Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMID 17507921)

Published in Clin Pharmacol Ther on May 16, 2007

Authors

C W Hendrix1, E J Fuchs, K J Macura, L A Lee, T L Parsons, R P Bakshi, W A Khan, A Guidos, J P Leal, R Wahl

Author Affiliations

1: Department of Medicine, Division of Clinical Pharmacology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. chendrix@jhmi.edu

Articles citing this

First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy. PLoS One (2011) 1.84

Rectal microbicides: can we make them and will people use them? AIDS Behav (2011) 1.41

Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials. J Acquir Immune Defic Syndr (2010) 1.24

Technological development and advances in single-photon emission computed tomography/computed tomography. Semin Nucl Med (2008) 1.23

Antiretroviral tissue kinetics: in vivo imaging using positron emission tomography. Antimicrob Agents Chemother (2009) 1.11

Clinical evaluation of microbicide formulations. Antiviral Res (2010) 1.05

Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men. J Acquir Immune Defic Syndr (2012) 1.04

HIV transmission: time for translational studies to bridge the gap. Sci Transl Med (2011) 0.97

Isoosmolar enemas demonstrate preferential gastrointestinal distribution, safety, and acceptability compared with hyperosmolar and hypoosmolar enemas as a potential delivery vehicle for rectal microbicides. AIDS Res Hum Retroviruses (2013) 0.96

Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging. Br J Clin Pharmacol (2012) 0.95

Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment. J Control Release (2015) 0.83

Simultaneous Evaluation of Safety, Acceptability, Pericoital Kinetics, and Ex Vivo Pharmacodynamics Comparing Four Rectal Microbicide Vehicle Candidates. AIDS Res Hum Retroviruses (2015) 0.82

Advances in HIV microbicide development. Future Med Chem (2011) 0.81

Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides. Sex Transm Dis (2013) 0.81

A Pilot Study Measuring the Distribution and Permeability of a Vaginal HIV Microbicide Gel Vehicle Using Magnetic Resonance Imaging, Single Photon Emission Computed Tomography/Computed Tomography, and a Radiolabeled Small Molecule. AIDS Res Hum Retroviruses (2015) 0.78

A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02). AIDS Res Hum Retroviruses (2015) 0.78

Multicompartmental Pharmacokinetic Model of Tenofovir Delivery to the Rectal Mucosa by an Enema. PLoS One (2017) 0.78

Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1. Mol Biol Int (2012) 0.77

Preparing for rectal microbicides: sociocultural factors affecting product uptake among potential South American users. Am J Public Health (2014) 0.77

Rectal pre-exposure prophylaxis (PrEP). Antiviral Res (2013) 0.75

In Vivo Rectal Mucosal Barrier Function Imaging in a Large-Animal Model by Using Confocal Endomicroscopy: Implications for Injury Assessment and Use in HIV Prevention Studies. Antimicrob Agents Chemother (2016) 0.75

Articles by these authors

(truncated to the top 100)

Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science (1996) 5.31

Guide to the assessment of percentage "impairment" of the back, neck and pelvis. Australasian College of Rehabilitation Medicine. Med J Aust (1992) 4.59

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74

Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol (1998) 3.68

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers. Antimicrob Agents Chemother (2000) 3.28

Outbreaks of Salmonella enteritidis infections in the United States, 1985-1991. J Infect Dis (1994) 2.94

Epidemiologic study of ocular refraction among schoolchildren in Taiwan in 1995. Optom Vis Sci (1999) 2.93

Large contribution of natural aerosols to uncertainty in indirect forcing. Nature (2013) 2.78

Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab (1992) 2.70

Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide. Biol Blood Marrow Transplant (2002) 2.69

T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections. N Engl J Med (1988) 2.63

Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide. Blood (2001) 2.49

Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood (1998) 2.36

Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest (1984) 2.10

Correction of PET data for partial volume effects in human cerebral cortex by MR imaging. J Comput Assist Tomogr (1990) 2.09

Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. Mol Cell Biol (1997) 1.92

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo. Proc Natl Acad Sci U S A (2000) 1.89

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat Cell Biol (2001) 1.83

Epidemiologic study of the prevalence and severity of myopia among schoolchildren in Taiwan in 2000. J Formos Med Assoc (2001) 1.79

111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl Med Commun (2003) 1.78

Feasibility of outpatient management of fever in cancer patients with low-risk neutropenia: results of a prospective randomized trial. Am J Med (1995) 1.75

Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis. Lancet (1998) 1.75

GLAUCOMA SECONDARY TO CHOROIDAL SARCOMA. THE TREATMENT OF PAINFUL BLIND GLAUCOMATOUS EYES. Br J Ophthalmol (1925) 1.74

Compilation of DNA sequences of Escherichia coli (update 1991). Nucleic Acids Res (1991) 1.73

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol (1992) 1.69

Balancing justice and autonomy in clinical research with healthy volunteers. Clin Pharmacol Ther (2007) 1.68

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Epidemic cholera in Burundi: patterns of transmission in the Great Rift Valley Lake region. Lancet (1997) 1.66

Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicol Sci (2001) 1.62

Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56

Compilation of DNA sequences of Escherichia coli (update 1992). Nucleic Acids Res (1992) 1.52

p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300. Cancer Res (1998) 1.51

Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant (2008) 1.45

Anti-ribosomal and 'P-peptide'-specific autoantibodies bind to T lymphocytes. Clin Exp Immunol (1997) 1.45

Comparison of the reliability and validity of outcome instruments for cutaneous dermatomyositis. Br J Dermatol (2008) 1.44

How allergenic are hypoallergenic infant formulae? Clin Exp Allergy (1992) 1.42

The allergen of Ficus benjamina in house dust. Clin Exp Allergy (1995) 1.39

Upper gastrointestinal tract injury in patients receiving kayexalate (sodium polystyrene sulfonate) in sorbitol: clinical, endoscopic, and histopathologic findings. Am J Surg Pathol (2001) 1.39

Compilation of DNA sequences of Escherichia coli (update 1990). Nucleic Acids Res (1990) 1.36

Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase. Nat Med (1996) 1.35

Compilation of DNA sequences of Escherichia coli (update 1993). Nucleic Acids Res (1993) 1.34

Mortality, morbidity, and microbiology of endemic cholera among hospitalized patients in Dhaka, Bangladesh. Am J Trop Med Hyg (2001) 1.31

Cutaneous manifestations of neonatal lupus without heart block: characteristics of mothers and children enrolled in a national registry. J Pediatr (2000) 1.25

Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem (1993) 1.23

Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7  TeV. Phys Rev Lett (2012) 1.23

Safety and pharmacokinetics of escalating daily doses of the antituberculosis drug rifapentine in healthy volunteers. Clin Pharmacol Ther (2012) 1.23

Epidemiology and etiology of diarrhea in colony-born Macaca nemestrina. Lab Anim Sci (1987) 1.20

Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19

Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76  TeV. Phys Rev Lett (2012) 1.19

Alendronate-associated esophageal injury: pathologic and endoscopic features. Mod Pathol (1999) 1.18

Catecholamines predict outcome in traumatic brain injury. Ann Neurol (1987) 1.18

The importance of organ geometry and boundary constraints for planning of medical interventions. Med Eng Phys (2008) 1.17

Transient hypogonadotropic hypogonadism caused by critical illness. J Clin Endocrinol Metab (1985) 1.17

Interpretation of the Widal test in the diagnosis of typhoid fever in Bangladeshi children. Ann Trop Paediatr (1996) 1.16

Care seeking during fatal childhood illnesses: Siaya District, Kenya, 1998. Am J Public Health (2001) 1.16

CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB. Cancer Res (1998) 1.15

Antimutagenic activity of green tea polyphenols. Mutat Res (1989) 1.14

Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem (1993) 1.12

Autoantibodies to SS-A/Ro in infants with congenital heart block. J Pediatr (1983) 1.12

Subacute cutaneous lupus erythematosus associated with hydrochlorothiazide therapy. Ann Intern Med (1985) 1.11

Search for a W' or techni-ρ decaying into WZ in pp Collisions at sqrt[s] = 7  TeV. Phys Rev Lett (2012) 1.10

Treatment of shigellosis: III. Comparison of one- or two-dose ciprofloxacin with standard 5-day therapy. A randomized, blinded trial. Ann Intern Med (1992) 1.09

Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy. Phys Rev Lett (2012) 1.09

A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. J Biol Chem (2001) 1.08

Search for supersymmetry at the LHC in events with jets and missing transverse energy. Phys Rev Lett (2011) 1.08

Risk factors for mortality due to shigellosis: a case-control study among severely-malnourished children in Bangladesh. J Health Popul Nutr (2005) 1.08

Search for stopped Gluinos in pp collisions at square root s=7 TeV. Phys Rev Lett (2011) 1.07

Pollen load size, reproductive success, and progeny kinship of naturally pollinated flowers of the tropical dry forest tree Pachira quinata (Bombacaceae). Am J Bot (2001) 1.07

Maternal and fetal outcome in neonatal lupus erythematosus. Ann Intern Med (1987) 1.06

Measurement of the Υ1S, Υ2S, and Υ3S polarizations in pp collisions at sqrt[s] = 7 TeV. Phys Rev Lett (2013) 1.05

Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. J Toxicol Environ Health A (2001) 1.02

Yersinia enterocolitica: a frequent seasonal stool isolate from children at an urban hospital in the southeast United States. J Clin Microbiol (1991) 1.01

Penicillin-resistant pneumococci in Bangladeshi children. Lancet (1991) 1.01

Effect of semen sampling frequency on seminal antiretroviral drug concentration. Clin Pharmacol Ther (2007) 1.01

Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus. Lupus (2004) 1.01

The predictive value of catecholamines in assessing outcome in traumatic brain injury. J Neurosurg (1987) 1.00

Childhood asthma and human leukocyte antigen type. Tissue Antigens (2007) 1.00

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A (1995) 0.99

Palmitoyl-protein thioesterase and the molecular pathogenesis of infantile neuronal ceroid lipofuscinosis. Neuropediatrics (1997) 0.99

Measurement of the polarization of W bosons with large transverse momenta in W + jets events at the LHC. Phys Rev Lett (2011) 0.99

Concentration of autoantibodies to native 60-kd Ro/SS-A and denatured 52-kd Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum (1994) 0.99

Endoscopic findings predict the histologic diagnosis in gastrointestinal graft-versus-host disease. Endoscopy (2002) 0.99

Measurement of the inclusive jet cross section in pp collisions at √s = 7 TeV. Phys Rev Lett (2011) 0.98

Search for neutral minimal supersymmetric standard model Higgs bosons decaying to tau pairs in pp collisions at √s=7 TeV. Phys Rev Lett (2011) 0.97

Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice. Cancer Res (1988) 0.97

Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial. Gut (2003) 0.97

Xenograft tolerance. Immunol Rev (1994) 0.96

Measurement of associated production of vector bosons and top quark-antiquark pairs in pp collisions at sqrt[s]=7  TeV. Phys Rev Lett (2013) 0.95

Search for dark matter and large extra dimensions in pp collisions yielding a photon and missing transverse energy. Phys Rev Lett (2012) 0.95

Effects of manipulating pallidal and nigral GABA on striatally-mediated head-turning in the rat [proceedings]. Br J Pharmacol (1977) 0.95

Clinical efficacy of lorazepam in prophylaxis of anticipatory, acute, and delayed nausea and vomiting induced by high doses of cisplatin. A prospective randomized trial. Am J Clin Oncol (1995) 0.95

Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A/Ro and SS-B/La. Another possible mechanism for estradiol influence of lupus erythematosus. J Immunol (1988) 0.94

Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. III. Efficacy and safety of unfractionated and high-molecular-weight preparations in rhinoconjunctivitis and asthma. J Allergy Clin Immunol (1989) 0.94

Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicity in Sencar mice. Cancer Res (1989) 0.93

Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen. Bone Marrow Transplant (2008) 0.92

An animal model of antibody binding in cutaneous lupus. Arthritis Rheum (1986) 0.92

Hematopoietic SCT from partially HLA-mismatched (HLA-haploidentical) related donors. Bone Marrow Transplant (2008) 0.92

Compilation of DNA sequences of Escherichia coli K12 (ECD and ECDC; update 1995). Nucleic Acids Res (1996) 0.92

Protection against benzo[a]pyrene- and N-nitrosodiethylamine-induced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice. Carcinogenesis (1992) 0.92

Expression of fibronectin, laminin, and factor VIII-related antigen during development of the human cutaneous microvasculature. J Invest Dermatol (1985) 0.92