Published in Immunol Rev on August 01, 2007
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A logical model provides insights into T cell receptor signaling. PLoS Comput Biol (2007) 2.25
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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol (2006) 1.43
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol (2006) 1.41
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol (2007) 1.41
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CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules. Blood (2011) 1.10
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Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med (2012) 1.07
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Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency. Pediatr Res (2006) 1.05
p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival. Biochem Biophys Res Commun (2003) 1.04
Adaptors and linkers in T and B cells. Curr Opin Immunol (2004) 1.04
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS One (2011) 1.03
Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. J Biol Chem (2009) 1.02
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. Blood (2007) 1.02
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J Immunol (2009) 1.02
Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells. J Immunol (2008) 1.02
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood (2006) 1.00
Fyn regulates the duration of TCR engagement needed for commitment to effector function. J Immunol (2007) 1.00
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood (2007) 0.99
The role of adaptor proteins in lymphocyte activation. Mol Immunol (2004) 0.99
Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function. Mol Cell Biol (2005) 0.98
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells. PLoS One (2010) 0.96
Transmembrane adapters: attractants for cytoplasmic effectors. Immunol Rev (2003) 0.94
Sos1 regulates sustained TCR-mediated Erk activation. Eur J Immunol (2014) 0.93
Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNFalpha-induced apoptosis in colorectal tumor cells. Am J Pathol (2009) 0.92
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Mol Cell Biol (2005) 0.92
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes. Mol Cell Biol (2007) 0.92
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26. J Immunol (2007) 0.91
SIT and TRIM determine T cell fate in the thymus. J Immunol (2008) 0.90
Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells. Oncogene (2005) 0.90
Deletion of the LIME adaptor protein minimally affects T and B cell development and function. Eur J Immunol (2007) 0.90
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TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. EMBO Rep (2012) 0.89
Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins. Immunol Rev (2008) 0.88
Regulation of T cell homeostasis by the transmembrane adaptor protein SIT. J Immunol (2008) 0.88
The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow. J Biol Chem (2013) 0.88
In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction. Eur J Immunol (2007) 0.88
Mechanisms of opioid-mediated inhibition of human T cell receptor signaling. J Immunol (2009) 0.88
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol (2007) 0.88
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. J Immunol (2008) 0.88
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo. J Leukoc Biol (2009) 0.87
Normal T-cell development and immune functions in TRIM-deficient mice. Mol Cell Biol (2006) 0.87
A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration. Eur J Immunol (2008) 0.86
Lipid-binding hSH3 domains in immune cell adapter proteins. J Mol Biol (2006) 0.86
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. J Cell Biol (2008) 0.86
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling. PLoS One (2011) 0.86
A novel flow cytometric assay focusing on perforin release mechanisms of cytotoxic T lymphocytes. J Immunol Methods (2004) 0.85
Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke. Acta Neuropathol (2014) 0.84
Integrating signals from the T-cell receptor and the interleukin-2 receptor. PLoS Comput Biol (2011) 0.84
TCR-induced activation of Ras proceeds at the plasma membrane and requires palmitoylation of N-Ras. J Immunol (2010) 0.83
The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. J Neurosci (2014) 0.82
Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein. J Immunol (2002) 0.82
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation. J Immunol Methods (2012) 0.81
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function. Eur J Immunol (2012) 0.81
T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional mu-opioid receptors. Mol Pharmacol (2008) 0.81
Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta. Infect Immun (2010) 0.81
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. PLoS One (2011) 0.80
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells. Mol Cell Biol (2013) 0.80
First insight into the kinome of human regulatory T cells. PLoS One (2012) 0.80
The adapter protein ADAP is required for selected dendritic cell functions. Cell Commun Signal (2012) 0.80
Stoichiometry and intracellular fate of TRIM-containing TCR complexes. Cell Commun Signal (2010) 0.80
Right time, right place: the organization of membrane proximal signaling. Semin Immunol (2005) 0.79
TCR activation kinetics and feedback regulation in primary human T cells. Cell Commun Signal (2013) 0.79
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. Cell Commun Signal (2013) 0.79
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Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma. Eur J Cancer (2009) 0.78
Molecular regulation of cytoskeletal rearrangements during T cell signalling. Results Probl Cell Differ (2006) 0.78
Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters. Mol Cell Proteomics (2013) 0.78
The SLP-76 Src homology 2 domain is required for T cell development and activation. J Immunol (2011) 0.78
CD26/DP IV in T cell activation and autoimmunity. Adv Exp Med Biol (2006) 0.77
Metallic wear debris may regulate CXCR4 expression in vitro and in vivo. J Biomed Mater Res A (2014) 0.77
T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice. J Immunol (2013) 0.77
TCR-triggered extracellular superoxide production is not required for T-cell activation. Cell Commun Signal (2014) 0.77
Transmembrane adapters: structure, biochemistry and biology. Semin Immunol (2004) 0.77