Antisense transcription in the human cytomegalovirus transcriptome.

PubWeight™: 1.40‹?› | Rank: Top 5%

🔗 View Article (PMC 2045512)

Published in J Virol on August 08, 2007

Authors

Guojuan Zhang1, Bindu Raghavan, Mark Kotur, Jacquelyn Cheatham, Daniel Sedmak, Charles Cook, James Waldman, Joanne Trgovcich

Author Affiliations

1: The Ohio State University, Department of Pathology, 4162 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.

Articles citing this

Decoding human cytomegalovirus. Science (2012) 2.98

High-resolution human cytomegalovirus transcriptome. Proc Natl Acad Sci U S A (2011) 1.67

Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs. RNA (2010) 1.44

Discrete clusters of virus-encoded micrornas are associated with complementary strands of the genome and the 7.2-kilobase stable intron in murine cytomegalovirus. J Virol (2007) 1.39

High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection. J Virol (2011) 1.28

The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes. J Virol (2010) 1.11

Making sense of antisense: seemingly noncoding RNAs antisense to the master regulator of Kaposi's sarcoma-associated herpesvirus lytic replication do not regulate that transcript but serve as mRNAs encoding small peptides. J Virol (2010) 1.05

The DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery. Proc Natl Acad Sci U S A (2012) 1.04

Dual analysis of the murine cytomegalovirus and host cell transcriptomes reveal new aspects of the virus-host cell interface. PLoS Pathog (2013) 0.99

High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive recombination. J Virol (2015) 0.98

Temporal profiling of the coding and noncoding murine cytomegalovirus transcriptomes. J Virol (2011) 0.93

Global bidirectional transcription of the Epstein-Barr virus genome during reactivation. J Virol (2013) 0.93

Identification and expression analysis of herpes B virus-encoded small RNAs. J Virol (2011) 0.91

Roles of host and viral microRNAs in human cytomegalovirus biology. Virus Res (2010) 0.91

A method enabling high-throughput sequencing of human cytomegalovirus complete genomes from clinical isolates. PLoS One (2014) 0.89

Anguillid herpesvirus 1 transcriptome. J Virol (2012) 0.88

Elongin B-mediated epigenetic alteration of viral chromatin correlates with efficient human cytomegalovirus gene expression and replication. MBio (2011) 0.87

A lytic viral long noncoding RNA modulates the function of a latent protein. J Virol (2013) 0.87

Comparative genomics of carp herpesviruses. J Virol (2012) 0.84

Nucleosome maps of the human cytomegalovirus genome reveal a temporal switch in chromatin organization linked to a major IE protein. Proc Natl Acad Sci U S A (2013) 0.83

Pervasive transcription of a herpesvirus genome generates functionally important RNAs. MBio (2014) 0.83

Transcriptional interference networks coordinate the expression of functionally related genes clustered in the same genomic loci. Front Genet (2012) 0.82

Complex expression of the UL136 gene of human cytomegalovirus results in multiple protein isoforms with unique roles in replication. J Virol (2014) 0.81

Characterization of novel transcripts in pseudorabies virus. Viruses (2015) 0.79

Functional annotation of human cytomegalovirus gene products: an update. Front Microbiol (2014) 0.79

Human cytomegalovirus transcriptome activity differs during replication in human fibroblast, epithelial and astrocyte cell lines. J Gen Virol (2012) 0.79

An antisense transcript in the human cytomegalovirus UL87 gene region. Virol J (2011) 0.78

The carboxy terminal region of the human cytomegalovirus immediate early 1 (IE1) protein disrupts type II inteferon signaling. Viruses (2014) 0.76

Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P. Virol J (2010) 0.76

Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation. Viruses (2016) 0.76

Analysis and mapping of a 3' coterminal transcription unit derived from human cytomegalovirus open reading frames UL30-UL32. Virol J (2013) 0.75

Identification of the alternative splicing of the UL49 locus of human cytomegalovirus. Biomed Res Int (2015) 0.75

Articles cited by this

A greedy algorithm for aligning DNA sequences. J Comput Biol (2000) 47.89

Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr Top Microbiol Immunol (1990) 16.31

Antisense transcription in the mammalian transcriptome. Science (2005) 15.69

Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98

Non-coding RNA. Hum Mol Genet (2006) 10.57

Ribo-gnome: the big world of small RNAs. Science (2005) 10.10

Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol (2003) 8.54

Structural analysis of the major immediate early gene of human cytomegalovirus. J Virol (1984) 6.67

Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. J Virol (1996) 6.64

Plaque assay of cytomegalovirus strains of human origin. Proc Soc Exp Biol Med (1970) 5.90

Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169. Virology (1983) 4.58

Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc Natl Acad Sci U S A (2003) 4.37

Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol (2004) 4.30

In search of antisense. Trends Biochem Sci (2004) 3.93

The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J Gen Virol (2003) 3.48

Retracted Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript. Nature (2006) 3.47

Over 20% of human transcripts might form sense-antisense pairs. Nucleic Acids Res (2004) 3.45

Antisense transcripts with FANTOM2 clone set and their implications for gene regulation. Genome Res (2003) 3.40

Antisense transcripts in the human genome. Trends Genet (2002) 3.33

Computational discovery of sense-antisense transcription in the human and mouse genomes. Genome Biol (2002) 3.28

A cis-acting element within the 5' leader of a cytomegalovirus beta transcript determines kinetic class. Cell (1986) 3.20

A subset of viral transcripts packaged within human cytomegalovirus particles. Science (2000) 3.19

Proteins associated with purified human cytomegalovirus particles. J Virol (1996) 3.01

Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals. Proc Natl Acad Sci U S A (1996) 2.87

Regulation of cytomegalovirus late gene expression: gamma genes are controlled by posttranscriptional events. J Virol (1986) 2.84

DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression. J Virol (1999) 2.80

Identification and characterization of human cytomegalovirus-encoded microRNAs. J Virol (2005) 2.73

A human cytomegalovirus early gene has three inducible promoters that are regulated differentially at various times after infection. J Virol (1989) 2.70

Replication of wild-type and mutant human cytomegalovirus in life-extended human diploid fibroblasts. J Virol (2000) 2.41

Translational control of cytomegalovirus gene expression is mediated by upstream AUG codons. J Virol (1988) 2.35

Expression of a herpes simplex virus 1 open reading frame antisense to the gamma(1)34.5 gene and transcribed by an RNA 3' coterminal with the unspliced latency-associated transcript. J Virol (1994) 2.34

Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science (2007) 2.29

Reevaluation of human cytomegalovirus coding potential. Proc Natl Acad Sci U S A (2003) 2.27

Glycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins. J Virol (2000) 2.26

Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J Intern Med (2006) 2.22

Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species. Nucleic Acids Res (2006) 2.21

Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: a model for latency. Proc Natl Acad Sci U S A (2002) 2.15

Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts. Trends Genet (2005) 2.04

Detection and preliminary characterization of herpes simplex virus type 1 transcripts in latently infected human trigeminal ganglia. J Virol (1988) 1.92

Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs. J Virol (2002) 1.92

Marek's disease virus encodes MicroRNAs that map to meq and the latency-associated transcript. J Virol (2006) 1.91

Disclosing hidden transcripts: mouse natural sense-antisense transcripts tend to be poly(A) negative and nuclear localized. Genome Res (2005) 1.85

Expression of the human cytomegalovirus UL36-38 immediate early region during permissive infection. Virology (1991) 1.83

Expression of a human cytomegalovirus late gene is posttranscriptionally regulated by a 3'-end-processing event occurring exclusively late after infection. Mol Cell Biol (1986) 1.78

Human cytomegalovirus expresses novel microRNAs during productive viral infection. Cell Microbiol (2005) 1.76

Nucleotide sequence of the most abundantly transcribed early gene of human cytomegalovirus strain AD169. Virus Res (1987) 1.73

Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are 3' coterminal and encode a putative zinc finger transactivator protein. J Virol (1992) 1.66

Coding sequence-dependent ribosomal arrest at termination of translation. Mol Cell Biol (1996) 1.54

Preservation of natural endothelial cytopathogenicity of cytomegalovirus by propagation in endothelial cells. Arch Virol (1991) 1.52

Precise localization of genes on large animal virus genomes: use of lambda gt11 and monoclonal antibodies to map the gene for a cytomegalovirus protein family. Proc Natl Acad Sci U S A (1985) 1.50

Discordant expression of the immediate-early 1 and 2 gene regions of human cytomegalovirus at early times after infection involves posttranscriptional processing events. J Virol (1991) 1.48

Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit. J Virol (1989) 1.45

Overlapping transcripts, double-stranded RNA and antisense regulation: a genomic perspective. Cell Mol Life Sci (2006) 1.41

Overlapping antisense transcription in the human genome. Comp Funct Genomics (2002) 1.40

The DNA sequence of the human cytomegalovirus genome. DNA Seq (1991) 1.38

Organization and expression of the major genes from the long inverted repeat of the human cytomegalovirus genome. Virology (1986) 1.38

Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts. Nucleic Acids Res (2005) 1.37

The three major immediate-early transcripts of bovine herpesvirus 1 arise from two divergent and spliced transcription units. J Virol (1991) 1.37

Characterization of an antisense transcript spanning the UL81-82 locus of human cytomegalovirus. J Virol (2005) 1.32

Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infection. J Virol (2005) 1.24

Antisense overlapping open reading frames in genes from bacteria to humans. Nucleic Acids Res (1994) 1.18

Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein. J Virol (2001) 1.15

The heterogenous regions in herpes simplex virus 1 DNA. Microbiologica (1983) 1.11

Ribosomal release without peptidyl tRNA hydrolysis at translation termination in a eukaryotic system. RNA (1998) 1.08

Molecular cloning and analysis of three cDNA clones homologous to human cytomegalovirus RNAs present during late infection. J Virol (1986) 1.08

Human cytomegalovirus UL102 gene. J Virol (1995) 1.07

Antisense RNA mediates transcriptional processing in an archaebacterium, indicating a novel kind of RNase activity. Mol Microbiol (1993) 1.06

Two overlapping transcription units which extend across the L-S junction of herpes simplex virus type 1. J Virol (1995) 1.05

T lymphocyte activation by cytomegalovirus-infected, allogeneic cultured human endothelial cells. Transplantation (1992) 1.03

Properties of two 5'-coterminal RNAs transcribed part way and across the S component origin of DNA synthesis of the herpes simplex virus 1 genome. Proc Natl Acad Sci U S A (1988) 1.02

Analysis of splice variants of the immediate-early 1 region of human cytomegalovirus. J Virol (2004) 1.00

Identification of latency-associated transcripts that map antisense to the ICP4 homolog gene of Marek's disease virus. J Virol (1994) 0.99

The IR3 gene of equine herpesvirus type 1: a unique gene regulated by sequences within the intron of the immediate-early gene. DNA Seq (1992) 0.99

Identification of novel transcripts complementary to the Marek's disease virus homologue of the ICP4 gene of herpes simplex virus. J Gen Virol (1994) 0.98

Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription. J Virol (1996) 0.98

Human cytomegalovirus open reading frame UL11 encodes a highly polymorphic protein expressed on the infected cell surface. Arch Virol (1997) 0.95

UL27.5 is a novel gamma2 gene antisense to the herpes simplex virus 1 gene encoding glycoprotein B. J Virol (1998) 0.94

Identification of glycoprotein gpTRL10 as a structural component of human cytomegalovirus. J Virol (2002) 0.94

Abundant early expression of gpUL4 from a human cytomegalovirus mutant lacking a repressive upstream open reading frame. J Virol (2001) 0.90

Transactivation of latent Marek's disease herpesvirus genes in QT35, a quail fibroblast cell line, by herpesvirus of turkeys. J Virol (2000) 0.89

Epstein-Barr virus lytic replication is controlled by posttranscriptional negative regulation of BZLF1. J Virol (1995) 0.89

The BamHI J fragment (0.706 to 0.737 map units) of pseudorabies virus is transcriptionally active during viral replication. J Virol (1990) 0.88

Inability of cytomegalovirus infection of cultured endothelial cells to induce HLA class II antigen expression. Transplantation (1990) 0.87

Repression by RAZ of Epstein-Barr virus bZIP transcription factor EB1 is dimerization independent. J Gen Virol (1996) 0.86

The major open reading frame of the beta2.7 transcript of human cytomegalovirus: in vitro expression of a protein posttranscriptionally regulated by the 5' region. J Virol (1998) 0.86

Analysis of transcripts expressed from the UL47 gene of human cytomegalovirus. Arch Pharm Res (1999) 0.86

Latency of Epstein-Barr virus is stabilized by antisense-mediated control of the viral immediate-early gene BZLF-1. J Med Virol (1999) 0.85

Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice. Virol J (2006) 0.85

Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice. J Virol (2000) 0.84

Diagnostic approaches to cytomegalovirus infection in bone marrow and organ transplantation. Transpl Infect Dis (1999) 0.83

Equine herpesvirus 4 DNA in trigeminal ganglia of naturally infected horses detected by direct in situ PCR. J Gen Virol (1997) 0.78

Detection of latency-associated transcripts of equid herpesvirus 1 in equine leukocytes but not in trigeminal ganglia. J Virol (1997) 0.78

Identification and characterization of two antisense transcripts from the major immediate early region of rat cytomegalovirus. Arch Virol (2005) 0.78

Articles by these authors

Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Am J Pathol (2002) 7.17

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A (2002) 1.73

Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61

Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation. J Leukoc Biol (2012) 1.47

Discrepancies in the regulation of plasma adiponectin and TNF-alpha levels and adipose tissue gene expression in obese African Americans with glucose intolerance: a pilot study using rosiglitazone. Ethn Dis (2005) 1.41

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo. PLoS Pathog (2012) 1.40

Lipopolysaccharide, tumor necrosis factor alpha, or interleukin-1beta triggers reactivation of latent cytomegalovirus in immunocompetent mice. J Virol (2006) 1.37

Methodological challenges in utilizing miRNAs as circulating biomarkers. J Cell Mol Med (2014) 1.34

Staphylococcus infection-associated glomerulonephritis mimicking IgA nephropathy. Clin J Am Soc Nephrol (2006) 1.26

Rate of decline of the Oriental white-backed vulture population in India estimated from a survey of diclofenac residues in carcasses of ungulates. PLoS One (2007) 1.13

Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis. J Immunol (2012) 1.01

Cytomegalovirus reactivation in critically ill immunocompetent hosts: a decade of progress and remaining challenges. Antiviral Res (2011) 1.00

Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res (2013) 0.99

Dual analysis of the murine cytomegalovirus and host cell transcriptomes reveal new aspects of the virus-host cell interface. PLoS Pathog (2013) 0.99

Use of C4d as a diagnostic adjunct in lung allograft biopsies. Am J Transplant (2003) 0.97

A comparison of outcomes between open and laparoscopic surgical repair of recurrent inguinal hernias. Surg Endosc (2011) 0.97

Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. Cancer Res (2012) 0.96

The association between Chance fractures and intra-abdominal injuries revisited: a multicenter review. Am Surg (2005) 0.96

PCR assay detects Mannheimia haemolytica in culture-negative pneumonic lung tissues of bighorn sheep (Ovis canadensis) from outbreaks in the western USA, 2009-2010. J Wildl Dis (2013) 0.95

A role for cytoplasmic PML in cellular resistance to viral infection. PLoS One (2008) 0.94

Human cytomegalovirus regulates bioactive sphingolipids. J Biol Chem (2008) 0.93

Temporal profiling of the coding and noncoding murine cytomegalovirus transcriptomes. J Virol (2011) 0.93

Elephants in academic medicine. Acad Med (2011) 0.91

Antiviral prevention of sepsis induced cytomegalovirus reactivation in immunocompetent mice. Antiviral Res (2009) 0.91

High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. J Med Chem (2003) 0.90

Pain and wound healing in surgical patients. Ann Behav Med (2006) 0.88

IL-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis. J Immunol (2004) 0.87

Do deans and teaching hospital CEOs agree on what it takes to be a successful clinical department chair? Acad Med (2011) 0.87

Rock stars in academic medicine. Acad Med (2010) 0.85

CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection. Viral Immunol (2009) 0.85

Widespread evidence of viral miRNAs targeting host pathways. BMC Bioinformatics (2013) 0.85

A flow cytometry-based method for detecting antibody responses to murine cytomegalovirus infection. J Virol Methods (2007) 0.81

Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma. Cutis (2008) 0.80

Terbinafine-induced dermatomyositis: a case report and literature review of drug-induced dermatomyositis. J Cutan Pathol (2008) 0.80

15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death. Kidney Int (2002) 0.78

Cutaneous sarcomatoid B-cell lymphoma. Am J Dermatopathol (2007) 0.77

Lack of added predictive value of portable chest radiography in diagnosing ventilator-associated pulmonary infection. Surg Infect (Larchmt) (2014) 0.77

N-acyl-L-phenylalanine derivatives as potent VLA-4 antagonists that mimic a cyclic peptide conformation. Bioorg Med Chem Lett (2002) 0.77

Bispectral index values, sedation-agitation scores, and plasma Lorazepam concentrations in critically ill surgical patients. Am J Crit Care (2012) 0.75