PubRank

Kira J Weissman

Author PubWeight™ 27.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chem Biol 2005 2.61
2 Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol 2007 2.43
3 The structure of docking domains in modular polyketide synthases. Chem Biol 2003 1.98
4 Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications. Angew Chem Int Ed Engl 2008 1.32
5 Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chem Biol 2007 1.27
6 Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. J Am Chem Soc 2008 1.11
7 Broad substrate specificity of ketoreductases derived from modular polyketide synthases. Chembiochem 2006 0.96
8 Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro. Chembiochem 2006 0.96
9 Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin. Chembiochem 2007 0.95
10 Multienzyme docking in hybrid megasynthetases. Nat Chem Biol 2007 0.94
11 Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases. Chem Biol 2010 0.92
12 Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS. Chembiochem 2010 0.90
13 Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatus. J Biol Chem 2007 0.90
14 Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens. Chem Biol 2009 0.89
15 Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases. Chembiochem 2008 0.88
16 Heterologous expression and genetic engineering of the tubulysin biosynthetic gene cluster using Red/ET recombineering and inactivation mutagenesis. Chem Biol 2012 0.88
17 Improved catalytic activity of a purified multienzyme from a modular polyketide synthase after coexpression with Streptomyces chaperonins in Escherichia coli. Chembiochem 2008 0.86
18 An unusual thioesterase promotes isochromanone ring formation in ajudazol biosynthesis. Chembiochem 2010 0.83
19 Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis. Angew Chem Int Ed Engl 2009 0.83
20 DKxanthene biosynthesis--understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism. Chem Biol 2008 0.83
21 Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversity. Chem Biol 2010 0.83
22 Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690. Mol Biosyst 2011 0.82
23 Insights into multienzyme docking in hybrid PKS-NRPS megasynthetases revealed by heterologous expression and genetic engineering. Chembiochem 2010 0.79
24 Autonomous folding of interdomain regions of a modular polyketide synthase. FEBS J 2007 0.78
25 Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004. Chem Biol 2010 0.77
26 Biosynthesis: a twist in the tail. Nat Chem Biol 2011 0.75