[Therapeutic agents targetting protein-protein interactions: myth or reality?].

PubWeight™: 0.75‹?›

🔗 View Article (PMID 17349288)

Published in Med Sci (Paris) on March 01, 2007

Authors

Béatrice Laudet1, Renaud Prudent, Odile Filhol, Claude Cochet

Author Affiliations

1: Inserm U873, Institut de Recherches en Technologies et Sciences pour le Vivant, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France.

Articles by these authors

Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol (2002) 2.51

A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature (2008) 2.10

Spatial organization of the extracellular matrix regulates cell-cell junction positioning. Proc Natl Acad Sci U S A (2012) 1.88

Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality. Mol Cell Biol (2003) 1.85

Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer. Eur J Cancer (2007) 1.38

A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels. Lab Chip (2011) 1.33

Engrailed homeoprotein secretion is a regulated process. Development (2002) 1.16

Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits. Mol Cell Biol (2003) 1.12

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth. Cancer Res (2012) 1.12

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem (2012) 1.04

Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations. Blood (2010) 1.04

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2. Cancer Res (2010) 1.03

Protein kinase CK2: a new view of an old molecular complex. EMBO Rep (2004) 1.03

Protein kinase CK2 regulates CDC25B phosphatase activity. Oncogene (2003) 1.00

Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum. Eukaryot Cell (2008) 0.98

Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative immunohistochemistry in tissue microarrays. Eur J Cancer (2010) 0.98

New protein kinase CK2 inhibitors: jumping out of the catalytic box. Chem Biol (2009) 0.96

Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon. Mol Cell Biol (2010) 0.93

Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter. J Biol Chem (2004) 0.93

Adenovirus infection targets the cellular protein kinase CK2 and RNA-activated protein kinase (PKR) into viral inclusions of the cell nucleus. Microsc Res Tech (2002) 0.92

Antitumoral activity of allosteric inhibitors of protein kinase CK2. Oncotarget (2011) 0.91

Identification of chemical inhibitors of protein-kinase CK2 subunit interaction. Mol Cell Biochem (2008) 0.90

Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction. Biochem J (2007) 0.87

Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines. PLoS One (2013) 0.87

Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2. Chem Biol (2008) 0.86

Dynamic localization/association of protein kinase CK2 subunits in living cells: a role in its cellular regulation? Ann N Y Acad Sci (2002) 0.86

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. FASEB J (2010) 0.85

Structure-based discovery of small molecules targeting different surfaces of protein-kinase CK2. Biochim Biophys Acta (2009) 0.85

Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles. J Virol (2007) 0.85

Expanding the chemical diversity of CK2 inhibitors. Mol Cell Biochem (2008) 0.84

Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity. Cell Mol Life Sci (2015) 0.83

Highlighting protein kinase CK2 movement in living cells. Mol Cell Biochem (2005) 0.82

Knocking out the regulatory beta subunit of protein kinase CK2 in mice: gene dosage effects in ES cells and embryos. Mol Cell Biochem (2005) 0.81

Protein kinase CK2 and cell polarity. Mol Cell Biochem (2008) 0.80

Novel in silico-designed estradiol analogues are cytotoxic to a multidrug-resistant cell line at nanomolar concentrations. Cancer Chemother Pharmacol (2014) 0.78

Regulation of epithelial to mesenchymal transition: CK2β on stage. Mol Cell Biochem (2011) 0.78

In vitro and in vivo assays of protein kinase CK2 activity. Methods Enzymol (2010) 0.77

Salicylaldehyde derivatives as new protein kinase CK2 inhibitors. Biochim Biophys Acta (2008) 0.77

HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2. Biol Chem (2007) 0.77

[Protein kinase CK2: an enzyme that likes to be different]. Med Sci (Paris) (2003) 0.76

The antiapoptotic protein ICBP90 is a target for protein kinase 2. Ann N Y Acad Sci (2004) 0.76

Phosphorylation of the C subunit (p66) of human DNA polymerase delta. Biochem Biophys Res Commun (2007) 0.76

Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell. Mol Cell Biochem (2011) 0.76

Protein kinases curb cell death. Sci Signal (2011) 0.75

[Polyoxometalates. A new class of inorganic CK2 inhibitors]. Med Sci (Paris) (2008) 0.75

Novel synthetic pharmacophores inducing a stabilization of cellular microtubules. Curr Cancer Drug Targets (2015) 0.75

[Protein kinase CK2 and cancer: further clues are accumulating]. Bull Cancer (2002) 0.75