Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMID 17534580)

Published in J Neurooncol on May 30, 2007

Authors

Chandra M Das1, Dolly Aguilera, Hernan Vasquez, Preethi Prasad, Ming Zhang, Johannes E Wolff, Vidya Gopalakrishnan

Author Affiliations

1: Department of Pediatrics, Unit 853, University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

Articles citing this

Molecular and therapeutic potential and toxicity of valproic acid. J Biomed Biotechnol (2010) 2.13

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro Oncol (2009) 1.51

Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer. Future Oncol (2011) 1.34

Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells. J Biomed Biotechnol (2012) 1.09

Enhanced antitumor efficacy of low-dose Etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts. Clin Cancer Res (2011) 1.06

Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group report. Clin Cancer Res (2010) 0.99

Seizure prognosis in brain tumors: new insights and evidence-based management. Oncologist (2014) 0.98

Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL. J Neurooncol (2009) 0.93

Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway. BMC Cancer (2014) 0.90

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells. PLoS One (2012) 0.87

Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail. Cell Adh Migr (2015) 0.84

Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression. BMC Urol (2012) 0.83

Phase I pharmacokinetic and pharmacodynamic evaluation of combined valproic acid/doxorubicin treatment in dogs with spontaneous cancer. Clin Cancer Res (2010) 0.82

Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid. J Biol Chem (2013) 0.81

Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells. Int J Clin Oncol (2011) 0.81

Cell type-specific anti-cancer properties of valproic acid: independent effects on HDAC activity and Erk1/2 phosphorylation. BMC Cancer (2010) 0.81

Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines. Eur J Cancer (2010) 0.80

Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma. Neuro Oncol (2014) 0.80

A Phase I Protocol of Hydralazine and Valproic Acid in Advanced, Previously Treated Solid Cancers. Transl Oncol (2014) 0.79

Molecular dissection of the valproic acid effects on glioma cells. Oncotarget (2016) 0.76

Sodium valproate inhibits the growth of human cholangiocarcinoma in vitro and in vivo. Gastroenterol Res Pract (2013) 0.76

The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol (2016) 0.76

Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges. Oncol Lett (2016) 0.75

Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia. Oncotarget (2016) 0.75

Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression. Oncotarget (2017) 0.75

Articles by these authors

(truncated to the top 100)

A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A (2013) 6.88

Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa. J Virol (2006) 5.25

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature (2007) 4.00

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model. PLoS Med (2007) 2.86

A jumping profile Hidden Markov Model and applications to recombination sites in HIV and HCV genomes. BMC Bioinformatics (2006) 2.25

Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol (2010) 2.08

The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis. J Immunol (2007) 1.87

Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells (2006) 1.84

Genome sequence diversity and clues to the evolution of variola (smallpox) virus. Science (2006) 1.84

Shear stress regulates forward and reverse planar cell polarity of vascular endothelium in vivo and in vitro. Circ Res (2006) 1.84

Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol (2006) 1.83

Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells. J Urol (2003) 1.79

An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer. Nucleic Acids Res (2010) 1.73

Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers. J Carcinog (2011) 1.70

Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview. Ultrason Sonochem (2004) 1.70

Does the investing layer of the deep cervical fascia exist? Anesthesiology (2005) 1.69

Single-stranded DNA aptamers that bind differentiated but not parental cells: subtractive systematic evolution of ligands by exponential enrichment. J Biotechnol (2003) 1.67

Dose-ranging comparison of rifampin and rifapentine in two pathologically distinct murine models of tuberculosis. Antimicrob Agents Chemother (2012) 1.63

Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay. Clin Chem (2003) 1.62

jpHMM: improving the reliability of recombination prediction in HIV-1. Nucleic Acids Res (2009) 1.61

The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res (2010) 1.58

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2011) 1.58

Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections. PLoS Pathog (2011) 1.57

Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India. Virology (2009) 1.51

Changes in integrin expression during adipocyte differentiation. Cell Metab (2005) 1.51

Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J Neurosci (2012) 1.47

Sarcophaga (Hoa)flexuosa Ho (Diptera: Sarcophagidae): association of sexes using morphological and molecular approaches, and a redefinition of Hoa Rohdendorf. Zootaxa (2013) 1.46

BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation. J Immunol (2007) 1.45

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci (2011) 1.44

Integration of light- and brassinosteroid-signaling pathways by a GATA transcription factor in Arabidopsis. Dev Cell (2010) 1.43

Three-dimensional finite element analysis of the foot during standing--a material sensitivity study. J Biomech (2005) 1.43

Simple model for testing drugs against nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother (2010) 1.43

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers have no beneficial effect on ablation outcome in chronic persistent atrial fibrillation. Acta Cardiol (2009) 1.42

Ventricular non-compaction cardiomyopathy: prenatal diagnosis and pathology. Prenat Diagn (2014) 1.42

The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease. Cardiology (2013) 1.41

A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol (2004) 1.41

Transcranial segment of the trigeminal nerve: macro-/microscopic anatomical study using sheet plastination. Acta Neurochir (Wien) (2013) 1.39

Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger. Leuk Res (2006) 1.39

Direct observation of nanoparticle-cancer cell nucleus interactions. ACS Nano (2012) 1.39

Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506). Blood (2009) 1.39

B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. J Immunol (2009) 1.38

Sno/scaRNAbase: a curated database for small nucleolar RNAs and cajal body-specific RNAs. Nucleic Acids Res (2006) 1.33

Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage. J Cell Sci (2007) 1.33

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A (2009) 1.33

Functional activity of natural antibody is altered in Cr2-deficient mice. J Immunol (2002) 1.29

In vivo dissection of the Tat translocation pathway in Escherichia coli. J Mol Biol (2002) 1.28

Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med (2014) 1.27

Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27

Enterotoxigenic bacteroides fragilis: a potential instigator of colitis. Inflamm Bowel Dis (2007) 1.27

Combined use of fasting plasma glucose and glycated hemoglobin A1c in the screening of diabetes and impaired glucose tolerance. Acta Diabetol (2009) 1.26

Maspin expression in invasive breast cancer: association with other prognostic factors. J Pathol (2003) 1.25

Development of a finite element model of female foot for high-heeled shoe design. Clin Biomech (Bristol, Avon) (2007) 1.25

Adverse events of acupuncture: a systematic review of case reports. Evid Based Complement Alternat Med (2013) 1.23

Short-course therapy with daily rifapentine in a murine model of latent tuberculosis infection. Am J Respir Crit Care Med (2009) 1.21

Proteomics identification of desmin as a potential oncofetal diagnostic and prognostic biomarker in colorectal cancer. Mol Cell Proteomics (2009) 1.20

Isoniazid or moxifloxacin in rifapentine-based regimens for experimental tuberculosis? Am J Respir Crit Care Med (2008) 1.19

Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells. Am J Pathol (2010) 1.17

Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J Biol Chem (2007) 1.17

JNK pathway: diseases and therapeutic potential. Acta Pharmacol Sin (2007) 1.17

Glutamate receptor antagonists protect from virus-induced neural degeneration. Ann Neurol (2004) 1.16

SDF-1 recruits cardiac stem cell-like cells that depolarize in vivo. Cell Transplant (2007) 1.16

Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM. Surgery (2004) 1.16

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A (2012) 1.16

Attenuation of skeletal muscle reperfusion injury with intravenous 12 amino acid peptides that bind to pathogenic IgM. Surgery (2006) 1.15

Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design. J Virol (2013) 1.15

Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J Ethnopharmacol (2012) 1.15

Size-tunable hydrothermal synthesis of SnS2 nanocrystals with high performance in visible light-driven photocatalytic reduction of aqueous Cr(VI). Environ Sci Technol (2011) 1.13

Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice. Cancer Res (2011) 1.13

Maspin plays an essential role in early embryonic development. Development (2004) 1.13

Structural and functional abnormalities in migraine patients without aura. NMR Biomed (2012) 1.11

Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. FASEB J (2006) 1.11

Conversion of myoblasts to physiologically active neuronal phenotype. Genes Dev (2004) 1.11

A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree. Mol Vis (2010) 1.10

Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem Biophys Res Commun (2006) 1.10

Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis. Clin Exp Metastasis (2007) 1.10

A preliminary study of the dysregulation of the resting networks in first-episode medication-naive adolescent depression. Neurosci Lett (2011) 1.10

PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons. Neurotoxicology (2007) 1.10

A comparison of murine smooth muscle cells generated from embryonic versus induced pluripotent stem cells. Stem Cells Dev (2009) 1.09

Laparoscopy or not: a meta-analysis of the surgical effects of laparoscopic versus open appendicectomy. Surg Laparosc Endosc Percutan Tech (2010) 1.08

The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy. Clin Cancer Res (2010) 1.08

Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol (2006) 1.08

Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration. PLoS One (2012) 1.07

Sample preparation method for isolation of single-cell types from mouse liver for proteomic studies. Proteomics (2011) 1.07

Visualization and quantification of renal R2* changes during water diuresis. J Magn Reson Imaging (2003) 1.07

Effect of biochar amendment on sorption and leaching of nitrate, ammonium, and phosphate in a sandy soil. Chemosphere (2012) 1.06

Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function. J Biol Chem (2011) 1.06

Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells. J Biol Chem (2013) 1.06

Comparing sequences without using alignments: application to HIV/SIV subtyping. BMC Bioinformatics (2007) 1.05

Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection. Biochem J (2009) 1.05

Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer. Biochem Biophys Res Commun (2002) 1.04

A 3-dimensional finite element model of the human foot and ankle for insole design. Arch Phys Med Rehabil (2005) 1.04

Malignant progression in choroid plexus papillomas. J Neurosurg (2007) 1.04

Effects of plantar fascia stiffness on the biomechanical responses of the ankle-foot complex. Clin Biomech (Bristol, Avon) (2004) 1.04

Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins. BMC Cancer (2005) 1.03

The effect of extracellular calcium and inorganic phosphate on the growth and osteogenic differentiation of mesenchymal stem cells in vitro: implication for bone tissue engineering. Biomed Mater (2009) 1.03

MyD88 and Trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis. Anesthesiology (2011) 1.03

Smurf control in bone cells. J Cell Biochem (2010) 1.03

Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the lymph nodes in mice. Transl Oncol (2010) 1.02