodiversity and biogeography of phages in modern stromatolites and thrombolites. Nature (2008) 2.70
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. J Biol Chem (2004) 2.66
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem (2005) 2.64
Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins. J Am Coll Cardiol (2006) 2.57
Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011). Chem Rev (2013) 2.38
Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci (2003) 2.20
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity (2013) 2.20
Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney Int (2009) 2.19
Paradoxical action of fulvestrant in estradiol-induced regression of tamoxifen-stimulated breast cancer. J Natl Cancer Inst (2003) 2.18
Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol (2006) 2.17
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney Int (2012) 2.12
Mutation analysis of the MVK gene in Chinese patients with disseminated superficial actinic porokeratosis. J Dermatol Sci (2013) 2.04
Characterization of the bell-shaped vibratory angular rate gyro. Sensors (Basel) (2013) 2.04
Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. Sci Transl Med (2013) 2.03
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nat Struct Mol Biol (2010) 1.98
Transcriptional adaptation of Shigella flexneri during infection of macrophages and epithelial cells: insights into the strategies of a cytosolic bacterial pathogen. Infect Immun (2005) 1.96
Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther (2008) 1.96
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet (2011) 1.95
Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. J Biol Chem (2005) 1.91
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. Int J Radiat Oncol Biol Phys (2007) 1.89
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol (2012) 1.88
Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa. Proc Natl Acad Sci U S A (2008) 1.86
Generation of hair cells by stepwise differentiation of embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.81
Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol (2011) 1.80
Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine (2004) 1.74
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem (2002) 1.73
Sustainable power generation in microbial fuel cells using bicarbonate buffer and proton transfer mechanisms. Environ Sci Technol (2007) 1.72
Pelvic fracture-associated urethral injuries in girls: experience with primary repair. BJU Int (2004) 1.72
Effectiveness of rapid initial dose escalation of up to forty milligrams per day of oral olanzapine in acute agitation. J Clin Psychopharmacol (2003) 1.70
Advancing the science of mHealth. J Health Commun (2012) 1.69
X-ray phase-attenuation duality and phase retrieval. Opt Lett (2005) 1.68
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol (2011) 1.67
Research on bell-shaped vibratory angular rate gyro's character of resonator. Sensors (Basel) (2013) 1.66
A new theory of phase-contrast x-ray imaging based on Wigner distributions. Med Phys (2004) 1.66
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase. Proc Natl Acad Sci U S A (2010) 1.65
A Bi2 WO6 -based hybrid photocatalyst with broad spectrum photocatalytic properties under UV, visible, and near-infrared irradiation. Adv Mater (2013) 1.65
Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. J Immunol (2011) 1.65
The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol (2004) 1.64
Inactivation of a two-component signal transduction system, SaeRS, eliminates adherence and attenuates virulence of Staphylococcus aureus. Infect Immun (2006) 1.63
Anesthetic preconditioning combined with postconditioning offers no additional benefit over preconditioning or postconditioning alone. Anesth Analg (2007) 1.58
Retracted Ultrasonography reinvents the originally described technique for ganglion impar neurolysis in perianal cancer pain. Anesth Analg (2008) 1.58
An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector. J Virol (2003) 1.56
Therapeutic efficacy of add-on yogasana intervention in stabilized outpatient schizophrenia: Randomized controlled comparison with exercise and waitlist. Indian J Psychiatry (2012) 1.55
Construction of genetic linkage maps and comparative genome analysis of catfish using gene-associated markers. Genetics (2009) 1.55
One week of nitrofurantoin before percutaneous nephrolithotomy significantly reduces upper tract infection and urosepsis: a prospective controlled study. Urology (2010) 1.54
Quality assessment parameters for EST-derived SNPs from catfish. BMC Genomics (2008) 1.54
Arogyasree: an enhanced grid-based approach to mobile telemedicine. Int J Telemed Appl (2010) 1.53
A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling. Stem Cells (2007) 1.53
Clinical implementation of x-ray phase-contrast imaging: theoretical foundations and design considerations. Med Phys (2003) 1.53
Is there an adjunctive role of tamsulosin to extracorporeal shockwave lithotripsy for upper ureteric stones: results of an open label randomized nonplacebo controlled study. Urology (2009) 1.52
A nonproton ligand sensor in the acid-sensing ion channel. Neuron (2010) 1.52
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Res (2007) 1.51
Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model. Chin Med J (Engl) (2008) 1.48
Emergence of genotype I of Japanese encephalitis virus as the dominant genotype in Asia. J Virol (2011) 1.46
Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Mol Endocrinol (2004) 1.46
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China. J Clin Microbiol (2005) 1.46
Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects. Breast Cancer Res Treat (2010) 1.46
Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells (2013) 1.46
Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Mol Cell Biol (2010) 1.45
Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity. Nano Lett (2007) 1.43
Generation of genome-scale gene-associated SNPs in catfish for the construction of a high-density SNP array. BMC Genomics (2011) 1.43
Indoleamine 2, 3-Dioxgenase Transfected Mesenchymal Stem Cells Induce Kidney Allograft Tolerance by Increasing the Production and Function of Regulatory T Cells. Transplantation (2015) 1.41
Complete sequence determination of a novel reptile iridovirus isolated from soft-shelled turtle and evolutionary analysis of Iridoviridae. BMC Genomics (2009) 1.40
Drug compliance after stroke and myocardial infarction: a comparative study. Neurol India (2007) 1.40
Six novel mutations of ATP2C1 identified in eight Chinese patients with Hailey-Hailey disease. Indian J Dermatol Venereol Leprol (2013) 1.40
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol (2005) 1.40
Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel. Circ Res (2010) 1.40
Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res (2012) 1.39
[Retrospective study of application of interspinous implants for degenerative lumbar diseases]. Zhonghua Yi Xue Za Zhi (2009) 1.39
Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology (2007) 1.39
Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence. Mol Microbiol (2007) 1.38
Power densities using different cathode catalysts (Pt and CoTMPP) and polymer binders (nafion and PTFE) in single chamber microbial fuel cells. Environ Sci Technol (2006) 1.38
Identification and characterization of catabolic para-nitrophenol 4-monooxygenase and para-benzoquinone reductase from Pseudomonas sp. strain WBC-3. J Bacteriol (2009) 1.37
Unexpected pressure waveform during pulmonary artery catheter placement. J Cardiothorac Vasc Anesth (2003) 1.37
Hemorrhagic cystitis: A challenge to the urologist. Indian J Urol (2010) 1.36
Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol (2011) 1.36
Maize-targeted mutagenesis: A knockout resource for maize. Proc Natl Acad Sci U S A (2003) 1.35
Genome-wide prediction and analysis of function-specific transcription factor binding sites. In Silico Biol (2004) 1.35
Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility. Am J Physiol Endocrinol Metab (2005) 1.35
Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling. J Biol Chem (2006) 1.35