Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex.

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMID 17505110)

Published in Acta Crystallogr D Biol Crystallogr on May 15, 2007

Authors

Yuxiang Huang1, Alena Fedarovich, Stephen Tomlinson, Christopher Davies

Author Affiliations

1: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

Articles citing this

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res (2009) 1.67

Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circ Cardiovasc Genet (2010) 1.60

Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. J Biol Chem (2009) 1.54

Transient GPI-anchored protein homodimers are units for raft organization and function. Nat Chem Biol (2012) 1.26

GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res (2011) 1.08

Deletion of GPIHBP1 causing severe chylomicronemia. J Inherit Metab Dis (2011) 1.06

Application of a novel inhibitor of human CD59 for the enhancement of complement-dependent cytolysis on cancer cells. Cell Mol Immunol (2011) 0.90

High-resolution structures of bacterially expressed soluble human CD59. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.90

The good and evil of complement activation in HIV-1 infection. Cell Mol Immunol (2010) 0.89

Initiation and regulation of complement during hemolytic transfusion reactions. Clin Dev Immunol (2012) 0.80

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Hum Genomics (2016) 0.79

Removal of the tag from His-tagged ILYd4, a human CD59 inhibitor, significantly improves its physical properties and its activity. Curr Pharm Des (2012) 0.78

A new blood group antigen is defined by anti-CD59, detected in a CD59-deficient patient. Transfusion (2014) 0.77

GPIHBP1 and the processing of triglyceride-rich lipoproteins. Clin Lipidol (2010) 0.75

Articles by these authors

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90

Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics (2006) 5.59

Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. J Clin Invest (2005) 1.70

A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury. J Immunol (2008) 1.70

Grapes on steroids. Brassinosteroids are involved in grape berry ripening. Plant Physiol (2005) 1.61

A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration. Invest Ophthalmol Vis Sci (2009) 1.54

Complement function in mAb-mediated cancer immunotherapy. Trends Immunol (2004) 1.52

Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother (2009) 1.50

Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation. J Clin Invest (2003) 1.46

Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem (2009) 1.45

A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer. Blood (2012) 1.45

Sequestration of auxin by the indole-3-acetic acid-amido synthetase GH3-1 in grape berry (Vitis vinifera L.) and the proposed role of auxin conjugation during ripening. J Exp Bot (2010) 1.37

Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations. Biochemistry (2010) 1.27

Massively parallel pathogen identification using high-density microarrays. Microb Biotechnol (2008) 1.26

Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells. Mol Pharmacol (2008) 1.23

A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice. J Clin Invest (2009) 1.21

Isolation, functional characterization, and expression analysis of grapevine (Vitis vinifera L.) hexose transporters: differential roles in sink and source tissues. J Exp Bot (2007) 1.20

Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A (2013) 1.19

Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma. Am J Pathol (2006) 1.17

Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer. Cancer Res (2005) 1.16

The grapevine gene nomenclature system. BMC Genomics (2014) 1.14

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem (2011) 1.12

Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex. J Biol Chem (2003) 1.11

Transcriptional analysis of late ripening stages of grapevine berry. BMC Plant Biol (2011) 1.11

Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance. J Biol Chem (2008) 1.10

A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice. J Immunol (2007) 1.10

Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol (2009) 1.09

Complement-dependent P-selectin expression and injury following ischemic stroke. J Immunol (2006) 1.09

High-level chromosomally mediated tetracycline resistance in Neisseria gonorrhoeae results from a point mutation in the rpsJ gene encoding ribosomal protein S10 in combination with the mtrR and penB resistance determinants. Antimicrob Agents Chemother (2005) 1.09

Defining the CD59-C9 binding interaction. J Biol Chem (2006) 1.09

Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases. Biochemistry (2007) 1.08

Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL/lpr mice. J Immunol (2008) 1.07

Targeted inhibition of complement activation prevents features of preeclampsia in mice. Kidney Int (2010) 1.04

The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol (2012) 1.03

Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding. J Mol Biol (2006) 1.03

Crystal structure of Escherichia coli penicillin-binding protein 5 bound to a tripeptide boronic acid inhibitor: a role for Ser-110 in deacylation. Biochemistry (2005) 1.03

Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. J Immunol (2011) 1.02

CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. Adv Exp Med Biol (2013) 1.01

Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. J Immunol (2005) 1.01

Identification of amino acids conferring high-level resistance to expanded-spectrum cephalosporins in the penA gene from Neisseria gonorrhoeae strain H041. Antimicrob Agents Chemother (2013) 1.01

Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation. J Mol Biol (2009) 1.01

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int (2011) 1.00

Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion. Mol Immunol (2010) 0.99

The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. J Mol Biol (2004) 0.99

Acyl substrate preferences of an IAA-amido synthetase account for variations in grape (Vitis vinifera L.) berry ripening caused by different auxinic compounds indicating the importance of auxin conjugation in plant development. J Exp Bot (2011) 0.99

The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain. J Biol Chem (2004) 0.98

The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Mol Immunol (2011) 0.98

Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes? Biochemistry (2006) 0.96

The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury. Am J Pathol (2010) 0.95

The nursing shortage and the scope for reducing it by redefining their role. Health Serv Manage Res (2005) 0.95

pH, inhibitor, and substrate specificity studies on Escherichia coli penicillin-binding protein 5. Biochim Biophys Acta (2002) 0.95

CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants. Circ Res (2011) 0.94

Experimental infection of a bovine model with human isolates of Mycobacterium avium subsp. paratuberculosis. Vet Immunol Immunopathol (2011) 0.94

Insights into the human CD59 complement binding interface toward engineering new therapeutics. J Biol Chem (2005) 0.94

Ketamine-xylazine-acepromazine compared with isoflurane for anesthesia during liver transplantation in rodents. J Am Assoc Lab Anim Sci (2010) 0.93

A tumor-expressed inhibitor of the early but not late complement lytic pathway enhances tumor growth in a rat model of human breast cancer. Cancer Res (2002) 0.92

Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation. J Immunol (2010) 0.92

Upregulated expression of complement inhibitory proteins on bladder cancer cells and anti-MUC1 antibody immune selection. Int J Cancer (2008) 0.92

The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria. J Biol Chem (2012) 0.92

Crystal structure of pi initiator protein-iteron complex of plasmid R6K: implications for initiation of plasmid DNA replication. Proc Natl Acad Sci U S A (2006) 0.91

Modulation of protective T cell immunity by complement inhibitor expression on tumor cells. Cancer Res (2008) 0.90

Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proc Natl Acad Sci U S A (2013) 0.90

Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle. J Mol Biol (2008) 0.90

Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae. Acta Crystallogr D Biol Crystallogr (2006) 0.89

Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q. J Biol Chem (2004) 0.89

The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice. Arthritis Rheum (2011) 0.89

A novel phosphoglucose isomerase (PGI)/phosphomannose isomerase from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16-A resolution. J Biol Chem (2004) 0.89

Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure. PLoS One (2011) 0.88

Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system. J Biol Chem (2004) 0.87

Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo. J Immunol (2004) 0.87

Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection. Am J Respir Cell Mol Biol (2013) 0.87

Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis. J Immunol (2012) 0.86

Crystal structures of covalent complexes of β-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity. Biochemistry (2010) 0.86

Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis. Plant Cell (2012) 0.86

Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis. J Mol Biol (2010) 0.85

Complement inhibition alleviates paraquat-induced acute lung injury. Am J Respir Cell Mol Biol (2011) 0.85

Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus. J Biol Chem (2003) 0.85

The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. J Immunol (2011) 0.85

A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitor. Virol J (2010) 0.85

Evidence for structural plasticity of heavy chain complementarity-determining region 3 in antibody-ssDNA recognition. J Mol Biol (2005) 0.84

Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell-mediated cytotoxicity. Blood (2002) 0.84

Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat. PLoS One (2012) 0.83

A novel tool for studying auxin-metabolism: the inhibition of grapevine indole-3-acetic acid-amido synthetases by a reaction intermediate analogue. PLoS One (2012) 0.83

Enhancement of antibody-dependent mechanisms of tumor cell lysis by a targeted activator of complement. Cancer Res (2007) 0.83

Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. Cancer Res (2006) 0.83

The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition. Mol Immunol (2011) 0.82

Inhibition of a complement regulator in vivo enhances antibody therapy in a model of mammary adenocarcinoma. Int J Cancer (2004) 0.82

Complement-dependent inflammation and injury in a murine model of brain dead donor hearts. Circ Res (2009) 0.82

Overexpression and enzymatic characterization of Neisseria gonorrhoeae penicillin-binding protein 4. Eur J Biochem (2004) 0.81

A role for complement in the enhanced susceptibility of steatotic livers to ischemia and reperfusion injury. J Immunol (2009) 0.81

The role of acid sphingomyelinase and caspase 5 in hypoxia-induced HuR cleavage and subsequent apoptosis in hepatocytes. Biochim Biophys Acta (2012) 0.81

Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes. Biochemistry (2004) 0.81

Targeted inhibition of complement using complement receptor 2-conjugated inhibitors attenuates EAE. Neurosci Lett (2012) 0.81

Differential expression of FAK and Pyk2 in metastatic and non-metastatic EL4 lymphoma cell lines. Clin Exp Metastasis (2011) 0.81

Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner. Shock (2011) 0.80

Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid. J Cell Biochem (2015) 0.80

A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Adv Exp Med Biol (2010) 0.80

Upregulation of the δ opioid receptor in liver cancer promotes liver cancer progression both in vitro and in vivo. Int J Oncol (2013) 0.80

Donor brain death exacerbates complement-dependent ischemia/reperfusion injury in transplanted hearts. Circulation (2013) 0.80