Published in Oncogene on August 13, 2007
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. Cancer Metastasis Rev (2008) 2.06
Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res (2010) 1.37
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. J Biol Chem (2010) 1.34
RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells. Breast Cancer Res (2010) 1.25
Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J (2009) 1.22
Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents. Proc Natl Acad Sci U S A (2011) 0.95
Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. Oncotarget (2016) 0.89
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). Biochemistry (2011) 0.89
Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer. Mol Cancer Ther (2012) 0.88
Retinoblastoma loss modulates DNA damage response favoring tumor progression. PLoS One (2008) 0.88
WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Oncogene (2016) 0.87
MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle (2014) 0.86
EAPP: gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest. Oncogene (2011) 0.85
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation. J Biol Chem (2010) 0.85
From integrative genomics to therapeutic targets. Cancer Res (2013) 0.83
Phosphatases reverse p53-mediated cell cycle checkpoints. Proc Natl Acad Sci U S A (2014) 0.83
Genetic characterization of breast cancer and implications for clinical management. J Cell Mol Med (2009) 0.81
HDM2 promotes WIP1-mediated medulloblastoma growth. Neuro Oncol (2012) 0.81
Wip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signaling. Oncotarget (2016) 0.79
PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. Oncogene (2015) 0.78
Absence of Wip1 partially rescues Atm deficiency phenotypes in mice. Oncogene (2011) 0.78
Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions. Cell Cycle (2011) 0.76
Chemical biologists gather in Heidelberg. Nat Chem Biol (2009) 0.75
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell (1997) 15.96
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23
floricaula: a homeotic gene required for flower development in antirrhinum majus. Cell (1990) 6.52
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol (2000) 6.40
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell (1992) 6.26
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science (1995) 6.03
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A (1999) 5.78
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol (1997) 5.66
Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial. Med J Aust (1999) 5.40
Context, composition and heterogeneity: using multilevel models in health research. Soc Sci Med (1998) 5.35
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03
A molecular technique for identification of bacteria using small subunit ribosomal RNA sequences. Biotechniques (1994) 4.73
Effect of community-based peer counsellors on exclusive breastfeeding practices in Dhaka, Bangladesh: a randomised controlled trial [see commments]. Lancet (2000) 4.67
MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology (2002) 4.67
Controlled trial of three approaches to the treatment of severe malnutrition. Lancet (1995) 4.59
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell (2000) 4.53
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A (2000) 3.95
BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene (2006) 3.91
Pathological changes in virus infections of the lower respiratory tract in children. J Clin Pathol (1970) 3.83
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. J Med Chem (1995) 3.72
Preclinical prediction of AD using neuropsychological tests. J Int Neuropsychol Soc (2001) 3.62
Preclinical prediction of Alzheimer's disease using SPECT. Neurology (1998) 3.60
Neural activity relating to generation and representation of galvanic skin conductance responses: a functional magnetic resonance imaging study. J Neurosci (2000) 3.49
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature (1991) 3.43
"White coat" versus "sustained" borderline hypertension in Tecumseh, Michigan. Hypertension (1990) 3.30
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene (2006) 3.27
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J (2001) 3.21
DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst (1999) 3.07
COPD prevalence in a random population survey: a matter of definition. Eur Respir J (2007) 2.97
Asthma care in general practice--time for revolution? Br J Gen Pract (1991) 2.93
BRCA2 mutations in primary breast and ovarian cancers. Nat Genet (1996) 2.91
The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations. Br J Cancer (2005) 2.85
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf. Methods Enzymol (1995) 2.82
Smoking and deprivation: are there neighbourhood effects? Soc Sci Med (1999) 2.79
Xist has properties of the X-chromosome inactivation centre. Nature (1997) 2.78
Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth (2000) 2.75
Measurement of systemic oxygen uptake during low-flow anaesthesia with a standard technique vs. a novel method. Anaesthesia (2002) 2.73
Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev Dyn (2005) 2.71
The primary health care non-team. BMJ (1994) 2.66
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood (1999) 2.65
A comparison of reinforcer assessment methods: the utility of verbal and pictorial choice procedures. J Appl Behav Anal (1996) 2.63
Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol Aging (1995) 2.62
Health-related behaviour in context: a multilevel modelling approach. Soc Sci Med (1996) 2.57
An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. EMBO J (1992) 2.56
Insulin coma therapy in schizophrenia. J R Soc Med (2000) 2.49
Integrating pharmacy fully into the primary care team. BMJ (1995) 2.47
Oral contraceptives and breast cancer. Progress report of an epidemiological study. Lancet (1975) 2.46
Response inhibition and impulsivity: an fMRI study. Neuropsychologia (2003) 2.45
Brown adipose tissue and heat production in the newborn infant. J Pathol Bacteriol (1966) 2.43
Isolation and sequence of a human cytochrome P-450 cDNA clone. Proc Natl Acad Sci U S A (1985) 2.42
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet (1997) 2.41
Understanding the Italian Experience. Br J Psychiatry (1985) 2.41
Basal-like breast carcinomas: clinical outcome and response to chemotherapy. J Clin Pathol (2006) 2.40
Why have mortality rates for severe malnutrition remained so high? Bull World Health Organ (1996) 2.39
Molecular technique for rapid identification of mycobacteria. J Clin Microbiol (1996) 2.37
Distinct clinical phenotypes of airways disease defined by cluster analysis. Eur Respir J (2009) 2.37
Rapid construction of large synthetic genes: total chemical synthesis of two different versions of the bovine prochymosin gene. Gene (1987) 2.36
The influence of vector behavior on malaria transmission. Am J Trop Med Hyg (1972) 2.34
Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Mol Ther (2000) 2.34
Genetic diversity of Campylobacter jejuni isolates from farm animals and the farm environment. Appl Environ Microbiol (2003) 2.32
Quantitative aspects of placental structure. J Pathol Bacteriol (1966) 2.30
Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation. Cell (1993) 2.30
Do places matter? A multi-level analysis of regional variations in health-related behaviour in Britain. Soc Sci Med (1993) 2.30
A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res (1992) 2.26
Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. J Natl Cancer Inst (1996) 2.20
Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr Biol (1999) 2.17
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. J Biol Chem (1997) 2.15
Cleft lip with or without cleft palate: associations with transforming growth factor alpha and retinoic acid receptor loci. Am J Hum Genet (1992) 2.12
Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. Oncogene (2010) 2.11
TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J Exp Med (2000) 2.10
Proportional classifications of COPD phenotypes. Thorax (2008) 2.10
Asthma--still a challenge for general practice. J R Coll Gen Pract (1989) 2.08
Isolation of vero cytotoxin-producing Escherichia coli O157 from wild birds. J Appl Microbiol (1997) 2.08
Estimation of the hypoxic cell-sensitiser misonidazole and its O-demethylated metabolite in biological materials by reversed-phase high-performance liquid chromatography. J Chromatogr (1978) 2.08
A double-blind comparison of quinine sulphate and placebo in muscle cramps. Age Ageing (1983) 2.07
The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med (1998) 2.04
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. J Biol Chem (1996) 2.04
Properties and composition of the isolated ribosomal DNA satellite of Xenopus laevis. Nature (1968) 2.04
Measuring hygiene practices: a comparison of questionnaires with direct observations in rural Zaïre. Trop Med Int Health (1997) 1.99
Quality of life measured by the St George's Respiratory Questionnaire and spirometry. Eur Respir J (2009) 1.99
Further evidence for an association between genetic variation in transforming growth factor alpha and cleft lip and palate. Am J Hum Genet (1991) 1.98
The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med (1998) 1.91
Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Curr Biol (1994) 1.87
Cattle and sheep farms as reservoirs of Campylobacter. J Appl Microbiol (2003) 1.86
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res (2001) 1.86
Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science (1985) 1.85
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors. Int J Radiat Oncol Biol Phys (1994) 1.84
A new route to spirooxindoles. Org Lett (2000) 1.84
Predicting small-area health-related behaviour: a comparison of smoking and drinking indicators. Soc Sci Med (2000) 1.82
Interpretation of trauma radiographs by junior doctors in accident and emergency departments: a cause for concern? J Accid Emerg Med (1997) 1.81
Vacuum blotting enhances nucleic acid transfer. Trends Genet (1988) 1.80
The rapid resolution of naturally occurring amino acids by thin-layer chromatography. J Chromatogr (1966) 1.78
DT-diaphorase and cancer chemotherapy. Biochem Pharmacol (1992) 1.78
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. Mol Cell Biol (1999) 1.77
The characteristics of ferritin from human tissues, serum and blood cells. Clin Sci Mol Med (1975) 1.75
Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles. Neurology (1997) 1.75
Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development? J Natl Cancer Inst (1999) 1.70