Published in Int Orthop on August 01, 2007
Use and efficacy of bone morphogenetic proteins in fracture healing. Int Orthop (2011) 1.49
Teriparatide, a nonsurgical solution for femoral nonunion? A report of three cases. Osteoporos Int (2012) 1.29
Biological aspects of bone, cartilage and tendon regeneration. Int Orthop (2007) 1.26
WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity. J Bone Miner Res (2011) 1.23
Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. Biomaterials (2009) 1.23
Atrophic femoral nonunion successfully treated with teriparatide. Eur J Orthop Surg Traumatol (2012) 1.23
Successful treatment of sternal fracture nonunion with teriparatide. Osteoporos Int (2009) 1.13
Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7. Int J Nanomedicine (2011) 1.06
Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2). Bone (2011) 1.04
Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study. Clin Orthop Relat Res (2009) 1.03
The clinical use of bone morphogenetic proteins revisited: a novel biocompatible carrier device OSTEOGROW for bone healing. Int Orthop (2013) 1.00
Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle. Biomaterials (2014) 0.99
Elucidating multiscale periosteal mechanobiology: a key to unlocking the smart properties and regenerative capacity of the periosteum? Tissue Eng Part B Rev (2013) 0.97
Gene therapy approaches to regenerating bone. Adv Drug Deliv Rev (2012) 0.97
Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification. Tissue Eng Part A (2010) 0.96
Creation of bony microenvironment with CaP and cell-derived ECM to enhance human bone-marrow MSC behavior and delivery of BMP-2. Biomaterials (2011) 0.96
Current medical treatment strategies concerning fracture healing. Clin Cases Miner Bone Metab (2013) 0.95
Steroid regulation of proliferation and osteogenic differentiation of bone marrow stromal cells: a gender difference. J Steroid Biochem Mol Biol (2009) 0.94
Microstructured titanium regulates interleukin production by osteoblasts, an effect modulated by exogenous BMP-2. Acta Biomater (2012) 0.93
Biological aspects of segmental bone defects management. Int Orthop (2015) 0.93
In vivo transplantation of autogenous marrow-derived cells following rapid intraoperative magnetic separation based on hyaluronan to augment bone regeneration. Tissue Eng Part A (2012) 0.92
Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2. Stem Cells Transl Med (2012) 0.90
Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures. Int Orthop (2008) 0.87
A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2. Tissue Eng Part B Rev (2016) 0.87
Efficacy of minimally invasive techniques for enhancement of fracture healing: evidence today. Int Orthop (2010) 0.86
In vivo behaviour of low-temperature calcium-deficient hydroxyapatite: comparison with deproteinised bovine bone. Int Orthop (2010) 0.84
Custom-made composite scaffolds for segmental defect repair in long bones. Int Orthop (2010) 0.83
Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. J Orthop Res (2010) 0.83
Recombinant human BMP-2 increases the incidence and rate of healing in complex ankle arthrodesis. Clin Orthop Relat Res (2013) 0.83
Bone morphogenetic protein and orthopaedic surgery: can we legitimate its off-label use? Int Orthop (2014) 0.82
Ultrasound stimulation increases proliferation of MC3T3-E1 preosteoblast-like cells. J Ther Ultrasound (2014) 0.82
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation. Beilstein J Org Chem (2015) 0.82
Repair of segmental long-bone defects by stem cell concentrate augmented scaffolds: a clinical and positron emission tomography--computed tomography analysis. Int Orthop (2013) 0.82
The Masquelet technique for membrane induction and the healing of ovine critical sized segmental defects. PLoS One (2014) 0.81
Coordinated regulation of mesenchymal stem cell differentiation on microstructured titanium surfaces by endogenous bone morphogenetic proteins. Bone (2014) 0.80
Repetitive recombinant human bone morphogenetic protein 2 injections improve the callus microarchitecture and mechanical stiffness in a sheep model of distraction osteogenesis. Orthop Rev (Pavia) (2012) 0.80
Hyaluronan-based heparin-incorporated hydrogels for generation of axially vascularized bioartificial bone tissues: in vitro and in vivo evaluation in a PLDLLA-TCP-PCL-composite system. J Mater Sci Mater Med (2011) 0.80
Small-molecule based musculoskeletal regenerative engineering. Trends Biotechnol (2014) 0.80
Serum albumin enhances bone healing in a nonunion femoral defect model in rats: a computer tomography micromorphometry study. Int Orthop (2013) 0.80
Bone Morphogenic Protein--mRNA upregulation after exposure to low frequency electric field. Int Orthop (2011) 0.79
Runx2 overexpression in bone marrow stromal cells accelerates bone formation in critical-sized femoral defects. Tissue Eng Part A (2010) 0.79
Impacts of age and gender on bone marrow profiles of BMP7, BMPRs and Stro-1⁺ cells in patients with total hip replacement. Int Orthop (2011) 0.79
Use of Teriparatide to improve fracture healing: What is the evidence? World J Orthop (2015) 0.79
Management of tibial non-union with tricalcium phosphate and BMP 7. BMJ Case Rep (2010) 0.79
Clinical need for bone morphogenetic proteins. Int Orthop (2017) 0.78
Recommendations and considerations for the use of biologics in orthopedic surgery. BioDrugs (2012) 0.78
Biomimetic approaches to complex craniofacial defects. Ann Maxillofac Surg (2015) 0.78
Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells. Stem Cell Res Ther (2015) 0.78
Bone morphogenetic protein 7 (BMP-7) influences tendon-bone integration in vitro. PLoS One (2015) 0.78
Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration. Pharm Res (2017) 0.78
Angiopoietin-1 peptide QHREDGS promotes osteoblast differentiation, bone matrix deposition and mineralization on biomedical materials. Biomater Sci (2014) 0.77
Biodistribution of Fracture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing. Biomacromolecules (2015) 0.77
Evaluation of rhBMP-2 and bone marrow derived stromal cell mediated bone regeneration using transgenic fluorescent protein reporter mice. J Biomed Mater Res A (2014) 0.76
Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. PLoS One (2016) 0.76
Far-red fluorescence gene reporter tomography for determination of placement and viability of cell-based gene therapies. Opt Express (2013) 0.75
Gene gun transferring-bone morphogenetic protein 2 (BMP-2) gene enhanced bone fracture healing in rabbits. Int J Clin Exp Med (2015) 0.75
Local application of BMP-2 specific plasmids in fibrin glue does not promote implant fixation. BMC Musculoskelet Disord (2011) 0.75
Long-term functional outcome and quality of life after successful surgical treatment of tibial nonunions. Int Orthop (2014) 0.75
Best one hundred papers of International Orthopaedics: a bibliometric analysis. Int Orthop (2017) 0.75
Bone: formation by autoinduction. Science (1965) 13.34
Novel regulators of bone formation: molecular clones and activities. Science (1988) 10.74
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet (2006) 7.05
Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am (2002) 5.95
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am (2001) 5.13
Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am (2002) 3.64
Growth and transplantation of a custom vascularised bone graft in a man. Lancet (2004) 3.01
Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. N Engl J Med (1996) 2.94
Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine (Phila Pa 1976) (2002) 2.74
Orthopaedic applications of osteogenic protein-1 (BMP-7). Int Orthop (2001) 1.81
Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies. J Bone Joint Surg Am (2006) 1.48
Regulation of BMP-induced transcription in cultured human bone marrow stromal cells. J Bone Joint Surg Am (2003) 1.43
Direct percutaneous gene delivery to enhance healing of segmental bone defects. J Bone Joint Surg Am (2006) 1.32
BMP signaling components are expressed in human fracture callus. Bone (2003) 1.31
Repair of a resistant tibial non-union with a recombinant bone morphogenetic protein-7 (rh-BMP-7). Int Orthop (2003) 1.27
A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J Bone Joint Surg Am (2003) 1.21
Tissue transformation into bone in vivo. A potential practical application. JAMA (1991) 1.16
Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model. J Bone Joint Surg Am (2004) 0.98
rhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations. J Bone Joint Surg Am (2006) 0.96
Use of calcium-based demineralized bone matrix/allograft for nonunions and posttraumatic reconstruction of the appendicular skeleton: preliminary results and complications. J Trauma (2007) 0.92
Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res (2010) 6.00
Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res (2013) 5.76
Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem (2003) 4.34
The clinical importance of meniscal tears demonstrated by magnetic resonance imaging in osteoarthritis of the knee. J Bone Joint Surg Am (2003) 3.39
Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res (2010) 3.33
Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis. J Bone Joint Surg Am (2007) 3.04
The role of growth factors in the repair of bone. Biology and clinical applications. J Bone Joint Surg Am (2002) 2.82
Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A (2008) 2.65
Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res (2002) 2.62
Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis. J Bone Joint Surg Am (2012) 2.31
The biology of fracture healing. Injury (2011) 2.26
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res (2003) 2.24
Fracture healing: the diamond concept. Injury (2007) 2.13
Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty. A meta-analysis. J Bone Joint Surg Am (2005) 2.05
Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am (2005) 2.02
Safety of simultaneous bilateral total knee arthroplasty. A meta-analysis. J Bone Joint Surg Am (2007) 1.89
Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function. Bone (2008) 1.89
Grades of recommendation. J Bone Joint Surg Am (2005) 1.68
Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing. J Bone Miner Res (2009) 1.68
Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity. J Bone Miner Res (2007) 1.67
Factors associated with citation rates in the orthopedic literature. Can J Surg (2007) 1.63
Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures. J Bone Miner Res (2007) 1.59
Qualitative and quantitative differences between bone graft obtained from the medullary canal (with a Reamer/Irrigator/Aspirator) and the iliac crest of the same patient. J Bone Joint Surg Am (2012) 1.50
BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. J Cell Biochem (2003) 1.48
Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res (2002) 1.48
Three-dimensional reconstruction of fracture callus morphogenesis. J Histochem Cytochem (2006) 1.48
How to design a good case series. J Bone Joint Surg Am (2009) 1.46
Recognizing and preventing burnout among orthopaedic leaders. Clin Orthop Relat Res (2008) 1.44
Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease. Cancer Res (2004) 1.43
Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis. J Orthop Res (2004) 1.43
Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling. J Bone Miner Res (2008) 1.42
Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment. J Bone Joint Surg Am (2008) 1.40
Poor citation of prior evidence in hip fracture trials. J Bone Joint Surg Am (2011) 1.40
Fracture healing in the elderly patient. Exp Gerontol (2006) 1.32
The prevalence and severity of burnout among academic orthopaedic departmental leaders. J Bone Joint Surg Am (2007) 1.32
Interobserver agreement in the application of levels of evidence to scientific papers in the American volume of the Journal of Bone and Joint Surgery. J Bone Joint Surg Am (2004) 1.32
Direct percutaneous gene delivery to enhance healing of segmental bone defects. J Bone Joint Surg Am (2006) 1.32
Electrical stimulation for long-bone fracture-healing: a meta-analysis of randomized controlled trials. J Bone Joint Surg Am (2008) 1.30
Bone morphogenetic proteins in orthopaedic surgery. Cytokine Growth Factor Rev (2009) 1.28
Application of histomorphometric methods to the study of bone repair. J Bone Miner Res (2005) 1.26
Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis. Bone (2012) 1.25
Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells. Bone (2007) 1.25
High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing. Am J Pathol (2009) 1.20
Do inhibitors of cyclooxygenase-2 impair bone healing? J Bone Miner Res (2002) 1.18
New technologies for the enhancement of skeletal repair. Injury (2007) 1.17
Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing. J Bone Miner Res (2008) 1.16
Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells. J Bone Miner Res (2002) 1.13
The role of endogenous bone morphogenetic proteins in normal skeletal repair. Injury (2009) 1.13
Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS One (2009) 1.11
TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1. J Bone Miner Res (2010) 1.11
Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment. Bone (2008) 1.10
Analysis of fracture healing by large-scale transcriptional profile identified temporal relationships between metalloproteinase and ADAMTS mRNA expression. Matrix Biol (2006) 1.10
Mechanical stimulation alters tissue differentiation and molecular expression during bone healing. J Orthop Res (2009) 1.09
Use of bone morphogenetic proteins for musculoskeletal applications. An overview. J Bone Joint Surg Am (2004) 1.09
COX inhibitors and their effects on bone healing. Expert Opin Drug Saf (2004) 1.03
The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation. J Bone Miner Res (2011) 1.03
The use of calcium phosphate bone cement in fracture treatment. A meta-analysis of randomized trials. J Bone Joint Surg Am (2008) 1.03
The diamond concept--open questions. Injury (2008) 1.02
Induction of a neoarthrosis by precisely controlled motion in an experimental mid-femoral defect. J Orthop Res (2002) 0.99
Tumor necrosis factor alpha activation of the apoptotic cascade in murine articular chondrocytes is associated with the induction of metalloproteinases and specific pro-resorptive factors. Arthritis Rheum (2003) 0.98
Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing. Bone (2008) 0.97
How good is the orthopaedic literature? Indian J Orthop (2008) 0.97
Bisphosphonates in orthopaedic surgery. J Bone Joint Surg Am (2005) 0.97
Who did what? (Mis)perceptions about authors' contributions to scientific articles based on order of authorship. J Bone Joint Surg Am (2003) 0.96
Revival of bone strength: the bottom line. J Bone Miner Res (2005) 0.96
Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing. J Orthop Res (2007) 0.95
Emerging bone healing therapies. J Orthop Trauma (2010) 0.95
Anabolic agents and bone quality. Clin Orthop Relat Res (2011) 0.94
Use of clinical assessment tools in the evaluation of fracture healing. Injury (2010) 0.94
Increased VEGF expression in the epiphyseal cartilage after ischemic necrosis of the capital femoral epiphysis. J Bone Miner Res (2004) 0.94
Effects of the local mechanical environment on vertebrate tissue differentiation during repair: does repair recapitulate development? J Exp Biol (2003) 0.93
Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose. Hum Gene Ther (2007) 0.92
Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration. Biochem Biophys Res Commun (2011) 0.92
Chemokine expression is upregulated in chondrocytes in diabetic fracture healing. Bone (2012) 0.91
Managing bone defects. J Orthop Trauma (2011) 0.90
Growth factors: beyond bone morphogenetic proteins. J Orthop Trauma (2010) 0.90
An AOA critical issue. The future of the orthopaedic surgeon-proceduralist or keeper of the musculoskeletal system? J Bone Joint Surg Am (2005) 0.89
Orthopaedic war injuries: from combat casualty care to definitive treatment: a current review of clinical advances, basic science, and research opportunities. Instr Course Lect (2008) 0.89
Osteogenic effects of traumatic brain injury on experimental fracture-healing. J Bone Joint Surg Am (2006) 0.88
The validity of claims made in orthopaedic print advertisements. J Bone Joint Surg Am (2003) 0.88
Can we improve fixation and outcomes in the treatment of femoral neck fractures? The use of pharmaceuticals. J Orthop Trauma (2009) 0.87
Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study. Trials (2014) 0.86
American Orthopaedic Association symposium: Evaluating the flood of orthopaedic media and marketing information. J Bone Joint Surg Am (2005) 0.84
Absence of mouse pleiotrophin does not affect bone formation in vivo. Bone (2004) 0.83
Functional role of Runx3 in the regulation of aggrecan expression during cartilage development. J Cell Physiol (2013) 0.83
Bone morphogenetic proteins in musculoskeletal medicine. Injury (2009) 0.82
Healing Time and Complications in Operatively Treated Atypical Femur Fractures Associated With Bisphosphonate Use: A Multicenter Retrospective Cohort. J Orthop Trauma (2016) 0.82
Variability in the approach to total hip arthroplasty in patients with displaced femoral neck fractures. J Arthroplasty (2011) 0.79
Urine matrix metalloproteinases (MMPs) as biomarkers for the progression of fracture healing. Injury (2012) 0.79
Skeletal trauma generates systemic BMP2 activation that is temporally related to the mobilization of CD73+ cells. J Orthop Res (2013) 0.79
Recombinant human bone morphogenetic proteins in the treatment of fractures. Foot Ankle Clin (2005) 0.79
Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model. Arthritis Rheum (2010) 0.78
Overview of osteoporosis: pathophysiology and determinants of bone strength. Eur Spine J (2003) 0.78
Estrogen regulation of growth and alkaline phosphatase expression by cultured human bone marrow stromal cells. J Orthop Res (2002) 0.78
Beyond a reasonable doubt? Bisphosphonates and atypical femur fractures. Bone (2012) 0.78
Fracture healing: a harmony of optimal biology and optimal fixation? Injury (2007) 0.78
Reuse of external fixation components: a randomized trial. J Orthop Trauma (2008) 0.77
Mice expressing a constitutively active PTH/PTHrP receptor in osteoblasts show reduced callus size but normal callus morphology during fracture healing. Acta Orthop (2007) 0.77
Fracture repair: challenges and opportunities. J Bone Joint Surg Am (2008) 0.76