Published in Chem Res Toxicol on June 08, 2007
A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests. BMC Genomics (2011) 0.90
Haptenation: chemical reactivity and protein binding. J Allergy (Cairo) (2011) 0.83
Substituent effects on the reactivity of benzoquinone derivatives with thiols. Chem Res Toxicol (2012) 0.79
Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency. BMC Pharmacol Toxicol (2014) 0.78
On exploring structure-activity relationships. Methods Mol Biol (2013) 0.78
Fragment-based prediction of skin sensitization using recursive partitioning. J Comput Aided Mol Des (2011) 0.78
QSAR models of human data can enrich or replace LLNA testing for human skin sensitization. Green Chem (2016) 0.77
Prediction of skin sensitization with a particle swarm optimized support vector machine. Int J Mol Sci (2009) 0.77
Methyl methacrylate and respiratory sensitization: a critical review. Crit Rev Toxicol (2011) 0.75
Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers. Toxicology (2013) 0.75
Modeling skin sensitization potential of mechanistically hard-to-be-classified aniline and phenol compounds with quantum mechanistic properties. BMC Pharmacol Toxicol (2014) 0.75
Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization. Contact Dermatitis (2005) 2.26
Determinants of skin sensitisation potential. J Appl Toxicol (2008) 2.11
Reactivity assays, substances, samples and in vitro alternatives: why should we care? Contact Dermatitis (2009) 1.93
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth. Environ Health Perspect (2004) 1.84
Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. Nat Genet (2011) 1.84
Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. J Allergy Clin Immunol (2011) 1.62
Key issues for the assessment of the allergenic potential of genetically modified foods: breakout group reports. Environ Health Perspect (2003) 1.53
Peanut sensitisation and allergy: influence of early life exposure to peanuts. Br J Nutr (2010) 1.46
Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol (2011) 1.46
Di-(2-ethylhexyl) phthalate is without adjuvant effect in mice on ovalbumin. Toxicology (2007) 1.44
Updating the skin sensitization in vitro data assessment paradigm in 2009. J Appl Toxicol (2009) 1.42
Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response. Eur J Immunol (2004) 1.40
A stepwise approach for defining the applicability domain of SAR and QSAR models. J Chem Inf Model (2005) 1.37
A novel model of sensitization and oral tolerance to peanut protein. Immunology (2004) 1.35
Challenges and approaches for the development of safer immunomodulatory biologics. Nat Rev Drug Discov (2013) 1.35
Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis (2005) 1.35
Epidermal Langerhans cell migration and sensitisation to chemical allergens. APMIS (2003) 1.25
Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case. ALTEX (2011) 1.24
Consensus report on the future of animal-free systemic toxicity testing. ALTEX (2014) 1.20
Impaired Langerhans cell migration in psoriasis. J Exp Med (2006) 1.16
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX (2012) 1.15
Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Contact Dermatitis (2003) 1.14
In vitro skin irritation: facts and future. State of the art review of mechanisms and models. Toxicol In Vitro (2004) 1.13
Immunogenicity of therapeutic proteins: influence of aggregation. J Immunotoxicol (2013) 1.10
Allergic contact dermatitis: is the reactive chemistry of skin sensitizers the whole story? Contact Dermatitis (2013) 1.09
Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells. Immunology (2008) 1.08
Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen. Toxicol Lett (2004) 1.05
The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses. J Immunol Methods (2006) 1.03
The need to decide if all estrogens are intrinsically similar. Environ Health Perspect (2004) 1.03
An assessment of the ability of phthalates to influence immune and allergic responses. Toxicology (2010) 1.02
Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1alpha and IL-1beta during irritant- and allergen-induced cutaneous immune responses. Toxicol Appl Pharmacol (2002) 1.00
IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J Leukoc Biol (2007) 0.98
Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones. Mol Cell Neurosci (2008) 0.96
Comparative assessment of methods to develop QSARs for the prediction of the toxicity of phenols to Tetrahymena pyriformis. Chemosphere (2002) 0.96
Allergic contact dermatitis. Int Immunopharmacol (2002) 0.95
Regulation of expression of the novel IL-1 receptor family members in the mouse brain. J Neurochem (2005) 0.94
Evidence-based toxicology for the 21st century: opportunities and challenges. ALTEX (2013) 0.94
Patch test frequency to p-phenylenediamine: follow up over the last 6 years. Contact Dermatitis (2007) 0.93
Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta. Immunology (2002) 0.93
Assessment of allergenic potential of genetically modified foods: an agenda for future research. Environ Health Perspect (2003) 0.92
The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides. J Invest Dermatol (2007) 0.92
Experimental reactivity parameters for toxicity modeling: application to the acute aquatic toxicity of SN2 electrophiles to Tetrahymena pyriformis. Chem Res Toxicol (2010) 0.91
Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay. Chem Res Toxicol (2007) 0.90
The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain? Mol Neurobiol (2003) 0.90
Assessment of the inherent allergenic potential of proteins in mice. Environ Health Perspect (2003) 0.89
Integrated Testing Strategies (ITS) for safety assessment. ALTEX (2014) 0.89
Description of the electronic structure of organic chemicals using semiempirical and ab initio methods for development of toxicological QSARs. J Chem Inf Model (2005) 0.89
Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals. Methods (2007) 0.89
Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens. Environ Health Perspect (2002) 0.89
Categorical QSAR Models for skin sensitization based upon local lymph node assay classification measures part 2: 4D-fingerprint three-state and two-2-state logistic regression models. Toxicol Sci (2007) 0.88
Computer-aided knowledge generation for understanding skin sensitization mechanisms: the TOPS-MODE approach. Chem Res Toxicol (2003) 0.87
Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones. Mol Cell Neurosci (2007) 0.87
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation. Mol Cell Endocrinol (2006) 0.87
Langerhans cell mobilization distinguishes between early-onset and late-onset psoriasis. J Invest Dermatol (2010) 0.87
Measurement of cytokine expression and Langerhans cell migration in human skin following suction blister formation. Exp Dermatol (2004) 0.87
A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation. J Appl Toxicol (2013) 0.86
Local lymph node data for the evaluation of skin sensitization alternatives: a second compilation. Dermatitis (2010) 0.86
Skin irritation, false positives and the local lymph node assay: a guideline issue? Regul Toxicol Pharmacol (2011) 0.85
Use of a B cell marker (B220) to discriminate between allergens and irritants in the local lymph node assay. Toxicol Sci (2002) 0.85
A mouse model for food allergy using intraperitoneal sensitization. Methods (2007) 0.85
Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice. J Appl Toxicol (2013) 0.85
The impact of LLNA group size on the identification and potency classification of skin sensitizers: a review of published data. Cutan Ocul Toxicol (2009) 0.85
Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain. J Neuroimmunol (2003) 0.85
Quantitative risk assessment for skin sensitisation: consideration of a simplified approach for hair dye ingredients. Regul Toxicol Pharmacol (2012) 0.85
Comparative analysis of skin sensitization potency of acrylates (methyl acrylate, ethyl acrylate, butyl acrylate, and ethylhexyl acrylate) using the local lymph node assay. Contact Dermatitis (2007) 0.84
The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses. Cytokine (2005) 0.84
Extra domain A-positive fibronectin-positive feedback loops and their association with cutaneous inflammatory disease. Clin Dermatol (2011) 0.84
4D-fingerprint categorical QSAR models for skin sensitization based on the classification of local lymph node assay measures. Chem Res Toxicol (2007) 0.84
Assessment of protein allergenicity on the basis of immune reactivity: animal models. Environ Health Perspect (2003) 0.84
Differential immunogenicity and allergenicity of native and recombinant human lactoferrins: role of glycosylation. Eur J Immunol (2012) 0.83