Published in J Biomech on May 18, 2007
Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci U S A (2010) 1.30
The role of osteocytes in bone mechanotransduction. Osteoporos Int (2009) 0.92
Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. J Biomech (2010) 0.87
Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process. Proc Natl Acad Sci U S A (2013) 0.87
Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis. Biophys J (2015) 0.83
Bone's responses to mechanical loading are impaired in type 1 diabetes. Bone (2015) 0.83
Nitric oxide signaling in mechanical adaptation of bone. Osteoporos Int (2013) 0.82
Loading and skeletal development and maintenance. J Osteoporos (2010) 0.80
Engineering parameters in bioreactor's design: a critical aspect in tissue engineering. Biomed Res Int (2013) 0.80
Mechanosignaling in bone health, trauma and inflammation. Antioxid Redox Signal (2013) 0.76
Experimental studies of bone mechanoadaptation: bridging in vitro and in vivo studies with multiscale systems. Interface Focus (2016) 0.76
PLS3 mutations in X-linked osteoporosis with fractures. N Engl J Med (2013) 1.66
Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes. Am J Physiol Endocrinol Metab (2011) 1.45
Osteoblast isolation from murine calvaria and long bones. Methods Mol Biol (2012) 1.43
Dynamic shear stress in parallel-plate flow chambers. J Biomech (2005) 1.42
Adipose tissue-derived mesenchymal stem cells acquire bone cell-like responsiveness to fluid shear stress on osteogenic stimulation. Tissue Eng (2006) 1.39
Osteoblast isolation from murine calvariae and long bones. Methods Mol Med (2003) 1.36
Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption. Bone (2007) 1.33
Stem cells from adipose tissue allow challenging new concepts for regenerative medicine. Tissue Eng (2007) 1.30
Osteocyte morphology in fibula and calvaria --- is there a role for mechanosensing? Bone (2008) 1.17
Round versus flat: bone cell morphology, elasticity, and mechanosensing. J Biomech (2008) 1.15
Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation. Biochem Biophys Res Commun (2006) 1.12
Nitric oxide production by bone cells is fluid shear stress rate dependent. Biochem Biophys Res Commun (2004) 1.11
The effect of cage stiffness on the rate of lumbar interbody fusion: an in vivo model using poly(l-lactic Acid) and titanium cages. Spine (Phila Pa 1976) (2002) 1.11
The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts. Biochem Biophys Res Commun (2005) 1.10
Buccal fat pad, an oral access source of human adipose stem cells with potential for osteochondral tissue engineering: an in vitro study. Tissue Eng Part C Methods (2010) 1.08
Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density--is there a role for mechanosensing? Bone (2009) 1.07
The role of dorsal shear forces in the pathogenesis of adolescent idiopathic scoliosis--a hypothesis. Med Hypotheses (2005) 1.07
Bone cell responses to high-frequency vibration stress: does the nucleus oscillate within the cytoplasm? FASEB J (2006) 1.07
A comparison of strain and fluid shear stress in stimulating bone cell responses--a computational and experimental study. FASEB J (2004) 1.05
Simulated-physiological loading conditions preserve biological and mechanical properties of caprine lumbar intervertebral discs in ex vivo culture. PLoS One (2012) 1.05
Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon--a proposal. J Biomech (2003) 1.05
Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat. Spine (Phila Pa 1976) (2007) 1.04
Effect of long-term preservation on the mechanical properties of cortical bone in goats. Acta Orthop (2008) 1.04
Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase. Biochem Biophys Res Commun (2009) 1.01
Shear stress inhibits while disuse promotes osteocyte apoptosis. Biochem Biophys Res Commun (2004) 1.01
Reproducible long-term disc degeneration in a large animal model. Spine (Phila Pa 1976) (2008) 0.99
Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes. J Orthop Res (2009) 0.99
MRI T2* mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model. Eur Spine J (2014) 0.96
Bioabsorbable poly-L-lactic acid cages for lumbar interbody fusion: three-year follow-up radiographic, histologic, and histomorphometric analysis in goats. Spine (Phila Pa 1976) (2002) 0.96
Effects of dorsal versus ventral shear loads on the rotational stability of the thoracic spine: a biomechanical porcine and human cadaveric study. Spine (Phila Pa 1976) (2007) 0.96
Detection of living cells in non-processed but deep-frozen bone allografts. Cell Tissue Bank (2005) 0.95
The Src inhibitor AZD0530 reversibly inhibits the formation and activity of human osteoclasts. Mol Cancer Res (2009) 0.94
Bio imaging of intracellular NO production in single bone cells after mechanical stimulation. J Bone Miner Res (2006) 0.94
Release of nitric oxide, but not prostaglandin E2, by bone cells depends on fluid flow frequency. J Orthop Res (2006) 0.92
Polyamines modulate nitric oxide production and COX-2 gene expression in response to mechanical loading in human adipose tissue-derived mesenchymal stem cells. Stem Cells (2006) 0.92
Mechanosensitivity of dental pulp stem cells is related to their osteogenic maturity. Eur J Oral Sci (2010) 0.91
Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE. Calcif Tissue Int (2010) 0.90
Effectiveness of preoperative planning in the restoration of balance and view in ankylosing spondylitis. Neurosurg Focus (2008) 0.90
Dynamic and static overloading induce early degenerative processes in caprine lumbar intervertebral discs. PLoS One (2013) 0.90
Radiographic, histologic, and chemical evaluation of bioresorbable 70/30 poly-L-lactide-CO-D, L-lactide interbody fusion cages in a goat model. Spine (Phila Pa 1976) (2006) 0.89
Inertial shear forces and the use of centrifuges in gravity research. What is the proper control? J Biomech Eng (2003) 0.89
ASKyphoplan: a program for deformity planning in ankylosing spondylitis. Eur Spine J (2007) 0.89
Flow-related mechanics of the intervertebral disc: the validity of an in vitro model. Spine (Phila Pa 1976) (2005) 0.88
Cyclic mechanical stretch reduces myofibroblast differentiation of primary lung fibroblasts. Biochem Biophys Res Commun (2010) 0.88
Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model. Integr Biol (Camb) (2012) 0.87
Contribution of vertebral [corrected] bodies, endplates, and intervertebral discs to the compression creep of spinal motion segments. J Biomech (2008) 0.86
Adjacent segment degeneration: observations in a goat spinal fusion study. Spine (Phila Pa 1976) (2008) 0.86
Initial stress-kick is required for fluid shear stress-induced rate dependent activation of bone cells. Ann Biomed Eng (2005) 0.86
Collagen type V enhances matrix contraction by human periodontal ligament fibroblasts seeded in three-dimensional collagen gels. Matrix Biol (2006) 0.86
Mechanical loading prevents the stimulating effect of IL-1β on osteocyte-modulated osteoclastogenesis. Biochem Biophys Res Commun (2012) 0.85
WNT5A induces osteogenic differentiation of human adipose stem cells via rho-associated kinase ROCK. Cytotherapy (2010) 0.85
Primary spinal segment stability with a stand-alone cage: in vitro evaluation of a successful goat model. Acta Orthop (2006) 0.85
Collagen type V modulates fibroblast behavior dependent on substrate stiffness. Biochem Biophys Res Commun (2009) 0.85
Interactive effects of PTH and mechanical stress on nitric oxide and PGE2 production by primary mouse osteoblastic cells. Am J Physiol Endocrinol Metab (2003) 0.84
A biomechanical analysis of the self-retaining pedicle hook device in posterior spinal fixation. Eur Spine J (2007) 0.84
The use of poly-L-lactic acid in lumbar interbody cages: design and biomechanical evaluation in vitro. Eur Spine J (2002) 0.84
Cell mediated contraction in 3D cell-matrix constructs leads to spatially regulated osteogenic differentiation. Integr Biol (Camb) (2013) 0.83
Biomechanical and rheological characterization of mild intervertebral disc degeneration in a large animal model. J Orthop Res (2012) 0.83
Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering. Open Orthop J (2008) 0.83
The use of high-resolution magnetic resonance imaging for monitoring interbody fusion and bioabsorbable cages: an ex vivo pilot study. Neurosurg Focus (2004) 0.83
Isolation of primary avian osteocytes. Methods Mol Biol (2012) 0.82
One-step surgical procedure for the treatment of osteochondral defects with adipose-derived stem cells in a caprine knee defect: a pilot study. Biores Open Access (2013) 0.82
Short (15 minutes) bone morphogenetic protein-2 treatment stimulates osteogenic differentiation of human adipose stem cells seeded on calcium phosphate scaffolds in vitro. Tissue Eng Part A (2012) 0.82
Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes. Calcif Tissue Int (2011) 0.82
Low-intensity pulsed ultrasound affects RUNX2 immunopositive osteogenic cells in delayed clinical fracture healing. Bone (2009) 0.82
Centrifuges and inertial shear forces. J Gravit Physiol (2004) 0.82
Differential effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on gene expression of collagen-modifying enzymes in human adipose tissue-derived mesenchymal stem cells. Tissue Eng Part A (2009) 0.81
Mechanical loading by fluid shear stress of myotube glycocalyx stimulates growth factor expression and nitric oxide production. Cell Biochem Biophys (2014) 0.81
Does bioresorbable cage material influence segment stability in spinal interbody fusion? Clin Orthop Relat Res (2006) 0.81
Human dental pulp cells exhibit bone cell-like responsiveness to fluid shear stress. Cytotherapy (2010) 0.81
VDR dependent and independent effects of 1,25-dihydroxyvitamin D3 on nitric oxide production by osteoblasts. Steroids (2011) 0.81
Lumbar body fusion with a bioresorbable cage in a goat model is delayed by the use of a carboxymethylcellulose-stabilized collagenous rhOP-1 device. J Orthop Res (2007) 0.80
Alkaline phosphatase-induced mineral deposition to anchor collagen fibrils to a solid surface. Biomaterials (2007) 0.80
Fibroblasts from women with pelvic organ prolapse show differential mechanoresponses depending on surface substrates. Int Urogynecol J (2013) 0.80
Inorganic phosphate stimulates DMP1 expression in human periodontal ligament fibroblasts embedded in three-dimensional collagen gels. Cells Tissues Organs (2010) 0.80
Human maxillary sinus floor elevation as a model for bone regeneration enabling the application of one-step surgical procedures. Tissue Eng Part B Rev (2012) 0.79
Linear patterning of mesenchymal condensations is modulated by geometric constraints. J R Soc Interface (2014) 0.79
Mechanically loaded myotubes affect osteoclast formation. Calcif Tissue Int (2013) 0.79
Four-year follow-up of poly-L-lactic Acid cages for lumbar interbody fusion in goats. J Long Term Eff Med Implants (2005) 0.79
Three-dimensional loading model for periodontal ligament regeneration in vitro. Tissue Eng Part C Methods (2009) 0.79
Osteocyte isolation and culture. Methods Mol Med (2003) 0.79
Endothelial nitric oxide synthase is not essential for nitric oxide production by osteoblasts subjected to fluid shear stress in vitro. Calcif Tissue Int (2012) 0.79
Time-dependent failure of amorphous polylactides in static loading conditions. J Mater Sci Mater Med (2010) 0.79
Increased endoplasmic reticulum stress in mouse osteocytes with aging alters Cox-2 response to mechanical stimuli. Calcif Tissue Int (2014) 0.78
MT1-MMP modulates the mechanosensitivity of osteocytes. Biochem Biophys Res Commun (2011) 0.78
Nitric oxide is involved in the down-regulation of SOST expression induced by mechanical loading. Calcif Tissue Int (2013) 0.78
Intradiscal pressure depends on recent loading and correlates with disc height and compressive stiffness. Eur Spine J (2014) 0.78
Differences in proliferation, differentiation, and cytokine production by bone cells seeded on titanium-nitride and cobalt-chromium-molybdenum surfaces. J Biomater Appl (2012) 0.78
Reaming debris as a novel source of autologous bone to enhance healing of bone defects. J Biomed Mater Res A (2011) 0.78
A novel approach revealing the effect of a collagenous membrane on osteoconduction in maxillary sinus floor elevation with β-tricalcium phosphate. Eur Cell Mater (2013) 0.78