Published in Nat Struct Mol Biol on July 08, 2007
Eukaryotic DNA ligases: structural and functional insights. Annu Rev Biochem (2008) 2.44
Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions. J Biol Chem (2011) 1.60
DNA ligases: progress and prospects. J Biol Chem (2009) 1.59
Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3'-OH monoribonucleotide. J Biol Chem (2008) 1.36
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states. Biochemistry (2010) 1.32
Two DNA-binding and nick recognition modules in human DNA ligase III. J Biol Chem (2008) 1.30
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol (2010) 1.30
The sequential 2',3'-cyclic phosphodiesterase and 3'-phosphate/5'-OH ligation steps of the RtcB RNA splicing pathway are GTP-dependent. Nucleic Acids Res (2012) 1.19
Mechanism of replication machinery assembly as revealed by the DNA ligase-PCNA-DNA complex architecture. Proc Natl Acad Sci U S A (2009) 1.16
RNA 3'-phosphate cyclase (RtcA) catalyzes ligase-like adenylylation of DNA and RNA 5'-monophosphate ends. J Biol Chem (2010) 1.12
The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair. RNA (2007) 1.07
Structure-activity relationships in human RNA 3'-phosphate cyclase. RNA (2009) 1.04
The associative nature of adenylyl transfer catalyzed by T4 DNA ligase. Proc Natl Acad Sci U S A (2008) 1.02
Substrate induced population shifts and stochastic gating in the PBCV-1 mRNA capping enzyme. J Am Chem Soc (2009) 1.00
Kinetic characterization of single strand break ligation in duplex DNA by T4 DNA ligase. J Biol Chem (2011) 0.99
Functional dissection of the DNA interface of the nucleotidyltransferase domain of chlorella virus DNA ligase. J Biol Chem (2011) 0.96
Dynamics of phosphodiester synthesis by DNA ligase. Proc Natl Acad Sci U S A (2008) 0.96
Efficient DNA ligation in DNA-RNA hybrid helices by Chlorella virus DNA ligase. Nucleic Acids Res (2013) 0.94
Structural insights into the role of domain flexibility in human DNA ligase IV. Structure (2012) 0.92
Kinetic analysis of DNA strand joining by Chlorella virus DNA ligase and the role of nucleotidyltransferase motif VI in ligase adenylylation. J Biol Chem (2012) 0.85
Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity. PLoS Genet (2013) 0.84
Solution NMR studies of Chlorella virus DNA ligase-adenylate. J Mol Biol (2009) 0.84
Structure-function analysis of the OB and latch domains of chlorella virus DNA ligase. J Biol Chem (2011) 0.84
Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. PLoS One (2013) 0.84
Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc Natl Acad Sci U S A (2015) 0.82
Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms. Expert Opin Drug Discov (2009) 0.82
The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. Nucleic Acids Res (2012) 0.82
Structure-guided Mutational Analysis of the Nucleotidyltransferase Domain of Escherichia coli DNA Ligase (LigA). J Biol Chem (2009) 0.81
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease. Prog Biophys Mol Biol (2015) 0.81
Effects of DNA3'pp5'G capping on 3' end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance. Nucleic Acids Res (2015) 0.80
Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism. PLoS One (2013) 0.79
Kinetic mechanism and fidelity of nick sealing by Escherichia coli NAD+-dependent DNA ligase (LigA). Nucleic Acids Res (2016) 0.78
Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallogr D Biol Crystallogr (2014) 0.77
Sequence-specific 1H N, 13C, and 15N backbone resonance assignments of the 34 kDa Paramecium bursaria Chlorella virus 1 (PBCV1) DNA ligase. Biomol NMR Assign (2009) 0.76
Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis. Nucleic Acids Res (2016) 0.76
Archaeal Nucleic Acid Ligases and Their Potential in Biotechnology. Archaea (2015) 0.76
Sensitive and specific miRNA detection method using SplintR Ligase. Nucleic Acids Res (2016) 0.75
The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase. PLoS One (2016) 0.75
Selectivity of Enzymatic Conversion of Oligonucleotide Probes during Nucleotide Polymorphism Analysis of DNA. Acta Naturae (2010) 0.75
Structure of RNA 3'-phosphate cyclase bound to substrate RNA. RNA (2014) 0.75
Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47
Follicular lymphoma international prognostic index. Blood (2004) 7.20
Results of a trial of PET-directed therapy for early-stage Hodgkin's lymphoma. N Engl J Med (2015) 5.44
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol (2012) 5.16
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol (2010) 4.72
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature (2005) 4.63
Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell (2006) 4.30
Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell (2002) 4.09
CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma. Blood (2004) 4.05
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet (2004) 3.47
Circadian orchestration of the hepatic proteome. Curr Biol (2006) 3.37
Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat Struct Mol Biol (2006) 3.15
Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. Nature (2005) 2.91
The polynucleotide ligase and RNA capping enzyme superfamily of covalent nucleotidyltransferases. Curr Opin Struct Biol (2004) 2.69
Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst (2007) 2.65
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell (2003) 2.65
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J (2005) 2.54
Concordance between four European centres of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma. Eur J Nucl Med Mol Imaging (2010) 2.48
Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature (2010) 2.41
Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. J Natl Cancer Inst (2002) 2.41
Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II. Mol Cell (2003) 2.22
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet (2006) 2.20
Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat Genet (2008) 2.20
A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. Structure (2004) 2.15
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nat Struct Mol Biol (2007) 2.13
A general relationship between disorder, aggregation and charge transport in conjugated polymers. Nat Mater (2013) 2.11
Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat Struct Mol Biol (2006) 2.07
Electron-pinned defect-dipoles for high-performance colossal permittivity materials. Nat Mater (2013) 2.05
Structure and mechanism of RNA ligase. Structure (2004) 2.00
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains. Proc Natl Acad Sci U S A (2002) 1.93
Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain (2005) 1.92
Structural genomics: a pipeline for providing structures for the biologist. Protein Sci (2002) 1.91
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev (2008) 1.90
Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc Natl Acad Sci U S A (2005) 1.90
Deciphering the RNA polymerase II CTD code in fission yeast. Mol Cell (2011) 1.89
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nat Struct Mol Biol (2005) 1.86
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
Ten years of dengue drug discovery: progress and prospects. Antiviral Res (2013) 1.84
Comparison of ABVD and alternating or hybrid multidrug regimens for the treatment of advanced Hodgkin's lymphoma: results of the United Kingdom Lymphoma Group LY09 Trial (ISRCTN97144519). J Clin Oncol (2005) 1.83
Fluorescence lifetime imaging system for in vivo studies. Mol Imaging (2007) 1.83
What messenger RNA capping tells us about eukaryotic evolution. Nat Rev Mol Cell Biol (2002) 1.82
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell (2013) 1.82
RtcB is the RNA ligase component of an Escherichia coli RNA repair operon. J Biol Chem (2011) 1.82
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Mol Cell (2010) 1.78
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways. Curr Opin Struct Biol (2007) 1.76
Portability and fidelity of RNA-repair systems. Proc Natl Acad Sci U S A (2004) 1.76
Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine. Structure (2005) 1.74
Information chaos in primary care: implications for physician performance and patient safety. J Am Board Fam Med (2011) 1.72
Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing. Mol Cell Biol (2004) 1.70
Small ubiquitin-like modifier modulates abscisic acid signaling in Arabidopsis. Plant Cell (2003) 1.70
Processing the message: structural insights into capping and decapping mRNA. Curr Opin Struct Biol (2005) 1.69
RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell (2006) 1.66
EMAGE--Edinburgh Mouse Atlas of Gene Expression: 2008 update. Nucleic Acids Res (2007) 1.66
Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo. Oncogene (2004) 1.64
Structural insights to how mammalian capping enzyme reads the CTD code. Mol Cell (2011) 1.64
Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell (2004) 1.64
RNA repair: an antidote to cytotoxic eukaryal RNA damage. Mol Cell (2008) 1.64
Left ventricular strain patterns in dilated cardiomyopathy predict response to cardiac resynchronization therapy: timing is not everything. J Am Soc Echocardiogr (2009) 1.61
Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions. J Biol Chem (2011) 1.60
Genetic and biochemical analysis of the functional domains of yeast tRNA ligase. J Biol Chem (2003) 1.60
Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5. Proc Natl Acad Sci U S A (2004) 1.60
Functional interaction between telomere protein TPP1 and telomerase. Genes Dev (2010) 1.60
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chem Biol (2010) 1.60
Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5. J Biol Chem (2002) 1.59
Biochemical and genetic analysis of the four DNA ligases of mycobacteria. J Biol Chem (2004) 1.54
Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme. EMBO J (2002) 1.54
RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. J Biol Chem (2011) 1.53
Organic thin-film electronics from vitreous solution-processed rubrene hypereutectics. Nat Mater (2005) 1.53
Structural and biochemical analysis of the Obg GTP binding protein. Structure (2002) 1.52
RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates. Proc Natl Acad Sci U S A (2012) 1.51
Novel 3'-ribonuclease and 3'-phosphatase activities of the bacterial non-homologous end-joining protein, DNA ligase D. J Biol Chem (2005) 1.50
Mutational analysis of bacteriophage T4 RNA ligase 1. Different functional groups are required for the nucleotidyl transfer and phosphodiester bond formation steps of the ligation reaction. J Biol Chem (2003) 1.50
Mutational analysis defines the 5'-kinase and 3'-phosphatase active sites of T4 polynucleotide kinase. Nucleic Acids Res (2002) 1.50
RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2. J Biol Chem (2004) 1.49
Complications following prostate needle biopsy requiring hospital admission or emergency department visits - experience from 1000 consecutive cases. BJU Int (2012) 1.48
Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Mol Cell (2007) 1.48
Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proc Natl Acad Sci U S A (2006) 1.48
An end-healing enzyme from Clostridium thermocellum with 5' kinase, 2',3' phosphatase, and adenylyltransferase activities. RNA (2005) 1.48
Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. Mol Cell (2009) 1.46
Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction. J Mol Biol (2007) 1.46
The Drosophila clock protein Timeless is a member of the Arm/HEAT family. Curr Biol (2002) 1.46
Chlorambucil versus observation after anti-Helicobacter therapy in gastric MALT lymphomas: results of the international randomised LY03 trial. Br J Haematol (2008) 1.46
Tat stimulates cotranscriptional capping of HIV mRNA. Mol Cell (2002) 1.43
In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. Clin Cancer Res (2006) 1.42
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. J Bacteriol (2007) 1.42
Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. Mol Cell (2004) 1.41
Randomized comparison of the stanford V regimen and ABVD in the treatment of advanced Hodgkin's Lymphoma: United Kingdom National Cancer Research Institute Lymphoma Group Study ISRCTN 64141244. J Clin Oncol (2009) 1.40