Published in Toxicol Appl Pharmacol on July 04, 2007
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology (2010) 2.48
Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol (2008) 2.33
Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice. Am J Physiol Gastrointest Liver Physiol (2015) 2.18
Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta (2010) 1.88
Alcohol and lipid metabolism. Am J Physiol Endocrinol Metab (2008) 1.79
Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology (2009) 1.44
Binge ethanol and liver: new molecular developments. Alcohol Clin Exp Res (2013) 1.13
Alcohol sensitivity in Drosophila: translational potential of systems genetics. Genetics (2009) 0.99
Chronic alcohol exposure alters gene expression in HepG2 cells. Alcohol Clin Exp Res (2011) 0.95
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. Genome Biol (2012) 0.93
¹H and ³¹P NMR lipidome of ethanol-induced fatty liver. Alcohol Clin Exp Res (2010) 0.93
Alcohol-induced alterations of the hepatocyte cytoskeleton. World J Gastroenterol (2010) 0.90
Evaluation of the Chinese Medicinal Herb, Graptopetalum paraguayense, as a Therapeutic Treatment for Liver Damage in Rat Models. Evid Based Complement Alternat Med (2012) 0.83
CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway. PLoS One (2014) 0.80
Toxicogenomic biomarkers for liver toxicity. J Toxicol Pathol (2009) 0.80
Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes. BMC Genomics (2011) 0.80
Alteration of gene expression by exposure to a magnetic field at 23 kHz is not detected in astroglia cells. J Radiat Res (2013) 0.78
Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation. J Lipid Res (2013) 0.78
Deleted copy number variation of Hanwoo and Holstein using next generation sequencing at the population level. BMC Genomics (2014) 0.78
A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration. BMC Genomics (2016) 0.77
RGC-32 Deficiency Protects against Hepatic Steatosis by Reducing Lipogenesis. J Biol Chem (2015) 0.77
Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue. Exp Ther Med (2015) 0.77
A snapshot of the hepatic transcriptome: ad libitum alcohol intake suppresses expression of cholesterol synthesis genes in alcohol-preferring (P) rats. PLoS One (2014) 0.76
X-ray-induced changes in the expression of inflammation-related genes in human peripheral blood. Int J Mol Sci (2014) 0.75
Impaired liver function in Xenopus tropicalis exposed to benzo[a]pyrene: transcriptomic and metabolic evidence. BMC Genomics (2014) 0.75
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Mapping human genetic diversity in Asia. Science (2009) 7.40
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes (2008) 3.45
Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. Hepatology (2014) 3.31
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron (2008) 2.88
Identification of new genetic risk variants for type 2 diabetes. PLoS Genet (2010) 2.62
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet (2011) 2.27
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem (2002) 2.16
Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07
Properties of WNK1 and implications for other family members. J Biol Chem (2005) 1.89
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (2004) 1.82
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem (2003) 1.80
ArrayXPath: mapping and visualizing microarray gene-expression data with integrated biological pathway resources using Scalable Vector Graphics. Nucleic Acids Res (2004) 1.79
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics (2010) 1.79
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
SET binding factor 1 (SBF1) mutation causes Charcot-Marie-Tooth disease type 4B3. Neurology (2013) 1.72
A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. Breast Cancer Res (2012) 1.62
ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. Hepatology (2002) 1.54
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J (2006) 1.51
Strain-specific mammary proliferative lesion development following lifetime oral administration of ochratoxin A in DA and Lewis rats. Int J Cancer (2003) 1.49
A genome-wide association study of a coronary artery disease risk variant. J Hum Genet (2013) 1.46
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat Cell Biol (2012) 1.46
Lack of effects of sodium 2-mercaptoethane sulfonate (mesna) on Ochratoxin A induced renal tumorigenicity following life-time oral administration of Ochratoxin A in DA and Lewis rats. Toxicol Lett (2003) 1.42
CD49f enhances multipotency and maintains stemness through the direct regulation of OCT4 and SOX2. Stem Cells (2012) 1.40
Successful stem cell therapy using umbilical cord blood-derived multipotent stem cells for Buerger's disease and ischemic limb disease animal model. Stem Cells (2006) 1.39
Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells. Stem Cells Dev (2008) 1.33
Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells. Stem Cells (2012) 1.32
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway. J Biol Chem (2003) 1.29
Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2. Mol Cell (2010) 1.29
Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. Hepatology (2009) 1.29
Penta-O-galloyl-beta-D-glucose suppresses tumor growth via inhibition of angiogenesis and stimulation of apoptosis: roles of cyclooxygenase-2 and mitogen-activated protein kinase pathways. Carcinogenesis (2005) 1.27
Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Clin Chim Acta (2008) 1.27
DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS One (2011) 1.27
Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy (2009) 1.26
Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer. Clin Cancer Res (2002) 1.26
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. Cell Mol Life Sci (2010) 1.25
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Carcinogenesis (2004) 1.25
Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS One (2011) 1.19
Identification of radiation-specific responses from gene expression profile. Oncogene (2002) 1.16
Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett (2005) 1.15
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis. Blood (2008) 1.15
Additional cases of Chronic Wasting Disease in imported deer in Korea. J Vet Med Sci (2005) 1.12
Body distribution of inhaled fluorescent magnetic nanoparticles in the mice. J Occup Health (2008) 1.10
Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol Cell Endocrinol (2004) 1.10
Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials. Biofactors (2006) 1.10
Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets. Semin Liver Dis (2002) 1.09
Mesenchymal stem cells transfer mitochondria to the cells with virtually no mitochondrial function but not with pathogenic mtDNA mutations. PLoS One (2012) 1.08
Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells. J Vet Sci (2009) 1.08
OCT4A contributes to the stemness and multi-potency of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs). Biochem Biophys Res Commun (2009) 1.08
Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res (2006) 1.08
The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Carcinogenesis (2002) 1.08
Ras/MAP kinase pathways are involved in Ras specific apoptosis induced by sodium butyrate. Cancer Lett (2004) 1.07
Genomic profile analysis of diffuse-type gastric cancers. Genome Biol (2014) 1.07
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. Mol Pharmacol (2002) 1.07
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor. J Biol Chem (2004) 1.06
Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2. Gastroenterology (2013) 1.06
XRCC1 genetic polymorphism and breast cancer risk. Pharmacogenetics (2002) 1.06
Inhibitor of DNA binding 1 activates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1alpha. Mol Cancer Res (2007) 1.06
α-Lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization. Arterioscler Thromb Vasc Biol (2010) 1.05
NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival. Cancer Lett (2002) 1.04
Implication of NOD1 and NOD2 for the differentiation of multipotent mesenchymal stem cells derived from human umbilical cord blood. PLoS One (2010) 1.04
Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients. Breast Cancer Res Treat (2008) 1.04
Roles of p38 and JNK mitogen-activated protein kinase pathways during cantharidin-induced apoptosis in U937 cells. Biochem Pharmacol (2004) 1.03
Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells. Nutr Cancer (2005) 1.03
Prevalence of swine viral and bacterial pathogens in rodents and stray cats captured around pig farms in Korea. J Vet Med Sci (2013) 1.03
MTA1 overexpression correlates significantly with tumor grade and angiogenesis in human breast cancers. Cancer Sci (2006) 1.03
Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int J Cancer (2008) 1.03
In vivo bioluminescence imaging of cord blood derived mesenchymal stem cell transplantation into rat myocardium. Ann Nucl Med (2006) 1.03
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1. Biochem Pharmacol (2010) 1.03
REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. PLoS One (2010) 1.02
Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ. PLoS One (2012) 1.02
Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem (2004) 1.01
Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res (2014) 1.01
Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging. Cell Mol Life Sci (2010) 1.01
A novel class of pyranocoumarin anti-androgen receptor signaling compounds. Mol Cancer Ther (2007) 1.00
Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells. Mol Endocrinol (2004) 1.00
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest (2014) 1.00
Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer. Cancer Res (2008) 1.00
Apoptotic effect of quercetin on HT-29 colon cancer cells via the AMPK signaling pathway. J Agric Food Chem (2010) 1.00
Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia. Eur Neuropsychopharmacol (2002) 0.99
The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha. FEBS Lett (2004) 0.99
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. Biochem Pharmacol (2011) 0.99
A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicol Appl Pharmacol (2004) 0.99
Mylabris phalerlata induces apoptosis by caspase activation following cytochrome c release and Bid cleavage. Life Sci (2003) 0.98
Aging-related genes in mesenchymal stem cells: a mini-review. Gerontology (2013) 0.98
Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription. Mol Cancer Ther (2004) 0.98
Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure. Biochem Biophys Res Commun (2007) 0.98
Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein. Breast Cancer Res (2010) 0.97
Effect of exercise on hepatic gene expression in an obese mouse model using cDNA microarrays. Obesity (Silver Spring) (2006) 0.97
NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling. Stem Cells (2005) 0.97
Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer (2002) 0.97
Molecular basis of R-type calcium channels in central amygdala neurons of the mouse. Proc Natl Acad Sci U S A (2002) 0.97
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett (2008) 0.97
Comparison of canine umbilical cord blood-derived mesenchymal stem cell transplantation times: involvement of astrogliosis, inflammation, intracellular actin cytoskeleton pathways, and neurotrophin-3. Cell Transplant (2011) 0.97
Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha. J Biol Chem (2004) 0.97