Published in Trends Cardiovasc Med on May 01, 2007
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Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE(-/-) mice. Sci Rep (2017) 0.75
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Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circ Res (2014) 1.93
Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA (2002) 1.83
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Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J Clin Invest (2013) 1.64
Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation (2008) 1.62
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med (2010) 1.62
Ganglioside-linked terminal sialic acid moieties on murine macrophages function as attachment receptors for murine noroviruses. J Virol (2009) 1.61
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease. Mol Genet Metab (2007) 1.61
Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency. Circulation (2005) 1.28
Lysosomal phospholipase A2 and phospholipidosis. Mol Cell Biol (2006) 1.23
Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2005) 1.22
Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells. Mol Genet Metab (2008) 1.21
Heparin cofactor II inhibits arterial thrombosis after endothelial injury. J Clin Invest (2002) 1.18
Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis. Arthritis Rheum (2012) 1.18
Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice. Hepatology (2009) 1.16
Fabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis. J Am Soc Nephrol (2003) 1.15
P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue. Circ Res (2010) 1.14
Ventricular tachycardia associated with transmyocardial migration of an epicardial pacing wire. Ann Thorac Surg (2004) 1.12
Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages. J Biol Chem (2004) 1.11
Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy. J Inherit Metab Dis (2010) 1.10
Decreased nitric oxide bioavailability in a mouse model of Fabry disease. J Am Soc Nephrol (2009) 1.09
Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol (2006) 1.08
Visceral adipose tissue and atherosclerosis. Curr Vasc Pharmacol (2009) 1.07
Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase. J Biol Chem (2002) 1.07
Monocyte chemoattractant protein-1 deficiency protects against visceral fat-induced atherosclerosis. Arterioscler Thromb Vasc Biol (2010) 1.05
Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease. PLoS One (2010) 1.04
Caveolin-associated accumulation of globotriaosylceramide in the vascular endothelium of alpha-galactosidase A null mice. J Biol Chem (2007) 1.02
The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages. J Immunol (2008) 1.00
An in vitro model of Fabry disease. J Am Soc Nephrol (2005) 1.00
A role for lysosomal phospholipase A2 in drug induced phospholipidosis. Drug Metab Lett (2007) 1.00
Ceramide 1-phosphate, a mediator of phagocytosis. J Biol Chem (2005) 0.99
Vascular dysfunction in the alpha-galactosidase A-knockout mouse is an endothelial cell-, plasma membrane-based defect. Clin Exp Pharmacol Physiol (2008) 0.99
Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. J Innate Immun (2009) 0.97
Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase. PLoS One (2010) 0.95
Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues. J Lipid Res (2005) 0.94
The role of negatively charged lipids in lysosomal phospholipase A2 function. J Lipid Res (2009) 0.93
Obesity-induced endothelial dysfunction is prevented by deficiency of P-selectin glycoprotein ligand-1. Diabetes (2012) 0.93
Ceramides and glucosylceramides are independent antagonists of insulin signaling. J Biol Chem (2013) 0.92
The acylation of lipophilic alcohols by lysosomal phospholipase A2. J Lipid Res (2007) 0.92
Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells. Am J Physiol Renal Physiol (2007) 0.92
Src kinase mediates the regulation of phospholipase C-gamma activity by glycosphingolipids. J Biol Chem (2003) 0.90
Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage. J Biol Chem (2011) 0.90
Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells. Arthritis Rheum (2006) 0.90
Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells. J Lipid Res (2004) 0.89
Acute myocardial infarction leads to acceleration of atherosclerosis. Atherosclerosis (2013) 0.88
Positional specificity of lysosomal phospholipase A2. J Lipid Res (2006) 0.88
Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice. J Lipid Res (2008) 0.88
Regulation of phospholipase C-gamma activity by glycosphingolipids. J Biol Chem (2002) 0.88
Paradoxical roles of perivascular adipose tissue in atherosclerosis and hypertension. Circ J (2012) 0.88
Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain. J Lipid Res (2011) 0.87
P-selectin glycoprotein ligand-1 inhibition blocks increased leukocyte-endothelial interactions associated with sickle cell disease in mice. Blood (2012) 0.87
Paradoxical protection from atherosclerosis and thrombosis in a mouse model of sickle cell disease. Br J Haematol (2013) 0.87
Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler Thromb Vasc Biol (2005) 0.87
Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. J Lab Clin Med (2002) 0.86
The measurement of lysosomal phospholipase A2 activity in plasma. J Lipid Res (2010) 0.86
Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition. Proc Natl Acad Sci U S A (2013) 0.85
Plasminogen activator inhibitor-1 in vascular thrombosis. Curr Drug Targets (2007) 0.85
Differential involvement of COX1 and COX2 in the vasculopathy associated with the alpha-galactosidase A-knockout mouse. Am J Physiol Heart Circ Physiol (2009) 0.84
P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis (2011) 0.84
Atherosclerosis and leukocyte-endothelial adhesive interactions are increased following acute myocardial infarction in apolipoprotein E deficient mice. Atherosclerosis (2010) 0.84
Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. Blood (2002) 0.84
Leptin-induced endothelial dysfunction is mediated by sympathetic nervous system activity. J Am Heart Assoc (2013) 0.83
Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor. Biochim Biophys Acta (2012) 0.82
Blood pressure and vascular effects of leptin in humans. Metab Syndr Relat Disord (2007) 0.82
Targeting MCP-1 to reduce vascular complications of obesity. Recent Pat Cardiovasc Drug Discov (2009) 0.82
Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation. Stroke (2006) 0.81
Ceramide-1-phosphate in phagocytosis and calcium homeostasis. Adv Exp Med Biol (2010) 0.81
Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes. Blood (2003) 0.81
Strategies to reduce vascular risk associated with obesity. Curr Vasc Pharmacol (2007) 0.80
Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochem Res (2013) 0.80
1-O-acylceramides are natural components of human and mouse epidermis. J Lipid Res (2013) 0.80
Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. J Lipid Res (2007) 0.80
Competitive bidding for interventional cardiology supplies: lessons learned during round 2. Am J Manag Care (2002) 0.79
Glycosphingolipid Mediated Caveolin-1 Oligomerization. J Glycomics Lipidomics (2012) 0.79
Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia. Atherosclerosis (2010) 0.79
Increased stroke size following MCA occlusion in a mouse model of sickle cell disease. Blood (2014) 0.79
Adiponectin: vascular protection from the fat? Arterioscler Thromb Vasc Biol (2006) 0.79
Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA. Biochem Biophys Res Commun (2005) 0.78
Animal models of thrombosis. Curr Opin Hematol (2009) 0.77
Endothelial nitric oxide synthase uncoupling and microvascular dysfunction in the mesentery of mice deficient in α-galactosidase A. Am J Physiol Gastrointest Liver Physiol (2013) 0.77
A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity. Anal Biochem (2012) 0.77
Lysosomal phospholipase A2: a novel player in host immunity to Mycobacterium tuberculosis. Eur J Immunol (2014) 0.77
Enhanced phagocytosis through inhibition of de novo ceramide synthesis. J Biol Chem (2002) 0.76
Thinking about rare kidney diseases. J Am Soc Nephrol (2005) 0.76
Valsartan Improves Insulin Sensitivity without Altering Vascular Function in Healthy Overweight Adults without the Metabolic Syndrome. Metab Syndr Relat Disord (2007) 0.76
Haploinsufficiency of E-selectin ligand-1 is associated with reduced atherosclerotic plaque macrophage content while complete deficiency leads to early embryonic lethality in mice. Atherosclerosis (2012) 0.75
Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Expert Rev Mol Med (2002) 0.75