Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.

PubWeight™: 1.08‹?› | Rank: Top 10%

🔗 View Article (PMC 2277025)

Published in J Physiol on July 12, 2007

Authors

Eva Breunig1, Klaus Michel, Florian Zeller, Stefan Seidl, Claus Werner Hann v Weyhern, Michael Schemann

Author Affiliations

1: Department of Human Biology, Technische Universität München, Hochfeldweg 2, Freising-Weihenstephan, Germany.

Articles citing this

Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X₁, P2X₂, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission. Neuropharmacology (2015) 1.45

The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol (2009) 1.22

Fast calcium and voltage-sensitive dye imaging in enteric neurones reveal calcium peaks associated with single action potential discharge. J Physiol (2011) 0.99

Potential for developing purinergic drugs for gastrointestinal diseases. Inflamm Bowel Dis (2014) 0.90

The mast cell degranulator compound 48/80 directly activates neurons. PLoS One (2012) 0.88

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev (2015) 0.88

Activity of protease-activated receptors in primary cultured human myenteric neurons. Front Neurosci (2012) 0.86

Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine. Am J Physiol Gastrointest Liver Physiol (2009) 0.86

Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction. Br J Pharmacol (2013) 0.85

Identification of histamine receptors and effects of histamine on murine and simian colonic excitability. Neurogastroenterol Motil (2011) 0.83

Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol (2012) 0.83

Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside. J Neurogastroenterol Motil (2016) 0.83

Histamine H₄ receptors in the gastrointestinal tract. Br J Pharmacol (2015) 0.82

Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor. PLoS One (2013) 0.81

Translational neuropharmacology: the use of human isolated gastrointestinal tissues. Br J Pharmacol (2013) 0.81

Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol (2014) 0.80

Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol (2013) 0.80

Communication between mast cells and rat submucosal neurons. Pflugers Arch (2014) 0.78

Reduced Responses of Submucous Neurons from Irritable Bowel Syndrome Patients to a Cocktail Containing Histamine, Serotonin, TNFα, and Tryptase (IBS-Cocktail). Front Neurosci (2015) 0.76

Anti-Hu antibodies activate enteric and sensory neurons. Sci Rep (2016) 0.75

Possible therapeutic role of IgE blockade in irritable bowel syndrome. World J Gastroenterol (2016) 0.75

Articles cited by this

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology (2004) 4.05

The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev Neurosci (2003) 2.71

The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov (2005) 1.67

Anti-immunoglobulin E-stimulated ion transport in human large and small intestine. Gastroenterology (1993) 1.64

Mast cells are closely apposed to nerves in the human gastrointestinal mucosa. Gastroenterology (1989) 1.61

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther (2004) 1.58

Enteric neuroimmunophysiology and pathophysiology. Gastroenterology (2004) 1.53

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther (2005) 1.52

Key role of mast cells and their major secretory products in inflammatory bowel disease. World J Gastroenterol (2004) 1.48

Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology (2005) 1.30

What is the physiological function of mast cells? Exp Dermatol (2003) 1.26

The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol Sci (2005) 1.26

Functional gastrointestinal disorders and mast cells: implications for therapy. Neurogastroenterol Motil (2006) 1.23

Plasticity of the enteric nervous system during intestinal inflammation. Neurogastroenterol Motil (2005) 1.23

Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease. Neurogastroenterol Motil (2001) 1.22

Allergic reactions of rat jejunal mucosa. Ion transport responses to luminal antigen and inflammatory mediators. Gastroenterology (1990) 1.20

Keynote review: histamine H3 receptor antagonists reach out for the clinic. Drug Discov Today (2005) 1.19

Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine. J Physiol (1984) 1.13

The human enteric nervous system. Neurogastroenterol Motil (2004) 1.13

Neuroimmune communication in the submucous plexus of guinea pig colon after sensitization to milk antigen. Am J Physiol (1994) 1.12

Histamine: A mediator of inflammation. J Allergy Clin Immunol (2003) 1.12

Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut (2005) 1.11

Cutting-edge technology. III. Imaging and the gastrointestinal tract: mapping the human enteric nervous system. Am J Physiol Gastrointest Liver Physiol (2002) 1.10

Mucosal histamine content and histamine secretion in Crohn's disease, ulcerative colitis and allergic enteropathy. Int Arch Allergy Immunol (1995) 1.08

Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat. Eur J Pharmacol (2005) 1.05

Multisite optical recording of excitability in the enteric nervous system. Neurogastroenterol Motil (1999) 1.03

Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia. Neuroscience (1988) 1.03

Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors. Gastroenterology (2005) 1.02

Regulation of ion transport by histamine in human colon. Eur J Pharmacol (1995) 0.99

Histamine, mast cells, and the enteric nervous system in the irritable bowel syndrome, enteritis, and food allergies. Gut (2006) 0.96

Histamine H3 receptor-mediated suppression of inhibitory synaptic transmission in the submucous plexus of guinea-pig small intestine. Eur J Pharmacol (2000) 0.95

Human mast cell mediator cocktail excites neurons in human and guinea-pig enteric nervous system. Neurogastroenterol Motil (2005) 0.91

Histamine receptors on submucous neurons in guinea pig colon. Am J Physiol (1993) 0.89

Roles of histamine and its receptors in allergic and inflammatory bowel diseases. World J Gastroenterol (2005) 0.89

Immune regulation of human colonic electrolyte transport in vitro. Gut (1995) 0.89

Species-related pharmacological heterogeneity of histamine H(3) receptors. Eur J Pharmacol (2001) 0.86

Cholinergic and VIP-ergic pathways mediate histamine H2 receptor-induced cyclical secretion in the guinea pig colon. Am J Physiol (1995) 0.84

Genetic and pharmacological aspects of histamine H3 receptor heterogeneity. Life Sci (2003) 0.84

Histamine H3-receptor isoforms. Inflamm Res (2004) 0.81

Articles by these authors

The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut (2010) 3.12

Combined transcriptome and genome analysis of single micrometastatic cells. Nat Biotechnol (2002) 2.48

Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J Vasc Surg (2008) 2.24

Intratumoral spatial distribution of hypoxia and angiogenesis assessed by 18F-FAZA and 125I-Gluco-RGD autoradiography. J Nucl Med (2008) 2.22

Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun (2013) 2.08

Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med (2006) 1.98

Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation. Gastroenterology (2011) 1.96

Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. Gastroenterology (2006) 1.66

Irritable bowel syndrome--the main recommendations. Dtsch Arztebl Int (2011) 1.56

Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology (2009) 1.50

Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med (2009) 1.41

Stillbirth in week 19 of pregnancy followed by maternal death as a consequence of refused chemotherapy for non-hodgkin's lymphoma--significance of adjuvant chemotherapy in women of reproductive age. Onkologie (2010) 1.38

Optical pumping of a single hole spin in a quantum dot. Nature (2008) 1.32

Combined reporter gene PET and iron oxide MRI for monitoring survival and localization of transplanted cells in the rat heart. J Nucl Med (2009) 1.28

Mast cell-nerve axis with a focus on the human gut. Biochim Biophys Acta (2011) 1.22

Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography. Cardiovasc Res (2008) 1.21

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen. Gut (2013) 1.20

Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function. Am J Physiol Gastrointest Liver Physiol (2006) 1.19

Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT. Eur J Nucl Med Mol Imaging (2008) 1.17

Diet-induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line-derived neurotrophic factor. J Physiol (2011) 1.14

ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. Cancer Res (2010) 1.14

Cutting-edge technology. III. Imaging and the gastrointestinal tract: mapping the human enteric nervous system. Am J Physiol Gastrointest Liver Physiol (2002) 1.10

Bacterial proteases in IBD and IBS. Gut (2011) 1.05

Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system. J Comp Neurol (2005) 1.05

Multifunctional rapidly adapting mechanosensitive enteric neurons (RAMEN) in the myenteric plexus of the guinea pig ileum. J Physiol (2009) 1.04

Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J Comp Neurol (2008) 1.04

Virokinin, a bioactive peptide of the tachykinin family, is released from the fusion protein of bovine respiratory syncytial virus. J Biol Chem (2003) 1.04

Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis. Arterioscler Thromb Vasc Biol (2007) 1.04

Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors. Gastroenterology (2005) 1.02

Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol (2008) 1.01

Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo. Basic Res Cardiol (2008) 0.99

Inflammatory infiltrates and neovessels are relevant sources of MMPs in abdominal aortic aneurysm wall. Pathobiology (2009) 0.97

Idiopathic aneurysm of the common iliac artery in an 11-year-old child. J Vasc Surg (2009) 0.96

Retracted Novel role of the CXC chemokine receptor 3 in inflammatory response to arterial injury: involvement of mTORC1. Circ Res (2008) 0.95

Mechanosensitive enteric neurons in the myenteric plexus of the mouse intestine. PLoS One (2012) 0.95

Modern techniques for the diagnostic evaluation of the trephine bone marrow biopsy: methodological aspects and applications. Prog Histochem Cytochem (2008) 0.95

Ruminal muscle of sheep is innervated by non-polarized pathways of cholinergic and nitrergic myenteric neurones. Cell Tissue Res (2002) 0.94

Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice. J Physiol (2013) 0.92

Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice. Circulation (2005) 0.91

Amelanotic esophageal malignant melanoma: case report and short review of the literature. Case Rep Gastroenterol (2008) 0.91

Enteric nervous system. Curr Opin Gastroenterol (2005) 0.89

Reticular groove and reticulum are innervated by myenteric neurons with different neurochemical codes. Anat Rec A Discov Mol Cell Evol Biol (2003) 0.89

Voltage-controlled optics of a quantum dot. Phys Rev Lett (2004) 0.89

Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid. FASEB J (2012) 0.88

Demonstration of functional neuronal beta3-adrenoceptors within the enteric nervous system. Gastroenterology (2007) 0.88

Recordings from human myenteric neurons using voltage-sensitive dyes. J Neurosci Methods (2010) 0.87

Enteric nervous system. Curr Opin Gastroenterol (2006) 0.87

Activity of protease-activated receptors in primary cultured human myenteric neurons. Front Neurosci (2012) 0.86

The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin. Gastroenterology (2009) 0.86

Activity of protease-activated receptors in the human submucous plexus. Gastroenterology (2011) 0.85

Age-associated plasticity in the intrinsic innervation of the ovine rumen. J Anat (2003) 0.84

Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men. Am J Gastroenterol (2007) 0.84

The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions. Arterioscler Thromb Vasc Biol (2006) 0.84

EMAP-II downregulation contributes to the beneficial effects of rapamycin after vascular injury. Cardiovasc Res (2007) 0.84

Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography. J Am Coll Cardiol (2006) 0.84

Rectal carcinoma: high-spatial-resolution MR imaging and T2 quantification in rectal cancer specimens. Radiology (2006) 0.84

Prognostic significance of p21WAF1/CIP1, p27Kip1, p53 and E-cadherin expression in gastric cancer. J Clin Pathol (2007) 0.83

Multicenter double-blinded randomized controlled trial of standard abdominal wound edge protection with surgical dressings versus coverage with a sterile circular polyethylene drape for prevention of surgical site infections: a CHIR-Net trial (BaFO; NCT01181206). Ann Surg (2014) 0.83

Selective activation of human intestinal mast cells by Escherichia coli hemolysin. J Immunol (2008) 0.82

Enteric nervous system. Curr Opin Gastroenterol (2007) 0.82

Optical detection of single-electron spin resonance in a quantum dot. Phys Rev Lett (2008) 0.82

Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor. PLoS One (2013) 0.81

Intrinsic innervation patterns of the smooth muscle in the rumen and reticulum of lambs. J Anat (2004) 0.80

Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations. World J Gastroenterol (2010) 0.79

Republished: bacterial proteases in IBD and IBS. Postgrad Med J (2013) 0.78

Cholinergic and noncholinergic innervation of the smooth muscle layers in the bovine abomasum. Anat Rec (2002) 0.78

Calbindin-immunoreactive neurones in the ovine rumen. Anat Rec A Discov Mol Cell Evol Biol (2004) 0.77

Fiber-based confocal microscope for cryogenic spectroscopy. Rev Sci Instrum (2008) 0.77

Unexpected early failure of a decellularized right ventricle to pulmonary artery graft. Ann Thorac Surg (2008) 0.76

Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction. Am J Physiol Cell Physiol (2011) 0.76

Message from the editors: consolidation. Neurogastroenterol Motil (2004) 0.75

Shaping enteric neurosciences for the future. Neurogastroenterol Motil (2005) 0.75

Vaginal carcinoma in a female-to-male transsexual. J Sex Med (2010) 0.75