Published in Circ Res on March 16, 2007
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev (2009) 4.62
Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol (2010) 4.12
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease. Am J Hum Genet (2009) 2.50
MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00
Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature (2013) 1.89
Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation (2012) 1.69
Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. Br J Pharmacol (2008) 1.67
Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest (2008) 1.63
NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways. Circulation (2015) 1.62
Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton. Am J Physiol Cell Physiol (2012) 1.53
Vascular smooth muscle progenitor cells: building and repairing blood vessels. Circ Res (2011) 1.46
Kruppel-like Factors (KLFs) in muscle biology. J Mol Cell Cardiol (2007) 1.41
Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci U S A (2009) 1.33
Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase. J Biol Chem (2009) 1.28
Robust identification of local adaptation from allele frequencies. Genetics (2013) 1.21
Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor. FEBS Lett (2007) 1.19
Vascular smooth muscle phenotypic diversity and function. Physiol Genomics (2010) 1.18
MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration. Genes Dev (2012) 1.10
Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest (2012) 1.10
Myocardin in biology and disease. J Biomed Res (2014) 1.06
Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res (2010) 1.05
MicroRNA-modulated targeting of vascular smooth muscle cells. J Clin Invest (2009) 1.02
Synergistic activation of cardiac genes by myocardin and Tbx5. PLoS One (2011) 1.02
Transforming growth factor-β1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. J Biol Chem (2011) 1.01
Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts. Inflamm Bowel Dis (2014) 1.00
Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. Mol Cell Biol (2010) 1.00
Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β. Hum Mol Genet (2013) 0.97
The induction of yes-associated protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arterioscler Thromb Vasc Biol (2012) 0.97
Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis. Physiol Genomics (2008) 0.97
Distinct effects of voltage- and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle. J Biol Chem (2010) 0.94
Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis. J Biomed Res (2013) 0.93
Targeted deletion of the zebrafish obscurin A RhoGEF domain affects heart, skeletal muscle and brain development. Dev Biol (2009) 0.93
Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes. Clin Sci (Lond) (2010) 0.93
G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation. Mol Pharmacol (2015) 0.89
Heavy and light roles: myosin in the morphogenesis of the heart. Cell Mol Life Sci (2012) 0.89
Phosphorylation of myocardin by extracellular signal-regulated kinase. J Biol Chem (2009) 0.89
Reciprocal regulation controlling the expression of CPI-17, a specific inhibitor protein for the myosin light chain phosphatase in vascular smooth muscle cells. Am J Physiol Cell Physiol (2012) 0.88
Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway. Beilstein J Org Chem (2013) 0.88
Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development. Proc Natl Acad Sci U S A (2015) 0.87
Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element. J Mol Cell Cardiol (2009) 0.87
Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells. Exp Mol Med (2010) 0.86
Kruppel-like factor 4: transcriptional regulator of proliferation, or inflammation, or differentiation, or all three? Circ Res (2008) 0.86
Formin homology domain-containing protein 1 regulates smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2010) 0.86
Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells. Circ Res (2011) 0.85
MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype. Exp Cell Res (2012) 0.84
Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta-induced epithelial to mesenchymal transition of lens epithelial cells. Mol Vis (2013) 0.84
Predicting tissue specific cis-regulatory modules in the human genome using pairs of co-occurring motifs. BMC Bioinformatics (2012) 0.83
Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Arterioscler Thromb Vasc Biol (2010) 0.83
Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle. Cell Mol Life Sci (2013) 0.83
Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc (2014) 0.82
Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem (2014) 0.82
RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med (2014) 0.82
MicroRNA miR145 regulates TGFBR2 expression and matrix synthesis in vascular smooth muscle cells. Circ Res (2014) 0.82
Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J Exp Med (2012) 0.81
Characterization of Pax3-expressing cells from adult blood vessels. J Cell Sci (2011) 0.81
Prostaglandin E2 inhibits α-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A. J Biol Chem (2014) 0.81
A rare human sequence variant reveals myocardin autoinhibition. J Biol Chem (2008) 0.80
Loss of serum response factor induces microRNA-mediated apoptosis in intestinal smooth muscle cells. Cell Death Dis (2015) 0.80
Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart. PLoS One (2011) 0.80
Myocardin: dominant driver of the smooth muscle cell contractile phenotype. Arterioscler Thromb Vasc Biol (2008) 0.80
Phenylephrine induces elevated RhoA activation and smooth muscle alpha-actin expression in Pkd2+/- vascular smooth muscle cells. Hypertens Res (2009) 0.80
A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish. Sci Rep (2015) 0.80
Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes. J Biol Chem (2012) 0.80
Myocardin Family Members Drive Formation of Caveolae. PLoS One (2015) 0.79
MicroRNA-206 inhibits stemness and metastasis of breast cancer by targeting MKL1/IL11 pathway. Clin Cancer Res (2016) 0.79
The FOX transcription factors regulate vascular pathology, diabetes and Tregs. Front Biosci (Schol Ed) (2009) 0.79
Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature. Development (2012) 0.79
Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications. PLoS One (2012) 0.79
Identification of gene co-regulatory modules and associated cis-elements involved in degenerative heart disease. BMC Med Genomics (2009) 0.78
Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease. Hum Genet (2009) 0.78
Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis. Sci Rep (2016) 0.77
Modulation of smooth muscle cell phenotype: the other side of the story. Circ Res (2012) 0.77
Maturation and differentiation of the fetal vasculature. Clin Obstet Gynecol (2013) 0.77
Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing. Physiol Rep (2015) 0.77
MKL1 inhibits cell cycle progression through p21 in podocytes. BMC Mol Biol (2015) 0.77
In search of novel targets for heart disease: myocardin and myocardin-related transcriptional cofactors. Biochem Res Int (2012) 0.77
Vasotrophic regulation of age-dependent hypoxic cerebrovascular remodeling. Curr Vasc Pharmacol (2013) 0.76
Deck of CArGs. Circ Res (2008) 0.76
Ezh2 restricts the smooth muscle lineage during mouse lung mesothelial development. Development (2016) 0.76
Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopenia. Mol Metab (2016) 0.75
Myocardin-related transcription factor-A: mending a broken heart. Circ Res (2010) 0.75
Dicing up microRNA gene expression profiles in normal and neoplastic smooth muscle cells. Am J Pathol (2010) 0.75
Transcriptome Dynamics and Potential Roles of Sox6 in the Postnatal Heart. PLoS One (2016) 0.75
Novel insights into the disease etiology of laminopathies. Rare Dis (2013) 0.75
Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells. J Am Heart Assoc (2015) 0.75
Multi-phenotypic Role of Serum Response Factor in the Gastrointestinal System. J Neurogastroenterol Motil (2016) 0.75
Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites. Development (2017) 0.75
Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. Cell Signal (2016) 0.75
PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats. Sci Rep (2017) 0.75
Redox regulation of the actin cytoskeleton and its role in the vascular system. Free Radic Biol Med (2017) 0.75
Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1. Sci Rep (2014) 0.75
Epithelial-to-Pericyte Transition in Cancer. Cancers (Basel) (2017) 0.75
BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity. Arterioscler Thromb Vasc Biol (2017) 0.75
Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease. Heart Fail Rev (2016) 0.75