Published in J Bone Miner Res on July 01, 2007
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5. Sci Signal (2009) 1.30
Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5). Am J Physiol Cell Physiol (2011) 1.15
Mechanical design criteria for intervertebral disc tissue engineering. J Biomech (2010) 1.09
BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res (2010) 1.08
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Mol Biol (2008) 1.03
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J (2010) 0.99
Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes. Am J Physiol Cell Physiol (2009) 0.98
Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation. Arterioscler Thromb Vasc Biol (2011) 0.97
Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A (2010) 0.96
Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res (2009) 0.94
Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. J Biol Chem (2009) 0.92
Aquaporin expression in the human intervertebral disc. J Mol Histol (2008) 0.90
Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression. Exp Mol Med (2008) 0.88
Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP). Am J Physiol Renal Physiol (2013) 0.88
Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP. Matrix Biol (2014) 0.87
C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling. Am J Physiol Cell Physiol (2010) 0.85
NFAT5-mediated expression of S100A4 contributes to proliferation and migration of renal carcinoma cells. Front Physiol (2014) 0.85
Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues. Matrix Biol (2013) 0.84
Physicochemical and biomechanical stimuli in cell-based articular cartilage repair. Curr Rheumatol Rep (2015) 0.84
C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. PLoS One (2013) 0.84
Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. Exp Biol Med (Maywood) (2012) 0.83
Placental TonEBP/NFAT5 osmolyte regulation in an ovine model of intrauterine growth restriction. Biol Reprod (2012) 0.81
PKC-α contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2. Am J Physiol Renal Physiol (2014) 0.80
Database of osmoregulated proteins in mammalian cells. Physiol Rep (2014) 0.79
High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. Am J Physiol Renal Physiol (2013) 0.79
14-3-3-β and -{varepsilon} contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity. Physiol Rep (2014) 0.78
Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Curr Stem Cell Res Ther (2015) 0.77
The Guanine Nucleotide Exchange Factor Brx: A Link between Osmotic Stress, Inflammation and Organ Physiology and Pathophysiology. Expert Rev Endocrinol Metab (2010) 0.77
Cell signaling pathways related to pain receptors in the degenerated disk. Global Spine J (2013) 0.75
How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5? World J Nephrol (2016) 0.75
RNA sequencing reveals a role of TonEBP in regulation of pro-inflammatory genes in response to hyperosmolarity in healthy nucleus pulposus cells: A homeostatic response? J Biol Chem (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis. N Engl J Med (2007) 6.72
Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res (2009) 3.77
Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine (Phila Pa 1976) (2003) 3.73
Does the load-sharing classification predict ligamentous injury, neurological injury, and the need for surgery in patients with thoracolumbar burst fractures?: Clinical article. J Neurosurg Spine (2012) 3.38
Complications associated with single-level transforaminal lumbar interbody fusion. Spine J (2009) 2.99
Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials (2005) 2.60
Transoral robotic surgery for oropharyngeal cancer: long-term quality of life and functional outcomes. JAMA Otolaryngol Head Neck Surg (2013) 2.31
Optimization of an enrichment process for circulating tumor cells from the blood of head and neck cancer patients through depletion of normal cells. Biotechnol Bioeng (2009) 2.16
Nonacid reflux in patients with chronic cough on acid-suppressive therapy. Chest (2006) 2.14
Electron vortex beams with high quanta of orbital angular momentum. Science (2011) 2.01
Imaging and tracking of tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding. J Am Chem Soc (2007) 1.98
Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem (2006) 1.97
Proposal of a modified, treatment-oriented classification of odontoid fractures. Spine J (2005) 1.94
Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol (2004) 1.93
Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc. Arthritis Rheum (2008) 1.91
Injury of the posterior ligamentous complex of the thoracolumbar spine: a prospective evaluation of the diagnostic accuracy of magnetic resonance imaging. Spine (Phila Pa 1976) (2009) 1.86
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine (Phila Pa 1976) (2004) 1.86
Mortality rates in geriatric patients with spinal cord injuries. J Neurosurg Spine (2007) 1.78
Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine (Phila Pa 1976) (2004) 1.77
HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway. Autophagy (2007) 1.73
The impact of epidural steroid injections on the outcomes of patients treated for lumbar disc herniation: a subgroup analysis of the SPORT trial. J Bone Joint Surg Am (2012) 1.70
Dysphagia and soft-tissue swelling after anterior cervical surgery: a radiographic analysis. Spine J (2012) 1.67
Comparison of transcranial electric motor and somatosensory evoked potential monitoring during cervical spine surgery. J Bone Joint Surg Am (2004) 1.63
Primary prophylaxis of overt hepatic encephalopathy in patients with cirrhosis: an open labeled randomized controlled trial of lactulose versus no lactulose. J Gastroenterol Hepatol (2012) 1.62
Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine (Phila Pa 1976) (2007) 1.60
Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59
Dysphagia after anterior cervical decompression and fusion: prevalence and risk factors from a longitudinal cohort study. Spine (Phila Pa 1976) (2005) 1.58
Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease. Arthritis Rheum (2011) 1.58
Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum (2009) 1.56
The value of PET/CT to assess clinically negative necks. Eur Arch Otorhinolaryngol (2012) 1.56
Intracranial arachnoid cysts: current concepts and treatment alternatives. Clin Neurol Neurosurg (2007) 1.55
Decellularized vein as a potential scaffold for vascular tissue engineering. J Vasc Surg (2004) 1.54
Use of a novel receptor-targeted (CD206) radiotracer, 99mTc-tilmanocept, and SPECT/CT for sentinel lymph node detection in oral cavity squamous cell carcinoma: initial institutional report in an ongoing phase 3 study. JAMA Otolaryngol Head Neck Surg (2013) 1.54
The use of bone morphogenetic protein in lumbar spine surgery. J Bone Joint Surg Am (2008) 1.52
Cost-utility analysis in spine care: a systematic review. Spine J (2012) 1.49
Current management review of thoracolumbar cord syndromes. Spine J (2011) 1.46
Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. Am J Physiol Cell Physiol (2007) 1.45
Prophylaxis of hepatic encephalopathy in acute variceal bleed: a randomized controlled trial of lactulose versus no lactulose. J Gastroenterol Hepatol (2011) 1.44
Methodological systematic review: mortality in elderly patients with cervical spine injury: a critical appraisal of the reporting of baseline characteristics, follow-up, cause of death, and analysis of risk factors. Spine (Phila Pa 1976) (2010) 1.43
Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med (2012) 1.42
Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. J Clin Oncol (2010) 1.40
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem (2011) 1.39
Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res (2002) 1.38
The role of proximal pH monitoring. Am J Gastroenterol (2005) 1.38
Industry support and correlation to study outcome for papers published in Spine. Spine (Phila Pa 1976) (2005) 1.37
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun (2012) 1.36
Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. Am J Pathol (2013) 1.36
Degenerative cervical spondylosis: clinical syndromes, pathogenesis, and management. J Bone Joint Surg Am (2007) 1.36
Impact of neck and arm pain on overall health status. Spine (Phila Pa 1976) (2003) 1.36
Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. J Orthop Res (2007) 1.35
Transforaminal lumbar interbody fusion: the effect of various instrumentation techniques on the flexibility of the lumbar spine. Spine (Phila Pa 1976) (2004) 1.33
Significance of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: initial results. Arch Otolaryngol Head Neck Surg (2010) 1.32
Reliability of a novel classification system for thoracolumbar injuries: the Thoracolumbar Injury Severity Score. Spine (Phila Pa 1976) (2006) 1.30
Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine (Phila Pa 1976) (2006) 1.30
Protease-triggered unveiling of bioactive nanoparticles. Small (2008) 1.30
Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord. Dev Dyn (2010) 1.29
An analysis of persistent symptoms in acid-suppressed patients undergoing impedance-pH monitoring. Clin Gastroenterol Hepatol (2008) 1.29
Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo. Gastroenterology (2009) 1.29
Neurologic deficit following percutaneous vertebral stabilization. Spine (Phila Pa 1976) (2007) 1.28
Early management of mesenteric cyst prevents catastrophes: a single centre analysis of 17 cases. Afr J Paediatr Surg (2010) 1.28
Tuning size and sensing properties in colloidal gold nanostars. Langmuir (2010) 1.28
Mesoporous silica beads embedded with semiconductor quantum dots and iron oxide nanocrystals: dual-function microcarriers for optical encoding and magnetic separation. Anal Chem (2006) 1.25
Image-guided spine surgery: a cadaver study comparing conventional open laminoforaminotomy and two image-guided techniques for pedicle screw placement in posterolateral fusion and nonfusion models. Spine (Phila Pa 1976) (2002) 1.25
Frank Stinchfield Award. Titanium surface with biologic activity against infection. Clin Orthop Relat Res (2004) 1.25
Outcome measures for traumatic brain injury. Clin Neurol Neurosurg (2011) 1.25
Graft options in posterolateral and posterior interbody lumbar fusion. Spine (Phila Pa 1976) (2010) 1.24
Congenital pouch colon with rectal atresia: a case report. J Pediatr Surg (2010) 1.24
The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Crit Rev Oral Biol Med (2002) 1.23
Duration of symptoms resulting from lumbar disc herniation: effect on treatment outcomes: analysis of the Spine Patient Outcomes Research Trial (SPORT). J Bone Joint Surg Am (2011) 1.23
The adoption of a new classification system: time-dependent variation in interobserver reliability of the thoracolumbar injury severity score classification system. Spine (Phila Pa 1976) (2007) 1.22
Aggressive osteoblastoma of the maxilla: a case report and review of the literature. Head Neck Pathol (2010) 1.22
The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials (2008) 1.21
Outcomes of transoral robotic surgery: a preliminary clinical experience. Otolaryngol Head Neck Surg (2011) 1.21
Confocal images of circulating tumor cells obtained using a methodology and technology that removes normal cells. Mol Pharm (2009) 1.20
All-angle negative refraction and active flat lensing of ultraviolet light. Nature (2013) 1.20
Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck. PLoS One (2012) 1.20
Adult degenerative scoliosis: a review. Neurosurgery (2008) 1.18
TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. J Biol Chem (2006) 1.18