Published in Nat Rev Cancer on April 01, 2007
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J (2008) 4.79
Structural basis of protein kinase C isoform function. Physiol Rev (2008) 4.00
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene (2008) 3.63
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol (2009) 3.15
Hydrogen sulfide mediates cardioprotection through Nrf2 signaling. Circ Res (2009) 2.83
Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab (2009) 2.81
Caspases and kinases in a death grip. Cell (2009) 2.47
Protein kinase C, an elusive therapeutic target? Nat Rev Drug Discov (2012) 2.33
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2014) 2.01
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell (2014) 1.96
Protein kinase C isoforms: Multi-functional regulators of cell life and death. Front Biosci (Landmark Ed) (2009) 1.93
PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab (2008) 1.92
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86
Noncovalent wild-type-sparing inhibitors of EGFR T790M. Cancer Discov (2012) 1.86
Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions. Cell Cycle (2011) 1.74
Lipid activation of protein kinases. J Lipid Res (2008) 1.68
EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal (2009) 1.66
Multitargeting by curcumin as revealed by molecular interaction studies. Nat Prod Rep (2011) 1.62
Functionally diverse microRNA effector complexes are regulated by extracellular signaling. Mol Cell (2013) 1.60
Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol (2010) 1.60
Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res (2009) 1.58
Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol (2014) 1.58
Protein kinase C epsilon: an oncogene and emerging tumor biomarker. Mol Cancer (2009) 1.56
Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). Blood (2007) 1.52
Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities. Nat Chem (2011) 1.52
PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. J Invest Dermatol (2010) 1.46
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res (2009) 1.43
A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell (2012) 1.40
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res (2008) 1.39
Deletion of Protein Kinase C-ε Attenuates Mitochondrial Dysfunction and Ameliorates Ischemic Renal Injury. Am J Physiol Renal Physiol (2016) 1.38
Membranes: a meeting point for lipids, proteins and therapies. J Cell Mol Med (2008) 1.37
Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol (2007) 1.36
Identification of metabolites with anticancer properties by computational metabolomics. Mol Cancer (2008) 1.35
Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell (2015) 1.31
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab. Cancer Biol Ther (2011) 1.31
Diacylglycerol kinases in immune cell function and self-tolerance. Immunol Rev (2008) 1.28
Protein kinase C pharmacology: refining the toolbox. Biochem J (2013) 1.27
Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol Microbiol (2008) 1.26
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene (2013) 1.25
Total synthesis of bryostatin 1. J Am Chem Soc (2010) 1.25
Protein kinases and phosphatases in the control of cell fate. Enzyme Res (2011) 1.23
Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells (2011) 1.22
Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc (2009) 1.21
Wealth of opportunity - the C1 domain as a target for drug development. Curr Drug Targets (2008) 1.21
Cancer stem cells and radioresistance. Int J Radiat Biol (2014) 1.20
Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity. Proc Natl Acad Sci U S A (2011) 1.18
The atypical PKCs in inflammation: NF-κB and beyond. Immunol Rev (2012) 1.17
Novel insights into G protein and G protein-coupled receptor signaling in cancer. Curr Opin Cell Biol (2014) 1.14
Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility. BMC Cell Biol (2009) 1.11
Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration. J Biol Chem (2011) 1.11
ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. J Biol Chem (2009) 1.10
Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem (2009) 1.10
Protein kinase C and cancer: what we know and what we do not. Oncogene (2013) 1.09
Molecular mechanisms of mouse skin tumor promotion. Cancers (Basel) (2010) 1.09
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Cancer Cell (2013) 1.08
Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction. J Biol Chem (2010) 1.08
Exocyst function is regulated by effector phosphorylation. Nat Cell Biol (2011) 1.08
The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses. Org Lett (2009) 1.08
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1. Angew Chem Int Ed Engl (2010) 1.06
Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway. Mol Cell Biol (2007) 1.06
Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Mol Biol Cell (2010) 1.06
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environ Health Perspect (2015) 1.05
Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res (2010) 1.05
Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion. Cancer Immunol Immunother (2010) 1.04
The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation. Mol Cell Biol (2010) 1.03
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. J Biol Chem (2010) 1.03
B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ. Blood (2013) 1.02
MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis. Carcinogenesis (2014) 1.02
Global analysis of DNA methylation by Methyl-Capture sequencing reveals epigenetic control of cisplatin resistance in ovarian cancer cell. PLoS One (2011) 1.01
PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. PLoS One (2011) 1.00
Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. Oncogene (2010) 1.00
Heparanase cooperates with Ras to drive breast and skin tumorigenesis. Cancer Res (2014) 0.99
Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system. Reprod Biol Endocrinol (2009) 0.99
Diacylglycerol kinases as sources of phosphatidic acid. Biochim Biophys Acta (2009) 0.99
Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system. Anal Biochem (2013) 0.99
Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res (2014) 0.99
Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. J Biol Chem (2011) 0.97
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res (2008) 0.96
Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. Mol Pharmacol (2010) 0.96
Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia. Genes Cancer (2011) 0.96
Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem (2011) 0.96
p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function. J Biol Chem (2011) 0.95
The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer (2016) 0.95
Role for PKC δ in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells. J Signal Transduct (2010) 0.94
Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKCalpha phosphorylation. Int J Cancer (2010) 0.94
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun (2015) 0.94
PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens. Mol Carcinog (2009) 0.94
Protein kinase C controls lysosome biogenesis independently of mTORC1. Nat Cell Biol (2016) 0.93
Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem (2010) 0.93
Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules. Am J Physiol Renal Physiol (2011) 0.92
MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activation. J Biol Chem (2014) 0.92
Protein kinase C signaling and cell cycle regulation. Front Immunol (2013) 0.92
A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem (2008) 0.92
Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis. Oncogene (2010) 0.92
Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes. Cell Mol Life Sci (2014) 0.91
Phorbol-12-myristate 13-acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression. Biochemistry (2008) 0.91
Protein kinase Cβ deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling. J Lipid Res (2011) 0.91
Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε. J Biol Chem (2012) 0.91
Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle (2010) 2.91
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell (2010) 2.86
C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochim Biophys Acta (2006) 1.98
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell (2004) 1.79
Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions. Cell Cycle (2011) 1.74
Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61
Divergence and complexities in DAG signaling: looking beyond PKC. Trends Pharmacol Sci (2003) 1.52
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem (2003) 1.51
Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. J Biol Chem (2005) 1.24
Phospholipase cbeta is critical for T cell chemotaxis. J Immunol (2007) 1.22
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. J Biol Chem (2001) 1.21
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci (2007) 1.20
Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol Cell Biol (2006) 1.19
Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. Biochem J (2003) 1.18
Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: a key role for protein kinase C delta. J Biol Chem (2005) 1.14
ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. J Biol Chem (2009) 1.10
Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J (2006) 1.09
The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell (2012) 1.08
Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain. Cancer Res (2003) 1.08
Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1. Biochem J (2008) 1.07
Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells. J Biochem Mol Biol (2005) 1.05
Contribution of individual PKC isoforms to breast cancer progression. IUBMB Life (2011) 1.05
Protein kinase C delta enhances proliferation and survival of murine mammary cells. Mol Carcinog (2007) 1.04
Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Res (2006) 1.04
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. J Biol Chem (2010) 1.03
S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. J Biol Chem (2007) 1.02
Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac. Biochem J (2007) 1.01
PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. Pancreas (2010) 1.01
Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms. Curr Drug Targets (2004) 1.01
Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21. J Biol Chem (2005) 1.00
NFkappaB-independent signaling to the cyclin D1 gene by Rac. Cell Cycle (2007) 0.99
Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin. J Biol Chem (2008) 0.98
Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. J Biol Chem (2003) 0.98
Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J Biol Chem (2001) 0.97
PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors (2005) 0.97
Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. J Biol Chem (2011) 0.97
Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells. J Cell Sci (2005) 0.97
Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci Signal (2012) 0.96
Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. Mol Pharmacol (2010) 0.96
Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis (2009) 0.95
p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function. J Biol Chem (2011) 0.95
Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1. Mol Pharmacol (2013) 0.94
PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens. Mol Carcinog (2009) 0.94
Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J Biol Chem (2005) 0.93
p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Mol Biol Cell (2010) 0.91
A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites. Cell Host Microbe (2013) 0.89
The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A (2006) 0.89
A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem (2010) 0.89
Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol (2013) 0.88
Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C epsilon (PKCepsilon). J Biol Chem (2012) 0.88
Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation. Breast Cancer Res (2014) 0.87
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One (2012) 0.87
Phorbol ester-induced apoptosis and senescence in cancer cell models. Methods Enzymol (2008) 0.86
Atypical protein kinase C-zeta modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells. Mol Carcinog (2005) 0.86
Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts. J Biol Chem (2006) 0.85
Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells. Mol Pharmacol (2006) 0.84
Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase. Mol Carcinog (2003) 0.84
Regulation of the neuronal glutamate transporter excitatory amino acid carrier-1 (EAAC1) by different protein kinase C subtypes. Mol Pharmacol (2002) 0.84
Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model. Breast Cancer Res Treat (2009) 0.83
Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways. Exp Cell Res (2009) 0.83
Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity. Mol Cancer Ther (2002) 0.82
Regulation of vascular smooth muscle proliferation and migration by beta2-chimaerin, a non-protein kinase C phorbol ester receptor. Int J Mol Med (2006) 0.80
Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains. Biochemistry (2009) 0.79
Protein kinase C delta inhibits the production of proteolytic enzymes in murine mammary cells. Clin Exp Metastasis (2007) 0.79
Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. PLoS One (2013) 0.79
Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines. Mol Cell Endocrinol (2013) 0.78
Rac1 takes center stage in pancreatic cancer and ulcerative colitis: quantity matters. Gastroenterology (2011) 0.77
Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells. Biochem Pharmacol (2004) 0.77
Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol. Nat Commun (2013) 0.77
β3-chimaerin, a novel member of the chimaerin Rac-GAP family. Mol Biol Rep (2014) 0.77
Modulation of pancreatic tumor potential by overexpression of protein kinase C β1. Pancreas (2013) 0.77
Atypical Protein Kinase C-ζ Stimulates Thyrotropin-Independent Proliferation in Rat Thyroid Cells1. Endocrinology (2000) 0.75
Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C. Biochemistry (2002) 0.75