Published in BMC Genet on July 03, 2007
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol (2007) 3.45
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest (2011) 2.25
Mouse models of retinal ganglion cell death and glaucoma. Exp Eye Res (2008) 1.79
Early microglia activation in a mouse model of chronic glaucoma. J Comp Neurol (2011) 1.69
Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma. J Neuroinflammation (2015) 1.49
The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration. J Neurochem (2008) 1.48
Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc Natl Acad Sci U S A (2011) 1.47
Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest (2012) 1.44
Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Prog Retin Eye Res (2012) 1.40
Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma. Invest Ophthalmol Vis Sci (2011) 1.35
Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background. Genes Brain Behav (2009) 1.29
A Thy1-CFP DBA/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells. Vis Neurosci (2009) 1.06
Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One (2012) 1.04
Gpnmb is a melanoblast-expressed, MITF-dependent gene. Pigment Cell Melanoma Res (2008) 1.02
C57BL/6J, DBA/2J, and DBA/2J.Gpnmb mice have different visual signal processing in the inner retina. Mol Vis (2010) 1.00
Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma. PLoS One (2013) 0.99
Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target. Neuroscience (2012) 0.98
Electrophysiological deficits in the retina of the DBA/2J mouse. Doc Ophthalmol (2009) 0.97
Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. J Neurosci (2014) 0.95
Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model. BMC Neurosci (2007) 0.94
Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Invest Ophthalmol Vis Sci (2014) 0.94
DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury. Neurobiol Dis (2014) 0.92
Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data. BMC Genomics (2011) 0.92
Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes. PLoS Genet (2010) 0.92
GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet (2008) 0.90
Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains. Exp Eye Res (2011) 0.89
The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice. Sci Rep (2012) 0.89
Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma. Neurobiol Dis (2014) 0.88
Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension. BMC Neurosci (2008) 0.88
Innate immune network in the retina activated by optic nerve crush. Invest Ophthalmol Vis Sci (2013) 0.88
Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma. Front Neurosci (2014) 0.88
JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells. Exp Eye Res (2013) 0.88
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma. Mol Neurodegener (2016) 0.87
Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells. Invest Ophthalmol Vis Sci (2013) 0.87
Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro. Am J Pathol (2014) 0.85
Missing optomotor head-turning reflex in the DBA/2J mouse. Invest Ophthalmol Vis Sci (2011) 0.85
Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina. Vision Res (2010) 0.85
Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains. Pigment Cell Melanoma Res (2013) 0.83
Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma. Dis Model Mech (2015) 0.82
Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Exp Eye Res (2015) 0.80
Increased levels of extracellular ATP in glaucomatous retinas: Possible role of the vesicular nucleotide transporter during the development of the pathology. Mol Vis (2015) 0.78
Integrative properties of retinal ganglion cell electrical responsiveness depend on neurotrophic support and genotype in the mouse. Exp Eye Res (2015) 0.78
Aqueous humor phospholipids of DBA/2J and DBA/2J-Gpnmb(+)/SjJ mice. Biochimie (2015) 0.77
Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Exp Eye Res (2016) 0.77
Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma. PLoS One (2015) 0.77
Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice. Mol Vis (2016) 0.77
Functional protective effects of long-term memantine treatment in the DBA/2J mouse. Doc Ophthalmol (2013) 0.77
Segmental outflow of aqueous humor in mouse and human. Exp Eye Res (2016) 0.75
Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma. Front Neurosci (2016) 0.75
Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma. J Immunol (2016) 0.75
Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma. J Comp Neurol (2016) 0.75
YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech (2016) 0.75
Interaction of cochlin and mechanosensitive channel TREK-1 in trabecular meshwork cells influences the regulation of intraocular pressure. Sci Rep (2017) 0.75
Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci U S A (2017) 0.75
Number of people with glaucoma worldwide. Br J Ophthalmol (1996) 14.31
Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest Ophthalmol Vis Sci (1998) 3.61
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet (2001) 3.30
Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. Vis Neurosci (2005) 2.86
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet (2005) 2.68
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci (2006) 2.68
Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet (1999) 2.30
Genetic variation in laboratory mice. Nat Genet (2005) 2.12
Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Invest Ophthalmol Vis Sci (2006) 2.00
Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet (2001) 1.88
Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA/2NNia glaucomatous mice: comparison with RGC loss in aging C57/BL6 mice. Invest Ophthalmol Vis Sci (2003) 1.87
Complex genetics of glaucoma susceptibility. Annu Rev Genomics Hum Genet (2005) 1.85
nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts. Int J Cancer (1995) 1.84
The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type. Genetics (1990) 1.66
High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma. Proc Natl Acad Sci U S A (2005) 1.55
Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol (2006) 1.52
Retinal neurodegeneration in the DBA/2J mouse-a model for ocular hypertension. Acta Neuropathol (2004) 1.44
Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem (2005) 1.43
Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clin Cancer Res (2006) 1.41
By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma. J Exp Med (2003) 1.39
Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics (2006) 1.37
A unification hypothesis of pigment dispersion syndrome. Trans Am Ophthalmol Soc (1996) 1.17
The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06
Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med (2006) 3.58
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol (2007) 3.45
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet (2001) 3.30
Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants. Nat Biotechnol (2011) 3.25
Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol (2005) 2.98
Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science (2005) 2.92
Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. Vis Neurosci (2005) 2.86
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science (2011) 2.78
CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Hum Mol Genet (2003) 2.77
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet (2005) 2.68
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Science (2003) 2.41
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest (2011) 2.25
Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Curr Biol (2003) 2.25
Integration of transport-based models for phyllotaxis and midvein formation. Genes Dev (2009) 2.22
Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc Natl Acad Sci U S A (2002) 2.08
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Control of bud activation by an auxin transport switch. Proc Natl Acad Sci U S A (2009) 1.97
Elastic domains regulate growth and organogenesis in the plant shoot apical meristem. Science (2012) 1.91
Complex genetics of glaucoma susceptibility. Annu Rev Genomics Hum Genet (2005) 1.85
Glaucoma: thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes? Prog Retin Eye Res (2005) 1.83
Phenotype-based identification of mouse chromosome instability mutants. Genetics (2003) 1.74
Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice. EMBO J (2003) 1.74
Mechanical regulation of auxin-mediated growth. Curr Biol (2012) 1.71
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest (2011) 1.69
Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annu Rev Neurosci (2012) 1.65
Optical properties of the mouse eye. Biomed Opt Express (2011) 1.63
Effects of pressure overload on extracellular matrix expression in the heart of the atrial natriuretic peptide-null mouse. Hypertension (2003) 1.61
Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet (2003) 1.58
Silk film biomaterials for cornea tissue engineering. Biomaterials (2008) 1.58
High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma. Proc Natl Acad Sci U S A (2005) 1.55
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes. J Cell Sci (2004) 1.53
Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol (2006) 1.52
Anterior segment development relevant to glaucoma. Int J Dev Biol (2004) 1.50
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet (2013) 1.49
Anterior segment dysgenesis and the developmental glaucomas are complex traits. Hum Mol Genet (2002) 1.47
Intravitreal injection of AAV2 transduces macaque inner retina. Invest Ophthalmol Vis Sci (2011) 1.46
Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest (2012) 1.44
Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res (2002) 1.44
By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma. J Exp Med (2003) 1.39
Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses. J Physiol (2008) 1.36
Adaptive optics retinal imaging in the living mouse eye. Biomed Opt Express (2012) 1.36
Leaf shape evolution through duplication, regulatory diversification, and loss of a homeobox gene. Science (2014) 1.35
Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis. Hum Mol Genet (2007) 1.34
Ocular abnormalities in Large(myd) and Large(vls) mice, spontaneous models for muscle, eye, and brain diseases. Mol Cell Neurosci (2005) 1.33
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine. J Neurosci (2009) 1.30
JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death. Neurobiol Dis (2012) 1.25
Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma. Mol Cell Biol (2004) 1.23
BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons. J Neurosci (2009) 1.22
The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol (2009) 1.21
In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison. BMC Ophthalmol (2009) 1.20
Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development (2012) 1.20
Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration. Am J Physiol Cell Physiol (2009) 1.19
Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation. J Biol Chem (2010) 1.19
Leaf asymmetry as a developmental constraint imposed by auxin-dependent phyllotactic patterning. Plant Cell (2012) 1.18
Cellular force microscopy for in vivo measurements of plant tissue mechanics. Plant Physiol (2012) 1.18
A bHLH complex controls embryonic vascular tissue establishment and indeterminate growth in Arabidopsis. Dev Cell (2013) 1.18
Membrane frizzled-related protein is necessary for the normal development and maintenance of photoreceptor outer segments. Vis Neurosci (2008) 1.18
Positional information by differential endocytosis splits auxin response to drive Arabidopsis root meristem growth. Curr Biol (2011) 1.16
MATH5 controls the acquisition of multiple retinal cell fates. Mol Brain (2010) 1.15
Genetic dependence of central corneal thickness among inbred strains of mice. Invest Ophthalmol Vis Sci (2009) 1.12
Helicoidal multi-lamellar features of RGD-functionalized silk biomaterials for corneal tissue engineering. Biomaterials (2010) 1.12
Mutations in a P-type ATPase gene cause axonal degeneration. PLoS Genet (2012) 1.11
Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLoS Genet (2011) 1.11
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma. Mol Cell Biol (2006) 1.11