Published in J Neurosci on March 21, 2007
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci (2010) 8.09
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron (2007) 5.31
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell (2012) 4.71
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J Neurosci (2009) 3.37
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron (2011) 2.84
Computational influence of adult neurogenesis on memory encoding. Neuron (2009) 2.70
Unique processing during a period of high excitation/inhibition balance in adult-born neurons. Science (2012) 2.45
The Arc of synaptic memory. Exp Brain Res (2009) 2.30
Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol (2007) 2.27
Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nat Neurosci (2009) 2.21
Experience dictates stem cell fate in the adult hippocampus. Neuron (2011) 2.18
Antidepressants recruit new neurons to improve stress response regulation. Mol Psychiatry (2011) 2.11
Reversible modulations of neuronal plasticity by VEGF. Proc Natl Acad Sci U S A (2011) 2.06
Development of neural stem cell in the adult brain. Curr Opin Neurobiol (2008) 2.02
GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci (2009) 1.96
Optical controlling reveals time-dependent roles for adult-born dentate granule cells. Nat Neurosci (2012) 1.92
Adult neurogenesis: integrating theories and separating functions. Trends Cogn Sci (2010) 1.83
Synaptic integration and plasticity of new neurons in the adult hippocampus. J Physiol (2008) 1.82
Regulation and function of adult neurogenesis: from genes to cognition. Physiol Rev (2014) 1.79
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus. Hippocampus (2010) 1.67
Adult neural stem cells in the mammalian central nervous system. Cell Res (2009) 1.64
Reliable activation of immature neurons in the adult hippocampus. PLoS One (2009) 1.60
Neurogenesis, inflammation and behavior. Brain Behav Immun (2012) 1.58
Adult neurogenesis, mental health, and mental illness: hope or hype? J Neurosci (2008) 1.55
miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One (2011) 1.52
The input-output transformation of the hippocampal granule cells: from grid cells to place fields. J Neurosci (2009) 1.51
Adult-born hippocampal neurons promote cognitive flexibility in mice. Hippocampus (2012) 1.50
Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. Ann N Y Acad Sci (2009) 1.50
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training. Hippocampus (2009) 1.49
Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. Proc Natl Acad Sci U S A (2009) 1.48
Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Mol Psychiatry (2010) 1.47
The timing of differentiation of adult hippocampal neurons is crucial for spatial memory. PLoS Biol (2008) 1.44
Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron (2016) 1.43
Structural plasticity and hippocampal function. Annu Rev Psychol (2010) 1.40
Stem cell review series: role of neurogenesis in age-related memory disorders. Aging Cell (2008) 1.36
The timing for neuronal maturation in the adult hippocampus is modulated by local network activity. J Neurosci (2011) 1.32
Why and how physical activity promotes experience-induced brain plasticity. Front Neurosci (2010) 1.25
Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry (2008) 1.21
A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. EMBO J (2011) 1.20
Neurogenesis, learning and associative strength. Eur J Neurosci (2008) 1.18
Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A (2009) 1.17
Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain. Hippocampus (2009) 1.17
A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis. J Comp Neurol (2010) 1.17
Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons. Mol Psychiatry (2011) 1.15
Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2011) 1.11
The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study. Front Neurosci (2011) 1.11
Impact of diet on adult hippocampal neurogenesis. Genes Nutr (2009) 1.08
Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus. Brain Behav Immun (2012) 1.08
Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis. J Neurosci (2013) 1.07
Parenting and plasticity. Trends Neurosci (2010) 1.06
Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus. J Neurosci (2010) 1.06
Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons. Neuroscience (2008) 1.06
Neurogenesis in the dentate gyrus: carrying the message or dictating the tone. Front Neurosci (2013) 1.06
Modification of hippocampal circuitry by adult neurogenesis. Dev Neurobiol (2012) 1.04
Associative learning increases adult neurogenesis during a critical period. Eur J Neurosci (2010) 1.03
The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine. PLoS One (2010) 1.02
Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression. Behav Brain Res (2011) 1.01
Adult Hippocampal Neurogenesis, Fear Generalization, and Stress. Neuropsychopharmacology (2015) 1.01
Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APP(Sw,Ind) transgenic mice. PLoS One (2011) 1.00
GABA depolarization is required for experience-dependent synapse unsilencing in adult-born neurons. J Neurosci (2013) 1.00
Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning. Proc Natl Acad Sci U S A (2013) 0.99
Differential dendritic Ca2+ signalling in young and mature hippocampal granule cells. J Physiol (2008) 0.98
Sustained stress-induced changes in mice as a model for chronic depression. Psychopharmacology (Berl) (2010) 0.97
The role of additive neurogenesis and synaptic plasticity in a hippocampal memory model with grid-cell like input. PLoS Comput Biol (2011) 0.97
New neurons generated from running are broadly recruited into neuronal activation associated with three different hippocampus-involved tasks. Hippocampus (2012) 0.97
Neuropeptides in depression: role of VGF. Behav Brain Res (2008) 0.97
Structural plasticity in the dentate gyrus- revisiting a classic injury model. Front Neural Circuits (2013) 0.96
How informative are spatial CA3 representations established by the dentate gyrus? PLoS Comput Biol (2010) 0.96
Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. Proc Natl Acad Sci U S A (2012) 0.95
Adult neurogenesis and mental illness. Neuropsychopharmacology (2014) 0.94
Septo-temporal gradients of neurogenesis and activity in 13-month-old rats. Neurobiol Aging (2009) 0.94
Ongoing interplay between the neural network and neurogenesis in the adult hippocampus. Curr Opin Neurobiol (2010) 0.94
Induction of c-Fos, Zif268, and Arc from acute bouts of voluntary wheel running in new and pre-existing adult mouse hippocampal granule neurons. Neuroscience (2011) 0.93
Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus. J Neurosci (2013) 0.93
Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging (2008) 0.93
Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats. PLoS One (2011) 0.92
Parametric Anatomical Modeling: a method for modeling the anatomical layout of neurons and their projections. Front Neuroanat (2014) 0.91
Synaptic Network Activity Induces Neuronal Differentiation of Adult Hippocampal Precursor Cells through BDNF Signaling. Front Neurosci (2009) 0.90
Changing the rate and hippocampal dependence of trace eyeblink conditioning: slow learning enhances survival of new neurons. Neurobiol Learn Mem (2010) 0.90
Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus. Neuropharmacology (2010) 0.90
Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Front Syst Neurosci (2015) 0.89
Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis. Hippocampus (2015) 0.89
Complementary activation of hippocampal-cortical subregions and immature neurons following chronic training in single and multiple context versions of the water maze. Behav Brain Res (2011) 0.88
Temporally selective contextual encoding in the dentate gyrus of the hippocampus. Nat Commun (2014) 0.88
The social environment and neurogenesis in the adult Mammalian brain. Front Hum Neurosci (2012) 0.88
LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus. Mol Brain (2010) 0.88
Integrating ecology, psychology and neurobiology within a food-hoarding paradigm. Philos Trans R Soc Lond B Biol Sci (2010) 0.87
Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacol Biochem Behav (2011) 0.86
Neural injury alters proliferation and integration of adult-generated neurons in the dentate gyrus. J Neurosci (2013) 0.86
Dentate gyrus granule cell firing patterns can induce mossy fiber long-term potentiation in vitro. Hippocampus (2010) 0.86
Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease. Mol Neurodegener (2010) 0.86
Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis. PLoS One (2010) 0.86
The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice. Behav Brain Res (2010) 0.85
When are new hippocampal neurons, born in the adult brain, integrated into the network that processes spatial information? PLoS One (2011) 0.84
Fatherhood reduces the survival of adult-generated cells and affects various types of behavior in the prairie vole (Microtus ochrogaster ). Eur J Neurosci (2013) 0.84
Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. J Comp Neurol (2014) 0.84
A hypothesis for temporal coding of young and mature granule cells. Front Neurosci (2013) 0.84
Enrichment rescues contextual discrimination deficit associated with immediate shock. Hippocampus (2014) 0.83
Normal and epilepsy-associated pathologic function of the dentate gyrus. Prog Brain Res (2016) 0.83
Hippocampus-dependent learning influences hippocampal neurogenesis. Front Neurosci (2013) 0.83
Mechanisms and functional implications of adult neurogenesis. Cell (2008) 14.50
Functional neurogenesis in the adult hippocampus. Nature (2002) 11.17
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci (2010) 8.09
Mechanisms underlying inflammation in neurodegeneration. Cell (2010) 7.66
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell (2010) 7.51
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci (2005) 7.14
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature (2005) 6.95
Wnt signalling regulates adult hippocampal neurogenesis. Nature (2005) 6.66
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci (2006) 6.48
Astroglia induce neurogenesis from adult neural stem cells. Nature (2002) 6.41
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol (2009) 6.37
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell (2007) 5.32
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A (2007) 5.30
L1 retrotransposition in human neural progenitor cells. Nature (2009) 4.78
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science (2003) 4.52
Therapeutic interventions after spinal cord injury. Nat Rev Neurosci (2006) 4.51
Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development (2003) 4.49
In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A (2011) 4.38
A role for adult TLX-positive neural stem cells in learning and behaviour. Nature (2008) 4.14
Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci (2008) 4.01
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature (2006) 4.01
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci (2003) 3.98
Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci (2006) 3.78
Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol (2002) 3.76
Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A (2004) 3.60
Mosaic copy number variation in human neurons. Science (2013) 3.57
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A (2005) 3.56
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci (2009) 3.47
Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci (2006) 3.41
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J Neurosci (2009) 3.37
Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell (2008) 3.34
Synapse formation on neurons born in the adult hippocampus. Nat Neurosci (2007) 3.33
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature (2011) 3.30
Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature (2004) 3.25
L1 retrotransposition in neurons is modulated by MeCP2. Nature (2010) 3.25
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem (2009) 3.23
A functional study of miR-124 in the developing neural tube. Genes Dev (2007) 3.21
Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol (2006) 3.16
YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev (2008) 3.16
Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci (2002) 3.10
Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A (2006) 3.08
Development of a novel mouse glioma model using lentiviral vectors. Nat Med (2009) 3.08
Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One (2009) 3.07
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol (2004) 2.94
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci (2003) 2.93
Local generation of glia is a major astrocyte source in postnatal cortex. Nature (2012) 2.87
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron (2011) 2.84
Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci (2004) 2.80
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell (2010) 2.75
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci (2005) 2.75
Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One (2011) 2.74
Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol (2007) 2.71
Computational influence of adult neurogenesis on memory encoding. Neuron (2009) 2.70
Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature (2004) 2.54
Induced pluripotent stem cells: the new patient? Nat Rev Mol Cell Biol (2012) 2.50
Functional significance of adult neurogenesis. Curr Opin Neurobiol (2004) 2.49
Signaling in adult neurogenesis. Annu Rev Cell Dev Biol (2009) 2.47
Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron (2005) 2.46
Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci (2002) 2.45
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A (2003) 2.44
Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci (2010) 2.39
Generation of neuronal variability and complexity. Nature (2006) 2.39
Genomic anatomy of the hippocampus. Neuron (2008) 2.37
Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci (2003) 2.28
Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A (2005) 2.21
DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A (2005) 2.20
Integration of new neurons into functional neural networks. J Neurosci (2006) 2.18
LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet (2007) 2.13
LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci (2010) 2.12
Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A (2006) 2.10
Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J Neurosci (2007) 2.09
Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener (2011) 2.03
IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol (2004) 2.02
Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res (2002) 2.02
Neurodegenerative disease and adult neurogenesis. Eur J Neurosci (2011) 2.00
Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Mol Cell Neurosci (2006) 1.99
Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.99
Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2006) 1.97
GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci (2009) 1.96
Stem cells. Setting standards for human embryonic stem cells. Science (2003) 1.95
Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol (2009) 1.94
Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol (2008) 1.92
Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods (2012) 1.91
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis (2007) 1.90
Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat Neurosci (2008) 1.89
Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur J Neurosci (2006) 1.88
Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev (2006) 1.88
Epigenetic control of neural stem cell fate. Curr Opin Genet Dev (2004) 1.88
Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice. Elife (2013) 1.86
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
Adult neurogenesis: integrating theories and separating functions. Trends Cogn Sci (2010) 1.83
Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A (2006) 1.81
The adult substantia nigra contains progenitor cells with neurogenic potential. J Neurosci (2002) 1.78
Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci (2007) 1.77