Published in Nat Rev Immunol on March 01, 2007
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. Cell Host Microbe (2010) 3.27
Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol (2013) 3.23
Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. Blood (2007) 2.31
Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol (2012) 2.27
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity (2013) 1.96
The GAIT system: a gatekeeper of inflammatory gene expression. Trends Biochem Sci (2009) 1.88
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1. Proc Natl Acad Sci U S A (2007) 1.85
Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensis. PLoS Pathog (2013) 1.71
DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Mol Cell (2008) 1.70
Regulation of innate immune response by MAP kinase phosphatase-1. Cell Signal (2007) 1.65
Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli. Am J Physiol Heart Circ Physiol (2010) 1.46
TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest (2010) 1.45
Rice XB15, a protein phosphatase 2C, negatively regulates cell death and XA21-mediated innate immunity. PLoS Biol (2008) 1.42
The effects of airway microbiome on corticosteroid responsiveness in asthma. Am J Respir Crit Care Med (2013) 1.36
Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. Cytokine (2009) 1.28
Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice. J Immunol (2009) 1.27
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J Biol Chem (2009) 1.19
Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling. J Thromb Haemost (2011) 1.18
Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. Infect Immun (2009) 1.16
DUSPs, to MAP kinases and beyond. Cell Biosci (2012) 1.16
Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells. PLoS One (2011) 1.15
MAP kinase phosphatase-1 protects against inflammatory bone loss. J Dent Res (2009) 1.14
Acetylation of MKP-1 and the control of inflammation. Sci Signal (2008) 1.14
Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways. J Biol Chem (2013) 1.13
MKP-1 is necessary for T cell activation and function. J Biol Chem (2009) 1.13
Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen (2013) 1.13
The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons. J Comp Neurol (2010) 1.12
Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors. Clin Vaccine Immunol (2014) 1.11
MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase. J Biol Chem (2013) 1.11
A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. PLoS Pathog (2011) 1.10
T-cell development and function are modulated by dual specificity phosphatase DUSP5. J Biol Chem (2008) 1.10
MAP kinase phosphatase-1, a critical negative regulator of the innate immune response. Int J Clin Exp Med (2009) 1.09
The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS. Aging Dis (2010) 1.09
The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury. J Neurosci (2013) 1.08
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease. Life Sci (2011) 1.08
Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons. J Neurosci (2010) 1.07
Signaling regulation of fetoplacental angiogenesis. J Endocrinol (2011) 1.04
Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One (2011) 1.03
Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L. J Virol (2009) 1.02
Mucosal immunity and Candida albicans infection. Clin Dev Immunol (2011) 1.01
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. J Clin Invest (2009) 1.01
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J (2009) 0.99
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem (2012) 0.98
Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. Hum Mol Genet (2009) 0.97
Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity. Hypertension (2009) 0.97
Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages. Acta Pharmacol Sin (2009) 0.97
The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis. BMC Microbiol (2010) 0.96
MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression. Cell Signal (2017) 0.96
Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia. Am J Physiol Heart Circ Physiol (2010) 0.94
Epithelial cell innate response to Candida albicans. Adv Dent Res (2011) 0.94
Mitogen activated protein kinase phosphatases and cancer. Cancer Biol Ther (2010) 0.93
Targeting JNK by a new curcumin analog to inhibit NF-kB-mediated expression of cell adhesion molecules attenuates renal macrophage infiltration and injury in diabetic mice. PLoS One (2013) 0.93
Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes. Cell Mol Life Sci (2012) 0.93
Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores. PLoS One (2009) 0.91
H89, an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide. Inflamm Res (2009) 0.91
Down-regulation of cytokine-induced interleukin-8 requires inhibition of p38 mitogen-activated protein kinase (MAPK) via MAPK phosphatase 1-dependent and -independent mechanisms. J Biol Chem (2011) 0.91
Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2012) 0.90
Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasis. Front Immunol (2013) 0.89
Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling. J Biol Chem (2015) 0.89
MAPK signaling drives inflammation in LPS-stimulated cardiomyocytes: the route of crosstalk to G-protein-coupled receptors. PLoS One (2012) 0.89
MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses. Proc Natl Acad Sci U S A (2012) 0.89
The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. Int J Mol Sci (2014) 0.89
Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds. PLoS One (2012) 0.88
Inactivation of p38 MAPK during liver regeneration. Int J Biochem Cell Biol (2010) 0.88
Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice. Mol Med (2011) 0.87
Identification of NURR1 as a mediator of MIF signaling during chronic arthritis: effects on glucocorticoid-induced MKP1. Am J Pathol (2010) 0.87
Impaired Toll-like receptor 2 signalling in monocytes from 5-year-old allergic children. Clin Exp Immunol (2009) 0.87
Control of host cell phosphorylation by legionella pneumophila. Front Microbiol (2011) 0.87
Antithrombin is protective against myocardial ischemia and reperfusion injury. J Thromb Haemost (2013) 0.87
Anthrax lethal toxin and the induction of CD4 T cell immunity. Toxins (Basel) (2012) 0.87
Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway. Int J Mol Sci (2015) 0.86
Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: a role for STAT1 and MAPK pathways. J Neurochem (2012) 0.85
Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1). J Biol Chem (2012) 0.85
WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in LPS-stimulated RAW264.7 macrophages. Br J Pharmacol (2015) 0.85
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance. Pain (2013) 0.84
Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer. Int J Cancer (2013) 0.84
ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56(dim)CD16(+) and CD56(bright)CD16(dim/-) natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. J Transl Med (2016) 0.84
Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1). PLoS One (2011) 0.83
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology (2012) 0.83
The RNA editor gene ADAR1 is induced in myoblasts by inflammatory ligands and buffers stress response. Clin Transl Sci (2010) 0.83
Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-α expression and improves cardiac function during endotoxemia. Cardiovasc Res (2011) 0.82
Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation. J Biol Chem (2010) 0.82
The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-1. Int J Mol Med (2010) 0.82
Restoration of immune response gene induction in trophoblast tumor cells associated with cellular senescence. J Reprod Immunol (2009) 0.82
MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function. Mol Endocrinol (2012) 0.82
CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK. PLoS One (2014) 0.82
Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury. Am J Physiol Lung Cell Mol Physiol (2012) 0.82
Protective autoantibodies in the rheumatic diseases: lessons for therapy. Nat Rev Rheumatol (2013) 0.81
The macrophage migration inhibitory factor homolog of Entamoeba histolytica binds to and immunomodulates host macrophages. Infect Immun (2014) 0.81
7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo. PLoS One (2014) 0.81
Regulatory Roles of MAPK Phosphatases in Cancer. Immune Netw (2016) 0.81
The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids. Front Microbiol (2016) 0.80
PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus. BMC Neurosci (2013) 0.80
Differential expression of microRNAs in Francisella tularensis-infected human macrophages: miR-155-dependent downregulation of MyD88 inhibits the inflammatory response. PLoS One (2014) 0.80
Upregulation of Kupffer cell α2A-Adrenoceptors and downregulation of MKP-1 mediate hepatic injury in chronic alcohol exposure. Biochem Biophys Res Commun (2011) 0.80
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med (2005) 3.37
The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38. J Biol Chem (2004) 2.22
A Proactive Approach to Neonates Born at 23 Weeks of Gestation. Obstet Gynecol (2015) 2.02
Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.79
In vitro evaluation of radio-labeled aerosol delivery via a variable-flow infant CPAP system. Respir Care (2013) 1.44
Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria. J Immunol (2007) 1.40
Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice. J Immunol (2009) 1.27
Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase. Am J Physiol Lung Cell Mol Physiol (2009) 1.25
Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen. Pediatr Res (2009) 1.22
Triptolide induces anti-inflammatory cellular responses. Am J Transl Res (2009) 1.15
Spatiotemporal characteristics of acid refluxate and relationship to symptoms in premature and term infants with chronic lung disease. Am J Gastroenterol (2008) 1.11
Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation. Am J Physiol Lung Cell Mol Physiol (2010) 1.09
The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia. Life Sci (2008) 1.09
Assessing heparin dosing in neonates on venoarterial extracorporeal membrane oxygenation. ASAIO J (2007) 1.04
Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1. J Biol Chem (2009) 1.02
Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia. Am J Physiol Heart Circ Physiol (2008) 0.97
Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol (2005) 0.96
Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia. Am J Physiol Heart Circ Physiol (2010) 0.94
Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps. J Immunol (2012) 0.93
Alterations of the thioredoxin system by hyperoxia: implications for alveolar development. Am J Respir Cell Mol Biol (2009) 0.91
Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine. Eur J Pediatr (2010) 0.91
Factors associated with maternal visitation and participation in skin-to-skin care in an all referral level IIIc NICU. Acta Paediatr (2012) 0.90
Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity. Am J Physiol Lung Cell Mol Physiol (2008) 0.89
Hospital variation in nitric oxide use for premature infants. Pediatrics (2012) 0.88
L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs. Pediatr Res (2004) 0.86
Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol (2012) 0.86
Inhaled nitric oxide decreases leukocyte trafficking in the neonatal mouse lung during exposure to >95% oxygen. Pediatr Res (2010) 0.86
Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin. Am J Physiol Heart Circ Physiol (2008) 0.86
Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. J Mol Med (Berl) (2005) 0.85
Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats. Am J Physiol Lung Cell Mol Physiol (2007) 0.84
Hyperoxia increases hepatic arginase expression and ornithine production in mice. Toxicol Appl Pharmacol (2006) 0.83
Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats. J Appl Physiol (1985) (2004) 0.83
Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat. J Appl Physiol (1985) (2002) 0.82
Respiratory severity score on day of life 30 is predictive of mortality and the length of mechanical ventilation in premature infants with protracted ventilation. Pediatr Pulmonol (2014) 0.82
Lipopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells. Cell Physiol Biochem (2012) 0.81
MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation. Cell Biol Int (2014) 0.81
Exhaled NO is reduced at an early stage of hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol Lung Cell Mol Physiol (2002) 0.80
Mean airway pressure and response to inhaled nitric oxide in neonatal and pediatric patients. Lung (2006) 0.79
Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol (2011) 0.79
Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide. J Appl Physiol (1985) (2002) 0.79
Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II. Cell Physiol Biochem (2016) 0.78
Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen. Lung (2010) 0.78
Mid-term differences in right ventricular function in patients with congenital diaphragmatic hernia compared with controls. World J Pediatr (2012) 0.78
Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells. Clin Exp Pharmacol Physiol (2011) 0.77
Cancer in pregnancy: fetal and neonatal outcomes. Clin Obstet Gynecol (2011) 0.76
Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells. Clin Exp Pharmacol Physiol (2014) 0.75
Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine. Am J Physiol Heart Circ Physiol (2012) 0.75
In Reply. Obstet Gynecol (2016) 0.75
Beyond adverse drug events and bloodstream infections: broadening the scope of harm events. Pediatr Crit Care Med (2015) 0.75
Tissue Doppler changes in three neonates with congenital diaphragmatic hernia. ASAIO J (2009) 0.75
Skin Rounds: A Quality Improvement Approach to Enhance Skin Care in the Neonatal Intensive Care Unit. Adv Neonatal Care (2016) 0.75
If mothers had their say: research-informed intervention design for empowering mothers to establish smoke-free homes. Soc Work Health Care (2014) 0.75
Representativeness of enrollment into a perinatal research repository. J Matern Fetal Neonatal Med (2014) 0.75