Published in Genes Cells on March 01, 2007
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat Res (2009) 1.80
The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription. Mol Cell (2015) 1.59
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. EMBO J (2012) 1.30
The genetic and biochemical basis of FANCD2 monoubiquitination. Mol Cell (2014) 1.22
An atlas of altered expression of deubiquitinating enzymes in human cancer. PLoS One (2011) 1.17
A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair. Nucleic Acids Res (2013) 0.92
FANCL ubiquitinates β-catenin and enhances its nuclear function. Blood (2012) 0.89
Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg. Cancer Res (2010) 0.84
Towards a molecular understanding of the fanconi anemia core complex. Anemia (2012) 0.84
The PI3K/Akt1 pathway enhances steady-state levels of FANCL. Mol Biol Cell (2013) 0.78
FANCD2 influences replication fork processes and genome stability in response to clustered DSBs. Cell Cycle (2015) 0.77
Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks. Cell Discov (2016) 0.75
Nuclear alpha spectrin: Critical roles in DNA interstrand cross-link repair and genomic stability. Exp Biol Med (Maywood) (2016) 0.75
Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair. ISRN Mol Biol (2012) 0.75
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res (2014) 4.83
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem (2002) 2.68
Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line. Cancer Res (2007) 2.35
A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair. Mol Cell (2005) 2.15
Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. EMBO J (2003) 2.12
Deubiquitination of FANCD2 is required for DNA crosslink repair. Mol Cell (2007) 2.11
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res (2005) 2.05
DNA damage-induced MDMX degradation is mediated by MDM2. J Biol Chem (2003) 2.03
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. EMBO J (2007) 2.00
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Nat Struct Mol Biol (2011) 1.95
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res (2007) 1.92
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Mol Cell Biol (2003) 1.84
Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci U S A (2007) 1.83
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. Blood (2013) 1.79
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy. Am J Physiol Renal Physiol (2005) 1.78
Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Mol Cell Biol (2005) 1.65
Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial. J Hypertens (2014) 1.56
Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. EMBO J (2004) 1.56
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Radiation exposure to the surgeon and the patient during kyphoplasty. J Spinal Disord Tech (2008) 1.51
Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage. J Biol Chem (2002) 1.48
Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol Cell (2012) 1.47
Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats. Hypertens Res (2009) 1.46
Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. Cancer Res (2003) 1.46
Vertebral artery injury in C-1 lateral mass screw fixation. Case illustration. J Neurosurg Spine (2006) 1.43
Direct measurement of nitric oxide concentration in CAPD dialysate. Perit Dial Int (2009) 1.42
NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res (2009) 1.41
Polyclonality of BRAF mutations in acquired melanocytic nevi. J Natl Cancer Inst (2009) 1.40
Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Mol Cell Biol (2005) 1.33
Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells (2005) 1.32
DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation. Mol Cell Biol (2004) 1.31
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. EMBO J (2012) 1.30
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med (2002) 1.30
Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas. Int J Cancer (2009) 1.30
KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. Proc Natl Acad Sci U S A (2010) 1.25
High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi. J Invest Dermatol (2006) 1.25
A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo. J Pharmacol Exp Ther (2003) 1.23
Tonsillectomy and steroid pulse (TSP) therapy for patients with IgA nephropathy: a nationwide survey of TSP therapy in Japan and an analysis of the predictive factors for resistance to TSP therapy. Clin Exp Nephrol (2009) 1.23
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J (2002) 1.21
Eccrine porocarcinoma: clinical and pathological studies of 12 cases. J Dermatol (2007) 1.19
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell (2012) 1.19
MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2. Mol Cell (2013) 1.18
DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI. Nucleic Acids Res (2012) 1.18
Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. PLoS Genet (2011) 1.18
Fanconi anemia: a disorder defective in the DNA damage response. Int J Hematol (2011) 1.17
Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet (2002) 1.13
Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling. Am J Physiol Renal Physiol (2012) 1.12
A novel mutation ApoE2 Kurashiki (R158P) in a patient with lipoprotein glomerulopathy. J Atheroscler Thromb (2011) 1.12
Sentinel lymph node biopsy in Japan. Int J Clin Oncol (2009) 1.11
Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy. Nephrol Dial Transplant (2008) 1.08
A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy. Cancer Res (2006) 1.08
Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation. Mol Biol Cell (2009) 1.07
Oculocutaneous albinism type 4 is one of the most common types of albinism in Japan. Am J Hum Genet (2004) 1.07
Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages. J Invest Dermatol (2003) 1.06
Anti-tumor necrosis factor therapy increases serum adiponectin levels with the improvement of endothelial dysfunction in patients with rheumatoid arthritis. Mod Rheumatol (2007) 1.06
Copy-neutral loss of heterozygosity at the p53 locus in carcinogenesis of esophageal squamous cell carcinomas associated with p53 mutations. Clin Cancer Res (2011) 1.04
Effects of double-strand break repair proteins on vertebrate telomere structure. Nucleic Acids Res (2002) 1.04
Rap1b GTPase ameliorates glucose-induced mitochondrial dysfunction. J Am Soc Nephrol (2008) 1.04
Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer. Int J Clin Oncol (2012) 1.04
Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. J Invest Dermatol (2002) 1.03
Hsp90 regulates the Fanconi anemia DNA damage response pathway. Blood (2007) 1.03
ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway. Cancer Res (2012) 1.03
Radiation exposure to the surgeon during open lumbar microdiscectomy and minimally invasive microdiscectomy: a prospective, controlled trial. Spine (Phila Pa 1976) (2011) 1.02
Replication-associated repair of adenine:8-oxoguanine mispairs by MYH. Curr Biol (2002) 1.02
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02