Published in Structure on May 01, 2007
Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem (2009) 1.18
Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J Med Chem (2009) 1.06
The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. Mol Biochem Parasitol (2008) 0.98
Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function. Biochimie (2010) 0.88
Structure-function of falcipains: malarial cysteine proteases. J Trop Med (2012) 0.84
Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow. J Biomol Struct Dyn (2016) 0.82
The role of conserved residues of chagasin in the inhibition of cysteine peptidases. FEBS Lett (2008) 0.81
Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors. J Mol Model (2011) 0.80
Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site. J Mol Model (2014) 0.79
Inhibitor of cysteine proteases is critical for motility and infectivity of Plasmodium sporozoites. MBio (2013) 0.79
Centenary celebrations article: Cysteine proteases of human malaria parasites. J Parasit Dis (2011) 0.78
Solution structure of IseA, an inhibitor protein of DL-endopeptidases from Bacillus subtilis, reveals a novel fold with a characteristic inhibitory loop. J Biol Chem (2012) 0.77
The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Structure Based Docking and Molecular Dynamic Studies of Plasmodial Cysteine Proteases against a South African Natural Compound and its Analogs. Sci Rep (2016) 0.75
Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target. PLoS One (2014) 0.75
Microbial inhibitors of cysteine proteases. Med Microbiol Immunol (2016) 0.75
Statistical potential for assessment and prediction of protein structures. Protein Sci (2006) 8.98
Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol (2003) 7.15
The molecular architecture of the nuclear pore complex. Nature (2007) 6.93
Protein structure modeling with MODELLER. Methods Mol Biol (2008) 6.28
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Comparative protein structure modeling using MODELLER. Curr Protoc Protein Sci (2007) 5.81
Chemical genetics of Plasmodium falciparum. Nature (2010) 5.52
Determining the architectures of macromolecular assemblies. Nature (2007) 4.94
Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis (2008) 4.60
MODBASE, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2004) 4.54
ABVD versus BEACOPP for Hodgkin's lymphoma when high-dose salvage is planned. N Engl J Med (2011) 4.50
Outcome of the first electron microscopy validation task force meeting. Structure (2012) 4.35
Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell (2008) 4.00
Protein production and purification. Nat Methods (2008) 3.97
FoXS: a web server for rapid computation and fitting of SAXS profiles. Nucleic Acids Res (2010) 3.91
Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov (2004) 3.90
Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet (2002) 3.78
Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg (2003) 3.71
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
Tools for comparative protein structure modeling and analysis. Nucleic Acids Res (2003) 3.68
Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA (2007) 3.62
MODBASE: a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res (2006) 3.56
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A (2012) 3.42
ModLoop: automated modeling of loops in protein structures. Bioinformatics (2003) 3.31
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell (2005) 3.29
The molecular sociology of the cell. Nature (2007) 3.23
Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Lancet (2009) 3.21
Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet (2004) 3.12
Protein structure fitting and refinement guided by cryo-EM density. Structure (2008) 3.12
LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources. Bioinformatics (2005) 3.05
Study of the structural dynamics of the E coli 70S ribosome using real-space refinement. Cell (2003) 3.03
Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet (2007) 2.99
Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90. Structure (2008) 2.98
ModBase, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2010) 2.96
Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A (2011) 2.94
Statistical potentials for fold assessment. Protein Sci (2002) 2.92
Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol (2004) 2.90
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. BMJ (2009) 2.84
Alignment of protein sequences by their profiles. Protein Sci (2004) 2.80
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One (2008) 2.78
Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother (2006) 2.74
Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials (2006) 2.72
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature (2011) 2.71
Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg (2003) 2.68
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials (2007) 2.63
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A (2011) 2.58
Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov (2008) 2.58
Ca(2+)-regulated structural changes in troponin. Proc Natl Acad Sci U S A (2005) 2.56
Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis (2008) 2.56
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett (2003) 2.54
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis (2005) 2.51
EVA: Evaluation of protein structure prediction servers. Nucleic Acids Res (2003) 2.50
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol (2004) 2.47
Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop (2011) 2.46
Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol (2003) 2.44
Comparative protein structure modeling by iterative alignment, model building and model assessment. Nucleic Acids Res (2003) 2.44
Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis (2007) 2.44
Invasion of skin by Schistosoma cercariae. Trends Parasitol (2002) 2.44
Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Am J Trop Med Hyg (2006) 2.43
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis (2009) 2.42
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med (2012) 2.39
PIBASE: a comprehensive database of structurally defined protein interfaces. Bioinformatics (2005) 2.39
Reliability of assessment of protein structure prediction methods. Structure (2002) 2.39
Putting the pieces together: integrative modeling platform software for structure determination of macromolecular assemblies. PLoS Biol (2012) 2.37
Simple fold composition and modular architecture of the nuclear pore complex. Proc Natl Acad Sci U S A (2006) 2.35
Integrating diverse data for structure determination of macromolecular assemblies. Annu Rev Biochem (2008) 2.35
A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics (2011) 2.34
Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc Natl Acad Sci U S A (2004) 2.33
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med (2005) 2.33
Outcome of a workshop on archiving structural models of biological macromolecules. Structure (2006) 2.32
Drug discovery and development for neglected parasitic diseases. Nat Chem Biol (2006) 2.31
World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar J (2007) 2.30
Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda. Am J Trop Med Hyg (2007) 2.30
Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis (2008) 2.28
Comparative Protein Structure Modeling Using MODELLER. Curr Protoc Bioinformatics (2014) 2.17
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med (2007) 2.15
The C-type lectin fold as an evolutionary solution for massive sequence variation. Nat Struct Mol Biol (2005) 2.13
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother (2007) 2.12
Structure of the mammalian 80S ribosome at 8.7 A resolution. Structure (2008) 2.11
Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat Chem Biol (2011) 2.10
UCSF Chimera, MODELLER, and IMP: an integrated modeling system. J Struct Biol (2011) 2.10
Refinement of protein structures by iterative comparative modeling and CryoEM density fitting. J Mol Biol (2006) 2.06
Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial. J Appl Physiol (1985) (2008) 2.06
Outcome of a workshop on applications of protein models in biomedical research. Structure (2009) 2.05
Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies. J Mol Biol (2008) 2.05
High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis (2008) 2.05
Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics (2012) 2.03
MODBASE, a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res (2008) 2.02
MODBASE, a database of annotated comparative protein structure models. Nucleic Acids Res (2002) 2.01
Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother (2005) 2.00
ModView, visualization of multiple protein sequences and structures. Bioinformatics (2003) 1.99
Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. J Biol Chem (2011) 1.98
A structural perspective on protein-protein interactions. Curr Opin Struct Biol (2004) 1.98
Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis (2011) 1.98
A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A (2007) 1.97
Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis (2012) 1.97
Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg (2003) 1.96