A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMID 17268410)

Published in Eur J Clin Nutr on January 31, 2007

Authors

S Kolida1, D Meyer, G R Gibson

Author Affiliations

1: Department of Food Biosciences, Food Microbial Sciences Unit, The University of Reading, Reading, UK. s.kolida@reading.ac.uk

Associated clinical trials:

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study | NCT04543877

Articles citing this

Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations. Cell (2010) 3.70

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut (2012) 3.09

Eating for two: how metabolism establishes interspecies interactions in the gut. Cell Host Microbe (2011) 2.06

Metabolic modeling of species interaction in the human microbiome elucidates community-level assembly rules. Proc Natl Acad Sci U S A (2013) 1.84

Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis. J Clin Microbiol (2007) 1.60

Retracted Obesity as a consequence of gut bacteria and diet interactions. ISRN Obes (2014) 1.42

Multifunctional fructans and raffinose family oligosaccharides. Front Plant Sci (2013) 1.36

Substrate-driven gene expression in Roseburia inulinivorans: importance of inducible enzymes in the utilization of inulin and starch. Proc Natl Acad Sci U S A (2010) 1.16

Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals. PLoS One (2014) 1.00

Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals. Microbiome (2016) 0.93

A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers. Nutr J (2012) 0.91

Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 2: What to Look for and How to Recommend an Effective Fiber Therapy. Nutr Today (2015) 0.85

Changes in infants faecal characteristics and microbiota by inulin supplementation. J Clin Biochem Nutr (2008) 0.82

A randomised, double- blind, cross-over study investigating the prebiotic effect of agave fructans in healthy human subjects. J Nutr Sci (2015) 0.78

Consuming foods with added oligofructose improves stool frequency: a randomised trial in healthy young adults. J Nutr Sci (2014) 0.77

Influence of habitual dietary fibre intake on the responsiveness of the gut microbiota to a prebiotic: protocol for a randomised, double-blind, placebo-controlled, cross-over, single-centre study. BMJ Open (2016) 0.76

Inulin-Type β2-1 Fructans have Some Effect on the Antibody Response to Seasonal Influenza Vaccination in Healthy Middle-Aged Humans. Front Immunol (2015) 0.75

Gut Balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals. Gut Microbes (2012) 0.75

Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis. Int J Colorectal Dis (2011) 0.75

The Gut Microbiota from Lean and Obese Subjects Contribute Differently to the Fermentation of Arabinogalactan and Inulin. PLoS One (2016) 0.75

Effect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr (2016) 0.75

Effect of dietary prebiotic supplementation on advanced glycation, insulin resistance and inflammatory biomarkers in adults with pre-diabetes: a study protocol for a double-blind placebo-controlled randomised crossover clinical trial. BMC Endocr Disord (2014) 0.75

Prebiotic Potential of a Maize-Based Soluble Fibre and Impact of Dose on the Human Gut Microbiota. PLoS One (2016) 0.75

Specific signatures of the gut microbiota and increased levels of butyrate in children treated with fermented cow's milk containing heat-killed Lactobacillus paracasei CBA L74. Appl Environ Microbiol (2017) 0.75

Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population. Sci Rep (2017) 0.75

Tolerability and safety of the intake of bovine milk oligosaccharides extracted from cheese whey in healthy human adults. J Nutr Sci (2017) 0.75

Fermented Fiber Supplements Are No Better Than Placebo for a Laxative Effect. Dig Dis Sci (2016) 0.75

Articles by these authors

(truncated to the top 100)

Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl Environ Microbiol (1999) 16.09

Isolation of Helicobacter pylori from human faeces. Lancet (1992) 7.32

Use of a rapid assay of subforms of creatine kinase-MB to diagnose or rule out acute myocardial infarction. N Engl J Med (1994) 7.17

Multiple essential functions of neuregulin in development. Nature (1995) 5.66

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia (2007) 5.61

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor. J Thromb Haemost (2006) 4.58

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J Cell Biol (2001) 3.84

Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation (2001) 3.33

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol (1993) 3.32

Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity (1996) 2.96

Comparison of fermentation reactions in different regions of the human colon. J Appl Bacteriol (1992) 2.87

Ultrafast bond softening in bismuth: mapping a solid's interatomic potential with X-rays. Science (2007) 2.84

Functional food science and gastrointestinal physiology and function. Br J Nutr (1998) 2.78

A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD). J Thromb Haemost (2006) 2.56

Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr (1999) 2.49

Susceptibility locus for Alzheimer's disease on chromosome 10. Science (2000) 2.49

Production, metabolism, and excretion of hydrogen in the large intestine. Gastroenterology (1992) 2.34

CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway. J Biol Chem (2001) 2.32

Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost (1992) 2.31

Common-sense models of illness: the example of hypertension. Health Psychol (1985) 2.26

Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacol Ther (2008) 2.13

The bifidogenic nature of chicory inulin and its hydrolysis products. J Nutr (1998) 2.11

Diagnostic marker cooperative study for the diagnosis of myocardial infarction. Circulation (1999) 2.09

Development of a disease specific quality of life (QoL) questionnaire module to supplement the EORTC core cancer QoL questionnaire, the QLQ-C30 in patients with pancreatic cancer. EORTC Study Group on Quality of Life. Eur J Cancer (1999) 1.99

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J Cell Biol (1995) 1.91

Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications, is an inherited disorder. Blood (1996) 1.89

Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice. J Thromb Haemost (2005) 1.88

Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J Appl Bacteriol (1993) 1.87

Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. Tissue Antigens (2004) 1.86

Metabolism of dietary sulphate: absorption and excretion in humans. Gut (1991) 1.85

Evidence that three adhesive proteins interact with a common recognition site on activated platelets. J Biol Chem (1984) 1.83

Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD). J Thromb Haemost (2008) 1.81

Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology (1994) 1.73

Congenital upper eyelid eversion complicated by corneal perforation. Br J Ophthalmol (2005) 1.73

Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: a study of 111 cases. Blood (2001) 1.69

Platelet membrane glycoproteins implicated in ristocetin-induced aggregation. Studies of the proteins on platelets from patients with Bernard-Soulier syndrome and von Willebrand's disease. J Clin Invest (1976) 1.67

Evidence that the Ya and Yc subunits of glutathione transferase B (ligandin) are the products of separate genes. Eur J Biochem (1982) 1.65

Comparison of viable cell counts and fluorescence in situ hybridization using specific rRNA-based probes for the quantification of human fecal bacteria. FEMS Microbiol Lett (2000) 1.65

Cost-effectiveness of strategies to enhance mammography use. Eff Clin Pract (2001) 1.65

A novel class C beta-lactamase (FOX-2) in Escherichia coli conferring resistance to cephamycins. Antimicrob Agents Chemother (1997) 1.64

Impact, diagnosis and treatment of von Willebrand disease. Thromb Haemost (2000) 1.62

Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. J Clin Invest (1992) 1.62

Circulating procoagulant microparticles in women with unexplained pregnancy loss: a new insight. Thromb Haemost (2001) 1.60

Structure-function relationship of human von Willebrand factor. Blood (1987) 1.60

Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thromb Haemost (1995) 1.58

Influence of mode of delivery on gut microbiota composition in seven year old children. Gut (2004) 1.55

Thrombotic risk factors in pulmonary hypertension. Eur Respir J (2000) 1.54

International survey of patients with von Willebrand disease and angiodysplasia. Thromb Haemost (1993) 1.51

Agriculture. Transforming U.S. agriculture. Science (2011) 1.51

The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides--a human volunteer study. Br J Nutr (2001) 1.50

Academic stress, power motivation, and decrease in secretion rate of salivary secretory immunoglobulin A. Lancet (1983) 1.49

Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16). J Immunol (1998) 1.49

Acquired von Willebrand syndrome: data from an international registry. Thromb Haemost (2000) 1.48

Probiotics as modulators of the gut flora. Br J Nutr (2002) 1.46

Molecular procedure for rapid detection of Burkholderia mallei and Burkholderia pseudomallei. J Clin Microbiol (1998) 1.42

[Nononcologic abdominal surgery in the elderly]. Chirurg (2005) 1.38

Long-term follow-up of Stargardt's disease and fundus flavimaculatus. Ophthalmology (1998) 1.37

Influence of mucin on glycosidase, protease and arylamidase activities of human gut bacteria grown in a 3-stage continuous culture system. J Appl Bacteriol (1989) 1.35

Clostridium hathewayi sp. nov., from human faeces. Syst Appl Microbiol (2001) 1.34

Willebrand factor and ristocetin. I. Mechanism of rustocetin-induced platelet aggregation. Br J Haematol (1974) 1.29

Prebiotic effects of inulin and oligofructose. Br J Nutr (2002) 1.28

Cloning and developmental expression of the murine neurofilament gene family. Brain Res (1986) 1.28

The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr Biol (2000) 1.27

Pseudo-von Willebrand's disease. An intrinsic platelet defect with aggregation by unmodified human factor VIII/von Willebrand factor and enhanced adsorption of its high-molecular-weight multimers. N Engl J Med (1982) 1.26

Ser968Thr mutation within the A3 domain of von Willebrand factor (VWF) in two related patients leads to a defective binding of VWF to collagen. Thromb Haemost (2001) 1.25

Role of dietary sulphate in the regulation of methanogenesis in the human large intestine. Gut (1992) 1.24

Modification of the intestinal microflora using probiotics and prebiotics. Scand J Gastroenterol Suppl (1997) 1.24

Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man. Cancer Chemother Rep (1975) 1.24

The biochemistry of oligofructose, a nondigestible fiber: an approach to calculate its caloric value. Nutr Rev (1993) 1.24

Haemophilia B due to a de novo insertion of a human-specific Alu subfamily member within the coding region of the factor IX gene. Eur J Hum Genet (1993) 1.24

A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J Appl Microbiol (2001) 1.23

A novel mucin sulphatase from human faeces: its identification, purification and characterization. Clin Sci (Lond) (1992) 1.23

Effect of different carbohydrates on growth, polysaccharidase and glycosidase production by Bacteroides ovatus, in batch and continuous culture. J Appl Bacteriol (1990) 1.22

Multimeric structure of factor VIII/von Willebrand factor in von Willebrand's disease. J Lab Clin Med (1980) 1.19

Modulation of the human gut microflora towards improved health using prebiotics--assessment of efficacy. Curr Pharm Des (2005) 1.18

Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies. Blood (1985) 1.18

Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies. Vet Clin Pathol (2005) 1.17

Health benefits of probiotics: are mixtures more effective than single strains? Eur J Nutr (2011) 1.17

Report from a forum on US heart allocation policy. Am J Transplant (2015) 1.17

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2. Physiol Behav (2006) 1.15

Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components. EMBO J (2001) 1.14

Shear rate dependent inhibition of platelet adhesion and aggregation on collagenous surfaces by antibodies to human factor VIII/von Willebrand factor. Br J Haematol (1980) 1.14

Linkage analysis in families diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 VWD. J Thromb Haemost (2006) 1.14

Estimation of the von Willebrand factor-cleaving protease in plasma using monoclonal antibodies to vWF. Thromb Haemost (1999) 1.14

Expression of 14 von Willebrand factor mutations identified in patients with type 1 von Willebrand disease from the MCMDM-1VWD study. J Thromb Haemost (2009) 1.13

Nutritional aspects of dissimilatory sulfate reduction in the human large intestine. Curr Microbiol (1997) 1.12

Clinical, serologic, and epidemiologic characteristics of ocular toxocariasis. Am J Trop Med Hyg (1979) 1.11

Characteristics of Actinobacillus actinomycetemcomitans invasion of and adhesion to cultured epithelial cells. Adv Dent Res (1995) 1.11

Intranodal immunization with tumor lysate-pulsed dendritic cells enhances protective antitumor immunity. Cancer Res (2001) 1.10

Ten candidate ADAMTS13 mutations in six French families with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome). J Thromb Haemost (2004) 1.10

Formation of glycoprotein degrading enzymes by Bacteroides fragilis. FEMS Microbiol Lett (1991) 1.10

Standard nomenclature for factor VIII and von Willebrand factor: a recommendation by the International Committee on Thrombosis and Haemostasis. Thromb Haemost (1985) 1.10

Ocular complications of dental local anaesthesia. SADJ (1998) 1.10

Methemoglobinemia produced by high-dose intravenous nitroglycerin. Ann Intern Med (1982) 1.10

Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid. J Appl Microbiol (2001) 1.09

Vg1 RBP intracellular distribution and evolutionarily conserved expression at multiple stages during development. Mech Dev (1999) 1.09

Differential distribution of von Willebrand factor in endothelial cells. Comparison between normal pigs and pigs with von Willebrand disease. Arteriosclerosis (1987) 1.09

Bacterial biofilms in the human gastrointestinal tract. Curr Issues Intest Microbiol (2002) 1.09

von Willebrand factor ristocetin cofactor activity correlates with platelet function in a high shear stress system. Thromb Haemost (2000) 1.07

Purification and partial amino acid sequence of the chloroplast cytochrome b-559. J Biol Chem (1984) 1.07