Published in J Neurosci on March 14, 2007
Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One (2009) 1.49
Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci (2011) 1.09
Therapeutic strategies for tau mediated neurodegeneration. J Neurol Neurosurg Psychiatry (2012) 1.07
Protein phosphatases and Alzheimer's disease. Prog Mol Biol Transl Sci (2012) 1.03
One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Curr Genomics (2010) 0.99
Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am J Pathol (2009) 0.99
Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. J Alzheimers Dis (2008) 0.95
Physiological regulation of tau phosphorylation during hibernation. J Neurochem (2008) 0.94
Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatr Dis Treat (2010) 0.94
Folate and Alzheimer: when time matters. J Neural Transm (Vienna) (2012) 0.93
Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells. J Neurochem (2010) 0.91
Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study. Brain (2013) 0.89
Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain. J Neurosci (2012) 0.88
Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response. J Biol Chem (2008) 0.84
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy (2015) 0.84
APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. Neurodegener Dis (2012) 0.83
Dietary deficiency increases presenilin expression, gamma-secretase activity, and Abeta levels: potentiation by ApoE genotype and alleviation by S-adenosyl methionine. J Neurochem (2009) 0.83
Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice. Mol Ther (2013) 0.83
Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer's disease. ACS Chem Neurosci (2014) 0.82
The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton. Int J Alzheimers Dis (2013) 0.82
γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation. J Biol Chem (2012) 0.81
PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. PLoS One (2010) 0.81
Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease. Neurobiol Aging (2014) 0.79
Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug Response. Int J Mol Sci (2015) 0.79
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener (2015) 0.79
A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation. Elife (2016) 0.78
N-homocysteinylation induces different structural and functional consequences on acidic and basic proteins. PLoS One (2014) 0.77
Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells. J Biol Chem (2013) 0.77
Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Front Aging Neurosci (2014) 0.77
The N-terminal Set-β Protein Isoform Induces Neuronal Death. J Biol Chem (2015) 0.76
Serum homocysteine levels are correlated with behavioral and psychological symptoms of Alzheimer's disease. Neuropsychiatr Dis Treat (2014) 0.76
PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments. Proc Natl Acad Sci U S A (2016) 0.76
Knock-down of protein L-isoaspartyl O-methyltransferase increases β-amyloid production by decreasing ADAM10 and ADAM17 levels. Acta Pharmacol Sin (2011) 0.75
Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI. Sci Rep (2016) 0.75
Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice. Int J Mol Sci (2017) 0.75
Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease. Nutrients (2016) 0.75
Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies. Ann Clin Transl Neurol (2016) 0.75
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA (2008) 7.35
Intracranial pressure monitoring in brain-injured patients is associated with worsening of survival. J Trauma (2008) 4.85
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature (2006) 3.81
L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry (2012) 3.73
Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. PLoS One (2012) 3.11
D-dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: a cohort study. Ann Intern Med (2015) 2.63
A serum protein-based algorithm for the detection of Alzheimer disease. Arch Neurol (2010) 2.42
The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. Mol Pharmacol (2005) 2.21
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. J Cell Biol (2002) 2.18
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Comparative effectiveness of traumatic brain injury rehabilitation: differential outcomes across TBI model systems centers. J Head Trauma Rehabil (2014) 2.06
Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA (2012) 2.06
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood (2011) 2.02
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet (2011) 2.02
Cerebral vascular dysfunction during hypercholesterolemia. Stroke (2007) 1.94
GABA, gamma-hydroxybutyric acid, and neurological disease. Ann Neurol (2003) 1.91
Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity (2003) 1.84
Regionally selective atrophy after traumatic axonal injury. Arch Neurol (2010) 1.83
Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension (2008) 1.76
Diffusion tensor tractography of traumatic diffuse axonal injury. Arch Neurol (2008) 1.76
ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice. Blood (2011) 1.74
Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Arch Gen Psychiatry (2007) 1.72
Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. Am J Med (2012) 1.71
Folate, homocysteine, and negative symptoms in schizophrenia. Am J Psychiatry (2004) 1.65
Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci U S A (2004) 1.61
Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke (2004) 1.57
A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI. PLoS One (2011) 1.55
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem (2004) 1.55
The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. Crit Care Med (2011) 1.54
Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol (2004) 1.52
The homocysteine paradox. Arterioscler Thromb Vasc Biol (2008) 1.50
Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice. Circulation (2004) 1.48
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol (2004) 1.47
High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Proc Natl Acad Sci U S A (2006) 1.47
Creatine metabolism in combined methylmalonic aciduria and homocystinuria. Ann Neurol (2005) 1.46
Detection of β-amyloid oligomers as a predictor of neurological outcome after brain injury. J Neurosurg (2013) 1.46
Effect of hyperhomocysteinemia on protein C activation and activity. Blood (2002) 1.45
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr Biol (2003) 1.41
Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res (2004) 1.37
Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. EMBO J (2012) 1.37
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 1.37
Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects. JAMA Neurol (2013) 1.36
Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group. Arch Phys Med Rehabil (2010) 1.35
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol (2007) 1.35
Functional definition of seizure provides new insight into post-traumatic epileptogenesis. Brain (2009) 1.34
C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease. JAMA Neurol (2013) 1.34
Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol (2008) 1.33
Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem (2004) 1.33
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology (2009) 1.32
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site. Blood (2009) 1.32
ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice. Blood (2012) 1.31
A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev (2003) 1.31
Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. Blood (2007) 1.26
Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol (2004) 1.26
Dementia resulting from traumatic brain injury: what is the pathology? Arch Neurol (2012) 1.25
Assessing spatial relationships between axonal integrity, regional brain volumes, and neuropsychological outcomes after traumatic axonal injury. J Neurotrauma (2010) 1.25
Distinctive disruption patterns of white matter tracts in Alzheimer's disease with full diffusion tensor characterization. Neurobiol Aging (2011) 1.24
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab (2007) 1.24
Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood (2006) 1.20
Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res (2002) 1.20
Elevated serum pesticide levels and risk of Parkinson disease. Arch Neurol (2009) 1.19
Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. J Biol Chem (2007) 1.18
Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease. Neurobiol Aging (2010) 1.16
Quantity and quality of sleep in the surgical intensive care unit: are our patients sleeping? J Trauma (2007) 1.15
Decreased C-reactive protein levels in Alzheimer disease. J Geriatr Psychiatry Neurol (2009) 1.15
A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease. Am J Geriatr Psychiatry (2003) 1.14
A blood-based algorithm for the detection of Alzheimer's disease. Dement Geriatr Cogn Disord (2011) 1.14
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. J Clin Invest (2010) 1.14
Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury. Arch Neurol (2011) 1.14
Racial disparities in long-term functional outcome after traumatic brain injury. J Trauma (2007) 1.12
Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol (2002) 1.11
S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine. J Clin Psychopharmacol (2004) 1.11
Ethnic disparities exist in trauma care. J Trauma (2007) 1.10
Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler. J Alzheimers Dis (2009) 1.10
Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol (2006) 1.10
Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J Biol Chem (2005) 1.09
A comprehensive reliability assessment of quantitative diffusion tensor tractography. Neuroimage (2011) 1.09
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood (2003) 1.09
Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. Am J Physiol Gastrointest Liver Physiol (2010) 1.08
Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology (2010) 1.08