Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMID 17440019)

Published in J Clin Endocrinol Metab on April 17, 2007

Authors

Akas Jain1, Alex J Polotsky, Dana Rochester, Sarah L Berga, Tammy Loucks, Gohar Zeitlian, Karen Gibbs, Hanah N Polotsky, Sophia Feng, Barbara Isaac, Nanette Santoro

Author Affiliations

1: Department of Obstetrics, Gynecology, and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Associated clinical trials:

Reproductive Hormonal Alterations in Obesity | NCT01457703

Estrogen Sensitivity and Ovulatory Dysfunction in Obesity | NCT01381016

Articles citing this

Blunted sleep-related luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index. J Clin Endocrinol Metab (2009) 1.70

Current knowledge of obesity's effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol (2010) 1.21

Variants in hormone biosynthesis genes and risk of endometrial cancer. Cancer Causes Control (2008) 1.14

The impact of obesity on egg quality. J Assist Reprod Genet (2011) 1.14

Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet (2010) 1.12

Factors related to declining luteal function in women during the menopausal transition. J Clin Endocrinol Metab (2008) 1.07

Partial recovery of luteal function after bariatric surgery in obese women. Fertil Steril (2008) 1.02

Progesterone and ovulation across stages of the transition to menopause. Menopause (2009) 1.01

Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity. Brain Res (2010) 1.01

Determination of the source of androgen excess in functionally atypical polycystic ovary syndrome by a short dexamethasone androgen-suppression test and a low-dose ACTH test. Hum Reprod (2011) 0.94

Obesity and reproductive function. Obstet Gynecol Clin North Am (2012) 0.91

Adiposity and sex hormones across the menstrual cycle: the BioCycle Study. Int J Obes (Lond) (2012) 0.91

Weighing the impact of obesity on female reproductive function and fertility. Nutr Rev (2013) 0.90

Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab (2010) 0.90

Association of adolescent obesity and lifetime nulliparity--the Study of Women's Health Across the Nation (SWAN). Fertil Steril (2009) 0.89

Clinical review: Adolescent anovulation: maturational mechanisms and implications. J Clin Endocrinol Metab (2013) 0.89

Childhood obesity and its impact on the development of adolescent PCOS. Semin Reprod Med (2014) 0.89

Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One (2015) 0.83

The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr Rev (2016) 0.83

Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice. PLoS One (2015) 0.83

Dietary lipid and cholesterol induce ovarian dysfunction and abnormal LH response to stimulation in rabbits. PLoS One (2013) 0.82

High-fat diet decreases the expression of Kiss1 mRNA and kisspeptin in the ovary, and increases ovulatory dysfunction in postpubertal female rats. Reprod Biol Endocrinol (2014) 0.82

Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab (2015) 0.81

Blunted day-night changes in luteinizing hormone pulse frequency in girls with obesity: the potential role of hyperandrogenemia. J Clin Endocrinol Metab (2014) 0.81

Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med (2016) 0.81

LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity. Int J Pediatr Endocrinol (2010) 0.81

Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women. Clin Endocrinol (Oxf) (2014) 0.81

Effects of diet-induced obesity on metabolic parameters and reproductive function in female Ossabaw minipigs. Comp Med (2014) 0.81

Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women. J Clin Endocrinol Metab (2015) 0.80

Translational control of gene expression in the gonadotrope. Mol Cell Endocrinol (2013) 0.80

Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation-intrauterine insemination. Fertil Steril (2016) 0.79

Minireview: Metabolism of female reproduction: regulatory mechanisms and clinical implications. Mol Endocrinol (2014) 0.79

A comparison of methods for analyzing time series of pulsatile hormone data. Stat Med (2013) 0.78

Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women. Fertil Steril (2011) 0.78

Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: insight from animal models. Front Neuroendocrinol (2014) 0.78

Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med (2013) 0.78

Evidence of GnRH antagonist escape in obese women. J Clin Endocrinol Metab (2014) 0.77

Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. PLoS One (2015) 0.76

Prospective evaluation of nighttime hot flashes during pregnancy and postpartum. Fertil Steril (2013) 0.75

Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity (Silver Spring) (2017) 0.75

Neuroprotection via Reduction in Stress: Altered Menstrual Patterns as a Marker for Stress and Implications for Long-Term Neurologic Health in Women. Int J Mol Sci (2016) 0.75

Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring) (2014) 0.75

Articles by these authors

Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med (2014) 3.57

HIV infection and bone mineral density in middle-aged women. Clin Infect Dis (2006) 2.67

Androgen levels in older men who have or who are at risk of acquiring HIV infection. Clin Infect Dis (2005) 2.55

Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Ann Intern Med (2014) 2.48

Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. J Clin Endocrinol Metab (2003) 2.47

Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium. Biol Reprod (2009) 2.26

Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife--SWAN, the study of women's health across the nation. Am J Obstet Gynecol (2008) 2.15

Timing of hormone therapy, type of menopause, and coronary disease in women: data from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation. Menopause (2011) 2.06

Cognitive impairment associated with adjuvant therapy in breast cancer. Psychooncology (2006) 2.06

Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancer. Menopause (2007) 2.04

Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study. Fertil Steril (2007) 1.82

Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. N Engl J Med (2015) 1.65

Are vasomotor symptoms associated with sleep characteristics among symptomatic midlife women? Comparisons of self-report and objective measures. Menopause (2012) 1.65

Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: study of Women's Health Across the Nation. Menopause (2009) 1.64

Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization. Fertil Steril (2008) 1.64

Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome. Obstet Gynecol (2012) 1.62

Compounded bioidentical hormone therapy: identifying use trends and knowledge gaps among US women. Menopause (2015) 1.61

Women, hormones, and clinical trials: a beginning, not an end. J Appl Physiol (1985) (2005) 1.60

Hormone replacement therapy formulations and risk of epithelial ovarian carcinoma. Gynecol Oncol (2002) 1.60

Determination of menopausal status in women: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) Study. J Womens Health (Larchmt) (2004) 1.57

Circulating dehydroepiandrosterone sulfate levels in women who underwent bilateral salpingo-oophorectomy during the menopausal transition. Menopause (2011) 1.56

Implications of diminished ovarian reserve (DOR) extend well beyond reproductive concerns. Menopause (2008) 1.54

Ethnic differences in past hysterectomy for benign conditions. Womens Health Issues (2005) 1.52

Metabolic implications of menopause. Semin Reprod Med (2010) 1.48

Body shape and size and insulin resistance as early clinical predictors of hyperandrogenic anovulation in ethnic minority adolescent girls. J Adolesc Health (2008) 1.47

The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity. J Clin Endocrinol Metab (2002) 1.47

Does lifetime exposure to hormones predict pretreatment cognitive function in women before adjuvant therapy for breast cancer? Menopause (2013) 1.46

Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women's Health Across the Nation (SWAN). Diabetes Care (2004) 1.45

Assessing comprehension of clinical research. Contemp Clin Trials (2011) 1.44

Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol (2003) 1.44

Consistent ovulation may not be enough to make women healthy when approaching menopause: an update from the Study of Women's Health Across the Nation. Menopause (2015) 1.39

Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril (2009) 1.36

Androgen therapy in women: an Endocrine Society Clinical Practice guideline. J Clin Endocrinol Metab (2006) 1.30

Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism. J Clin Endocrinol Metab (2010) 1.29

Menopause symptoms in HIV-infected and drug-using women. Menopause (2005) 1.27

Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling. Cereb Cortex (2009) 1.26

HIV infection, drug use, and onset of natural menopause. Clin Infect Dis (2005) 1.24

Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation. J Clin Endocrinol Metab (2012) 1.24

Synergism between psychosocial and metabolic stressors: impact on reproductive function in cynomolgus monkeys. Am J Physiol Endocrinol Metab (2007) 1.23

Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition. J Clin Endocrinol Metab (2009) 1.22

Disorders of glucose metabolism among HIV-infected women. Clin Infect Dis (2005) 1.22

Postmenopausal hormone therapy: new questions and the case for new clinical trials. Menopause (2006) 1.18

Cardiovascular risk factor variation within a Hispanic cohort: SWAN, the Study of Women's Health Across the Nation. Ethn Dis (2010) 1.16

The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. Contemp Clin Trials (2012) 1.15

Menopausal symptoms and ethnicity: the Study of Women's Health Across the Nation. Womens Health (Lond Engl) (2009) 1.14

Relation of cardiovascular risk factors in women approaching menopause to menstrual cycle characteristics and reproductive hormones in the follicular and luteal phases. J Clin Endocrinol Metab (2006) 1.14

Impaired folliculogenesis and ovulation in older reproductive aged women. J Clin Endocrinol Metab (2003) 1.14

Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. Hum Reprod (2010) 1.13

Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet (2010) 1.12

Maternal recall of hypertensive disorders in pregnancy: a systematic review. J Womens Health (Larchmt) (2012) 1.11

Relationship of day-to-day reproductive hormone levels to sleep in midlife women. Arch Intern Med (2005) 1.08

Reproductive hormones and obesity: 9 years of observation from the Study of Women's Health Across the Nation. Am J Epidemiol (2010) 1.08

Age-related decline in fertility. Endocrinol Metab Clin North Am (2003) 1.08

Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury. J Neurotrauma (2011) 1.07

Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertil Steril (2011) 1.05

Endometrial thickness, Caucasian ethnicity, and age predict clinical pregnancy following fresh blastocyst embryo transfer: a retrospective cohort. Reprod Biol Endocrinol (2009) 1.04

Salivary cortisol reflects serum cortisol: analysis of circadian profiles. Ann Clin Biochem (2007) 1.03

Risk factor clustering in the insulin resistance syndrome and its relationship to cardiovascular disease in postmenopausal white, black, hispanic, and Asian/Pacific Islander women. Metabolism (2003) 1.03

Menstrual cycle differences between women with type 1 diabetes and women without diabetes. Diabetes Care (2003) 1.02

Androgen therapy in women: a reappraisal: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2014) 1.02

Partial recovery of luteal function after bariatric surgery in obese women. Fertil Steril (2008) 1.02

Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes. Am J Med (2011) 1.02

Transdermal estradiol for postpartum depression: a promising treatment option. Clin Obstet Gynecol (2009) 1.01

Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes. PLoS One (2012) 1.01

Total estrogen time and obstructive coronary disease in women: insights from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE). J Womens Health (Larchmt) (2009) 1.00

Predictors of chronic disease at midlife and beyond--the health risks of obesity. Maturitas (2009) 1.00

Sensitivity to stress-induced reproductive dysfunction linked to activity of the serotonin system. Fertil Steril (2005) 1.00

Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS). Atherosclerosis (2011) 0.99

Longitudinal changes in hypothalamic and ovarian function in perimenopausal women with anovulatory cycles: relationship with vasomotor symptoms. Fertil Steril (2008) 0.99

Adiposity and hot flashes in midlife women: a modifying role of age. J Clin Endocrinol Metab (2011) 0.98

Social subordination and polymorphisms in the gene encoding the serotonin transporter enhance estradiol inhibition of luteinizing hormone secretion in female rhesus monkeys. Biol Reprod (2009) 0.98

The relationship of bleeding patterns to daily reproductive hormones in women approaching menopause. Obstet Gynecol (2008) 0.97

Neuromuscular and biomechanical characteristics do not vary across the menstrual cycle. Knee Surg Sports Traumatol Arthrosc (2007) 0.97

Current status of the approach to assisted reproduction. Pediatr Clin North Am (2009) 0.95

Premature ovarian failure (POF): discordance between somatic and reproductive aging. Ageing Res Rev (2002) 0.95

Moderators of interventions designed to enhance physical and psychological functioning among younger women with early-stage breast cancer. J Clin Oncol (2007) 0.95

The nucleolar channel system of human endometrium is related to endoplasmic reticulum and R-rings. Mol Biol Cell (2007) 0.95

Factors affecting reproductive hormones in HIV-infected, substance-using middle-aged women. Menopause (2007) 0.94

Increased cortisol in the cerebrospinal fluid of women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab (2006) 0.93

Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study. Physiol Genomics (2012) 0.93

Relations between endogenous androgens and estrogens in postmenopausal women with suspected ischemic heart disease. J Clin Endocrinol Metab (2008) 0.93

The menopausal transition: characteristics and management. Best Pract Res Clin Endocrinol Metab (2003) 0.92

Postmenopausal hyperthecosis: functional dysregulation of androgenesis in climacteric ovary. Obstet Gynecol (2002) 0.91

Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women. Hum Reprod (2007) 0.90

How many eggs are needed to produce an assisted reproductive technology baby: is more always better? Fertil Steril (2011) 0.90

Postthaw blastomere survival is predictive of the success of frozen-thawed embryo transfer cycles. Fertil Steril (2004) 0.89

Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy population. Neuropsychopharmacology (2011) 0.89

Evolution of medical treatment for endometriosis: back to the roots? Hum Reprod Update (2007) 0.89

Association of adolescent obesity and lifetime nulliparity--the Study of Women's Health Across the Nation (SWAN). Fertil Steril (2009) 0.89