|
1
|
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.
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Gastroenterology
|
2007
|
13.20
|
|
2
|
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1.
|
J Biol Chem
|
2008
|
4.56
|
|
3
|
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas.
|
J Cell Biochem
|
2006
|
4.15
|
|
4
|
Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
|
Cancer Res
|
2008
|
3.16
|
|
5
|
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib.
|
J Biol Chem
|
2009
|
3.16
|
|
6
|
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.
|
J Clin Invest
|
2012
|
3.14
|
|
7
|
Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.
|
J Biol Chem
|
2008
|
3.00
|
|
8
|
Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.
|
Hepatology
|
2009
|
2.29
|
|
9
|
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas.
|
Oncogene
|
2003
|
1.64
|
|
10
|
Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
|
Hepatology
|
2012
|
1.53
|
|
11
|
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.
|
Proc Natl Acad Sci U S A
|
2004
|
1.49
|
|
12
|
DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2.
|
Mol Cell Biol
|
2005
|
1.41
|
|
13
|
Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade.
|
Cancer Res
|
2007
|
1.40
|
|
14
|
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.
|
J Biol Chem
|
2002
|
1.35
|
|
15
|
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.
|
Cancer Res
|
2009
|
1.26
|
|
16
|
Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors.
|
J Am Soc Mass Spectrom
|
2005
|
1.19
|
|
17
|
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.
|
Cancer Res
|
2005
|
1.17
|
|
18
|
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.
|
J Cell Biochem
|
2003
|
1.17
|
|
19
|
MicroRNAs activate natural killer cells through Toll-like receptor signaling.
|
Blood
|
2013
|
1.15
|
|
20
|
PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.
|
J Biol Chem
|
2008
|
1.07
|
|
21
|
Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription.
|
J Biol Chem
|
2006
|
1.06
|
|
22
|
Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene.
|
J Biol Chem
|
2004
|
1.03
|
|
23
|
Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.
|
Hepatology
|
2013
|
0.99
|
|
24
|
Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells.
|
J Biol Chem
|
2006
|
0.99
|
|
25
|
Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins.
|
J Cell Biochem
|
2006
|
0.96
|
|
26
|
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.
|
J Biol Chem
|
2003
|
0.95
|
|
27
|
Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.
|
Nanomedicine
|
2013
|
0.95
|
|
28
|
Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes.
|
Cancer Res
|
2010
|
0.94
|
|
29
|
Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma.
|
J Control Release
|
2013
|
0.94
|
|
30
|
Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
|
Mol Endocrinol
|
2008
|
0.93
|
|
31
|
Lipid nanoparticles for hepatic delivery of small interfering RNA.
|
Biomaterials
|
2012
|
0.93
|
|
32
|
Suppression of metallothionein-I/II expression and its probable molecular mechanisms.
|
Environ Health Perspect
|
2002
|
0.91
|
|
33
|
Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma.
|
J Biol Chem
|
2002
|
0.89
|
|
34
|
Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.
|
J Control Release
|
2013
|
0.88
|
|
35
|
Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain.
|
J Biol Chem
|
2007
|
0.87
|
|
36
|
Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.
|
J Cell Biochem
|
2013
|
0.83
|
|
37
|
MicroRNAs in Liver Health and Disease.
|
Curr Pathobiol Rep
|
2013
|
0.83
|
|
38
|
Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.
|
PLoS One
|
2012
|
0.83
|
|
39
|
Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.
|
PLoS One
|
2012
|
0.82
|
|
40
|
Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.
|
Am J Pathol
|
2013
|
0.81
|
|
41
|
Role of Noncoding RNAs as Biomarker and Therapeutic Targets for Liver Fibrosis.
|
Gene Expr
|
2015
|
0.79
|
|
42
|
Simultaneous metabolic labeling of cells with multiple amino acids: Localization and dynamics of histone acetylation and methylation.
|
Proteomics Clin Appl
|
2007
|
0.79
|
|
43
|
Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1.
|
Genes Cancer
|
2012
|
0.76
|
|
44
|
Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of both Sorafenib Sensitive and Resistant HCC Cells by Inhibiting ATP Production.
|
Gene Expr
|
2016
|
0.75
|