PubRank

George Kunos

Author PubWeight™ 111.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006 6.80
2 Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 2005 4.55
3 Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest 2008 3.13
4 Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med 2008 2.91
5 Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab 2008 2.91
6 Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci 2003 2.84
7 Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol 2007 2.81
8 Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci 2007 2.78
9 Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. Cell Metab 2012 2.76
10 Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest 2010 2.32
11 Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proc Natl Acad Sci U S A 2003 2.21
12 Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med 2013 2.19
13 Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation 2004 2.15
14 A biosynthetic pathway for anandamide. Proc Natl Acad Sci U S A 2006 2.08
15 Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. Gastroenterology 2012 2.01
16 Evidence for novel cannabinoid receptors. Pharmacol Ther 2005 2.00
17 In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology 2003 2.00
18 Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol 2003 1.95
19 Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J 2007 1.94
20 Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 2008 1.90
21 Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. Am J Physiol Heart Circ Physiol 2004 1.88
22 Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol 2005 1.76
23 Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. J Biol Chem 2003 1.70
24 Modulating the endocannabinoid system in human health and disease--successes and failures. FEBS J 2013 1.59
25 Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology 2007 1.59
26 N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proc Natl Acad Sci U S A 2006 1.52
27 Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. J Physiol 2004 1.51
28 The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One 2008 1.49
29 Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology 2015 1.48
30 Chronic alcohol produces neuroadaptations to prime dorsal striatal learning. Proc Natl Acad Sci U S A 2013 1.30
31 Endocannabinoids in liver disease. Hepatology 2011 1.27
32 Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. Neuroendocrinology 2005 1.26
33 The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. FASEB J 2007 1.26
34 G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. J Biol Chem 2003 1.24
35 Receptors for acylethanolamides-GPR55 and GPR119. Prostaglandins Other Lipid Mediat 2009 1.23
36 Blood pressure regulation by endocannabinoids and their receptors. Neuropharmacology 2005 1.23
37 Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. Am J Physiol Heart Circ Physiol 2007 1.22
38 Low doses of alcohol substantially decrease glucose metabolism in the human brain. Neuroimage 2005 1.18
39 Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. Neuropsychopharmacology 2006 1.16
40 Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. J Biol Chem 2010 1.14
41 Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. Eur J Pharmacol 2004 1.12
42 AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome. FASEB J 2008 1.11
43 Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. Proc Natl Acad Sci U S A 2011 1.09
44 Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function. Ann Surg 2008 1.09
45 Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations. Hypertension 2008 1.07
46 Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat. Alcohol Clin Exp Res 2009 1.06
47 Metabolic effects of chronic cannabis smoking. Diabetes Care 2013 1.04
48 Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chem Biol 2010 1.04
49 The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels. J Pharmacol Exp Ther 2008 1.03
50 Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury. Alcohol Clin Exp Res 2010 1.00
51 Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine. J Biol Chem 2002 0.98
52 CB(1) receptor antagonist SR141716A inhibits Ca(2+)-induced relaxation in CB(1) receptor-deficient mice. Hypertension 2002 0.97
53 Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides. Hepatology 2013 0.94
54 Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology 2010 0.94
55 Ethanol, endocannabinoids, and the cannabinoidergic signaling system. Alcohol Clin Exp Res 2002 0.93
56 Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers. Psychopharmacology (Berl) 2009 0.92
57 Cannabinoids cool the intestine. Nat Med 2004 0.90
58 Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain. J Biol Chem 2014 0.88
59 Paracrine transactivation of the CB1 cannabinoid receptor by AT1 angiotensin and other Gq/11 protein-coupled receptors. J Biol Chem 2009 0.87
60 Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. Proc Natl Acad Sci U S A 2013 0.87
61 Cannabinoid modulation of Kaposi's sarcoma-associated herpesvirus infection and transformation. Cancer Res 2007 0.86
62 Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity. Am J Physiol Endocrinol Metab 2013 0.86
63 Inhibition of human hair follicle growth by endo- and exocannabinoids. FASEB J 2007 0.86
64 Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption. Alcohol Clin Exp Res 2010 0.86
65 Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts. J Cardiovasc Pharmacol 2005 0.83
66 Circulating anandamide and blood pressure in patients with obstructive sleep apnea. J Hypertens 2012 0.82
67 Cannabinoids hurt, heal in cirrhosis. Nat Med 2006 0.82
68 Cirrhotic cardiomyopathy: an endocannabinoid connection? Br J Pharmacol 2005 0.81
69 Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids. J Hepatol 2010 0.78
70 The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release. FASEB J 2013 0.76
71 Endocannabinoids, CB1 receptors, and liver disease: hitting more than one bird with the same stone. Gastroenterology 2008 0.75
72 Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism. Addiction 2010 0.75
73 Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis. JCI Insight 2017 0.75
74 Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA. J Labelled Comp Radiopharm 2008 0.75
75 A tribute to Dr. Ting-Kai Li. Alcohol Clin Exp Res 2008 0.75