Published in Cell Cycle on February 03, 2007
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med (2009) 4.68
Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle (2008) 1.25
Temporal PTEN inactivation causes proliferation of saphenous vein smooth muscle cells of human CABG conduits. J Cell Mol Med (2008) 0.94
The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells. Oncotarget (2014) 0.85
NLK is a novel therapeutic target for PTEN deficient tumour cells. PLoS One (2012) 0.79
Radiosensitization of prostate cancer by priming the wild-type p53-dependent cellular senescence pathway. Cancer Biol Ther (2007) 0.77
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PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell (2003) 5.13
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res (2005) 5.07
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J (2004) 2.50
Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA. Mol Cell Biol (2006) 2.34
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PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem (2004) 1.25
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The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. Cell Death Differ (2005) 0.88
Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science (2011) 5.04
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med (2009) 4.68
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. Cancer Res (2008) 2.55
Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res (2010) 2.41
Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA. Mol Cell Biol (2006) 2.34
Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet (2013) 2.20
Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget (2010) 1.88
Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res (2002) 1.82
Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res (2011) 1.79
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer. Gastroenterology (2006) 1.73
Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. Cancer Res (2008) 1.65
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Suppression of tumorigenesis and activation of Wnt signaling by bone morphogenetic protein 4 in human cancer cells. Cancer Biol Ther (2004) 1.56
PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells. Cancer Res (2004) 1.49
B-Raf is dispensable for K-Ras-mediated oncogenesis in human cancer cells. Cancer Res (2004) 1.46
Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells. Radiat Oncol (2009) 1.42
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37
Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2. Cell Stress Chaperones (2002) 1.37
p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol (2012) 1.32
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. Cancer Res (2009) 1.29
Oncogenic mutations of PIK3CA in human cancers. Curr Top Microbiol Immunol (2010) 1.27
Proof-of-principle: oncogenic beta-catenin is a valid molecular target for the development of pharmacological inhibitors. Mol Cancer Ther (2002) 1.23
Sample type bias in the analysis of cancer genomes. Cancer Res (2009) 1.22
Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme. Cancer Res (2008) 1.19
IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in vitro and in vivo. Transpl Immunol (2004) 1.16
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A (2012) 1.15
Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells. Cell Immunol (2009) 1.13
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol (2011) 1.11
Epitope tagging of endogenous genes in diverse human cell lines. Nucleic Acids Res (2008) 1.09
Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1. Cancer Res (2003) 1.09
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun (2010) 1.08
In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates. J Exp Med (2011) 1.01
Soluble mediators from human neural stem cells play a critical role in suppression of T-cell activation and proliferation. J Neurosci Res (2009) 0.95
Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition. Mol Cancer Ther (2013) 0.93
NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN. J Cell Biochem (2007) 0.93
Immunomodulation of delayed-type hypersensitivity responses by mesenchymal stem cells is associated with bystander T cell apoptosis in the draining lymph node. J Immunol (2010) 0.91
Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor. Biochem Biophys Res Commun (2004) 0.90
Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines. J Biol Chem (2012) 0.90
Up-regulation of fibroblast growth factor-binding protein, by beta-catenin during colon carcinogenesis. Cancer Res (2003) 0.88
Murine mesenchymal stem cells suppress T lymphocyte activation through IL-2 receptor α (CD25) cleavage by producing matrix metalloproteinases. Stem Cell Rev (2011) 0.87
Islet isolation from adult designated pathogen-free pigs: use of the newer bovine nervous tissue-free enzymes and a revised donor selection strategy would improve the islet graft function. Xenotransplantation (2011) 0.87
Th1 and Th2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis. J Clin Virol (2008) 0.85
Pancreatic islets induce CD4(+) [corrected] CD25(-)Foxp3(+) [corrected] T-cell regulated tolerance to HY-mismatched skin grafts. Transplantation (2008) 0.82
Lack of inherited mutations of PTPRD in familial melanoma and melanoma-astrocytoma syndrome. Pigment Cell Melanoma Res (2009) 0.82
Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med (2002) 0.81
A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells. J Biomol Screen (2011) 0.81
Qualitative and quantitative comparison of N-glycans between pig endothelial and islet cells by high-performance liquid chromatography and mass spectrometry-based strategy. J Mass Spectrom (2009) 0.80
The role of the alternative complement pathway in early graft loss after intraportal porcine islet xenotransplantation. Transplantation (2014) 0.78
Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma. Hum Mutat (2014) 0.78
Dissociation between anti-porcine albumin and anti-Gal antibody responses in non-human primate recipients of intraportal porcine islet transplantation. Xenotransplantation (2015) 0.77
'Cables' suspends cancer in mice. Cancer Biol Ther (2005) 0.77
Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells. Phytother Res (2003) 0.76
Minimizing immunosuppression in islet xenotransplantation. Immunotherapy (2014) 0.76
Application of the multiplex cytokine analysis to monitor xenogeneic immune responses to the porcine islet graft in non-human primate. J Korean Med Sci (2013) 0.75
Human somatic cell knockouts reveal determinants of sensitivity and resistance to proteasome inhibitor PS-341. Cancer Biol Ther (2003) 0.75
Human somatic cell gene targeting. Curr Protoc Mol Biol (2003) 0.75
Effect of a Shortened Duration of FOLFOX Chemotherapy on the Survival Rate of Patients with Stage II and III Colon Cancer. Chemotherapy (2017) 0.75
Correction: In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates. J Exp Med (2016) 0.75
Synthesis of manganese nanoparticles in the liquid phase plasma. J Nanosci Nanotechnol (2013) 0.75
Preparation of Low Molecular Weight Heparin by Microwave Discharge Electrodeless Lamp/TiO2 Photo-Catalytic Reaction. J Nanosci Nanotechnol (2015) 0.75
Photocatalytic reaction characteristics of the titanium dioxide supported on the long phosphorescent phosphor by a low pressure chemical vapor deposition. J Nanosci Nanotechnol (2014) 0.75