1
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Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies.
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Lancet
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2002
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16.56
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2
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Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.
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N Engl J Med
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2015
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15.06
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3
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Class of antiretroviral drugs and the risk of myocardial infarction.
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N Engl J Med
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2007
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12.93
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4
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Combination antiretroviral therapy and the risk of myocardial infarction.
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N Engl J Med
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2003
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12.23
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5
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Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study.
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Arch Intern Med
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2006
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9.21
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6
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Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration.
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Lancet
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2008
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8.73
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7
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Outcomes from monitoring of patients on antiretroviral therapy in resource-limited settings with viral load, CD4 cell count, or clinical observation alone: a computer simulation model.
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Lancet
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2008
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7.70
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8
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Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD study.
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AIDS
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2003
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5.61
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9
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Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial.
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Crit Care Med
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2011
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5.28
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10
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Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort.
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AIDS
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2005
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4.40
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11
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Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes.
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Lancet
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2004
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3.59
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12
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Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study.
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Lancet Infect Dis
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2011
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3.59
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13
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Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D Study.
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AIDS
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2010
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3.47
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14
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The role of HIV in serious diseases other than AIDS.
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AIDS
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2008
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3.39
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15
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Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ Cell counts and HIV RNA levels during follow-up.
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J Infect Dis
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2008
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3.35
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16
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Projected life expectancy of people with HIV according to timing of diagnosis.
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AIDS
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2012
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3.09
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17
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Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study.
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J Infect Dis
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2013
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3.04
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18
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Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: exploratory analyses from the SMART trial.
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Antivir Ther
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2008
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2.93
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19
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Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients.
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AIDS
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2010
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2.85
|
20
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Considerations in the rationale, design and methods of the Strategic Timing of AntiRetroviral Treatment (START) study.
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Clin Trials
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2012
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2.71
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21
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Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study.
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Eur J Cardiovasc Prev Rehabil
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2010
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2.70
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22
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Current epidemiology of Pneumocystis pneumonia.
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Emerg Infect Dis
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2004
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2.70
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23
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Epidemiological evidence for cardiovascular disease in HIV-infected patients and relationship to highly active antiretroviral therapy.
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Circulation
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2008
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2.64
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24
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Invasive Candida infections and the harm from antibacterial drugs in critically ill patients: data from a randomized, controlled trial to determine the role of ciprofloxacin, piperacillin-tazobactam, meropenem, and cefuroxime.
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Crit Care Med
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2015
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2.62
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25
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Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE).
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PLoS Med
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2013
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2.49
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26
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HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies.
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AIDS
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2008
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2.27
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27
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Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection.
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J Infect Dis
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2009
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2.20
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28
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State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary.
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Circulation
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2008
|
2.17
|
29
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Chronic renal failure among HIV-1-infected patients.
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AIDS
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2007
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2.07
|
30
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Opportunistic disease and mortality in patients coinfected with hepatitis B or C virus in the strategic management of antiretroviral therapy (SMART) study.
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Clin Infect Dis
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2008
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2.06
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31
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Thrombocytopenia is associated with an increased risk of cancer during treated HIV disease.
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AIDS
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2014
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2.02
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32
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Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis.
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Clin Diagn Lab Immunol
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2005
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2.02
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33
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Diabetes mellitus, preexisting coronary heart disease, and the risk of subsequent coronary heart disease events in patients infected with human immunodeficiency virus: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D Study).
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Circulation
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2009
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2.01
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34
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When should antiretroviral therapy for HIV be started?
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BMJ
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2007
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1.95
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35
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Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy.
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AIDS
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2009
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1.90
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36
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Rate of accumulation of thymidine analogue mutations in patients continuing to receive virologically failing regimens containing zidovudine or stavudine: implications for antiretroviral therapy programs in resource-limited settings.
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J Infect Dis
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2009
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1.88
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37
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Mortality from HIV and TB coinfections is higher in Eastern Europe than in Western Europe and Argentina.
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AIDS
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2009
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1.81
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38
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The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: rationale, design, and methods of ESPRIT.
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Control Clin Trials
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2002
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1.73
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39
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Safe interruption of maintenance therapy against previous infection with four common HIV-associated opportunistic pathogens during potent antiretroviral therapy.
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Ann Intern Med
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2002
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1.70
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40
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Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.
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AIDS
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2011
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1.68
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41
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Cardiovascular implications from untreated human immunodeficiency virus infection.
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Eur Heart J
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2011
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1.64
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42
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The Coding Causes of Death in HIV (CoDe) Project: initial results and evaluation of methodology.
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Epidemiology
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2011
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1.59
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43
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Is it safe to discontinue primary Pneumocystis jiroveci pneumonia prophylaxis in patients with virologically suppressed HIV infection and a CD4 cell count <200 cells/microL?
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Clin Infect Dis
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2010
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1.54
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44
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Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies.
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Cancer
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2010
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1.53
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45
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Is there evidence for an increase in the death rate from liver-related disease in patients with HIV?
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AIDS
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2005
|
1.52
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46
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Relationship between antiretrovirals used as part of a cART regimen and CD4 cell count increases in patients with suppressed viremia.
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AIDS
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2006
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1.52
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47
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Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen.
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AIDS
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2007
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1.51
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48
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The changing pattern of Kaposi sarcoma in patients with HIV, 1994-2003: the EuroSIDA Study.
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Cancer
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2004
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1.39
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49
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The CD4 lymphocyte count and risk of clinical progression.
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Curr Opin HIV AIDS
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2006
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1.38
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50
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Feasibility and effectiveness of indicator condition-guided testing for HIV: results from HIDES I (HIV indicator diseases across Europe study).
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PLoS One
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2013
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1.36
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51
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Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers.
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AIDS
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2013
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1.34
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52
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Virological rebound after suppression on highly active antiretroviral therapy.
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AIDS
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2003
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1.34
|
53
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YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis.
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Clin Diagn Lab Immunol
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2002
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1.29
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54
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Factors associated with the development of opportunistic infections in HIV-1-infected adults with high CD4+ cell counts: a EuroSIDA study.
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J Infect Dis
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2006
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1.28
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55
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Regional changes over time in initial virologic response rates to combination antiretroviral therapy across Europe.
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J Acquir Immune Defic Syndr
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2006
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1.27
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56
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Does less frequent routine monitoring of patients on a stable, fully suppressed cART regimen lead to an increased risk of treatment failure?
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AIDS
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2008
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1.25
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57
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Randomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 Trial.
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J Infect Dis
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2003
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1.25
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58
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Potential impact on HIV incidence of higher HIV testing rates and earlier antiretroviral therapy initiation in MSM.
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AIDS
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2015
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1.23
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59
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Aging with HIV in Africa: the challenges of living longer.
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AIDS
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2012
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1.21
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60
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Pneumonia in HIV-infected persons: increased risk with cigarette smoking and treatment interruption.
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Am J Respir Crit Care Med
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2008
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1.21
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61
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The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study.
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AIDS
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2008
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1.18
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62
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Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis.
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J Infect Dis
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2008
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1.18
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63
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A randomized trial to evaluate lopinavir/ritonavir versus saquinavir/ritonavir in HIV-1-infected patients: the MaxCmin2 trial.
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Antivir Ther
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2005
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1.18
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64
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Risk of AIDS and death at given HIV-RNA and CD4 cell count, in relation to specific antiretroviral drugs in the regimen.
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AIDS
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2005
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1.16
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65
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Hepatitis C virus viremia increases the incidence of chronic kidney disease in HIV-infected patients.
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AIDS
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2012
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1.16
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66
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Soluble urokinase receptor is elevated in cerebrospinal fluid from patients with purulent meningitis and is associated with fatal outcome.
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Scand J Infect Dis
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2004
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1.15
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67
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Short-term clinical disease progression in HIV-1-positive patients taking combination antiretroviral therapy: the EuroSIDA risk-score.
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AIDS
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2007
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1.15
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68
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Predictors of hypertension and changes of blood pressure in HIV-infected patients.
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Antivir Ther
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2005
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1.14
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69
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Monitoring of long-term toxicities of HIV treatments: an international perspective.
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AIDS
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2003
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1.14
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70
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Transmission of drug resistant HIV and its potential impact on mortality and treatment outcomes in resource-limited settings.
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J Infect Dis
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2013
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1.13
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71
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Triple-class virologic failure in HIV-infected patients undergoing antiretroviral therapy for up to 10 years.
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Arch Intern Med
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2010
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1.12
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72
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Comparison of genotypic resistance profiles and virological response between patients starting nevirapine and efavirenz in EuroSIDA.
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AIDS
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2008
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1.11
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73
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Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: a EuroSIDA study.
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J Infect Dis
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2004
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1.09
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74
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The ability of four genotypic interpretation systems to predict virological response to ritonavir-boosted protease inhibitors.
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AIDS
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2007
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1.07
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75
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Prevalence and prognostic significance of ECG abnormalities in HIV-infected patients: results from the Strategies for Management of Antiretroviral Therapy study.
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J Electrocardiol
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2010
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1.06
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76
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Primary pneumocystis infection in infants hospitalized with acute respiratory tract infection.
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Emerg Infect Dis
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2007
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1.05
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77
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Hepatitis C virus coinfection does not influence the CD4 cell recovery in HIV-1-infected patients with maximum virologic suppression.
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J Acquir Immune Defic Syndr
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2009
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1.04
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78
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The Procalcitonin And Survival Study (PASS) - a randomised multi-center investigator-initiated trial to investigate whether daily measurements biomarker Procalcitonin and pro-active diagnostic and therapeutic responses to abnormal Procalcitonin levels, can improve survival in intensive care unit patients. Calculated sample size (target population): 1000 patients.
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BMC Infect Dis
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2008
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1.04
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79
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Predictors of advanced chronic kidney disease and end-stage renal disease in HIV-positive persons.
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AIDS
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2014
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1.03
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80
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Thymidine analogue mutation profiles: factors associated with acquiring specific profiles and their impact on the virological response to therapy.
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Antivir Ther
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2005
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1.03
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81
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Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study.
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J Int AIDS Soc
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2012
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1.03
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82
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Continued indinavir versus switching to indinavir/ritonavir in HIV-infected patients with suppressed viral load.
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AIDS
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2003
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0.99
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83
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Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study.
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AIDS
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2008
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0.99
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84
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Atazanavir is not associated with an increased risk of cardio- or cerebrovascular disease events.
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AIDS
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2013
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0.98
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85
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Antiretroviral drug-related liver mortality among HIV-positive persons in the absence of hepatitis B or C virus coinfection: the data collection on adverse events of anti-HIV drugs study.
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Clin Infect Dis
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2012
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0.98
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86
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Non-AIDS defining cancers in the D:A:D Study--time trends and predictors of survival: a cohort study.
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BMC Infect Dis
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2013
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0.98
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87
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A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non-AIDS related: results from the EuroSIDA study.
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HIV Clin Trials
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2011
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0.98
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88
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A coronary heart disease risk model for predicting the effect of potent antiretroviral therapy in HIV-1 infected men.
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Int J Epidemiol
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2007
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0.96
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89
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Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina: the EuroSIDA study.
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PLoS One
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2012
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0.95
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90
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Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine.
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AIDS
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2003
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0.95
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91
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Risk of discontinuation of nevirapine due to toxicities in antiretroviral-naive and -experienced HIV-infected patients with high and low CD4+ T-cell counts.
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Antivir Ther
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2007
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0.95
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92
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The metabolic syndrome in HIV.
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Best Pract Res Clin Endocrinol Metab
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2011
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0.94
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Presence of the metabolic syndrome is not a better predictor of cardiovascular disease than the sum of its components in HIV-infected individuals: data collection on adverse events of anti-HIV drugs (D:A:D) study.
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Diabetes Care
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2008
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0.94
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94
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Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts.
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J Infect Dis
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2002
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0.93
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95
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Influence of the blood bacterial load on the meningeal inflammatory response in Streptococcus pneumoniae meningitis.
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BMC Infect Dis
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2006
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0.93
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96
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Frequent hepatitis B virus rebound among HIV-hepatitis B virus-coinfected patients following antiretroviral therapy interruption.
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AIDS
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2010
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0.92
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97
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Impact of lamivudine on the risk of liver-related death in 2,041 HBsAg- and HIV-positive individuals: results from an inter-cohort analysis.
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Antivir Ther
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2006
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0.92
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98
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Tuberculosis among HIV-positive patients across Europe: changes over time and risk factors.
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AIDS
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2011
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0.91
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99
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Boosted protease inhibitors and the electrocardiographic measures of QT and PR durations.
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AIDS
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2011
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0.91
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100
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Editorial commentary: universal antiretroviral therapy for HIV infection?
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Clin Infect Dis
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2013
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0.91
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101
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A randomized trial to evaluate continuation versus discontinuation of lamivudine in individuals failing a lamivudine-containing regimen: the COLATE trial.
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Antivir Ther
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2006
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0.90
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102
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Attenuation of the bacterial load in blood by pretreatment with granulocyte-colony-stimulating factor protects rats from fatal outcome and brain damage during Streptococcus pneumoniae meningitis.
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Infect Immun
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2004
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0.89
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103
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Starting highly active antiretroviral therapy: why, when and response to HAART.
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J Antimicrob Chemother
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2004
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0.89
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104
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In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging.
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BMC Med Imaging
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2008
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0.89
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105
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Elevated triglycerides and risk of myocardial infarction in HIV-positive persons.
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AIDS
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2011
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0.89
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106
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Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination antiretroviral therapy in the EuroSIDA Study.
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J Acquir Immune Defic Syndr
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2008
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0.89
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107
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Baseline resistance and virological outcome in patients with virological failure who start a regimen containing abacavir: EuroSIDA study.
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Antivir Ther
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2004
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0.89
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108
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HIV survival benefit associated with earlier antiviral therapy.
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Ann Intern Med
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2004
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0.88
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109
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Markers of inflammation and activation of coagulation are associated with anaemia in antiretroviral-treated HIV disease.
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AIDS
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2014
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0.87
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110
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Modelled in vivo HIV fitness under drug selective pressure and estimated genetic barrier towards resistance are predictive for virological response.
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Antivir Ther
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2008
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0.87
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111
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Further research needed to support a policy of antiretroviral therapy as an HIV prevention initiative.
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Antivir Ther
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2013
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0.87
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112
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Analysis of virological efficacy in trials of antiretroviral regimens: drawbacks of not including viral load measurements after premature discontinuation of therapy.
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Antivir Ther
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2002
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0.87
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113
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Deteriorating renal function and clinical outcomes in HIV-positive persons.
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AIDS
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2014
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0.86
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114
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Blocking of leukocyte accumulation in the cerebrospinal fluid augments bacteremia and increases lethality in experimental pneumococcal meningitis.
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J Neuroimmunol
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2005
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0.86
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115
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CD4 cell count and viral load-specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use.
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AIDS
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2013
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0.86
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116
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Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial.
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BMJ Open
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2012
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HIV replication, inflammation, and the effect of starting antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunction.
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J Acquir Immune Defic Syndr
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118
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Estimated average annual rate of change of CD4(+) T-cell counts in patients on combination antiretroviral therapy.
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Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals.
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Antiretroviral therapy, immune suppression and renal impairment in HIV-positive persons.
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Curr Opin HIV AIDS
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2014
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Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients.
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PLoS One
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2013
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122
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Long-term exposure to combination antiretroviral therapy and risk of death from specific causes: no evidence for any previously unidentified increased risk due to antiretroviral therapy.
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2012
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The EuroSIDA study: Regional differences in the HIV-1 epidemic and treatment response to antiretroviral therapy among HIV-infected patients across Europe--a review of published results.
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Cent Eur J Public Health
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2008
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Limited but increasing use of treatment for hepatitis C across Europe in patients coinfected with HIV and hepatitis C.
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Scand J Infect Dis
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2006
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Biomarkers in HIV disease.
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Curr Opin HIV AIDS
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2010
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Short- and long-term mortality and causes of death in HIV/tuberculosis patients in Europe.
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Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis.
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J Antimicrob Chemother
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Absence of a relation between efavirenz plasma concentrations and toxicity-driven efavirenz discontinuations in the EuroSIDA study.
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Antivir Ther
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2009
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0.83
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129
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Platelet count kinetics following interruption of antiretroviral treatment.
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AIDS
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2013
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0.83
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130
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Hyaluronic acid levels predict increased risk of non-AIDS death in hepatitis-coinfected persons interrupting antiretroviral therapy in the SMART Study.
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Antivir Ther
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2011
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Haemoglobin and anaemia in the SMART study.
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Antivir Ther
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2011
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Are specific antiretrovirals associated with an increased risk of discontinuation due to toxicities or patient/physician choice in patients with hepatitis C virus coinfection?
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133
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Guidelines for managing cardiovascular risk: an evolving area.
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Curr Opin HIV AIDS
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2008
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Benchmarking HIV health care: from individual patient care to health care evaluation. An example from the EuroSIDA study.
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BMC Infect Dis
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Cost-effectiveness of strategies for monitoring the response to antiretroviral therapy in resource-limited settings.
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Arch Intern Med
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Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score.
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PLoS One
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Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count>or=300 cells/microL who were assigned to 7.5 MIU interleukin-2.
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Electrocardiographic spatial QRS-T angle and incident cardiovascular disease in HIV-infected patients (from the Strategies for the Management of Antiretroviral Therapy [SMART] study).
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Am J Cardiol
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2012
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The clinical benefits of antiretroviral therapy in severely immunocompromised HIV-1-infected patients with and without complete viral suppression.
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Antivir Ther
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2012
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Impact of HIV-1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue-based regimens in antiretroviral therapy (ART)-naive and ART-experienced patients.
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J Infect Dis
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Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid, a marker of liver fibrosis.
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AIDS
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