Published in Drug Metab Dispos on July 19, 2007
Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat. Drug Metab Dispos (2009) 1.15
Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. Philos Trans R Soc Lond B Biol Sci (2008) 1.06
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity. Drug Metab Dispos (2009) 1.04
The hidden side of drug action: brain temperature changes induced by neuroactive drugs. Psychopharmacology (Berl) (2012) 1.02
Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys. Psychopharmacology (Berl) (2007) 0.96
The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives. Br J Pharmacol (2010) 0.96
Nonhuman primate positron emission tomography neuroimaging in drug abuse research. J Pharmacol Exp Ther (2011) 0.85
Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys. Neuroscience (2011) 0.85
Nonhuman primate neuroimaging and the neurobiology of psychostimulant addiction. Ann N Y Acad Sci (2008) 0.84
Neuroimaging and drug taking in primates. Psychopharmacology (Berl) (2011) 0.83
Nonhuman primate neuroimaging and cocaine medication development. Exp Clin Psychopharmacol (2008) 0.82
Metabolism and disposition of 3,4-methylenedioxymethamphetamine ("ecstasy") in baboons after oral administration: comparison with humans reveals marked differences. J Pharmacol Exp Ther (2011) 0.82
The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male rats. Neuroendocrinology (2008) 0.80
A comparison of intraperitoneal and subcutaneous temperature in freely moving rhesus macaques. Physiol Behav (2011) 0.80
Mechanisms and environmental factors that underlying the intensification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced serotonin syndrome in rats. Psychopharmacology (Berl) (2014) 0.79
State-dependent and environmental modulation of brain hyperthermic effects of psychoactive drugs of abuse. Temperature (Austin) (2014) 0.79
Influence of thyroid hormones on 3,4-methylenedioxymethamphetamine-induced thermogenesis and reinforcing strength in monkeys. Behav Pharmacol (2008) 0.77
3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner. Neuropsychopharmacology (2017) 0.75
Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03
Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci (2002) 3.89
Why primate models matter. Am J Primatol (2014) 2.05
Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Mol Pharmacol (2006) 2.02
Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. J Neurosci (2004) 1.95
The effects of cocaine: a shifting target over the course of addiction. Prog Neuropsychopharmacol Biol Psychiatry (2007) 1.83
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. J Med Chem (2005) 1.74
Effects of Schedule I drug laws on neuroscience research and treatment innovation. Nat Rev Neurosci (2013) 1.70
Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys. Neuropsychopharmacology (2008) 1.67
Bulimic learning. Am J Pharm Educ (2010) 1.54
Assessment of the relative reinforcing strength of cocaine in socially housed monkeys using a choice procedure. J Pharmacol Exp Ther (2004) 1.27
Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. J Pharmacol Exp Ther (2002) 1.25
Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. J Pharmacol Exp Ther (2002) 1.25
Medication discovery for addiction: translating the dopamine D3 receptor hypothesis. Biochem Pharmacol (2012) 1.24
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. J Med Chem (2006) 1.22
Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate. J Neurosci (2002) 1.22
The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics. J Pharmacol Exp Ther (2003) 1.21
The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration. Neurosci Biobehav Rev (2004) 1.21
Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primates. Eur J Neurosci (2006) 1.20
Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states. Mol Pharmacol (2004) 1.19
Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. J Pharmacol Exp Ther (2003) 1.17
Pharmacology: uncoupling the agony from ecstasy. Nature (2003) 1.17
PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry (2005) 1.15
Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys. Neuropsychopharmacology (2010) 1.13
1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. J Med Chem (2006) 1.13
Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists. Mol Pharmacol (2005) 1.12
Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine. Psychopharmacology (Berl) (2004) 1.10
Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates. Neuropsychopharmacology (2012) 1.10
The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine. J Mol Med (Berl) (2004) 1.09
Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys. Neuropsychopharmacology (2008) 1.09
Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology (Berl) (2010) 1.08
Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation. Psychopharmacology (Berl) (2010) 1.08
A comparison of the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") with cocaine in rhesus monkeys. Drug Alcohol Depend (2004) 1.08
WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl) (2006) 1.07
Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain. Psychopharmacology (Berl) (2005) 1.06
Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. Philos Trans R Soc Lond B Biol Sci (2008) 1.06
Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey. J Neurosci (2003) 1.06
The reinforcing efficacy of the dopamine reuptake inhibitor 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys. J Pharmacol Exp Ther (2002) 1.05
WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. Behav Pharmacol (2009) 1.01
Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm. Psychopharmacology (Berl) (2014) 1.00
Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action. Pharmacol Biochem Behav (2007) 1.00
A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases. J Neurochem (2003) 0.99
Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter. Protein Sci (2006) 0.98
Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. J Pharmacol Exp Ther (2011) 0.98
Influence of abstinence and conditions of cocaine access on the reinforcing strength of cocaine in nonhuman primates. Drug Alcohol Depend (2006) 0.98
Hyperthermic syndromes induced by toxins. Clin Lab Med (2006) 0.97
Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement. Biol Psychiatry (2012) 0.97
Alpha1-adrenergic receptors mediate the locomotor response to systemic administration of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) in rats. Pharmacol Biochem Behav (2007) 0.97
Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor. Mol Pharmacol (2007) 0.97
Differential phospholipase C activation by phenylalkylamine serotonin 5-HT 2A receptor agonists. J Neurochem (2005) 0.96
Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. ACS Chem Neurosci (2012) 0.96
Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys. Psychopharmacology (Berl) (2007) 0.96
Toxin-induced hyperthermic syndromes. Med Clin North Am (2005) 0.96
Effects of dopamine D2/D3 receptor ligands on food-cocaine choice in socially housed male cynomolgus monkeys. J Pharmacol Exp Ther (2012) 0.95
Individual differences in the effects of environmental stimuli on cocaine choice in socially housed male cynomolgus monkeys. Psychopharmacology (Berl) (2011) 0.95
Effects of chronic cocaine self-administration on cognition and cerebral glucose utilization in Rhesus monkeys. Biol Psychiatry (2012) 0.95
A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia. Schizophr Res (2007) 0.94
Dantrolene use in 3,4-methylenedioxymethamphetamine (ecstasy)-mediated hyperthermia. Anesthesiology (2004) 0.93
Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology (Berl) (2008) 0.93
Mapping the catechol binding site in dopamine D₁ receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues. ChemMedChem (2011) 0.92
Brain imaging in nonhuman primates: insights into drug addiction. ILAR J (2008) 0.92
New victims of current drug laws. Nat Rev Neurosci (2013) 0.92
Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition. J Pharmacol Exp Ther (2008) 0.92
A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor. J Comput Aided Mol Des (2002) 0.91
Nonhuman primate models of social behavior and cocaine abuse. Psychopharmacology (Berl) (2012) 0.91
Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. Psychopharmacology (Berl) (2005) 0.91
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. J Med Chem (2003) 0.89
8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms. Bioorg Med Chem (2004) 0.89
Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine. Psychopharmacology (Berl) (2010) 0.88
The influence of reinforcing effects of cocaine on cocaine-induced increases in extinguished responding in cynomolgus monkeys. Psychopharmacology (Berl) (2007) 0.88
Effect of time-out duration on the reinforcing strength of cocaine assessed under a progressive-ratio schedule in rhesus monkeys. Behav Pharmacol (2008) 0.87
PET imaging of dopamine D2 receptor and transporter availability during acquisition of cocaine self-administration in rhesus monkeys. J Addict Med (2007) 0.87
Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. J Neurochem (2006) 0.87
Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates. Pharmacol Biochem Behav (2010) 0.87
A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride. CNS Neurosci Ther (2008) 0.87
Pharmacogenomics training using an instructional software system. Am J Pharm Educ (2011) 0.87
Effects of nicotinic acetylcholine receptor agonists on cognition in rhesus monkeys with a chronic cocaine self-administration history. Neuropharmacology (2012) 0.86
Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. Neuropsychopharmacology (2007) 0.86
PET imaging of striatal dopamine D2 receptors in nonhuman primates: increases in availability produced by chronic raclopride treatment. Synapse (2005) 0.86
A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia. Schizophr Res (2007) 0.85
Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther (2009) 0.85
Nelarabine in the treatment of refractory T-cell malignancies. Clin Med Insights Oncol (2010) 0.85
The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Pharmacol Biochem Behav (2006) 0.84
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem (2008) 0.84
Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation. Psychopharmacology (Berl) (2010) 0.84
Effects of chronic methylphenidate in adolescence on later methylphenidate self-administration in rhesus monkeys. Behav Pharmacol (2013) 0.83
Pharmacodynamic characterization of insulin on MDMA-induced thermogenesis. Eur J Pharmacol (2009) 0.83
In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol. Synapse (2002) 0.83
Aripiprazole (OPC-14597) fully substitutes for the 5-HT1A receptor agonist LY293284 in the drug discrimination assay in rats. Psychopharmacology (Berl) (2003) 0.83
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. J Med Chem (2005) 0.83