Alan Melcher

Author PubWeight™ 62.02‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors. Nat Med 2011 3.60
2 A simple method to cure established tumors by inflammatory killing of normal cells. Nat Biotechnol 2004 2.39
3 A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancer. Clin Cancer Res 2008 2.18
4 Cyclophosphamide facilitates antitumor efficacy against subcutaneous tumors following intravenous delivery of reovirus. Clin Cancer Res 2008 1.91
5 Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell therapy, oncolytic virotherapy and immunotherapy. Nat Med 2007 1.74
6 Cell carriers for oncolytic viruses: Fed Ex for cancer therapy. Mol Ther 2009 1.72
7 Reovirus activates human dendritic cells to promote innate antitumor immunity. J Immunol 2008 1.70
8 REO-10: a phase I study of intravenous reovirus and docetaxel in patients with advanced cancer. Clin Cancer Res 2010 1.53
9 Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma. Nat Biotechnol 2012 1.52
10 Synergistic effects of oncolytic reovirus and cisplatin chemotherapy in murine malignant melanoma. Clin Cancer Res 2009 1.50
11 Enhancing the efficacy of a weak allogeneic melanoma vaccine by viral fusogenic membrane glycoprotein-mediated tumor cell-tumor cell fusion. Cancer Res 2002 1.42
12 Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer. Cancer Res 2007 1.37
13 Potent selection of antigen loss variants of B16 melanoma following inflammatory killing of melanocytes in vivo. Cancer Res 2005 1.35
14 Type III IFN interleukin-28 mediates the antitumor efficacy of oncolytic virus VSV in immune-competent mouse models of cancer. Cancer Res 2010 1.27
15 The biology of the sodium iodide symporter and its potential for targeted gene delivery. Curr Cancer Drug Targets 2010 1.25
16 Short-course radiotherapy, with elective delay prior to surgery, in patients with unresectable rectal cancer who have poor performance status or significant co-morbidity. Radiother Oncol 2009 1.25
17 Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice. J Clin Invest 2010 1.22
18 Killing of normal melanocytes, combined with heat shock protein 70 and CD40L expression, cures large established melanomas. J Immunol 2006 1.20
19 Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer. BMC Cancer 2011 1.17
20 Improved systemic delivery of oncolytic reovirus to established tumors using preconditioning with cyclophosphamide-mediated Treg modulation and interleukin-2. Clin Cancer Res 2009 1.17
21 Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. FEBS Lett 2007 1.16
22 Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse. Mol Ther 2013 1.16
23 Activating systemic T-cell immunity against self tumor antigens to support oncolytic virotherapy with vesicular stomatitis virus. Hum Gene Ther 2011 1.16
24 Use of biological therapy to enhance both virotherapy and adoptive T-cell therapy for cancer. Mol Ther 2008 1.16
25 VSV oncolytic virotherapy in the B16 model depends upon intact MyD88 signaling. Mol Ther 2010 1.15
26 Interference of CD40L-mediated tumor immunotherapy by oncolytic vesicular stomatitis virus. Hum Gene Ther 2010 1.15
27 Antitumor immunity can be uncoupled from autoimmunity following heat shock protein 70-mediated inflammatory killing of normal pancreas. Cancer Res 2009 1.09
28 Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming. Mol Cancer 2011 1.04
29 Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples. Mod Pathol 2012 1.03
30 Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses. Clin Cancer Res 2007 1.02
31 Treg depletion-enhanced IL-2 treatment facilitates therapy of established tumors using systemically delivered oncolytic virus. Mol Ther 2008 1.00
32 Exploiting synergies between radiation and oncolytic viruses. Curr Opin Mol Ther 2008 0.99
33 Vesicular stomatitis virus-induced immune suppressor cells generate antagonism between intratumoral oncolytic virus and cyclophosphamide. Mol Ther 2010 0.95
34 A new genetic method to generate and isolate small, short-lived but highly potent dendritic cell-tumor cell hybrid vaccines. Nat Med 2003 0.93
35 Precise scheduling of chemotherapy primes VEGF-producing tumors for successful systemic oncolytic virotherapy. Mol Ther 2011 0.92
36 Live viruses to treat cancer. J R Soc Med 2013 0.89
37 Oncolytic viruses: time to compare, contrast, and combine? 5th international meeting on replicating oncolytic virus therapeutics. Banff, Alberta, Canada, 18-22 March 2009. Mol Ther 2009 0.88
38 Differential effects of Paclitaxel on dendritic cell function. BMC Immunol 2010 0.88
39 Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy. Clin Cancer Res 2006 0.87
40 Cryopreserved dendritic cells for intratumoral immunotherapy do not require re-culture prior to human vaccination. J Immunol Methods 2005 0.83
41 Autologous versus allogeneic peptide-pulsed dendritic cells for anti-tumour vaccination: expression of allogeneic MHC supports activation of antigen specific T cells, but impairs early naïve cytotoxic priming and anti-tumour therapy. Cancer Immunol Immunother 2007 0.83
42 The effect of cell cycle synchronization on tumor sensitivity to reovirus oncolysis. Mol Ther 2010 0.82
43 Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery. J Immunother 2009 0.81
44 CD40-mediated death and cytokine secretion in colorectal cancer: a potential target for inflammatory tumour cell killing. Int J Cancer 2007 0.80
45 Oncolytic viruses: do they have a role in anti-cancer therapy? Clin Med Oncol 2008 0.78
46 The efficacy versus toxicity profile of combination virotherapy and TLR immunotherapy highlights the danger of administering TLR agonists to oncolytic virus-treated mice. Mol Ther 2012 0.78
47 An intravenous stimulus package for oncolytic virotherapy. Mol Ther 2011 0.77
48 Future clinical potential of oncolytic virotherapy for pediatric CNS tumors. CNS Oncol 2013 0.77
49 The hitchhiker's guide to virotherapy. Oncotarget 2012 0.77
50 Talimogene laherparepvec in the treatment of melanoma. Expert Opin Biol Ther 2015 0.76
51 Cancer immunotherapy. N Engl J Med 2008 0.75
52 Adenovirally delivered enzyme prodrug therapy with herpes simplex virus-thymidine kinase in composite tissue free flaps shows therapeutic efficacy in rat models of glioma. Plast Reconstr Surg 2015 0.75
53 International symposium on CTL and immunostimulation, Pamplona (Spain), October 26th and 27th 2010. Cancer Immunol Immunother 2011 0.75