The centrosome in neuronal development.

SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron (2009) 3.10

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature (2009) 3.03

Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci (2011) 2.89

The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell (2009) 2.76

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development (2010) 2.31

A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell (2009) 2.21

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat Cell Biol (2011) 2.06

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet (2013) 2.06

Regulation of neuronal morphogenesis and positioning by ubiquitin-specific proteases in the cerebellum. PLoS One (2015) 1.96

Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev Cell (2010) 1.94

Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations. Curr Opin Genet Dev (2011) 1.84

Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol (2010) 1.82

A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Nat Neurosci (2011) 1.80

Cadherin-2 controls directional chain migration of cerebellar granule neurons. PLoS Biol (2009) 1.79

The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am J Hum Genet (2011) 1.71

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol (2011) 1.69

Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J Cell Biol (2011) 1.68

Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis. Dev Cell (2011) 1.60

Pericentrin in cellular function and disease. J Cell Biol (2009) 1.46

Neuronal polarity. Cold Spring Harb Perspect Biol (2009) 1.42

Modes and mishaps of neuronal migration in the mammalian brain. J Neurosci (2008) 1.39

Microtubule-based nuclear movement occurs independently of centrosome positioning in migrating neurons. Proc Natl Acad Sci U S A (2007) 1.35

Gap junctions: multifaceted regulators of embryonic cortical development. Trends Neurosci (2008) 1.34

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. EMBO J (2010) 1.34

Orientation and function of the nuclear-centrosomal axis during cell migration. Curr Opin Cell Biol (2011) 1.32

The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo. J Cell Biol (2010) 1.29

DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology (2010) 1.27

Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron (2010) 1.26

The genomic determinants of alcohol preference in mice. Mamm Genome (2008) 1.26

Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev (2010) 1.24

Maintaining genome stability in the nervous system. Nat Neurosci (2013) 1.24

Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex. Dev Cell (2012) 1.21

Secretory outposts for the local processing of membrane cargo in neuronal dendrites. Traffic (2008) 1.21

Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases. Neural Dev (2009) 1.21

Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the 'multi-tubulin' hypothesis. Biosci Rep (2010) 1.11

Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends Neurosci (2009) 1.08

PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci (2011) 1.05

The p21-activated kinase is required for neuronal migration in the cerebral cortex. Cereb Cortex (2008) 1.02

Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells. PLoS Genet (2012) 1.01

Development and distribution of neuronal cilia in mouse neocortex. J Comp Neurol (2012) 1.01

CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J Biol Chem (2010) 1.00

DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00

Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Dev Dyn (2010) 0.99

Functions of GSK-3 Signaling in Development of the Nervous System. Front Mol Neurosci (2011) 0.99

DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeleton. Front Cell Neurosci (2014) 0.99

Adult neurogenesis in the crayfish brain: proliferation, migration, and possible origin of precursor cells. Dev Neurobiol (2009) 0.98

SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization. J Cell Sci (2011) 0.96

DISC1: a key lead in studying cortical development and associated brain disorders. Neuroscientist (2013) 0.96

The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration. PLoS One (2013) 0.92

Mutations in the TSGA14 gene in families with autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet (2011) 0.88

A human IgM signals axon outgrowth: coupling lipid raft to microtubules. J Neurochem (2011) 0.87

Relocalization of a microtubule-anchoring protein, ninein, from the centrosome to dendrites during differentiation of mouse neurons. Histochem Cell Biol (2009) 0.87

TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. EMBO Rep (2010) 0.86

Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. EMBO Rep (2016) 0.86

Construction of a polarized neuron. J Physiol (2013) 0.86

SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex. Neuron (2014) 0.86

LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules. Scientifica (Cairo) (2013) 0.85

Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Histochem Cell Biol (2008) 0.85

Substrate topography determines neuronal polarization and growth in vitro. PLoS One (2013) 0.84

Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells. Cell Stress Chaperones (2013) 0.84

Sun1 deficiency leads to cerebellar ataxia in mice. Dis Model Mech (2015) 0.83

Semaphorins deployed to repel cell migrants at spinal cord borders. J Biol (2008) 0.83

Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells. J Neurochem (2012) 0.82

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration. J Cell Biol (2017) 0.82

Dynamic Force Generation by Neural Stem Cells. Cell Mol Bioeng (2009) 0.81

Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex. Front Cell Neurosci (2015) 0.81

Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem (2013) 0.79

Developmental disruptions underlying brain abnormalities in ciliopathies. Nat Commun (2015) 0.79

Caldesmon, an actin-linked regulatory protein, comes across glucocorticoids. Cell Adh Migr (2010) 0.79

Role of cytokine signaling during nervous system development. Int J Mol Sci (2013) 0.78

An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons. Cell Cycle (2010) 0.78

Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity. Development (2012) 0.78

Cortical interneurons migrating on a pure substrate of N-cadherin exhibit fast synchronous centrosomal and nuclear movements and reduced ciliogenesis. Front Cell Neurosci (2015) 0.76

Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development. PLoS One (2014) 0.76

Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases. Genes (Basel) (2017) 0.75

Convert your favorite protein modeling program into a mutation predictor: "MODICT". BMC Bioinformatics (2016) 0.75

During tangential migration, SDF1 lends the cytoskeleton a guiding hand. J Neurosci (2014) 0.75

Ontogeny of pioneer neurons in the antennal nervous system of the grasshopper Schistocerca gregaria. Dev Genes Evol (2016) 0.75

Guided self-organization and cortical plate formation in human brain organoids. Nat Biotechnol (2017) 0.75

Mutations in CEP290, which encodes a centrosomal protein, cause pleiotropic forms of Joubert syndrome. Nat Genet (2006) 3.97

Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nat Genet (2010) 3.66

Functional genomic screen for modulators of ciliogenesis and cilium length. Nature (2010) 3.63

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. Nat Genet (2012) 3.41

Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron (2004) 3.33

TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. Nat Genet (2011) 3.06

Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. J Cell Biol (2004) 3.01

Mutations in the AHI1 gene, encoding jouberin, cause Joubert syndrome with cortical polymicrogyria. Am J Hum Genet (2004) 2.76

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet (2009) 2.72

Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet (2008) 2.65

CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Hum Mol Genet (2008) 2.61

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell (2010) 2.49

The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome. Am J Hum Genet (2004) 2.47

Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol (2011) 2.40

Nucleokinesis in neuronal migration. Neuron (2005) 2.40

Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron (2006) 2.27

AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89

AHI1 gene mutations cause specific forms of Joubert syndrome-related disorders. Ann Neurol (2006) 1.89

Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci U S A (2006) 1.87

Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med (2009) 1.86

Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med (2011) 1.84

Linkage analysis in families with Joubert syndrome plus oculo-renal involvement identifies the CORS2 locus on chromosome 11p12-q13.3. Am J Hum Genet (2003) 1.84

CEP290 mutations are frequently identified in the oculo-renal form of Joubert syndrome-related disorders. Am J Hum Genet (2007) 1.82

Multiple dose-dependent effects of Lis1 on cerebral cortical development. J Neurosci (2003) 1.81

Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. Science (2012) 1.74

The primary cilium as a cellular signaling center: lessons from disease. Curr Opin Genet Dev (2009) 1.73

Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia. Am J Hum Genet (2012) 1.71

Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron (2004) 1.70

The role of primary cilia in neuronal function. Neurobiol Dis (2010) 1.69

Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain. Nat Neurosci (2006) 1.68

Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. Science (2012) 1.65

Modeling human disease in humans: the ciliopathies. Cell (2011) 1.60

Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell (2007) 1.56

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. Nat Genet (2012) 1.54

Distinguishing the four genetic causes of Jouberts syndrome-related disorders. Ann Neurol (2005) 1.54

Cerebellar development and disease. Curr Opin Neurobiol (2008) 1.53

NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs. Cell Rep (2013) 1.48

Cortical neuronal migration mutants suggest separate but intersecting pathways. Annu Rev Cell Dev Biol (2004) 1.45

The ciliopathies in neuronal development: a clinical approach to investigation of Joubert syndrome and Joubert syndrome-related disorders. Dev Med Child Neurol (2011) 1.44

Cilia in the nervous system: linking cilia function and neurodevelopmental disorders. Curr Opin Neurol (2011) 1.43

MKS3/TMEM67 mutations are a major cause of COACH Syndrome, a Joubert Syndrome related disorder with liver involvement. Hum Mutat (2009) 1.43

Genetic basis of Joubert syndrome and related disorders of cerebellar development. Hum Mol Genet (2005) 1.43

Transgenic mouse line with green-fluorescent protein-labeled Centrin 2 allows visualization of the centrosome in living cells. Transgenic Res (2004) 1.39

Mutations in the glycosylphosphatidylinositol gene PIGL cause CHIME syndrome. Am J Hum Genet (2012) 1.38

Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females. Brain (2002) 1.37

A novel cerebello-ocular syndrome with abnormal glycosylation due to abnormalities in dolichol metabolism. Brain (2010) 1.34

Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome. J Med Genet (2012) 1.32

Novel TMEM67 mutations and genotype-phenotype correlates in meckelin-related ciliopathies. Hum Mutat (2010) 1.32

Genetic mechanisms underlying abnormal neuronal migration in classical lissencephaly. Trends Genet (2007) 1.29

AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell (2013) 1.25

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium. Hum Mutat (2014) 1.21

Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. Am J Hum Genet (2011) 1.20

CCDC41 is required for ciliary vesicle docking to the mother centriole. Proc Natl Acad Sci U S A (2013) 1.13

Association of common variants in the Joubert syndrome gene (AHI1) with autism. Hum Mol Genet (2008) 1.12

Cystic kidney disease: the role of Wnt signaling. Trends Mol Med (2010) 1.10

GSK3beta and PKCzeta function in centrosome localization and process stabilization during Slit-mediated neuronal repolarization. Mol Cell Neurosci (2006) 1.10

Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A (2009) 1.07

A systems-biology approach to understanding the ciliopathy disorders. Genome Med (2011) 1.04

Identification of a novel recessive RELN mutation using a homozygous balanced reciprocal translocation. Am J Med Genet A (2007) 1.03

Selective expression of doublecortin and LIS1 in developing human cortex suggests unique modes of neuronal movement. Cereb Cortex (2002) 0.98

Virmid: accurate detection of somatic mutations with sample impurity inference. Genome Biol (2013) 0.97

Is mental retardation a defect of synapse structure and function? Pediatr Neurol (2003) 0.96

Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities. Am J Hum Genet (2013) 0.95

The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippocampal development. Cereb Cortex (2006) 0.94

Asparagine synthetase deficiency detected by whole exome sequencing causes congenital microcephaly, epileptic encephalopathy and psychomotor delay. Metab Brain Dis (2014) 0.93

Childhood primary angiitis of the central nervous system: two biopsy-proven cases. J Pediatr (2004) 0.93

Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Hum Genet (2014) 0.92

The molecular and genetic mechanisms of neocortex development. Clin Perinatol (2009) 0.91

A missense founder mutation in VLDLR is associated with Dysequilibrium Syndrome without quadrupedal locomotion. BMC Med Genet (2012) 0.90

Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation. Nat Commun (2013) 0.90

A mutation in KIF7 is responsible for the autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance. Orphanet J Rare Dis (2012) 0.90

Joubert syndrome: report of 11 cases. Turk J Pediatr (2013) 0.87

The genetic landscape of autism spectrum disorders. Dev Med Child Neurol (2013) 0.87

Genetic regulation of human brain development: lessons from Mendelian diseases. Ann N Y Acad Sci (2010) 0.86

Expanding CEP290 mutational spectrum in ciliopathies. Am J Med Genet A (2009) 0.85

Hemimegalencephaly, a paradigm for somatic postzygotic neurodevelopmental disorders. Curr Opin Neurol (2013) 0.85

Deletion 16p13.11 uncovers NDE1 mutations on the non-deleted homolog and extends the spectrum of severe microcephaly to include fetal brain disruption. Am J Med Genet A (2013) 0.85

A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS). Am J Med Genet A (2012) 0.84

A missed exit: Reelin sets in motion Dab1 polyubiquitination to put the break on neuronal migration. Genes Dev (2007) 0.84

Co-occurrence of distinct ciliopathy diseases in single families suggests genetic modifiers. Am J Med Genet A (2011) 0.83

Pathogenetic mechanisms of focal cortical dysplasia. Epilepsia (2014) 0.83

Simultaneous multiple-excitation multiphoton microscopy yields increased imaging sensitivity and specificity. BMC Biotechnol (2011) 0.81

Whole-exome sequencing identifies mutated c12orf57 in recessive corpus callosum hypoplasia. Am J Hum Genet (2013) 0.81

Phenotypic spectrum and prevalence of INPP5E mutations in Joubert syndrome and related disorders. Eur J Hum Genet (2013) 0.81

The very low density lipoprotein receptor-associated pontocerebellar hypoplasia and dysmorphic features in three Turkish patients. J Child Neurol (2012) 0.81

Cytoskeletal-associated proteins in the migration of cortical neurons. J Neurobiol (2004) 0.81

Can't get there from here: cilia and hydrocephalus. Nat Med (2012) 0.80

Mild paroxysmal kinesigenic dyskinesia caused by PRRT2 missense mutation with reduced penetrance. Neurology (2012) 0.80

Autism in several members of a family with generalized epilepsy with febrile seizures plus. J Child Neurol (2004) 0.78

Diencephalic-mesencephalic junction dysplasia: a novel recessive brain malformation. Brain (2012) 0.78

New recessive syndrome of microcephaly, cerebellar hypoplasia, and congenital heart conduction defect. Am J Med Genet A (2011) 0.77

TSEN54 gene-related pontocerebellar hypoplasia type 2 presenting with exaggerated startle response: report of two cases in a family. Turk J Pediatr (2015) 0.77

Expanding the clinical spectrum of SPG11 gene mutations in recessive hereditary spastic paraplegia with thin corpus callosum. Eur J Med Genet (2010) 0.77

Erratum: Mutation spectrum of Joubert syndrome and related disorders among Arabs. Hum Genome Var (2015) 0.77

Sun proteins enlighten nuclear movement in development. Neuron (2009) 0.76

Moving neurons back into place. Nat Med (2009) 0.76

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome: a case report. J Child Neurol (2012) 0.76

Stems cells and regeneration: special review issue. Hum Mol Genet (2008) 0.76

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science (2017) 0.76