Published in Infect Immun on May 21, 2007
Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4. Infect Immun (2014) 0.97
DNA from Porphyromonas gingivalis and Tannerella forsythia induce cytokine production in human monocytic cell lines. Mol Oral Microbiol (2010) 0.91
Involvement of SOCS3 in regulation of CD11c+ dendritic cell-derived osteoclastogenesis and severe alveolar bone loss. Infect Immun (2009) 0.81
Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. Cell Mol Immunol (2013) 0.76
In vitro antagonistic growth effects of Lactobacillus fermentum and lactobacillus salivarius and their fermentative broth on periodontal pathogens. Braz J Microbiol (2012) 0.76
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (1995) 12.24
CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol (2001) 9.19
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol (2004) 3.76
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity (2002) 3.25
Macrophages ingest and are activated by bacterial DNA. J Immunol (1996) 2.64
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity (2000) 2.54
Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol (1999) 2.23
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol (1997) 2.10
Genomic DNA released by dying cells induces the maturation of APCs. J Immunol (2001) 2.03
CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J Clin Immunol (2004) 1.98
Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation. J Immunol (2002) 1.89
Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun (1998) 1.86
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med (2006) 1.84
Exposing the immunology of naked DNA vaccines. Immunity (1995) 1.80
Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol (1997) 1.56
Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood (2000) 1.51
B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotides. Clin Cancer Res (2005) 1.49
Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses. J Immunol (2003) 1.45
Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. Eur J Immunol (2006) 1.45
Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr Opin Microbiol (2002) 1.43
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A (2002) 1.42
The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res (2004) 1.42
Suppressors of cytokine signalling: SOCS. APMIS (2002) 1.33
Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway. Shock (2002) 1.18
Oral immunization of humans with Streptococcus sobrinus glucosyltransferase. Infect Immun (1987) 1.14
Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun (2002) 1.12
Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection. Infect Immun (2001) 1.10
The scientific and public-health imperative for a vaccine against dental caries. Nat Rev Immunol (2006) 1.00
Regulation of cytokine receptor signaling by SOCS1. Immunol Rev (2003) 1.00
TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity. Vaccine (2003) 0.97
The suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action. Exp Hematol (2000) 0.96
Transcriptional control of impaired Th1 responses in patent lymphatic filariasis by T-box expressed in T cells and suppressor of cytokine signaling genes. Infect Immun (2005) 0.95
The role of Bacteroides gingivalis in periodontal disease. Adv Dent Res (1988) 0.94
A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. J Immunol (2005) 0.94
Microbial/host interactions: mechanisms involved in host responses to microbial antigens. Immunol Res (2002) 0.93
Diepitopic construct of functionally and epitopically complementary peptides enhances immunogenicity, reactivity with glucosyltransferase, and protection from dental caries. Infect Immun (2001) 0.92
Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. Eur J Clin Microbiol Infect Dis (1998) 0.92
Analysis of pp60c-src tyrosine kinase activity and phosphotyrosyl phosphatase activity in human colon carcinoma and normal human colon mucosal cells. J Cell Biochem (1987) 0.91
A DNA vaccine encoding a cell-surface protein antigen of Streptococcus mutans protects gnotobiotic rats from caries. J Dent Res (2002) 0.89
Differential expression of suppressors of cytokine signaling-1 and -3 and related cytokines in central nervous system during remitting versus non-remitting forms of experimental autoimmune encephalomyelitis. Int Immunol (2005) 0.88
A rapid and gentle method for isolation of genomic DNA from pathogenic Nocardia spp. Clin Diagn Lab Immunol (1996) 0.88
Immunostimulatory properties of genomic DNA from different bacterial species. Immunobiology (1999) 0.87
Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model. Infect Immun (2001) 0.86
Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid. Vaccine (2001) 0.85
Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis involves a T1-biased immune response. J Immunol (2003) 0.84
Mucosal immunization with DNA vaccines. Methods (2003) 0.83
Haemolysis of human erythrocytes by the Fusobacterium nucleatum associated with periodontal disease. Arch Oral Biol (1983) 0.83
Differential immunogenicity of a DNA vaccine containing the Streptococcus mutans wall-associated protein A gene versus that containing a truncated derivative antigen A lacking in the hydrophobic carboxyterminal region. DNA Cell Biol (2005) 0.81
Human tumor-derived genomic DNA transduced into a recipient cell induces tumor-specific immune responses ex vivo. Proc Natl Acad Sci U S A (2002) 0.81
Mucosal immunization against dental caries with plasmid DNA encoding pac gene of Streptococcus mutans in rats. Vaccine (2004) 0.80
Novel strategies using DNA for the induction of mucosal immunity. Crit Rev Immunol (1999) 0.78
Expression of repetitive human calcitonin genes in Escherichia coli. Biotechnol Appl Biochem (1989) 0.76
Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. J Periodontol (2009) 3.66
Distribution of selected bacterial species on intraoral surfaces. J Clin Periodontol (2003) 3.29
Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. J Clin Periodontol (2006) 2.73
Immune response: the key to bone resorption in periodontal disease. J Periodontol (2005) 2.22
Risk of psychopathology in adolescent offspring of mothers with psychopathology and recurrent depression. Br J Psychiatry (2012) 2.19
Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol (2003) 1.91
Relationship of destructive periodontal disease to the acute-phase response. J Periodontol (2003) 1.65
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol (2012) 1.51
A three-year prospective study of adult subjects with gingivitis. I: clinical periodontal parameters. J Clin Periodontol (2006) 1.49
Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray. J Periodontol (2012) 1.47
Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Arch Gen Psychiatry (2010) 1.46
Locally delivered doxycycline during supportive periodontal therapy: a 3-year study. J Periodontol (2008) 1.45
Clinical and microbiologic changes associated with the combined use of a powered toothbrush and a triclosan/copolymer dentifrice: a 3-year prospective study. J Periodontol (2007) 1.45
Long-term effect of the combined use of powered toothbrush and triclosan dentifrice in periodontal maintenance patients. J Clin Periodontol (2008) 1.41
Nebulized nitric oxide/nucleophile adduct reduces pulmonary vascular resistance in mechanically ventilated septicemic sheep. Crit Care Med (2005) 1.40
Microbiological goals of periodontal therapy. Periodontol 2000 (2006) 1.40
The effect of periodontal therapy on the composition of the subgingival microbiota. Periodontol 2000 (2006) 1.35
Antimicrobial effectiveness of an herbal mouthrinse compared with an essential oil and a chlorhexidine mouthrinse. J Am Dent Assoc (2008) 1.21
A Caries Vaccine? The state of the science of immunization against dental caries. Caries Res (2004) 1.19
Relationships between subgingival microbiota and GCF biomarkers in generalized aggressive periodontitis. J Clin Periodontol (2010) 1.16
Biofilms in the edentulous oral cavity. J Prosthodont (2008) 1.16
Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease. J Oral Microbiol (2010) 1.14
Functional analysis of glucan binding protein B from Streptococcus mutans. J Bacteriol (2006) 1.13
Introduction to microbial aspects of periodontal biofilm communities, development and treatment. Periodontol 2000 (2006) 1.13
Comparative analysis of Gtf isozyme production and diversity in isolates of Streptococcus mutans with different biofilm growth phenotypes. J Clin Microbiol (2004) 1.11
Microbiology of periodontal diseases: introduction. Periodontol 2000 (2005) 1.10
Serum IgG antibody response to periodontal pathogens in minority populations: relationship to periodontal disease status and progression. J Periodontal Res (2002) 1.08
Effects of periodontitis and smoking on the microbiota of oral mucous membranes and saliva in systemically healthy subjects. J Clin Periodontol (2003) 1.06
SGCE mutations cause psychiatric disorders: clinical and genetic characterization. Brain (2013) 1.05
The impact of periodontal infection on systemic diseases. Med Sci Monit (2003) 1.05
Microbial shifts during dental biofilm re-development in the absence of oral hygiene in periodontal health and disease. J Clin Periodontol (2011) 1.03
The reproducibility of curet sampling of subgingival biofilms. J Periodontol (2008) 1.02
Antibody to receptor activator of NF-κB ligand ameliorates T cell-mediated periodontal bone resorption. Infect Immun (2010) 1.00
The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies. J Clin Periodontol (2007) 1.00
Photodestruction of human dental plaque bacteria: enhancement of the photodynamic effect by photomechanical waves in an oral biofilm model. Lasers Surg Med (2003) 1.00
Downregulation of GbpB, a component of the VicRK regulon, affects biofilm formation and cell surface characteristics of Streptococcus mutans. Infect Immun (2010) 0.99
The Depression in Visual Impairment Trial (DEPVIT): trial design and protocol. BMC Psychiatry (2012) 0.98
Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. J Clin Periodontol (2007) 0.96
Characterization of salivary immunoglobulin A responses in children heavily exposed to the oral bacterium Streptococcus mutans: influence of specific antigen recognition in infection. Infect Immun (2005) 0.95
Effects of interferon beta on transcobalamin II-receptor expression and antitumor activity of nitrosylcobalamin. J Natl Cancer Inst (2002) 0.95
Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol (2012) 0.95
Visual impairment is associated with physical and mental comorbidities in older adults: a cross-sectional study. BMC Med (2014) 0.95
The Bipolar Interactive Psychoeducation (BIPED) study: trial design and protocol. BMC Psychiatry (2009) 0.94
CovR and VicRK regulate cell surface biogenesis genes required for biofilm formation in Streptococcus mutans. PLoS One (2013) 0.93
Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. J Autoimmun (2012) 0.93
Subgingival microbiota of chilean patients with chronic periodontitis. J Periodontol (2004) 0.91
Internet-based psychoeducation for bipolar disorder: a qualitative analysis of feasibility, acceptability and impact. BMC Psychiatry (2012) 0.91
Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups. J Affect Disord (2008) 0.90
Impact of socioeconomic deprivation on rate and cause of death in severe mental illness. BMC Psychiatry (2014) 0.89
Antipsychotic dose escalation as a trigger for neuroleptic malignant syndrome (NMS): literature review and case series report. BMC Psychiatry (2012) 0.88
Genetic diversity of competence gene loci in clinical genotypes of Streptococcus mutans. J Clin Microbiol (2006) 0.88
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects. J Periodontol (2010) 0.88
Application of the checkerboard immunoblotting technique to the quantification of host biomarkers in gingival crevicular fluid. J Periodontol (2009) 0.87
Multilevel analysis of clinical parameters in chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results. J Oral Microbiol (2012) 0.87
Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. J Clin Periodontol (2011) 0.86
A controlled, randomized-blinded clinical trial to assess the efficacy of a nitric oxide releasing patch in the treatment of cutaneous leishmaniasis by Leishmania (V.) panamensis. Am J Trop Med Hyg (2010) 0.86
Polarity at illness onset in bipolar I disorder and clinical course of illness. Bipolar Disord (2009) 0.86
Heaviness, health and happiness: a cross-sectional study of 163066 UK Biobank participants. J Epidemiol Community Health (2013) 0.86
Comparison between polymerase chain reaction-based and checkerboard DNA hybridization techniques for microbial assessment of subgingival plaque samples. J Clin Periodontol (2009) 0.86
Reducing the Hypomania Checklist (HCL-32) to a 16-item version. J Affect Disord (2010) 0.85
Developing an online psychoeducation package for bipolar disorder. J Ment Health (2011) 0.85
Effect of herbal, essential oil, and chlorhexidine mouthrinses on the composition of the subgingival microbiota and clinical periodontal parameters. J Clin Dent (2009) 0.85
Progression of destructive periodontal diseases in three urban minority populations: role of clinical and demographic factors. J Clin Periodontol (2003) 0.85
Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation. BMC Pulm Med (2012) 0.85
Multimorbidity and mental health: can psychiatry rise to the challenge? Br J Psychiatry (2013) 0.85
Relationships among interleukin-6, tumor necrosis factor-α, adipokines, vitamin D, and chronic periodontitis. J Periodontol (2011) 0.85
Gender differences in the association between adiposity and probable major depression: a cross-sectional study of 140,564 UK Biobank participants. BMC Psychiatry (2014) 0.84
Bipolarity is important during treatment with antidepressants. BMJ (2007) 0.84
Colonic ischemia associated with naratriptan use. J Clin Gastroenterol (2004) 0.84
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial. J Clin Periodontol (2014) 0.82
Microbiological changes associated with dental prophylaxis. J Am Dent Assoc (2004) 0.81
Improving the psychometric utility of the hypomania checklist (HCL-32): a Rasch analysis approach. J Affect Disord (2013) 0.81
Double blind, randomized, placebo controlled clinical trial for the treatment of diabetic foot ulcers, using a nitric oxide releasing patch: PATHON. Trials (2007) 0.80
The effect of apically repositioned flap surgery on clinical parameters and the composition of the subgingival microbiota: 12-month data. Int J Periodontics Restorative Dent (2002) 0.79
Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes. FEMS Immunol Med Microbiol (2011) 0.79
Age-specific salivary immunoglobulin A response to Streptococcus mutans GbpB. Clin Vaccine Immunol (2007) 0.79
Affective temperaments across the bipolar-unipolar spectrum: examination of the TEMPS-A in 927 patients and controls. J Affect Disord (2009) 0.79
Comparing clinical attachment level and pocket depth for predicting periodontal disease progression in healthy sites of patients with chronic periodontitis using multi-state Markov models. J Clin Periodontol (2014) 0.79
Is there a clinical prodrome of bipolar disorder? A review of the evidence. Expert Rev Neurother (2013) 0.78
Activation of Toll‐like receptor 9 inhibits lipopolysaccharide‐induced receptor activator of nuclear factor kappa‐ B ligand expression in rat B lymphocytes. Microbiol Immunol (2014) 0.77
Detecting recurrent major depressive disorder within primary care rapidly and reliably using short questionnaire measures. Br J Gen Pract (2014) 0.77
Survival of Dicor glass-ceramic dental restorations over 20 years: Part IV. The effects of combinations of variables. Int J Prosthodont (2010) 0.77
Microbiological basis for periodontal therapy. J Appl Oral Sci (2004) 0.77
Multilevel analysis of bacterial counts from chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results. J Oral Microbiol (2013) 0.77
Survival of glass-ceramic materials and involved clinical risk: variables affecting long-term survival. Pract Proced Aesthet Dent (2003) 0.77
Destructive periodontal diseases in minority populations. Dent Clin North Am (2003) 0.77
Dental caries vaccines: prospects and concerns. Expert Rev Vaccines (2010) 0.77
Lifetime hypomanic symptoms in remitted patients with schizophrenia and other psychotic disorders. Psychiatr Danub (2014) 0.76
Unipolar and bipolar depression: different of the same? Br J Psychiatry (2011) 0.76
Hepatitis C Virus Disease Progression in People Who Inject Drugs: Protocol for a Systematic Review and Meta-Analysis. JMIR Res Protoc (2015) 0.76
Comorbidity of depression and anxiety disorders in patients with hypertension. J Hypertens (2016) 0.76
Bipolar spectrum disorders in primary care: optimising diagnosis and treatment. Br J Gen Pract (2010) 0.76
Correction: Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants. PLoS One (2016) 0.75
Insulin resistance and depression: difference in patient groups could have been explained by other factors. BMJ (2005) 0.75
The West Midlands Matching Scheme 2000: a survey of participant satisfaction and outcomes. Med Educ (2003) 0.75
Carbamazepine and rebound mania. Am J Psychiatry (2004) 0.75
Evaluation of the whole genome DNA-DNA hybridization technique to identify bacteria in histological sections of periradicular lesions. J Endod (2004) 0.75