PubRank

Richard M Siegel

Author PubWeight™ 74.59‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011 4.81
2 Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 2002 4.21
3 Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell 2004 2.99
4 Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat Immunol 2004 2.55
5 Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 2004 2.36
6 Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Proc Natl Acad Sci U S A 2010 2.20
7 Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop. Blood 2010 2.10
8 The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol 2010 2.08
9 The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 2008 2.04
10 Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS). Blood 2006 1.61
11 Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest 2007 1.58
12 Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol 2007 1.40
13 Interaction of histone acetylases and deacetylases in vivo. Mol Cell Biol 2003 1.35
14 Lighting the fires within: the cell biology of autoinflammatory diseases. Nat Rev Immunol 2012 1.34
15 Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib. BMC Med Genet 2007 1.28
16 Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. J Biol Chem 2004 1.25
17 Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death. J Immunol 2009 1.19
18 TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation. Immunol Rev 2011 1.19
19 Measurement of apoptosis and other forms of cell death. Curr Protoc Immunol 2004 1.18
20 Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood 2010 1.14
21 Efficacy of etanercept in the tumor necrosis factor receptor-associated periodic syndrome: a prospective, open-label, dose-escalation study. Arthritis Rheum 2012 1.10
22 Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. J Virol 2002 1.09
23 Medicine. Progranulin resolves inflammation. Science 2011 1.09
24 Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders. Curr Opin Rheumatol 2009 1.06
25 Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J Immunol 2007 1.05
26 The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood 2009 1.04
27 The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities. Virology 2004 1.02
28 Falling into TRAPS--receptor misfolding in the TNF receptor 1-associated periodic fever syndrome. Arthritis Res Ther 2007 1.02
29 Autoimmunity versus tolerance: can dying cells tip the balance? Clin Immunol 2006 1.00
30 Type III secretion decreases bacterial and host survival following phagocytosis of Yersinia pseudotuberculosis by macrophages. Infect Immun 2008 1.00
31 T cell-directed therapies: lessons learned and future prospects. Nat Immunol 2007 0.98
32 CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J Immunol 2010 0.98
33 Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy. J Clin Invest 2015 0.96
34 Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J Immunol 2004 0.94
35 The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8. Apoptosis 2011 0.93
36 Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice. Toxicol Pathol 2004 0.92
37 New tricks from an old dog: mitochondrial redox signaling in cellular inflammation. Semin Immunol 2013 0.91
38 Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules. Cell Immunol 2011 0.91
39 Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi. J Immunol 2008 0.90
40 Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment. J Immunol 2006 0.90
41 Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses. Results Probl Cell Differ 2009 0.89
42 Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases. FEBS Lett 2011 0.87
43 Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection. J Immunol 2005 0.87
44 Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. J Clin Invest 2015 0.85
45 New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression. Ann N Y Acad Sci 2010 0.84
46 Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation. BMC Genomics 2014 0.84
47 A FAScinating receptor in self-tolerance. Immunity 2007 0.84
48 Mitochondrial ROS fire up T cell activation. Immunity 2013 0.83
49 The Yersinia effector protein YpkA induces apoptosis independently of actin depolymerization. J Immunol 2007 0.82
50 A rapid ex vivo clinical diagnostic assay for fas receptor-induced T lymphocyte apoptosis. J Clin Immunol 2012 0.79
51 Harnessing programmed cell death as a therapeutic strategy in rheumatic diseases. Nat Rev Rheumatol 2011 0.77
52 Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9-Producing T Cells. J Immunol 2015 0.77
53 Wishing away inflammation? New links between serotonin and TNF signaling. Mol Interv 2009 0.76
54 Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection. J Leukoc Biol 2013 0.76
55 Autoimmunity: twenty years in the Fas lane. J Immunol 2012 0.75
56 Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond. Semin Immunopathol 2015 0.75
57 A new web resource for NIH immunology. Nat Immunol 2006 0.75