Published in Mol Med on September 10, 2007
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The genetics of essential metal homeostasis during development. Genesis (2008) 1.19
Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells. J Biol Chem (2011) 1.06
Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol (2008) 1.06
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The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice. Gastroenterology (2012) 0.97
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Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter. Biochem J (2013) 0.89
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Cytosolic superoxide dismutase (SOD1) is critical for tolerating the oxidative stress of zinc deficiency in yeast. PLoS One (2009) 0.84
ROS and intracellular ion channels. Cell Calcium (2016) 0.83
Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder. Respir Res (2010) 0.83
Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION. J Biol Chem (2015) 0.82
Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface. J Biol Chem (2016) 0.82
Immediate early inflammatory gene responses of human umbilical vein endothelial cells to hemorrhagic venom. Inflamm Res (2010) 0.81
Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes. Proc Natl Acad Sci U S A (2014) 0.80
Systems analysis of transcriptional data provides insights into muscle's biological response to botulinum toxin. Muscle Nerve (2014) 0.80
The stoichiometric transition from Zn6Cu1-metallothionein to Zn7-metallothionein underlies the up-regulation of metallothionein (MT) expression: quantitative analysis of MT-metal load in eye cells. J Biol Chem (2012) 0.79
Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation. Genes Nutr (2014) 0.78
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Blockade of metallothioneins 1 and 2 increases skeletal muscle mass and strength. Mol Cell Biol (2016) 0.76
Effect of zinc and nitric oxide on monocyte adhesion to endothelial cells under shear stress. Ann Biomed Eng (2011) 0.75
Selective cysteine modification of metal-free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI-MS. Protein Sci (2017) 0.75
In silico assessment of S100A12 monomer and dimer structural dynamics: implications for the understanding of its metal-induced conformational changes. J Biol Inorg Chem (2014) 0.75
Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel) (2017) 0.75
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
The neurobiology of zinc in health and disease. Nat Rev Neurosci (2005) 5.07
Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol (2006) 2.68
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Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet (2002) 2.29
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Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc Natl Acad Sci U S A (1998) 2.01
Control of zinc transfer between thionein, metallothionein, and zinc proteins. Proc Natl Acad Sci U S A (1998) 1.95
Glutathione redox potential in response to differentiation and enzyme inducers. Free Radic Biol Med (1999) 1.75
Inhibitory sites in enzymes: zinc removal and reactivation by thionein. Proc Natl Acad Sci U S A (1999) 1.68
Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem (2006) 1.52
Targeting of metallothionein by L-homocysteine: a novel mechanism for disruption of zinc and redox homeostasis. Arterioscler Thromb Vasc Biol (2006) 1.51
Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation (2006) 1.45
Zinc coordination environments in proteins as redox sensors and signal transducers. Antioxid Redox Signal (2006) 1.43
Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling. Exp Cell Res (2003) 1.42
ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals (2005) 1.32
Obesity and hyperleptinemia in metallothionein (-I and -II) null mice. Proc Natl Acad Sci U S A (1998) 1.32
Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. J Am Coll Nutr (2003) 1.27
Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury. Curr Mol Med (2004) 1.23
The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling. Arch Biochem Biophys (2007) 1.22
Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells. Anal Biochem (2006) 1.21
The antioxidant function of metallothionein in the heart. Proc Soc Exp Biol Med (1999) 1.15
Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants. Biometals (2005) 1.13
History of zinc as related to brain function. J Nutr (2000) 1.08
Selenium prevents diabetes-induced alterations in [Zn2+]i and metallothionein level of rat heart via restoration of cell redox cycle. Am J Physiol Heart Circ Physiol (2005) 1.04
Zinc and excitotoxic brain injury: a new model. Neuroscientist (2004) 1.03
Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein. Proc Natl Acad Sci U S A (2001) 1.02
Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases. J Trace Elem Med Biol (2005) 1.02
Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med (2005) 1.01
Basal metallothionein in tumors: widespread presence of apoprotein. J Inorg Biochem (1994) 1.00
Oral administration of a zinc complex improves type 2 diabetes and metabolic syndromes. Biochem Biophys Res Commun (2006) 0.97
Prevention of spontaneous and experimentally induced diabetes in mice with zinc sulfate-enriched drinking water is associated with activation and reduction of NF-kappa B and AP-1 in islets, respectively. Exp Biol Med (Maywood) (2004) 0.96
Retracted Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes. Diabetes (2005) 0.93
Metallothionein disulfides are present in metallothionein-overexpressing transgenic mouse heart and increase under conditions of oxidative stress. J Biol Chem (2005) 0.92
Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. Carcinogenesis (2006) 0.92
Aldehydes release zinc from proteins. A pathway from oxidative stress/lipid peroxidation to cellular functions of zinc. FEBS J (2006) 0.92
Catalytic selenols couple the redox cycles of metallothionein and glutathione. Eur J Biochem (2001) 0.92
Different redox states of metallothionein/thionein in biological tissue. Biochem J (2007) 0.90
Diversity of metallothionein content and subcellular localization in the National Cancer Institute tumor panel. Cancer Chemother Pharmacol (1997) 0.84
Nitric oxide and zinc homeostasis in acute lung injury. Proc Am Thorac Soc (2005) 0.84
Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population. Biogerontology (2006) 0.84
A differential assay for the reduced and oxidized states of metallothionein and thionein. Anal Biochem (2004) 0.81
Coordination dynamics of zinc in proteins. Chem Rev (2009) 1.95
Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. Neuron (2011) 1.29
Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration. J Neurosci Methods (2006) 1.17
Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin. Eur J Biochem (2002) 0.87
Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C. Amino Acids (2014) 0.81
Sequence-specific Ni(II)-dependent peptide bond hydrolysis for protein engineering: reaction conditions and molecular mechanism. Inorg Chem (2010) 0.80
Conformational studies of hexapeptides containing two dehydroamino acid residues in positions 2 and 5 in peptide chain. Biopolymers (2008) 0.78
The high Zn(II) affinity of the tetracysteine tag affects its fluorescent labeling with biarsenicals. Chembiochem (2010) 0.77
[Biarsenical probes for specific and multifunctional modification of proteins]. Postepy Biochem (2014) 0.75
Interactions of Zn(II) ions with three His-containing peptide models of histone H2A. Bioinorg Chem Appl (2004) 0.75