Published in J Appl Physiol (1985) on March 08, 2007
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol (2012) 4.87
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab (2008) 3.78
FGF21 is an Akt-regulated myokine. FEBS Lett (2008) 2.29
Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism. J Biol Chem (2008) 2.03
A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes (2015) 1.81
Exercise training as a treatment for chronic inflammation in the elderly. Exerc Sport Sci Rev (2009) 1.59
The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance. Endocr Rev (2009) 1.57
Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Pediatr Diabetes (2011) 1.51
Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease. Front Neurol (2011) 1.41
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am J Physiol Endocrinol Metab (2008) 1.38
The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart. Trends Mol Med (2011) 1.24
Recovery after an Ironman triathlon: sustained inflammatory responses and muscular stress. Eur J Appl Physiol (2008) 1.12
The skeletal muscle secretome: an emerging player in muscle-bone crosstalk. Bonekey Rep (2012) 1.11
Biomarkers of peripheral muscle fatigue during exercise. BMC Musculoskelet Disord (2012) 1.11
Inflammation during obesity is not all bad: evidence from animal and human studies. Am J Physiol Endocrinol Metab (2012) 1.09
Hypercholesterolemia and microvascular dysfunction: interventional strategies. J Inflamm (Lond) (2010) 1.06
Irisin enhances osteoblast differentiation in vitro. Int J Endocrinol (2014) 1.06
Effect of nonmotorized wheel running on mammary carcinogenesis: circulating biomarkers, cellular processes, and molecular mechanisms in rats. Cancer Epidemiol Biomarkers Prev (2008) 1.05
Effects of a physical activity behavior change intervention on inflammation and related health outcomes in breast cancer survivors: pilot randomized trial. Integr Cancer Ther (2012) 1.03
Calprotectin is released from human skeletal muscle tissue during exercise. J Physiol (2008) 1.03
Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis. IUBMB Life (2009) 1.02
Electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise. PLoS One (2012) 1.00
Role of osteoglycin in the linkage between muscle and bone. J Biol Chem (2012) 0.98
Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation. PLoS One (2010) 0.97
Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women. J Appl Physiol (1985) (2009) 0.97
Irisin, two years later. Int J Endocrinol (2013) 0.97
Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease? World J Gastroenterol (2012) 0.96
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. J Mol Cell Cardiol (2010) 0.94
Vascular function and inflammation in rheumatoid arthritis: the role of physical activity. Open Cardiovasc Med J (2010) 0.94
The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair. Int J Biol Sci (2012) 0.94
Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Arch Med Sci (2015) 0.93
Endocrine crosstalk between muscle and bone. Curr Osteoporos Rep (2014) 0.93
Energetics and mammary carcinogenesis: effects of moderate-intensity running and energy intake on cellular processes and molecular mechanisms in rats. J Appl Physiol (1985) (2008) 0.92
Effects of resistance training on the inflammatory response. Nutr Res Pract (2010) 0.92
Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes (2009) 0.92
Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning? Heart Fail Rev (2012) 0.92
Contribution of IL-6 to the Hsp72, Hsp25, and alphaB-crystallin [corrected] responses to inflammation and exercise training in mouse skeletal and cardiac muscle. J Appl Physiol (1985) (2008) 0.91
The role of muscle cells in regulating cartilage matrix production. J Orthop Res (2010) 0.91
The effect of various cold-water immersion protocols on exercise-induced inflammatory response and functional recovery from high-intensity sprint exercise. Eur J Appl Physiol (2014) 0.90
The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK. J Diabetes Metab (2013) 0.90
Akt1-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction. Circ Heart Fail (2011) 0.89
Protective Effect of Irisin on Atherosclerosis via Suppressing Oxidized Low Density Lipoprotein Induced Vascular Inflammation and Endothelial Dysfunction. PLoS One (2016) 0.89
Messenger RNA sequencing and pathway analysis provide novel insights into the biological basis of chickens' feed efficiency. BMC Genomics (2015) 0.88
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise. Bone (2015) 0.88
Resting and exercise-induced IL-6 levels in children with Type 1 diabetes reflect hyperglycemic profiles during the previous 3 days. J Appl Physiol (1985) (2009) 0.88
Muscle-to-organ cross talk mediated by myokines. Adipocyte (2012) 0.88
Ursolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in men. Korean J Physiol Pharmacol (2014) 0.88
Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway. Aging Cell (2016) 0.87
Bone and muscle: Interactions beyond mechanical. Bone (2015) 0.87
Insulin-like 6 is induced by muscle injury and functions as a regenerative factor. J Biol Chem (2010) 0.86
A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome. BMC Immunol (2013) 0.86
Peeling back the evolutionary layers of molecular mechanisms responsive to exercise-stress in the skeletal muscle of the racing horse. DNA Res (2013) 0.85
Musclin is an activity-stimulated myokine that enhances physical endurance. Proc Natl Acad Sci U S A (2015) 0.84
Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice. Pain (2016) 0.83
Exercise and the microbiota. Gut Microbes (2015) 0.83
Initial pulmonary respiration causes massive diaphragm damage and hyper-CKemia in Duchenne muscular dystrophy dog. Sci Rep (2013) 0.83
Toxoplasma gondii-skeletal muscle cells interaction increases lipid droplet biogenesis and positively modulates the production of IL-12, IFN-g and PGE2. Parasit Vectors (2014) 0.83
Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia. PLoS One (2012) 0.82
A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults. Sports Med Open (2015) 0.82
Do high blood hepcidin concentrations contribute to low ferritin levels in young tennis players at the end of tournament season? J Sports Sci Med (2013) 0.82
Cardiac molecular-acclimation mechanisms in response to swimming-induced exercise in Atlantic salmon. PLoS One (2013) 0.81
Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. Eur J Appl Physiol (2009) 0.81
Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches. Arthritis (2012) 0.81
Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle. BMC Genomics (2011) 0.81
Role of Adiposity-Driven Inflammation in Depressive Morbidity. Neuropsychopharmacology (2016) 0.80
Sarcopenia is associated with Framingham risk score in the Korean population: Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2011. J Geriatr Cardiol (2015) 0.80
Investigating the mechanisms of massage efficacy: the role of mechanical immunomodulation. J Athl Train (2014) 0.80
Does 20-min arm crank ergometer exercise increase plasma interleukin-6 in individuals with cervical spinal cord injury? Eur J Appl Physiol (2011) 0.80
Effect of treadmill exercise on interleukin-15 expression and glucose tolerance in zucker diabetic Fatty rats. Diabetes Metab J (2013) 0.79
Molecular and Cellular Mechanisms of Muscle Aging and Sarcopenia and Effects of Electrical Stimulation in Seniors. Eur J Transl Myol (2015) 0.79
Salivary estradiol, interleukin-6 production, and the relationship to substrate metabolism during exercise in females. Eur J Appl Physiol (2011) 0.79
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function. Br J Pharmacol (2017) 0.79
Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines. Mol Metab (2017) 0.78
Isolation and characterization of muscle fatigue substance with anti-tumor activities. J Cancer (2013) 0.78
Physiology of Mechanotransduction: How Do Muscle and Bone "Talk" to One Another? Clin Rev Bone Miner Metab (2014) 0.78
Proteomic analysis of the palmitate-induced myotube secretome reveals involvement of the annexin A1-formyl peptide receptor 2 (FPR2) pathway in insulin resistance. Mol Cell Proteomics (2015) 0.78
Effects of prolonged endurance exercise on vascular endothelial and inflammation markers. J Sports Sci Med (2012) 0.78
Chronic Exercise Training Down-Regulates TNF-α and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading. Acta Histochem Cytochem (2012) 0.78
Medium term effects of including manual therapy in a pulmonary rehabilitation program for chronic obstructive pulmonary disease (COPD): a randomized controlled pilot trial. J Man Manip Ther (2016) 0.78
Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation. Int J Mol Sci (2017) 0.78
Inflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exercise. Mediators Inflamm (2016) 0.77
The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting. Semin Cell Dev Biol (2015) 0.77
Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10. Front Physiol (2015) 0.77
Increased air velocity during exercise in the heat leads to equal reductions in hydration shifts and interleukin-6 with age. Eur J Appl Physiol (2014) 0.77
Evaluation of functional, autonomic and inflammatory outcomes in children with asthma. World J Clin Cases (2015) 0.77
A Potential Role for Pro-Inflammatory Cytokines in the Development of Insulin Resistance in Horses. Animals (Basel) (2012) 0.77
Research in the exercise sciences: where we are and where do we go from here--Part II. Exerc Sport Sci Rev (2010) 0.77
Moderate Treadmill Exercise Protects Synaptic Plasticity of the Dentate Gyrus and Related Signaling Cascade in a Rat Model of Alzheimer's Disease. Mol Neurobiol (2014) 0.76
Evaluation of the inflammatory response to two different intensities of exercise in individuals with heart failure. Inflammation (2012) 0.76
Acute pro- and anti-inflammatory responses to resistance exercise in patients with coronary artery disease: a pilot study. J Sports Sci Med (2015) 0.76
Skeletal muscle as an endocrine organ: Role of [Na(+)]i/[K(+)]i-mediated excitation-transcription coupling. Genes Dis (2015) 0.76
Altered molecular adaptation to exercise in children with type 1 diabetes: beyond hypoglycemia. Pediatr Diabetes (2008) 0.76
Impact of aerobic exercise on levels of IL-4 and IL-10: results from two randomized intervention trials. Cancer Med (2016) 0.75
Physiological Roles of Adipokines, Hepatokines, and Myokines in Ruminants. Asian-Australas J Anim Sci (2016) 0.75
Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise. Nutr Metab (Lond) (2016) 0.75
Investigating the Cellular and Metabolic Responses of World-Class Canoeists Training: A Sportomics Approach. Nutrients (2016) 0.75
Effects of myokines on bone. Bonekey Rep (2016) 0.75
Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn. PLoS One (2016) 0.75
Associations between muscle-related cytokines and selected patient outcomes in the ICU. Biol Res Nurs (2014) 0.75
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab (2003) 2.59
Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle. J Physiol (2010) 2.16
Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem (2008) 2.07
Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes (2004) 1.73
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Med (2010) 1.64
Retracted Interleukin-6 receptor expression in contracting human skeletal muscle: regulating role of IL-6. FASEB J (2005) 1.39
Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc (2010) 1.30
Beneficial health effects of exercise--the role of IL-6 as a myokine. Trends Pharmacol Sci (2007) 1.28
Physiological roles of muscle-derived interleukin-6 in response to exercise. Curr Opin Clin Nutr Metab Care (2007) 1.23
Tumor necrosis factor-alpha modulates human in vivo lipolysis. J Clin Endocrinol Metab (2007) 1.20
Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? FASEB J (2007) 1.19
Exercise induces a marked increase in plasma follistatin: evidence that follistatin is a contraction-induced hepatokine. Endocrinology (2010) 1.18
Cholinergic status modulations in human volunteers under acute inflammation. J Mol Med (Berl) (2007) 1.15
Plasma YKL-40: a BMI-independent marker of type 2 diabetes. Diabetes (2008) 1.14
Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle. J Appl Physiol (1985) (2005) 1.12
Glucose ingestion during endurance training does not alter adaptation. J Appl Physiol (1985) (2009) 1.10
Interleukin-6 production by contracting human skeletal muscle: autocrine regulation by IL-6. Biochem Biophys Res Commun (2003) 1.08
Skeletal muscle adaptation: training twice every second day vs. training once daily. J Appl Physiol (1985) (2004) 1.05
PGC-1beta is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family. J Appl Physiol (1985) (2007) 0.99
Plasma and muscle myostatin in relation to type 2 diabetes. PLoS One (2012) 0.98
IL-6 activates HSP72 gene expression in human skeletal muscle. Biochem Biophys Res Commun (2002) 0.96
Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. J Physiol (2003) 0.95
Acute moderate elevation of TNF-alpha does not affect systemic and skeletal muscle protein turnover in healthy humans. J Clin Endocrinol Metab (2008) 0.93
Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. Am J Physiol Endocrinol Metab (2011) 0.92
Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6. PLoS One (2012) 0.92
Role of vitamin C and E supplementation on IL-6 in response to training. J Appl Physiol (1985) (2011) 0.87
Deficient leukemia inhibitory factor signaling in muscle precursor cells from patients with type 2 diabetes. Am J Physiol Endocrinol Metab (2012) 0.85
Endurance training enhances skeletal muscle interleukin-15 in human male subjects. Endocrine (2013) 0.84
Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol (1985) (2007) 0.75