Published in Neurotherapeutics on July 01, 2007
Inflammation, microglia, and Alzheimer's disease. Neurobiol Dis (2009) 2.44
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Neuroimaging in repetitive brain trauma. Alzheimers Res Ther (2014) 0.81
The relationship between serial [(18) F]PBR06 PET imaging of microglial activation and motor function following stroke in mice. Mol Imaging Biol (2014) 0.79
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Molecular Imaging Markers to Track Huntington's Disease Pathology. Front Neurol (2017) 0.75
Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies. Front Neurosci (2016) 0.75
Synaptic conversion of chloride-dependent synapses in spinal nociceptive circuits: roles in neuropathic pain. Pain Res Treat (2011) 0.75
Improved Automated Radiosynthesis of [(11)C]PBR28. Sci Pharm (2015) 0.75
Molecular imaging of vascular inflammation. Eur J Nucl Med Mol Imaging (2010) 0.75
Rubor, calor, tumor, dolor, functio laesa... or molecular imaging. Eur J Nucl Med Mol Imaging (2007) 0.75
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology (2012) 3.30
Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol (2005) 2.68
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis (2005) 2.59
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. J Nucl Med (2009) 1.58
11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. J Nucl Med (2007) 1.53
Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study. Neuroimage (2004) 1.52
DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med (2008) 1.49
Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans. J Nucl Med (2009) 1.44
Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun (2011) 1.44
[11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Mol Imaging Biol (2009) 1.43
Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.43
The translocator protein. J Nucl Med (2011) 1.22
Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand. Bioorg Med Chem (2005) 1.21
Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. ACS Chem Neurosci (2015) 1.15
In vivo detection of microglial activation in frontotemporal dementia. Ann Neurol (2004) 1.15
Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography. Curr Med Chem (2009) 1.14
Development of ligands for the peripheral benzodiazepine receptor. Curr Med Chem (2006) 1.13
Glutamate induces directed chemotaxis of microglia. Eur J Neurosci (2009) 1.13
Effects of ionizing radiation on mitochondria. Free Radic Biol Med (2013) 1.11
Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation. Nucl Med Biol (2011) 1.06
Imaging sigma receptors: applications in drug development. Curr Pharm Des (2007) 1.06
Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds. Chem Rev (2011) 1.04
In vivo imaging of neuroinflammation. Eur Neuropsychopharmacol (2002) 1.04
Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor. Neuropsychopharmacology (2013) 1.02
The 18 kDa translocator protein, microglia and neuroinflammation. Brain Pathol (2014) 1.02
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[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats. PLoS One (2013) 1.00
A linear wavelet filter for parametric imaging with dynamic PET. IEEE Trans Med Imaging (2003) 1.00
P2X purinergic receptor ligands: recently patented compounds. Expert Opin Ther Pat (2010) 0.99
The translocator protein (18 kDa): central nervous system disease and drug design. J Med Chem (2009) 0.99
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration. Mov Disord (2004) 0.95
Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cell Mol Life Sci (2014) 0.94
Reduced PBR/TSPO expression after minocycline treatment in a rat model of focal cerebral ischemia: a PET study using [(18)F]DPA-714. Mol Imaging Biol (2011) 0.92
The translocator protein (TSPO): a novel target for cancer chemotherapy. Int J Biochem Cell Biol (2013) 0.92
Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter. Bioorg Med Chem (2005) 0.91
Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling. Bioorg Med Chem Lett (2009) 0.90
Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. Eur J Pharmacol (2006) 0.89
Molecular probes for P2X7 receptor studies. Curr Med Chem (2007) 0.88
Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV. J Neurovirol (2014) 0.88
Ex vivo and in vivo evaluation of (2R,3R)-5-[(18)F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter. Synapse (2007) 0.88
Radiation dosimetry and biodistribution of the TSPO ligand 11C-DPA-713 in humans. J Nucl Med (2012) 0.87
18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons. J Nucl Med (2009) 0.87
Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury. J Peripher Nerv Syst (2004) 0.86
The therapeutic potential of sigma (σ) receptors for the treatment of central nervous system diseases: evaluation of the evidence. Curr Pharm Des (2012) 0.85
The 18 kDa translocator protein (peripheral benzodiazepine receptor) expression in the bone of normal, osteoprotegerin or low calcium diet treated mice. PLoS One (2012) 0.84
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. J Neurooncol (2007) 0.84
Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatum. ACS Chem Neurosci (2011) 0.84
The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse. ACS Chem Neurosci (2013) 0.84
Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand. Drug Metab Dispos (2012) 0.83
Evaluation of transmission methodology and attenuation correction for the microPET Focus 220 animal scanner. Phys Med Biol (2006) 0.83
The translocator protein as a drug target in Alzheimer's disease. Expert Rev Neurother (2014) 0.83
The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chem Neurosci (2014) 0.83
Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J Biol Chem (2009) 0.83
Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues. ACS Chem Neurosci (2016) 0.83
Cubyl amides: novel P2X7 receptor antagonists. Bioorg Med Chem Lett (2008) 0.82
Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazine σ₁ receptor ligands. Bioorg Med Chem Lett (2011) 0.82
Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). Bioorg Med Chem Lett (2010) 0.81
Acetylenic pyridines for use in PET imaging of nicotinic receptors. ChemMedChem (2007) 0.81
The potential role of echocardiographic strain imaging for evaluating cardiotoxicity due to cancer therapy. Heart Lung Circ (2010) 0.81
Radiotracer imaging studies in hepatic encephalopathy: ISHEN practice guidelines. Liver Int (2009) 0.81
Predicted ionisation in mitochondria and observed acute changes in the mitochondrial transcriptome after gamma irradiation: a Monte Carlo simulation and quantitative PCR study. Mitochondrion (2013) 0.80
[Microglia--biology and relevance to disease]. Ugeskr Laeger (2005) 0.80
The development of radiotracers for imaging sigma (σ) receptors in the central nervous system (CNS) using positron emission tomography (PET). J Labelled Comp Radiopharm (2013) 0.80
[11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies. J Neurol Sci (2004) 0.80
Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands. J Med Chem (2010) 0.80
Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT. Br J Pharmacol (2012) 0.79
Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands. Bioorg Med Chem Lett (2005) 0.79
Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells. Chem Commun (Camb) (2011) 0.79
Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[(11)C]one, as a potent NR(1A)/2B subtype selective NMDA PET radiotracer. Bioorg Med Chem (2003) 0.79
Green fluorescent protein alters the transcriptional regulation of human mitochondrial genes after gamma irradiation. J Fluoresc (2013) 0.79
Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. J Biol Inorg Chem (2010) 0.78
Sequential 123I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and 18F-FDG PET imaging). Eur J Nucl Med Mol Imaging (2004) 0.78
Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis. Arthritis Res Ther (2014) 0.78
Oral pre-treatment with epigallocatechin gallate in 6-OHDA lesioned rats produces subtle symptomatic relief but not neuroprotection. Brain Res Bull (2009) 0.78
Ligands for peripheral benzodiazepine binding sites in glial cells. Brain Res Brain Res Rev (2005) 0.78
The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia. CNS Drugs (2015) 0.78
The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett (2013) 0.77
Development of radioligands for in vivo imaging of GABA(A)-benzodiazepine receptors. Mini Rev Med Chem (2004) 0.77
Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorg Med Chem Lett (2011) 0.77
Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Neurosci Lett (2007) 0.77
First Demonstration of Positive Allosteric-like Modulation at the Human Wild Type Translocator Protein (TSPO). J Med Chem (2015) 0.76
The role of positron emission tomography in the discovery and development of new drugs; as studied in laboratory animals. Eur J Drug Metab Pharmacokinet (2004) 0.76
(E)-[125I]-5-AOIBV: a SPECT radioligand for the vesicular acetylcholine transporter. Nucl Med Biol (2007) 0.76
WAY 267,464, a non-peptide oxytocin receptor agonist, impairs social recognition memory in rats through a vasopressin 1A receptor antagonist action. Psychopharmacology (Berl) (2015) 0.76
N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as σ receptor ligands with potential neuroprotective effects. Bioorg Med Chem (2013) 0.75
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. Bioorg Med Chem (2009) 0.75
Unitary hormonal models, peripheral markers, and evaluation of response to drug: a response to Weisman and Feldman. Psychoneuroendocrinology (2013) 0.75
A σ(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs). Bioorg Med Chem Lett (2012) 0.75
Intrinsic microtubule GTP-cap dynamics in semi-confined systems: kinetochore-microtubule interface. J Biol Phys (2012) 0.75
11-{[2-(3-Fluoro-phen-yl)eth-yl](meth-yl)amino}-penta-cyclo-[5.4.0.0.0.0]undecan-8-one. Acta Crystallogr Sect E Struct Rep Online (2010) 0.75
Proceedings of the 2007 international brain research organisation satellite meeting "movement disorders: focus on the thalamus and basal ganglia" held in Sydney, Australia, 10-11 July 2007. Brain Res Bull (2008) 0.75
Behavioural effects of trishomocubanes in rats with unilateral 6-hydroxydopamine lesions. Behav Brain Res (2008) 0.75
[18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET. J Labelled Comp Radiopharm (2014) 0.75
Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands. Bioorg Med Chem Lett (2006) 0.75
Influence of trishomocubanes on sigma receptor binding of N-(1-benzyl-piperidin-4-yl)-4-[123I]iodobenzamide in vivo in the rat brain. Med Chem (2005) 0.75
Courage, luck and patience: in celebration of the 80th birthday of Georg W. Kreutzberg. Acta Neuropathol (2012) 0.75
Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg Med Chem Lett (2012) 0.75
N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (σ) receptor ligands. Bioorg Med Chem Lett (2011) 0.75
Dopamine D1 receptor imaging in the rodent and primate brain using the isoquinoline +-[11C]A-69024 and positron emission tomography. J Pharm Sci (2008) 0.75