Published in J Med Chem on April 25, 2007
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Assessing the performance of OMEGA with respect to retrieving bioactive conformations. J Mol Graph Model (2003) 2.78
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Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol (2004) 2.30
Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2. J Pharmacol Exp Ther (2005) 1.88
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Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. J Physiol (2010) 1.58
Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Mol Pharmacol (2007) 1.56
A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. PLoS Biol (2007) 1.56
The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure. Mol Cell (2005) 1.53
Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants. J Biol Chem (2009) 1.46
Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion. Structure (2003) 1.45
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Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proc Natl Acad Sci U S A (2007) 1.36
Escitalopram versus citalopram: the surprising role of the R-enantiomer. Psychopharmacology (Berl) (2004) 1.33
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. J Biol Chem (2009) 1.33
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Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J Immunol (2003) 1.25
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. FEBS Lett (2005) 1.22
Docking performance of the glide program as evaluated on the Astex and DUD datasets: a complete set of glide SP results and selected results for a new scoring function integrating WaterMap and glide. J Comput Aided Mol Des (2012) 1.21
Gaboxadol--a new awakening in sleep. Curr Opin Pharmacol (2005) 1.19
Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Mol Pharmacol (2013) 1.15
Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling. Neuropharmacology (2008) 1.15
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. J Biol Chem (2009) 1.13
Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX. J Med Chem (2003) 1.10
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. Biochem Pharmacol (2004) 1.10
Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. Eur Neuropsychopharmacol (2012) 1.09
Inhibitors of histone demethylases. Bioorg Med Chem (2011) 1.06
Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists. J Physiol (2004) 1.05
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. J Mol Biol (2006) 1.04
Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. Comb Chem High Throughput Screen (2008) 1.04
Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed. J Biol Chem (2011) 1.02
Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2. Proc Natl Acad Sci U S A (2005) 1.02
Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. Neuropharmacology (2010) 1.01
Improving database enrichment through ensemble docking. J Comput Aided Mol Des (2008) 1.00
The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen. J Immunol (2005) 1.00
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites. Chem Biol (2007) 1.00
Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain. Eur J Neurosci (2003) 0.99
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A (2012) 0.99
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Crystal structure of the covalent intermediate of amylosucrase from Neisseria polysaccharea. Biochemistry (2004) 0.98
Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis. Mol Pharmacol (2005) 0.98
Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism. PLoS One (2012) 0.98
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem (2002) 0.97
The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. Mol Pharmacol (2002) 0.97
Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B. Acta Crystallogr D Biol Crystallogr (2004) 0.97
Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp. J Mol Biol (2007) 0.97
Structure-activity relationships of selective GABA uptake inhibitors. Curr Top Med Chem (2006) 0.97
Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem (2008) 0.96
Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. FASEB J (2009) 0.96
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs. J Neurochem (2009) 0.95
A unique set of SH3-SH3 interactions controls IB1 homodimerization. EMBO J (2006) 0.95
Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom. Acta Crystallogr D Biol Crystallogr (2006) 0.95
Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration. Eur J Pharmacol (2007) 0.95
High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide. Acta Crystallogr D Biol Crystallogr (2005) 0.95
Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J Mol Biol (2009) 0.95
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity. J Med Chem (2003) 0.95