Published in Drug Resist Updat on April 03, 2007
The history of African trypanosomiasis. Parasit Vectors (2008) 2.26
Antiparasitic compounds that target DNA. Biochimie (2008) 2.00
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends Parasitol (2013) 1.44
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities. J Biol Chem (2008) 1.26
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. J Antimicrob Chemother (2013) 1.18
Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness. J Med Chem (2010) 1.13
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrob Agents Chemother (2011) 1.08
The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain. J Neurochem (2008) 1.07
Killing of trypanosomatid parasites by a modified bovine host defense peptide, BMAP-18. PLoS Negl Trop Dis (2009) 1.06
A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicol Sci (2012) 1.02
Symmetrical choline-derived dications display strong anti-kinetoplastid activity. J Antimicrob Chemother (2010) 1.01
Large, sequence-dependent effects on DNA conformation by minor groove binding compounds. Nucleic Acids Res (2009) 1.00
Assembly of the Trypanosoma brucei 60S ribosomal subunit nuclear export complex requires trypanosome-specific proteins P34 and P37. Eukaryot Cell (2008) 0.94
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity. Antimicrob Agents Chemother (2009) 0.93
Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor. Antimicrob Agents Chemother (2009) 0.91
Heterocyclic diamidine interactions at AT base pairs in the DNA minor groove: effects of heterocycle differences, DNA AT sequence and length. J Phys Chem B (2008) 0.91
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Mol Pharmacol (2011) 0.91
Chemotherapy of human african trypanosomiasis. Interdiscip Perspect Infect Dis (2009) 0.89
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities. Antimicrob Agents Chemother (2007) 0.88
A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro. J Med Chem (2013) 0.87
High prevalence of drug resistance in animal trypanosomes without a history of drug exposure. PLoS Negl Trop Dis (2011) 0.87
Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma brucei. J Biol Chem (2011) 0.87
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. Int J Parasitol Drugs Drug Resist (2013) 0.86
Genetic dissection of drug resistance in trypanosomes. Parasitology (2013) 0.86
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. Antimicrob Agents Chemother (2010) 0.85
Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Front Pharmacol (2015) 0.84
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein. Mol Microbiol (2015) 0.84
Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib. Parasit Vectors (2009) 0.84
Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites. Chem Rev (2014) 0.83
High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target. Acta Crystallogr D Biol Crystallogr (2010) 0.82
First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness. Bioorg Med Chem Lett (2009) 0.82
Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling. Parasit Vectors (2013) 0.82
The molecular dynamics of Trypanosoma brucei UDP-galactose 4'-epimerase: a drug target for African sleeping sickness. Chem Biol Drug Des (2012) 0.82
Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. PLoS Negl Trop Dis (2009) 0.82
A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens. Nucleic Acids Res (2010) 0.82
Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei. Int J Parasitol Drugs Drug Resist (2015) 0.81
Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens. Int J Parasitol Drugs Drug Resist (2011) 0.81
Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis. PLoS Pathog (2015) 0.81
The animal trypanosomiases and their chemotherapy: a review. Parasitology (2016) 0.80
Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin. PLoS Negl Trop Dis (2010) 0.79
Glucose-6-phosphate dehydrogenase of trypanosomatids: characterization, target validation, and drug discovery. Mol Biol Int (2011) 0.78
Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes. PLoS One (2014) 0.78
New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents. Dalton Trans (2011) 0.78
Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors. ChemMedChem (2014) 0.78
Investigating the Chaperone Properties of a Novel Heat Shock Protein, Hsp70.c, from Trypanosoma brucei. J Parasitol Res (2014) 0.78
Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome. PLoS Negl Trop Dis (2015) 0.77
Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity. ACS Med Chem Lett (2011) 0.77
The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! Front Pharmacol (2015) 0.77
In Silico Investigation of Flavonoids as Potential Trypanosomal Nucleoside Hydrolase Inhibitors. Adv Bioinformatics (2015) 0.76
Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis. Parasitology (2013) 0.76
Temporizin and Temporizin-1 Peptides as Novel Candidates for Eliminating Trypanosoma cruzi. PLoS One (2016) 0.75
New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites. Front Pharmacol (2016) 0.75
Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy. Antimicrob Agents Chemother (2015) 0.75
Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei. ACS Med Chem Lett (2014) 0.75
In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei. Parasit Vectors (2016) 0.75
LC-MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics (2015) 0.75
Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase. PLoS Negl Trop Dis (2016) 0.75
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors. ChemMedChem (2016) 0.75
Effect of adjuvants on the humoral immune response to congopain in mice and cattle. BMC Vet Res (2012) 0.75
Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis. Front Immunol (2017) 0.75
Effects of treatment with the anti-parasitic drug diminazene aceturate on antioxidant enzymes in rat liver and kidney. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei. Parasitol Res (2016) 0.75
African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses? Front Immunol (2017) 0.75
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (2005) 1.94
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryot Cell (2003) 1.94
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends Parasitol (2003) 1.74
Trypanosoma brucei: a survey of pyrimidine transport activities. Exp Parasitol (2006) 1.68
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends Parasitol (2013) 1.44
Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes. Mol Pharmacol (2007) 1.43
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proc Natl Acad Sci U S A (2012) 1.26
An improved and highly sensitive microfluorimetric method for assessing susceptibility of Plasmodium falciparum to antimalarial drugs in vitro. Malar J (2006) 1.16
Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics (2008) 1.15
Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay. Anal Biochem (2008) 1.13
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrob Agents Chemother (2011) 1.08
Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS Negl Trop Dis (2013) 1.04
Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases. Handb Exp Pharmacol (2011) 1.03
Molecular interactions underlying the unusually high adenosine affinity of a novel Trypanosoma brucei nucleoside transporter. Mol Pharmacol (2006) 1.02
Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited. Mol Pharmacol (2005) 1.01
Symmetrical choline-derived dications display strong anti-kinetoplastid activity. J Antimicrob Chemother (2010) 1.01
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. Eur J Med Chem (2009) 0.96
Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. J Biol Chem (2003) 0.96
Cyclic-nucleotide signalling in protozoa. FEMS Microbiol Rev (2011) 0.94
Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance. Exp Parasitol (2005) 0.91
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Mol Pharmacol (2011) 0.91
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. Antimicrob Agents Chemother (2013) 0.90
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities. Antimicrob Agents Chemother (2007) 0.88
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Mol Biochem Parasitol (2010) 0.87
Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms. PLoS One (2013) 0.87
Predictive computational models of substrate binding by a nucleoside transporter. J Biol Chem (2009) 0.85
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. Antimicrob Agents Chemother (2010) 0.85
Purine nucleobase transport in amastigotes of Leishmania mexicana: involvement in allopurinol uptake. Antimicrob Agents Chemother (2005) 0.84
Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. PLoS Negl Trop Dis (2009) 0.82
Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. J Med Chem (2012) 0.81
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. J Med Chem (2013) 0.80
Validation of novel fluorescence assays for the routine screening of drug susceptibilities of Trichomonas vaginalis. J Antimicrob Chemother (2012) 0.78
Biosynthesis and uptake of thiamine (vitamin B1) in bloodstream form Trypanosoma brucei brucei and interference of the vitamin with melarsen oxide activity. Int J Parasitol (2005) 0.77
Protocols for the routine screening of drug sensitivity in the human parasite Trichomonas vaginalis. Methods Mol Biol (2015) 0.75