Published in Biochim Biophys Acta on July 12, 2007
Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proc Natl Acad Sci U S A (2008) 2.25
Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide. J Am Chem Soc (2008) 1.56
Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective. Acc Chem Res (2011) 1.46
The magic of bicelles lights up membrane protein structure. Chem Rev (2012) 1.33
Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophys J (2012) 1.31
A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity. Biochemistry (2008) 1.27
Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. J Am Chem Soc (2009) 1.26
Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide. J Am Chem Soc (2009) 1.25
Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment. Biochim Biophys Acta (2011) 1.20
Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitus. Exp Diabetes Res (2008) 1.15
Cholesterol reduces pardaxin's dynamics-a barrel-stave mechanism of membrane disruption investigated by solid-state NMR. Biochim Biophys Acta (2009) 1.12
Islets in type 2 diabetes: in honor of Dr. Robert C. Turner. Diabetes (2008) 1.11
NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286). J Am Chem Soc (2009) 1.06
Comprehensive analysis of lipid dynamics variation with lipid composition and hydration of bicelles using nuclear magnetic resonance (NMR) spectroscopy. Langmuir (2009) 0.98
Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol. J Biol Chem (2011) 0.97
Biphasic effects of insulin on islet amyloid polypeptide membrane disruption. Biophys J (2011) 0.97
K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis. J Am Chem Soc (2009) 0.97
Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry (2012) 0.95
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP. Biophys J (2013) 0.93
When detergent meets bilayer: birth and coming of age of lipid bicelles. Prog Nucl Magn Reson Spectrosc (2013) 0.92
Amyloidogenesis abolished by proline substitutions but enhanced by lipid binding. PLoS Comput Biol (2009) 0.91
Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation. PLoS Pathog (2012) 0.90
Retinal conformation and dynamics in activation of rhodopsin illuminated by solid-state H NMR spectroscopy. Photochem Photobiol (2009) 0.88
Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs. Chem Soc Rev (2014) 0.86
Probing ion channel activity of human islet amyloid polypeptide (amylin). Biochim Biophys Acta (2012) 0.86
The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by prion protein(106-126) is dependent on bilayer composition. J Biol Chem (2014) 0.85
Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy. Biochim Biophys Acta (2009) 0.85
Amphiphilic adsorption of human islet amyloid polypeptide aggregates to lipid/aqueous interfaces. J Mol Biol (2011) 0.83
Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels. Phys Chem Chem Phys (2014) 0.83
Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. Chem Commun (Camb) (2016) 0.82
Inhibition of Toxic IAPP Amyloid by Extracts of Common Fruits. J Funct Foods (2015) 0.82
The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH. Eur Biophys J (2010) 0.81
Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments. Phys Chem Chem Phys (2013) 0.80
IAPP aggregation and cellular toxicity are inhibited by 1,2,3,4,6-penta-O-galloyl-β-D-glucose. Amyloid (2013) 0.77
Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem (2015) 0.77
Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. J Diabetes Res (2015) 0.75
Nanotube array method for studying lipid-induced conformational changes of a membrane protein by solid-state NMR. Biophys J (2015) 0.75
Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β. J Biol Chem (2017) 0.75
The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP. J Diabetes Res (2015) 0.75
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem (2005) 4.23
The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes (1999) 3.30
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci U S A (1990) 3.29
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? Q Rev Biophys (2006) 2.47
Detergent-like actions of linear amphipathic cationic antimicrobial peptides. Biochim Biophys Acta (2006) 1.93
Solid-state NMR investigation of the membrane-disrupting mechanism of antimicrobial peptides MSI-78 and MSI-594 derived from magainin 2 and melittin. Biophys J (2006) 1.70
The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells. FEBS J (2006) 1.68
Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions. Biochemistry (2004) 1.60
Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Lett (2004) 1.59
An innovative procedure using a sublimable solid to align lipid bilayers for solid-state NMR studies. Biophys J (2002) 1.50
Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. J Mol Biol (2004) 1.44
Islet amyloid polypeptide inserts into phospholipid monolayers as monomer. J Mol Biol (2005) 1.35
A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release. J Neurosci (2001) 1.26
Multinuclear NMR studies of single lipid bilayers supported in cylindrical aluminum oxide nanopores. Langmuir (2004) 1.20
Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study. Biopolymers (2003) 1.17
Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions. J Mol Biol (2005) 1.12
Cell selectivity correlates with membrane-specific interactions: a case study on the antimicrobial peptide G15 derived from granulysin. Biochim Biophys Acta (2006) 1.06
Aggregation of an amyloidogenic fragment of human islet amyloid polypeptide. Biochim Biophys Acta (2000) 1.02
Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation. FEBS Lett (2001) 0.96
Solid-state NMR spectroscopic studies of an integral membrane protein inserted into aligned phospholipid bilayer nanotube arrays. J Am Chem Soc (2004) 0.95
15N and 31P solid-state NMR study of transmembrane domain alignment of M2 protein of influenza A virus in hydrated cylindrical lipid bilayers confined to anodic aluminum oxide nanopores. J Magn Reson (2005) 0.95
Micelle formation by a fragment of human islet amyloid polypeptide. Biophys J (2003) 0.94
Conformational studies of human islet amyloid peptide using molecular dynamics and simulated annealing methods. Biopolymers (1998) 0.89
[Islet amyloid and diabetes mellitus type 2]. Ned Tijdschr Geneeskd (2000) 0.80
Ultrastrong and stiff layered polymer nanocomposites. Science (2007) 3.40
Studies on anticancer activities of antimicrobial peptides. Biochim Biophys Acta (2007) 3.24
LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta (2006) 3.05
Membrane thinning due to antimicrobial peptide binding: an atomic force microscopy study of MSI-78 in lipid bilayers. Biophys J (2005) 1.81
NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry (2008) 1.65
The human beta-defensin-3, an antibacterial peptide with multiple biological functions. Biochim Biophys Acta (2006) 1.62
Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide. J Am Chem Soc (2008) 1.56
Solid-state NMR reveals structural and dynamical properties of a membrane-anchored electron-carrier protein, cytochrome b5. J Am Chem Soc (2007) 1.53
A partially folded structure of amyloid-beta(1-40) in an aqueous environment. Biochem Biophys Res Commun (2011) 1.51
An innovative procedure using a sublimable solid to align lipid bilayers for solid-state NMR studies. Biophys J (2002) 1.50
Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy. Biochemistry (2008) 1.47
The cytochromes P450 and b5 and their reductases--promising targets for structural studies by advanced solid-state NMR spectroscopy. Biochim Biophys Acta (2007) 1.47
Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective. Acc Chem Res (2011) 1.46
Misfolded proteins in Alzheimer's disease and type II diabetes. Chem Soc Rev (2011) 1.45
Structure and orientation of pardaxin determined by NMR experiments in model membranes. J Biol Chem (2004) 1.38
Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity. Proc Natl Acad Sci U S A (2010) 1.37
Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR. Biophys J (2005) 1.34
The magic of bicelles lights up membrane protein structure. Chem Rev (2012) 1.33
Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin. Biochim Biophys Acta (2008) 1.31
Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophys J (2012) 1.31
Small molecule modulators of copper-induced Abeta aggregation. J Am Chem Soc (2009) 1.30
Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy. J Am Chem Soc (2009) 1.29
Heteronuclear isotropic mixing separated local field NMR spectroscopy. J Chem Phys (2006) 1.27
A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity. Biochemistry (2008) 1.27
Time-resolved dehydration-induced structural changes in an intact bovine cortical bone revealed by solid-state NMR spectroscopy. J Am Chem Soc (2009) 1.26
Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. J Am Chem Soc (2009) 1.26
Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide. J Am Chem Soc (2009) 1.25
Structures of the dimeric and monomeric variants of magainin antimicrobial peptides (MSI-78 and MSI-594) in micelles and bilayers, determined by NMR spectroscopy. Biochemistry (2006) 1.24
Probing the "charge cluster mechanism" in amphipathic helical cationic antimicrobial peptides. Biochemistry (2010) 1.24
Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. J Am Chem Soc (2009) 1.24
Solid-state NMR analysis of the PGLa peptide orientation in DMPC bilayers: structural fidelity of 2H-labels versus high sensitivity of 19F-NMR. Biophys J (2005) 1.20
Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment. Biochim Biophys Acta (2011) 1.20
Chemical shift tensor - the heart of NMR: Insights into biological aspects of proteins. Prog Nucl Magn Reson Spectrosc (2010) 1.18
Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study. Biopolymers (2003) 1.17
The spectrum of antimicrobial activity of the bacteriocin subtilosin A. J Antimicrob Chemother (2007) 1.17
Bicelle-enabled structural studies on a membrane-associated cytochrome B5 by solid-state MAS NMR spectroscopy. Angew Chem Int Ed Engl (2008) 1.17
Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286). J Phys Chem B (2012) 1.14
Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers. Langmuir (2005) 1.13
A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. J Biol Chem (2013) 1.12
Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Proc Natl Acad Sci U S A (2013) 1.12
Role of zinc in human islet amyloid polypeptide aggregation. J Am Chem Soc (2010) 1.11
A high-resolution solid-state NMR approach for the structural studies of bicelles. J Am Chem Soc (2006) 1.11
Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption. Biochemistry (2012) 1.11
Orientation of the antimicrobial peptide PGLa in lipid membranes determined from 19F-NMR dipolar couplings of 4-CF3-phenylglycine labels. J Magn Reson (2004) 1.10
Two-dimensional homonuclear chemical shift correlation established by the cross-relaxation driven spin diffusion in solids. J Chem Phys (2008) 1.10
Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. J Am Chem Soc (2013) 1.07
Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target. Int J Biochem Cell Biol (2012) 1.07
High-resolution 2D NMR spectroscopy of bicelles to measure the membrane interaction of ligands. J Am Chem Soc (2007) 1.07
Antimicrobial activity and membrane selective interactions of a synthetic lipopeptide MSI-843. Biochim Biophys Acta (2005) 1.07
NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286). J Am Chem Soc (2009) 1.06
Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins. Angew Chem Int Ed Engl (2011) 1.06
Antimicrobial and membrane disrupting activities of a peptide derived from the human cathelicidin antimicrobial peptide LL37. Biophys J (2010) 1.06
NMR structure of pardaxin, a pore-forming antimicrobial peptide, in lipopolysaccharide micelles: mechanism of outer membrane permeabilization. J Biol Chem (2009) 1.05
Automatic assignment of the intrinsically disordered protein Tau with 441-residues. J Am Chem Soc (2010) 1.05
Helical hairpin structure of a potent antimicrobial peptide MSI-594 in lipopolysaccharide micelles by NMR spectroscopy. Chemistry (2009) 1.04
Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A. Chem Phys Lipids (2005) 1.03
Proton-evolved local-field solid-state NMR studies of cytochrome b5 embedded in bicelles, revealing both structural and dynamical information. J Am Chem Soc (2010) 1.03
Probing the spontaneous membrane insertion of a tail-anchored membrane protein by sum frequency generation spectroscopy. J Am Chem Soc (2010) 1.03
Solid-state NMR and molecular dynamics simulations reveal the oligomeric ion-channels of TM2-GABA(A) stabilized by intermolecular hydrogen bonding. Biochim Biophys Acta (2008) 1.02
Natural-abundance 43Ca solid-state NMR spectroscopy of bone. J Am Chem Soc (2010) 1.02
Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues. J Proteome Res (2011) 1.02
Sensitivity and resolution enhancement in solid-state NMR spectroscopy of bicelles. J Magn Reson (2006) 1.02
Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins. J Am Chem Soc (2010) 1.01
Using fluorous amino acids to probe the effects of changing hydrophobicity on the physical and biological properties of the beta-hairpin antimicrobial peptide protegrin-1. Biochemistry (2008) 1.01
Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion. Biophys J (2009) 1.00
Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR. Biochemistry (2013) 0.99
Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides. FEBS J (2009) 0.99
Comprehensive analysis of lipid dynamics variation with lipid composition and hydration of bicelles using nuclear magnetic resonance (NMR) spectroscopy. Langmuir (2009) 0.98
Structure, interactions, and antibacterial activities of MSI-594 derived mutant peptide MSI-594F5A in lipopolysaccharide micelles: role of the helical hairpin conformation in outer-membrane permeabilization. J Am Chem Soc (2010) 0.98
Using fluorous amino acids to modulate the biological activity of an antimicrobial peptide. Chembiochem (2008) 0.98
Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease. Chem Soc Rev (2014) 0.98
'Boomerang'-like insertion of a fusogenic peptide in a lipid membrane revealed by solid-state 19F NMR. Magn Reson Chem (2004) 0.98
Biphasic effects of insulin on islet amyloid polypeptide membrane disruption. Biophys J (2011) 0.97
Amphipathic helical cationic antimicrobial peptides promote rapid formation of crystalline states in the presence of phosphatidylglycerol: lipid clustering in anionic membranes. Biophys J (2010) 0.96
Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species. Inorg Chem (2011) 0.95
NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG. J Mol Biol (2011) 0.95
INEPT-based separated-local-field NMR spectroscopy: a unique approach to elucidate side-chain dynamics of membrane-associated proteins. J Am Chem Soc (2010) 0.95
Solution structure and interaction of the antimicrobial polyphemusins with lipid membranes. Biochemistry (2005) 0.95
The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency. Biochim Biophys Acta (2011) 0.95
Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry (2012) 0.95
Effects of antidepressants on the conformation of phospholipid headgroups studied by solid-state NMR. Magn Reson Chem (2004) 0.94
Membrane orientation of MSI-78 measured by sum frequency generation vibrational spectroscopy. Langmuir (2011) 0.94
Probing the transmembrane structure and topology of microsomal cytochrome-p450 by solid-state NMR on temperature-resistant bicelles. Sci Rep (2013) 0.93
Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences. PeerJ (2013) 0.93
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP. Biophys J (2013) 0.93
Solid state 19F NMR parameters of fluorine-labeled amino acids. Part II: aliphatic substituents. J Magn Reson (2007) 0.92
Dynamic interaction between membrane-bound full-length cytochrome P450 and cytochrome b5 observed by solid-state NMR spectroscopy. Sci Rep (2013) 0.92
When detergent meets bilayer: birth and coming of age of lipid bicelles. Prog Nucl Magn Reson Spectrosc (2013) 0.92
High-resolution structural insights into bone: a solid-state NMR relaxation study utilizing paramagnetic doping. J Phys Chem B (2012) 0.91
Limiting an antimicrobial peptide to the lipid-water interface enhances its bacterial membrane selectivity: a case study of MSI-367. Biochemistry (2010) 0.91
Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis. J Proteome Res (2012) 0.91
Pseudonegative thermal expansion and the state of water in graphene oxide layered assemblies. ACS Nano (2012) 0.91
A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc. J Mol Biol (2011) 0.91
Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides? Front Immunol (2012) 0.91
Fluorine--a new element in the design of membrane-active peptides. Mol Biosyst (2009) 0.89
Solid-state NMR spectroscopy of aligned lipid bilayers at low temperatures. J Am Chem Soc (2004) 0.89